Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review

References

• Altman J, Das GD. 1965. Post-natal origin of microneurones in the rat brain. Nature 207:953–956.
   PubMed Web of Science ®Google Scholar
• Amico F, Meisenzahl E, Koutsouleris N, Reiser M, Möller HJ, Frodl T. 2011. Structural MRI correlates for vulnerability and resilience to major depressive disorder. J Psychiatry Neurosci 36:15 22.
   PubMed Web of Science ®Google Scholar
• Anacker C, Zunszain PA, Carvalho LA, Pariante CM. 2011a. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinol 36:415 425.
   PubMed Web of Science ®Google Scholar
• Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, . 2011b. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiat 16:738 750.
   PubMed Web of Science ®Google Scholar
• Angevaren M, Aufdemkampe G, Vergaar HJ, Aleman A, Vanhees L. 2008. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev (3): CD005381.
   Google Scholar
• Anisman H, Ravindram AV, Griffiths J, Merali Z. 1999. IL-1 beta production in dysthymia after pharmacotherapy. Biol Psychiatry 46:1649–1655.
   PubMed Web of Science ®Google Scholar
• Balu DT. 2010. Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments. Exp Clin Psychopharmacol 18:71–77.
   Google Scholar
• Barsegyan A, Mackenzie SM, Kurose BD, McGaugh JL, Roozendaal B. 2010. Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism. Proc Natl Acad Sci USA 107:16655–16660.
   PubMed Web of Science ®Google Scholar
• Becker S, Wojtowicz JM. 2007. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn Sci 11: 70–76.
   PubMed Web of Science ®Google Scholar
• Bednarczyk MR, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJL. 2011. Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment. Hippocampus 21:1334 1347.
   Google Scholar
• Belanger M, Magistretti PJ. 2010. The role of astroglia in neuroprotection. Dialog Clin Neurosci 11:281–296.
   Google Scholar
• Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, . 2009. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiat 14:764–773.
   PubMed Web of Science ®Google Scholar
• Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, . 2011. Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci 31:4906–4916.
   Google Scholar
• Boku S, Nakagawa S, Koyama T. 2010. Glucocorticoids and lithium in adult hippocampal neurogenesis. Vitam Horm 82:421–431.
   Google Scholar
• Boku S, Nakagawa S, Masuda T, Nishikawa H, Kato A, Toda H, . 2011. Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells. Prog Neuropsychopharmacol Biol Psychiatr 35:111 117.
   Google Scholar
• Boldrini M, Arango V. 2010. Antidepressants, age, and neuroprogenitors. Neuropsychopharmacol Rev 35:351–352.
   Google Scholar
• Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. 2009. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34:2376–2389.
   PubMed Web of Science ®Google Scholar
• Bossini L, Tavanti M, Lombardelli A, Calossi S, Polizzotto NR, Galli R, . 2007. Changes in hippocampal volume in patients with post-traumatic stress disorder after sertraline treatment. J Clin Psychopharmacol 27:233–235.
   Google Scholar
• Chen H, Pandey GN, Dwivedi Y. 2006. Hippocampal cell proliferation regulation by repeated stress and antidepressants. Neuroreport 17:863–867.
   PubMed Web of Science ®Google Scholar
• Connor TJ, Leonard BE. 1998. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci 62:583–606.
   PubMed Web of Science ®Google Scholar
• Cowen DS, Takase LF, Fornal CA, Jacobs BL. 2008. Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetine. Brain Res 1228:14–19.
   PubMed Web of Science ®Google Scholar
• Crupi R, Mazzon E, Marino A, La Spada G, Bramanti P, Cuzzocrea S, Spina E. 2010. Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice. J Pineal Res 49:123–129.
   PubMed Web of Science ®Google Scholar
• DeCarolis NA, Eisch AJ. 2010. Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation. Neuropharmacology 58:884–893.
   PubMed Web of Science ®Google Scholar
• Delaloye C, de Bilbao F, Moy G, Baudois S, Weber K, Campos L, . 2009. Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder. Am J Geriatr Psychiatry 17:1012–1021.
