Functional investigation of a schizophrenia GWAS signal at the CDC42 gene

References

• Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265.
   PubMed Web of Science ®Google Scholar
• Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ, . 1999. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch Gen Psychiatry 56:162–168.
   PubMed Web of Science ®Google Scholar
• Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H, . 2009. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 325:1246–1250.
   PubMed Web of Science ®Google Scholar
• Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KC, . 2008. A genome-wide association study of global gene expression. Nat Genet 39:1202–1207.
   Google Scholar
• Harrison PJ. 1999. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122: 593–624.
   PubMed Web of Science ®Google Scholar
• Heasman SJ, Ridley AJ. 2008. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9:690–701.
   PubMed Web of Science ®Google Scholar
• Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, Kel OV, . 1998. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 26:362–367.
   PubMed Web of Science ®Google Scholar
• Hill JJ, Hashimoto T, Lewis DA. 2006. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 11: 557–566.
   PubMed Web of Science ®Google Scholar
• Ide M, Lewis DA. 2010. Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficits. Biol Psychiatry 68:25–32.
   PubMed Web of Science ®Google Scholar
• , International Schizophrenia ConsortiumPurcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748–752.
   PubMed Web of Science ®Google Scholar
• Kang R, Wan J, Arstikaitis P, Takahashi H, Huang K, Bailey AO, . 2008. Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature 456:904–909.
   PubMed Web of Science ®Google Scholar
• Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q, . 2011. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int J Cancer 128: 1269–1279.
   PubMed Web of Science ®Google Scholar
• Nobes CD, Hall A. 1995. Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 23:456–459.
   PubMed Web of Science ®Google Scholar
• Olenik C, Barth H, Just I, Aktories K, Meyer DK. 1997. Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain. Brain Res Mol Brain Res 52:263–269.
   PubMedGoogle Scholar
• Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, . 2008. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci USA 105:1931–1936.
   PubMed Web of Science ®Google Scholar
• Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, . 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559–575.
   PubMed Web of Science ®Google Scholar
• Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. 1999. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97:221–231.
   PubMed Web of Science ®Google Scholar
• Schizophrenia Psychiatric Genome-Wide Association Study. GWAS. Consortium. 2011. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43:969–976.
   PubMedGoogle Scholar
• Scott EK, Reuter JE, Luo L. 2003. Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci 23:3118–3123.
   PubMedGoogle Scholar
• Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S. 2006. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron 50:401–414.
   PubMedGoogle Scholar
• Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, . 2007. Population genomics of human gene expression. Nat Genet 39:1217–1224.
   PubMed Web of Science ®Google Scholar
• Threadgill R, Bobb K, Ghosh A. 1997. Regulation of dendritic growth and remodelling by Rho, Rac, and Cdc42. Neuron 19:625–634.
   PubMed Web of Science ®Google Scholar
• Zhu G, Lipsky RH, Xu K, Ali S, Hyde T, Kleinman J, . 2004. Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5’ nuclease assay. Psychopharmacology 177:178–184.
   PubMedGoogle Scholar