Ultrastructural abnormalities of astrocytes in the hippocampus in schizophrenia and duration of illness: A postortem morphometric study

References

• Amenta F, Bronzetti E, Sabbatini M, Vega JA. Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study. Microsc Res Tech 1998; 43: 29–33
   PubMedGoogle Scholar
• Arnold SE, Franz BR, Gur RC, Gur RE, Shapiro RM, Moberg PJ, et al. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry 1995; 152: 738–748
   PubMed Web of Science ®Google Scholar
• Arnold SE, Franz BR, Trojanowski JQ, Moberg PJ, Gur RE. Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia. Acta Neuropathol (Berlin) 1996; 91: 269–277
   PubMedGoogle Scholar
• Balijepalli S, Kenchappa RS, Boyd MR, Ravindranath V. Protein thiol oxidation by haloperidol results in inhibition of mitochondrial complex I in brain regions: comparison with atypical antipsychotics. Neurochem Int 2001; 38: 425–435
   PubMed Web of Science ®Google Scholar
• Bendikov I, Nadri C, Amar S, Panizzutti R, De Miranda J, Wolosker H, et al. A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia. Schizophr Res 2007; 90: 41–51
   PubMed Web of Science ®Google Scholar
• Benes FM, Sorensen I, Bird ED. Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr Bull 1991; 17: 597–608
   PubMed Web of Science ®Google Scholar
• Benes FM, Todtenkopf MS, Kostoulacos P. GluR5,6,7 subunit immune-reactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic-depressives. Hippocampus 2001; 11: 482–491
   PubMed Web of Science ®Google Scholar
• Cavalier L, Jazin E, Eriksson I, Prince J, Båve B, Oreland L, Gyllensten U. Decreased cytochrome-c oxidase activity and lack of age related accumulation of mtDNA in the brains of schizophrenics. Genomics 1995; 29: 217–228
   PubMedGoogle Scholar
• Chakos MH, Schobel SA, Gu H, Gerig G, Bradford D, Charles C, et al. Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatr 2005; 186: 26–31
   PubMed Web of Science ®Google Scholar
• Chambers JS, Thomas D, Saland L, Neve RL, Perrone-Bizzozero NI. Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia. Prog Neuropsychopharm Biol Psychiatry 2005; 29: 283–290
   PubMed Web of Science ®Google Scholar
• Cotter D, Kerwin R, Doshi B, Martin CS, Everall IP. Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia. Brain Res 1997; 765: 238–246
   PubMed Web of Science ®Google Scholar
• Cotter DR, Pariante CM, Everall IP. Glial cell abnormalities in major psychiatric disoders: The evidence and implications. Brain Res Bull 2001; 55: 585–595
   PubMed Web of Science ®Google Scholar
• Coyle JT, Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacol (Berlin) 2004; 174: 32–38
   PubMedGoogle Scholar
• Davis JM. Dose equivalent of the antipsychotic drugs. J Psychiatr Res 1974; 11: 65–69
   PubMed Web of Science ®Google Scholar
• Deloncle R, Huguet F, Fernandez B, Quellard N, Babin P, Guillard O. Ultrastructural study of rat hippocampus after chronic administration of aluminum L-glutamate: an acceleration of the aging process. Exp Gerontol 2001; 36: 231–244
   PubMed Web of Science ®Google Scholar
• Eastwood SL, Harrison PJ. Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections. Neuroscience 1999; 93: 99–106
   PubMed Web of Science ®Google Scholar
• Ghose S, Weickert CS, Colvin SM, Coyle JT, Herman MM, Hyde TM, et al. Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia. Neuropsychopharmacology 2004; 29: 117–125
   PubMed Web of Science ®Google Scholar
• Gothelf D, Soreni N, Nachman RP, Tyano S, Hiss Y, Reiner O, et al. Evidence for the involvement of the hippocampus in the pathophysiology of schizophrenia. Eur Neuropsychopharmacol 2000; 10: 389–395
   PubMedGoogle Scholar
• Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcusen N, et al. The new stereological tools: Dissector, fractionator, nucleator point sampled intercepts and their use in pathological research and diagnosis. Acta Pathol Microbiol Immunol Scand 1988; 96: 857–881
   PubMedGoogle Scholar
• Hansson E, Rönnbäck L. Glial neuronal signaling in the central nervous system. FASEB J 2003; 17: 341–348