   Google Scholar
• Deng W, Aimone JB, Gage FH. 2010. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nature Rev Neurosci 11:339–350.
   PubMed Web of Science ®Google Scholar
• Döbrössy MD, Drapeau E, Aurousseau C, Le Moal M, Piazza PV, Abrous DN. 2003. Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date. Mol Psychiatry 8:974–982.
   Google Scholar
• Drew MR, Hen R. 2007. Adult hippocampal neurogenesis as target for the treatment of depression. CNS Neurol Disord Drug Targets 6:205–218.
   PubMedGoogle Scholar
• Drzyzga ŁR, Marcinowska A, Obuchowicz E. 2009. Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies. Brain Res Bull 79:248–257.
   PubMed Web of Science ®Google Scholar
• Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, . 2008. The role of hippocampal Glu-1-Glu-2 receptors in manic-like behavior. J Neurosci 28:68–79.
   PubMed Web of Science ®Google Scholar
• Duman RS. 2004. Depression: a case of neuronal life and death? Biol Psychiatry 56:140–145.
   PubMed Web of Science ®Google Scholar
• Duman R, Monteggia LM. 2006. A neurotrophic model for stress related mood disorders. Biol Psychiatry 59:1116–1127.
   PubMed Web of Science ®Google Scholar
• Dupret D, Fabre A, Döbrössy MD, Panatier A, Rodríguez JJ, nLamarque S, . 2007. Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol 5(8):e214.
   Google Scholar
• Ebdrup BH, Glenthøj B, Rasmussen H, Aggernaes B, Langkilde AR, Paulson OB, . 2010. Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia. J Psychiatry Neurosci 35:95–104.
   PubMed Web of Science ®Google Scholar
• Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming GL, Overstreet-Wadiche LS. 2008. Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci 28: 11785–11791.
   Google Scholar
• Elder GA, De Gasperi R, Gama Sosa MA. 2006. Research update: neurogenesis in adult brain and neuropsychiatric disorders. Mt Sinai J Med 73:931–940.
   PubMed Web of Science ®Google Scholar
• Epp JR, Scott NA, Galea LA. 2011. Strain differences in neurogenesis and activation of new neurons in the dentate gyrus in response to spatial learning. Neurosci 172:342 354.
   PubMed Web of Science ®Google Scholar
• Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. 1998. Neurogenesis in the adult human hippocampus. Nature Med 4:1313–1317.
   PubMed Web of Science ®Google Scholar
• Farina C, Alois F, Meini E. 2007. Astrocytes are active players in cerebral innate immunity. Trends Immunol 28:138–145.
   PubMed Web of Science ®Google Scholar
• Fasano C, Poirier A, DesGroseillers L, Trudeau LE. 2008. Chronic activation of the D2 dopamine autoreceptor inhibits synaptogenesis in mesencephalic dopaminergic neurons in vitro. Eur J Neurosci 28:1480–1490.
   Google Scholar
• Gould E. 2007. How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 8:481–488.
   PubMedGoogle Scholar
• Gruber O, Tost H, Henseler I, Schmael C, Scherk H, Ende G, . 2010. Pathological amygdala activation during working memory performance: evidence for a pathophysiological trait marker in bipolar affective disorder. Human Brain Mapp 31:115–125.
   Google Scholar
• Gruber O, Zilles D, Kennel J, Gruber E, Falkai P. 2011. A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression. Eur Arch Psychiatry Clin Neurosci 261:179 184.
   Google Scholar
• Hajisoltani R, Rashidy-Pour A, Vafaei AA, Ghaderdoost B, Bandegi AR, Motamedi F. 2011. The glucocorticoid system is required for the voluntary exercise-induced enhancement of learning and memory in rats. Behav Brain Res 219:75–81.
   Google Scholar
• Hoffman BM, Blumenthal JA, Babyak MA, Smith PJ, Rogers SD, Doraiswamy PM, Sherwood A. 2008. Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med Sci Sports Exerc 40:1344–1352.
