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Brief Reports

Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

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Pages 985-990 | Received 25 Jan 2010, Accepted 28 Jun 2010, Published online: 07 Sep 2010

References

  • Arias B, Serrreti A, Mandelli L, Gasto C, Catalan R, Ronchi DD, Fanasas L. 2009. Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors. Pharmacogenet Genomics 19:121–128.
  • Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ. 2001. Dysbindin, a novel coiled-coil-containing protein interacts with the dystrobrevins in muscle and brain. J Biol Chem 276:24232–24241.
  • Bray NJ, Preece A, Williams NM, Moskvina M, Buckland PR, Owen MJ, O'Donovan MC. 2005. Haplotypes at the dystrobrevin binding protein 1 gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet 14:1947–1954.
  • DeRosse P, Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, . 2006. Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry 63:532–534.
  • Fallgatter AJ, Herrmann MJ, Hohoff C, Ehlis AC, Jarczok TA, Freitag CM, Deckert J. 2006. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals. Neuropsychopharmacology 31:2002–2010.
  • Gaysina D, Cohen-Woods S, Chow PC, Martucci L, Schosser A, Ball HA, . 2009. Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study. Am J Med Genet B Neuropsychiatr Genet 150:836–844.
  • Guo AY, Sun J, Riley BP, Thiselton DL, Kendler KS, Zhao Z. 2009. The dystrobrevin binding protein 1 gene: features and networks. Mol Psychiatry 14:18–29.
  • Harrison PJ, Weinberger DR. 2005. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40–68.
  • Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, . 2008. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in DTNBP1: a susceptibility gene for schizophrenia. Biochem Biophys Res Commun 373:298–302.
  • Kim JJ, Mandelli L, Pae CU, Ronchi DD, Jun TY, Lee C, . 2008. Is there a protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 32:375–379.
  • Levinson DF. 2006. The genetics of depression: a review. Biol Psychiatry 60:84–92.
  • Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, . 2003. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nature Genet 35:84–89.
  • Li D, He L. 2007. Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: A meta analysis. Schizophr Res 96:112–118.
  • Pae CU, Serretti A, Mandelli L, Ronchi DD, Patkar AA, Jun TY, . 2007. Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy. Pharmacogenet Genomics 17:69–75.
  • Pae CU, Ronchi DD, Mandelli L, Patkar AA, Jun TY, Serretti A. 2009. Dysbindin gene (DTNBP1) and schizophrenia in Korean population. Eur Arch Psychiatry Clin Neurosci 259:137–142.
  • Riley B, Kuo PH, Maher BS, Fanous AH, Sun J, Wormley B, . 2009. The dystrobrevin binding protein 1 gene (DTNBP1) is associated with schizophrenia in the Irish case Control Study of Schizophrenia (ICCSS) sample. Schizophr Res 115:245–253.
  • Souery D, Oswald P, Massat I, Bailer U, Bollen J, Demyttenaere K, . 2007. Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study. J Clin Psychiatry 68:1062–1070.
  • Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, . 2002. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 71:337–348.
  • Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, . 2004 . Human Dysbindin gene (DTNBP1) expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 6:544–555.
  • Wessman J, Paunio T, Tuulio-Henriksson A, Koivisto M, Partonen T, Suvisaari J, . 2009. Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biol Psychiatry 66:990–996.
  • Wirgenes KV, Djurovic S, Agartz I, Jonsson EG, Werge T, Melle I, Andreassen OA. 2009. Dysbindin and D-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. Neuropsychobiology 60:31–36.
  • Wray NR, James MR, Handoko HY, Dumenil T, Lind PA, Montgomery GW, Martin NG. 2008. Association study of candidate variants from a brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety and depression. Psychiatr Genet 18:219–225.
  • Yagasaki Y, Numakawa T, Kumamaru E, Hayashi T, Su TP, Kunugi H. 2006. Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor induced signaling for glutamate release. J Biol Chem 281: 12941–12949.
  • Zill P, Baghai TC, Engel R, Zwanzger P, Schule C, Eser D, . 2004.The dysbindin gene in major depression: An association study. Am J Med Genet B Neuropsychiatr Genet 129:55–58.

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