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Eastwood SL. Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 2001; 11: 508–519
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Law AJ, Eastwood SL. Glutamate receptors and transporters in the hippocampus in schizophrenia. Ann NY Acad Sci 2003; 1003: 94–101
   PubMedGoogle Scholar
• Haydon PG, Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 2006; 86: 1009–1031
   PubMed Web of Science ®Google Scholar
• Hovard CV, Reed MG. Unbiased stereology. Three-dimensional measurement in microscopy. Springer, New York 1998
   Google Scholar
• Johnston-Wilson NL, Sims CD, Hofmann JP, Anderson L, Shore AD, Torrey EF, et al. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol Psychiatry 2000; 5: 142–149
   PubMed Web of Science ®Google Scholar
• Inuwa IM, Peet M, Williams MA. QSAR modeling and transmission electron microscopy stereology of altered mitochondrial ultrastructure of white blood cells in patients diagnosed as schizophrenic and treated with antipsychotic drugs. Biotech Histochem 2005; 80: 133–137
   PubMed Web of Science ®Google Scholar
• Iwamoto K, Bundo M, Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Gen 2005; 14: 241–253
   PubMed Web of Science ®Google Scholar
• Karry R, Klein E, Ben Shachar D. Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study. Biol. Psychiatry 2004; 55: 676–684
   PubMed Web of Science ®Google Scholar
• Kung L, Roberts RC. Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study. Synapse 1999; 31: 67–75
   PubMed Web of Science ®Google Scholar
• Kettenmann H, Ransom BR. Neuroglia2nd ed. Oxford University Press, Oxford 2005
   Google Scholar
• Koehler RC, Gebremedhin D, Harder DR. Role of astrocytes in cerebrovascular regulation. J Appl Physiol 2006; 100: 307–317
   PubMed Web of Science ®Google Scholar
• Kolomeets NS, Orlovskaya DD, Rachmanova VI, Uranova NA. Ultrastructural alterations in hippocampal mossy fiber synapses in schizophrenia (a postmortem morphometric study). Synapse 2005; 57: 47–55
   PubMed Web of Science ®Google Scholar
• Kolomeets NS, Orlovskaya DD, Uranova NA. Decreased numerical density of ca3 hippocampal mossy fiber synapses in schizophrenia. Synapse 2007; 61: 615–621
   PubMedGoogle Scholar
• Kondziella D, Brenner E, Eyjolfsson EM, Markinhuhta KR, Carlsson ML, Sonnewald U. Glial neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology 2006; 31: 1880–1887
   PubMedGoogle Scholar
• Lalo U, Pankratov Y, Kirchhoff F, North RA, Verkhratsky A. NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes. J Neurosci 2006; 26: 2673–2683
   PubMed Web of Science ®Google Scholar
• Magistretti PJ, Pellerin L. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Phil Trans R Soc London B 1999; 354: 1155–1163
   PubMedGoogle Scholar
• Medoff DR, Holbomb HH, Lahti AC, Tamminga CA. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus 2001; 11: 543–550
   PubMed Web of Science ®Google Scholar
• Ohtani R, Kawashima S. Reduction of lipofuscin by centrophenoxine and chlorpromazine in the neurons of rat cerebral hemisphere in primary culture. Exp Gerontol 1983; 18: 105–112
   PubMedGoogle Scholar
• Peng TI, Greenamyre JT. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors. Mol Pharmacol 1998; 53: 974–980
   PubMedGoogle Scholar
• Pilegaard K, Ladefoged O. Total number of astrocytes in the molecular layer of the dentate gyrus of rats at different ages. Anal Quant Cytol Histol 1996; 18: 279–285
   PubMedGoogle Scholar
• Prince JA, Yassin MS, Oreland L. Neuroleptic-induced mitochondrial enzyme alterations in the rat brain. J Pharmacol Exp Ther 1997a; 280: 261–267
   PubMedGoogle Scholar
• Prince JA, Yassin MS, Oreland L. Normalization of cytochrome-c oxidase activity in the rat brain by neuroleptics after chronic treatment with PCP or methamphetamine. Neuropharmacology 1997b; 36: 1665–1678
   PubMedGoogle Scholar
• Rey M, Schulz P, Costa C, Dick P, Tissot R. Guidelines for the dosage of neuroleptics. 1: Chlorpromazine equivalents of orally administered neuroleptics. Int Clin Psychopharmacol 1989; 4: 95–104
   PubMed Web of Science ®Google Scholar