   PubMed Web of Science ®Google Scholar
• Hoffman BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, Blumenthal JA. 2011. Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med 73: 127–133.
   PubMed Web of Science ®Google Scholar
• Holick KA, Lee DC, Hen R, Dulawa SC. 2008. Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor. Neuropsychopharmacology 33:406–417.
   PubMed Web of Science ®Google Scholar
• Huang GJ, Bannerman D, Flint J. 2008. Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice. Mol Psychiatry 13:119–121.
   PubMed Web of Science ®Google Scholar
• Jaholkowski P, Kiryk A, Jedynak P, Ben Abdallah NM, Knapska E, Kowalczyk A, . 2009. New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning. Learn Mem 16:439–451.
   Google Scholar
• Kee N, Teixeira CM, Wang AH, Frankland PW. 2007. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neurosci 10:355–362.
   PubMed Web of Science ®Google Scholar
• Kempermann G. 2011. Adult neurogenesis 2: Stem cells and neuronal development in the adult brain. New York, NY: Oxford University Press.
   Google Scholar
• Kempermann G, Kronenberg G. 2003. Depressed new neurons – adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 54:499–503.
   PubMed Web of Science ®Google Scholar
• Kempermann G, Krebs J, Fabel K. 2008. The contribution of failing adult hippocampal neurogenesis to psychiatric disorders. Curr Opin Psychiatry 21:290–295.
   PubMed Web of Science ®Google Scholar
• Kendell ST, Krystal JH, Sana Cora G. 2005. Gaba and glutamate systems on therapeutic targets of depression and mood disorders. Expert Opin Ther Targets 9:153–168.
   PubMed Web of Science ®Google Scholar
• Kenis G, Maes M. 2002. Effects of antidepressants on the production of cytokines. Int J Neuropsychopharmacol 5:401–412.
   PubMed Web of Science ®Google Scholar
• Kennedy DP, Redcay E, Courchesne E. 2006. Failing to deactivate: resting functional abnormalities in autism. Proc Natl Acad Sci USA 103:8275–8280.
   PubMed Web of Science ®Google Scholar
• Khairova RA, Machado-Vierira R, Du J, Manji HK. 2009. A potential role for proinflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 12:561–578.
   PubMed Web of Science ®Google Scholar
• Klaus F, Amrein I. 2011. Running in laboratory and wild rodents: Differences in context sensitivity and plasticity of hippocampal neurogenesis. Behav Brain Res 2011 [Epub ahead of print] (doi:10.1016/j.bbr.2011.04.027).
   Google Scholar
• Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H. 2010. Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proc Natl Acad Sci USA 107:8434–8439.
   PubMed Web of Science ®Google Scholar
• Kohler SJ, Williams NI, Stanton GB, Cameron JL, Greenough WT. 2011. Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proc Natl Acad Sci USA 108:10326–10331.
   PubMed Web of Science ®Google Scholar
• Kornack DR, Rakic P. 2001. Cell proliferation without neurogenesis in adult primate neocortex. Science 294:2127–2130.
   PubMed Web of Science ®Google Scholar
• Krishnan V, Nestler EJ. 2008. The molecular neurobiology of depression. Nature 455:894–902.
   PubMed Web of Science ®Google Scholar
• Kucyi A, Alsuwaidan MT, Liauw SS, McIntyre RS. 2010. Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder. Postgrad Med 122:107–116.
   PubMed Web of Science ®Google Scholar
• Kunugi H, Hori H, Adachi N, Numakawa T. 2010. Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. Psychiatr Clin Neurosci 64:447–459.
   PubMed Web of Science ®Google Scholar
• Lau WM, Qiu G, Helmeste DM, Lee TMC, Tang SW, So KF. 2007. Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine. Restorative Neurol Neurosci 25:17–23.
   Google Scholar
• Lawlor DA, Hopker SW. 2001. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomized controlled trials. Br Med J 322:763–767.
   PubMed Web of Science ®Google Scholar
• Leonard BE. 2007. Inflammation, depression and dementia: are they connected? Neurchem Res 32:1749–1756.
   Google Scholar
• Leonard BE. 2010. The concept of depression as a dysfunction of the immune system. In: Cryan J, Leonard BE, editors. Modern trends in pharmacopsychiatry. vol 27. Basel: Karger. p 53–71.
   Google Scholar
• Leutgeb JK, Moser EI. 2007. Enigmas of the dentate gyrus. Neuron 55:176–178.
   Google Scholar
• Lucassen PJ, Stumpel MW, Wang Q, Aronica E. 2010. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology 58:940–949.
   PubMed Web of Science ®Google Scholar
• Maes M.1999. Major depression and activation of the inflammatory response system. Adv Exp Med Biol 461:25–46.
   PubMed Web of Science ®Google Scholar
• Maes M, Planken VD, Stevens WJ. 1992. Leucocytosis,monocytosis and neutrophilia in severe depression. J Psychiatr Res 26: 125–134.
   PubMed Web of Science ®Google Scholar
• Malberg JE, Duman RS. 2003. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28: 1562–1571.
   PubMed Web of Science ®Google Scholar
• Malberg JE, Eisch AJ, Nestler EJ, Duman RS. 2000. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104–9110.
   PubMed Web of Science ®Google Scholar
• Marlatt MW, Lucassen PJ, van Praag H. 2010. Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Res 1341:93–99.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 1999. Stress and hippocampal plasticity. Annu Rev Neurosci 22:105–122.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2000. The neurobiology of stress: from serendipity to clinical relevance. Brain Res 886:172–189.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2001. Plasticity of the hippocampus: adaptation to chronic stress and allosteric load. Ann NY Acad Sci 933: 265–277.
   PubMed Web of Science ®Google Scholar
• McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, . 2007. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317:94–99.
   PubMed Web of Science ®Google Scholar
• Mead GE, Morley W, Campbell P, Greig CA, McMurdo M, Lawlor DA. 2009. Exercise for depression. Cochrane Database Syst Rev (3):CD004366.
   Google Scholar
• Meitzen J, Thompson CK. 2008. Seasonal-like growth and regression of the avian song control system: neural and behavioral plasticity in adult male Gambel's white-crowned sparrows. Gen Comp Endocrinol 157:259–265.
   Web of Science ®Google Scholar
• Mendlewicz J, Kriwin P, Oswald P, Souery D, Alboni S, Brunello N. 2006. Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study. Int Clin Psychopharmacol 21:227–231.
   PubMed Web of Science ®Google Scholar
• Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L, . 2006. Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9:729–731.
   PubMed Web of Science ®Google Scholar
• Miller BH, Schultz LE, Gulati A, Cameron MD, Pletcher MT. 2008. Genetic regulation of behavioral and neuronal responses to fluoxetine. Neuropsychopharmacology 33:1312–1322.
   PubMed Web of Science ®Google Scholar
• Morgan D. 2007. Amyloid, memory and neurogenesis. Exp Neurol 205:330–335.
   Google Scholar
• Műller N, Schwarz MJ, Dehning S, Douhe A, Cerovecki A, Goldstein-Műller B, . 2006. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 11:680–684.
   PubMed Web of Science ®Google Scholar
• Myint A-M, Leonard BE, Steinbusch H, Kim Y-K. 2005. Th1,Th2,Th3 cytokine alterations in major depression. J Affect Disord 88:167–173.
   PubMed Web of Science ®Google Scholar
• Myint A-M, Kim Y-K, Verkerk R, Scharpé S, Steinbusch H, Leonard B. 2007. Kynurenine pathway in major depression:evidence of impaired neuroprotection. J Affect Disord 98:143–151.
   PubMed Web of Science ®Google Scholar
• Nasrallah HA, Hopkins T, Pixley SK. 2010. Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. Brain Res 1354:23–29.
   PubMed Web of Science ®Google Scholar
• Nedergaard M, Rausom B, Goldman SA. 2003. New roles for astrocyts: redefining the functional architecture of the brain. Trends Neurosci 26:523–530.