• Roberts GW, Colter N, Lofthouse R, Bogerts B, Zech M, Crow TJ. Gliosis in schizophrenia: a survey. Biol Psychiatry 1986; 21: 1043–1050
   PubMedGoogle Scholar
• Roberts GW, Colter N, Lofthouse R, Johnstone EC, Crow TJ. Is there gliosis in schizophrenia? Investigation of the temporal lobe. Biol Psychiatry 1987; 22: 1459–1468
   PubMed Web of Science ®Google Scholar
• Rosene DL, Van Hoesen GW. The hippocampal formation of the primate brain. Cerebral cortex, A Peters, EG Jones. Plenum Press, New York 1987; 345–456
   Google Scholar
• Rosoklija G, Toomayan G, Ellis SP, Keilp J, Mann JJ, Latov N, et al. Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings. Arch Gen Psychiatry 2000; 57: 349–356
   PubMed Web of Science ®Google Scholar
• Rothermundt M, Falkai P, Ponath G, Abel S, Burkle H, Diedrich M, et al. Glial cell dysfunction in schizophrenia indicated by increased S100B in the CSF. Mol Psychiatry 2004a; 9: 897–899
   PubMed Web of Science ®Google Scholar
• Rothermundt M, Ponath G, Glaser T, Hetzel G, Arolt V. S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia. Neuropsychopharmacology 2004b; 29: 1004–1011
   PubMed Web of Science ®Google Scholar
• Roy D, Pathak DN, Singh R. Effects of chlorpromazine on the activities of antioxidant enzymes and lipid peroxidation in the various regions of aging rat brain. J Neurochem 1984; 42: 628–633
   PubMed Web of Science ®Google Scholar
• Schroeter ML, Abdul-Khaliq H, Fruhauf S, Hohne R, Schick G, Diefenbacher A, et al. Serum S100B is increased during early treatment with antipsychotics and in deficit schizophrenia. Schizophr Res 2003; 62: 231–236
   PubMed Web of Science ®Google Scholar
• Smith SJ. Glia help synapses form and function. Curr Biol 1998; 8: R158–160
   Google Scholar
• Steffek AE, Haroutunian V, Meador-Woodruff JH. Serine racemase protein expression in cortex and hippocampus in schizophrenia. Neuroreport 2006; 17: 1181–1185
   PubMedGoogle Scholar
• Streck EL, Rezin GT, Barbosa LM, Assis LC, Grandi E, Quevedo J. Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain. Naunyn Schmiedebergs Arch Pharmacol 2007; 376: 127–133
   PubMedGoogle Scholar
• Sweatt JD. Hippocampal function in cognition. Psychopharmacology (Berlin) 2004; 174: 99–110
   PubMed Web of Science ®Google Scholar
• Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, et al. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry 1992; 49: 522–530
   PubMed Web of Science ®Google Scholar
• Tamminga CA. The neurobiology of cognition in schizophrenia. J Clin Psychiatry 2006; 67: e11
   Google Scholar
• Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry 1995; 52: 829–836
   PubMed Web of Science ®Google Scholar
• Uranova NA, Casanova MF, DeVaughn NM, Orlovskaya DD, Denisov DV. Ultrastructural alterations of synaptic contacts and astrocytes in postmortem caudate nucleus of schizophrenic patients. Letter to the Editor. Schizophr Res 1996; 22: 81–83
   PubMed Web of Science ®Google Scholar
• Uranova N, Orlovskaya D, Vikhreva O, Zimina I, Kolomeets N, Vostrikov V, Rachmanova V. Electron microscopy of oligodendroglia in severe mental illness. Brain Res Bull 2001; 55: 597–610
   PubMed Web of Science ®Google Scholar
• Uranova N, Bonartsev P, Brusov O, Morozova M, Rachmanova V, Orlovskaya D. The ultrastructure of lymphocytes in schizophrenia. World J Biol Psychiatry 2007; 8: 30–37
   PubMed Web of Science ®Google Scholar
• Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 2006; 63: 139–149
   PubMed Web of Science ®Google Scholar
• Webster MJ, O'Grady J, Kleinman JE, Weickert CS. Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 2005; 133: 453–461
   PubMed Web of Science ®Google Scholar
• Weinberger DR. Cell biology of the hippocampal formation in schizophrenia. Biol Psychiatry 1999; 45: 395–402
   PubMed Web of Science ®Google Scholar
• Weis S, Llenos IC, Dulay JR, Verma N, Sabunciyan S, Yolken RH. Changes in region- and cell type-specific expression patterns of neutral amino acid transporter 1 (ASCT-1) in the anterior cingulate cortex and hippocampus in schizophrenia, bipolar disorder and major depression. J Neural Transm 2007; 114: 261–271
   PubMedGoogle Scholar