   PubMed Web of Science ®Google Scholar
• Nibuya M, Morinobu S, Duman RS. 1995. Regulation of BDNF and trk B mRNA in rat brain by chronic ECS and antidepressant treatments. J Neurosci 15:7539–7547.
   PubMed Web of Science ®Google Scholar
• Parachikova A, Nichol KE, Cotman CW. 2008. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiol Dis 30:121–129.
   PubMed Web of Science ®Google Scholar
• Peng CH, Chiou SH, Chen SJ, Chou YC, Ku HH, Cheng CK, . 2008. Neuroprotection by imipramine against lipopolysaccharide induced apoptosis in hippocampal derived neuronal stem cells mediated by activation of BDNF and the MAPK pathway. Eur Neuropsychopharmacol 18:128–140.
   PubMed Web of Science ®Google Scholar
• Perera TD, Coplan JD, Lisanby SH, Lipira CM, Arif M, Carpio C, . 2007. Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci 27:4894–4901.
   PubMed Web of Science ®Google Scholar
• Perera TD, Park S, Nemirovskaya Y. 2008. Cognitive role of neurogenesis in depression and antidepressant treatment. Neuroscientist 14:326–338.
   PubMed Web of Science ®Google Scholar
• Perera TD, Dwork AJ, Keegan KA, Thirumangalakudi L, Lipira CM, Joyce N, . 2011. Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. Plos One 6(4):e17600 (doi: 10.1371/journal.pone.0017600).
   Web of Science ®Google Scholar
• Pickering M, Cumiskey D, O'Connor JJ. 2005. Actions of tumour necrosis factor alpha on glutamatergic synaptic transmission in the CNS. Exp Physiol 90:663–670.
   PubMed Web of Science ®Google Scholar
• Qiu G, Helmeste DM, Samaranayake AN, Lau WM, Lee TM, Tang SW, So KF. 2007. Modulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine. Neurosci Bull 23:131–136.
   Google Scholar
• Reif A, Fritzen S, Finger M, Strobel A, Lauer M, Schmitt A, Lesch K-P. 2006. Neural stem cell proliferation is decreased in schizophrenia, but not in depression. Mol Psychiatry 11: 514–522.
   PubMed Web of Science ®Google Scholar
• Ryan TJ, Grant SGN. 2009. The origin and evolution of synapses. Nat Rev Neurosci 10:701–712.
   PubMed Web of Science ®Google Scholar
• Sahay A, Hen R. 2007. Adult hippocampal neurogenesis in depression. Nature Neurosci 10:1110–1115.
   PubMed Web of Science ®Google Scholar
• Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, . 2011. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466–470.
   PubMed Web of Science ®Google Scholar
• Salvadore G, Nugent AC, Lemaitre H, Luckenbaugh DA, Tinsley R, Cannon DM, . 2011. Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder. Neuroimage 54:2643–2651.
   Web of Science ®Google Scholar
• Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, . 2003. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809.
   PubMed Web of Science ®Google Scholar
• Sapolsky RM.1983. Individual differences in cortisol secretory patterns in the wild baboon: role of negative feedback sensitivity. Endocrinology 113:2263–2267.
   PubMed Web of Science ®Google Scholar
• Sapolsky RM. 1986. Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels. J Neurosci 6:2240–2244.
   PubMed Web of Science ®Google Scholar
• Sapolsky RM. 1989. Hypercortisolism among socially subordinate wild baboons originates at the CNS level. Arch Gen Psychiatry 46:1047–1051.
   PubMed Web of Science ®Google Scholar
• Schloesser RJ, Huang J, Klein PS, Manji HK. 2008. Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33:110–133.
   PubMed Web of Science ®Google Scholar
• Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, . 2010. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 72:239–252.
   PubMed Web of Science ®Google Scholar
• Snyder JS, Cameron HA. 2011. Could adult hippocampal neurogenesis be relevant for human behavior? Behav Brain Res 28 June [Epub ahead of print].
   Google Scholar
• Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA. 2011. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458 461.
   PubMed Web of Science ®Google Scholar
• Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, . 2011. Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry 16:1177 1188.
   PubMed Web of Science ®Google Scholar
• Tang SW, Chu E, Hui T, Helmeste D, Law C. 2008. Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 431:62–65.
   PubMed Web of Science ®Google Scholar
• Tanis K, Newton SS, Duman RS. 2007. Targeting neurotrophic growth factor expression and signaling for antidepressant drug development. CNS Neurol Disord 6:151–160.
   PubMedGoogle Scholar
• Thomas RM, Peterson DA. 2008. Even neural stem cells get the blues: evidence for a molecular link between modulation of adult neurogenesis and depression. Gene Expr 14:183–193.
   PubMed Web of Science ®Google Scholar
• Thompson A, Boekhoorn K, Van Dam AM, Lucassen PJ. 2008. Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence? Genes Brain Behav 7(Suppl 1):28–42.
   Google Scholar
• Thompson CK, Bentley GE, Brenowitz EA .2007. Rapid seasonal-like regression of the adult avian song control system. Proc Natl Acad Sci USA 104:15520–15525.
   Google Scholar
• Tost H, Braus DF, Hakimi S, Ruf M, Vollmert C, Hohn F, Meyer-Lindenberg A. 2010. Acute D(2) receptor blockade induces rapid, reversible remodeling in human cortical–striatal circuits. Nat Neurosci 13:920–922.
   PubMed Web of Science ®Google Scholar
• Tottenham N, Hare TA, Quinn BT, McCarry TW, Nurse M, Gilhooly T, . 2010. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci 13:46–61.
   PubMed Web of Science ®Google Scholar
• Trouche S, Bontempi B, Roullet P, Rampon C. 2009. Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc Natl Acad Sci USA 106:5919–5924.
   Google Scholar
• Vaidya VA, Fernandes K, Jha S. 2007. Regulation of adult hippocampal neurogenesis: relevance to depression. Expert Rev Neurother 7:853–864.
   PubMedGoogle Scholar
• van der Plas EA, Boes AD, Wemmie JA, Tranel D, Nopoulos P. 2010. Amygdala volume correlates positively with fearfulness in normal healthy girls. Soc Cogn Affect Neurosci 5:424 431.
   PubMed Web of Science ®Google Scholar
• van Praag H. 2008. Neurogenesis and exercise: past and future directions. Neuromolecular Med 10:128–140.
   PubMed Web of Science ®Google Scholar
• van Praag H, Kempermann G, Gage FH. 1999. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266–270.
   PubMed Web of Science ®Google Scholar
• Vessal M, Darian-Smith C. 2010. Adult neurogenesis occurs in primate sensorimotor cortex following cervical dorsal rhizotomy. J Neurosci 30:8613–8623.
   PubMed Web of Science ®Google Scholar
• Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P. 2011. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci USA 108:9262–9267.
   PubMedGoogle Scholar
• Wignall EL, Dickson JM, Vaughan P, Farrow TF, Wilkinson ID, Hunter MD, Woodruff PW. 2004. Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder. Biol Psychiatry 56:832–836.
   PubMed Web of Science ®Google Scholar
• Witthaus H, Mendes U, Brüne M, Ozgürdal S, Bohner G, Gudlowski Y, . 2010. Hippocampal subdivision and amygdalar volumes in patients in an at-risk mental state for schizophrenia. J Psychiatr Neurosci 35:33–40.
   PubMedGoogle Scholar
• Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, . 2011. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun 25:135–146.
   PubMed Web of Science ®Google Scholar
• Yang H, Chuzi S, Sinicropi-Yao L, Johnson D, Chen Y, Clain A, . 2010. Type of residual symptom and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine. Eur Arch Psychiatry Clin Neurosci 260:145–150.
   Google Scholar
• Yuste R. 2010. Dendritic spines. Cambridge, MA: MIT Press.
   Google Scholar