1,334
Views
72
CrossRef citations to date
0
Altmetric
REVIEW ARTICLE

Can transcranial direct current stimulation (tDCS) alleviate symptoms and improve cognition in psychiatric disorders?

, , , , &
Pages 261-275 | Received 14 May 2013, Accepted 13 Dec 2013, Published online: 21 Jan 2014

References

  • Alonzo A, Brassil J, Taylor JL, Martin D, Loo CK. 2012. Daily transcranial direct current stimulation (tDCS) leads to greater increases in cortical excitability than second daily transcranial direct current stimulation. Brain Stim 5:208–213.
  • Andrade C. 2013. Once- to twice-daily, 3-year domiciliary maintenance transcranial direct current stimulation for severe, disabling, clozapine-refractory continuous auditory hallucinations in schizophrenia. J ECT 29:239–242.
  • Arfai E, Theano G, Montagu JD, Robin AA. 1970. A controlled study of polarization in depression. Br J Psychiatry 116: 433–434.
  • Baker AP. 1970. Brain stem polarization in the treatment of depression. S Afr Med J 44:473–475.
  • Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, Nathan PE. 2001. Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 39:376–389.
  • Berlim MT, Van den Eynde F, Daskalakis ZJ. 2013. Clinical utility of transcranial direct current stimulation (tDCS) for treating major depression: a systematic review and meta- analysis of randomized, double-blind and sham-controlled trials. J Psychiatr Res 47:1–7.
  • Blumberger DM, Tran LC, Fitzgerald PB, Hoy KE, Daskalakis ZJ. 2012. A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression. Front Psychiatry 3:74.
  • Boggio PS, Bermpohl F, Vergara AO, Muniz AL, Nahas FH, Leme PB et al. 2007. Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. J Affect Disord 101:91–98.
  • Boggio PS, Liguori P, Sultani N, Rezende L, Fecteau S, Fregni F. 2009. Cumulative priming effects of cortical stimulation on smoking cue-induced craving. Neurosci Lett 463:82–86.
  • Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, et al. 2008a. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol 11:249–254.
  • Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A et al. 2008b. Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study. Drug Alcohol Depend 92:55–60.
  • Boggio PS, Zaghi S, Villani AB, Fecteau S, Pascual-Leone A, Fregni F. 2010. Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC). Drug Alcohol Depend 112:220–225.
  • Brunelin J, Mondino M, Gassab L, Haesebaert F, Gaha L, Suaud-Chagny MF, et al. 2012a. Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry 169:719–724.
  • Brunelin J, Mondino M, Haesebaert F, Saoud M, Suaud-Chagny MF, Poulet E. 2012b. Efficacy and safety of bifocal tDCS as an interventional treatment for refractory schizophrenia. Brain Stimul 5:431–432.
  • Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F. 2011a. A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol 14: 1133–1145.
  • Brunoni AR, Ferrucci R, Bortolomasi M, Vergari M, Tadini L, Boggio PS, et al. 2011b. Transcranial direct current stimulation (tDCS) in unipolar vs. bipolar depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 35:96–101.
  • Brunoni AR, Zanao TA, Ferrucci R, Priori A, Valiengo L, de Oliveira JF, et al. 2012a. Bifrontal tDCS prevents implicit learning acquisition in antidepressant-free patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 43C:146–150.
  • Brunoni AR, Ferrucci R, Bortolomasi M, Scelzo E, Boggio PS, Fregni F, et al. 2013a. Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the Major Depressive Episode: Findings from a naturalistic study. Eur Psychiatry 28:356–361.
  • Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, et al. 2013b. The sertraline vs electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. J Am Med Assoc Psychiatry 6:1–9.
  • Costain R, Redfearn JW, Lippold OC. 1964. A controlled trial of the therapeutic effect of polarization of the brain in depressive illness. Br J Psychiatry 110:786–799.
  • Dell’Osso B, Zanoni S, Ferrucci R, Vergari M, Castellano F, D’Urso N, et al. 2012. Transcranial direct current stimulation for the outpatient treatment of poor-responder depressed patients. Eur Psychiatry 27:513–517.
  • Downar J, Daskalakis ZJ. 2012. New targets for rTMS in depression: a review of convergent evidence. Brain Stimul 2012 (September 7).
  • Fecteau S, Fregni F, Boggio PS, Camprodon JA, Pascual-Leone A. 2010. Neuromodulation of decision-making in the addictive brain. Subst Use Misuse 45:1766–1786.
  • Ferrucci R, Bortolomasi M, Brunoni AR, Vergari M, Tadini L, Giacopuzzi M, et al. 2009a. Comparative benefits of transcranial direct current stimultation (tDCS) treatment in patients with mild/moderate vs. severe depression. Clin Neuropsychiatry 6:246–251.
  • Ferrucci R, Bortolomasi M, Vergari M, Tadini L, Salvoro B, Giacopuzzi M, et al. 2009b. Transcranial direct current stimulation in severe, drug-resistant major depression. J Affect Disord 118:215–219.
  • Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A. 2006a. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord 8: 203–204.
  • Fregni F, Boggio PS, Nitsche MA, Rigonatti SP, Pascual-Leone A. 2006b. Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression. Depress Anxiety 23:482–484.
  • Fregni F, Liguori P, Fecteau S, Nitsche MA, Pascual-Leone A, Boggio PS. 2008a. Cortical stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue- provoked smoking craving: a randomized, sham-controlled study. J Clin Psychiatry 69:32–40.
  • Fregni F, Orsati F, Pedrosa W, Fecteau S, Tome FA, Nitsche MA, et al. 2008b. Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods. Appetite 51:34–41.
  • Fricke K, Seeber AA, Thirugnanasambandam N, Paulus W, Nitsche MA, Rothwell JC. 2011. Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex. J Neurophysiol 105:1141–1149.
  • Galvez V, Alonzo A, Martin D, Mitchell PB, Sachdev P, Loo CK. 2011. Hypomania induction in a patient with bipolar II disorder by transcranial direct current stimulation (tDCS). J ECT 27:256–258.
  • Giacobbe P, Mayberg HS, Lozano AM. 2009. Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulation. Exp Neurol 219:44–52.
  • Göder R, Baier PC, Beith B, Baecker C, Seeck-Hirschner M, Junghanns K, et al. 2013. Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia. Schizophr Res. 2013 Jan 18.
  • Goldman RL, Borckardt JJ, Frohman HA, O’Neil PM, Madan A, Campbell LK, et al. 2011. Prefrontal cortex transcranial direct current stimulation (tDCS) temporarily reduces food cravings and increases the self-reported ability to resist food in adults with frequent food craving. Appetite 56:741–746.
  • Goldstein RZ, Volkow ND. 2002. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159:1642–1652.
  • Gonçalves ÓF, Carvalho S, Leite J, Pocinho F, Relvas J, Fregni F. 2011. Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the thalamic level. Med Hypotheses 77:445–447.
  • Gorlyn M, Keilp JG, Grunebaum MF, Taylor BP, Oquendo MA, Bruder GE, et al. 2008. Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects. J Neural Transm 15:1213–1219.
  • Grimm S, Boesiger P, Beck J, Schuepbach D, Bermpohl F, Walter M, et al. 2009. Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology 34:932–943.
  • Grundey J, Thirugnanasambandam N, Kaminsky K, Drees A, Skwirba AC, Lang N, et al. 2012. Neuroplasticity in cigarette smokers is altered under withdrawal and partially restituted by nicotine exposition. J Neurosci 32:4156–4162.
  • Hanlon CA, Jones EM, Li X, Hartwell KJ, Brady KT, George MS. 2012. Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments. Drug Alcohol Depend 125:239–243.
  • Hasan A, Nitsche MA, Rein B, Schneider-Axmann T, Guse B, Gruber O, et al. 2011. Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation. Behav Brain Res 224:15–22.
  • Hasan A, Aborowa R, Nitsche MA, Marshall L, Schmitt A, Gruber O, et al. 2012a. Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation. Eur Arch Psychiatry Clin Neurosci 262:415–423.
  • Hasan A, Nitsche MA, Herrmann M, Schneider-Axmann T, Marshall L, Gruber O, et al. 2012b. Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study. Brain Stimul 5:475–483.
  • Higley AE, Crane NA, Spadoni AD, Quello SB, Goodell V, Mason BJ. 2011. Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals. Psychopharmacology (Berlin) 218:121–129.
  • Homan P, Kindler J, Federspiel A, Flury R, Hubl D, Hauf M, et al. 2011. Muting the voice: a case of arterial spin labeling-monitored transcranial direct current stimulation treatment of auditory verbal hallucinations. Am J Psychiatry 168: 853–854.
  • Iyer MB, Mattu U, Grafman J, Lomarev M, Sato S, Wassermann EM. 2005. Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology 64:872–875.
  • Jardri R, Pouchet A, Pins D, Thomas P. 2011. Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis. Am J Psychiatry 168:73–81.
  • Kalivas PW, Volkow ND. 2005. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162: 1403–1413.
  • Kalu UG, Sexton CE, Loo CK, Ebmeier KP. 2012. Transcranial direct current stimulation in the treatment of major depression: a meta-analysis. Psychol Med 42:1791–1800.
  • Kavanagh DJ, Statham DJ, Feeney GF, Young RM, May J, Andrade J. et al. 2013. Measurement of alcohol craving. Addict Behav 38:1572–1584.
  • Keeser D, Meindl T, Bor J, Palm U, Pogarell O, Mulert C, et al. 2011. Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI. J Neurosci 31:15284–15293.
  • Kemp AH, Gordon E, Rush AJ, Williams LM. 2008. Improving the prediction of treatment response in depression: integration of clinical, cognitive, psychophysiological, neuroimaging, and genetic measures. CNS spectrums. 13:1066–1086; quiz 87–88.
  • Kessler SK, Turkeltaub PE, Benson JG, Hamilton RH. 2012. Differences in the experience of active and sham transcranial direct current stimulation. Brain Stimul 5:155–162.
  • Koob GF, Rocio M, Carrera A, Gold LH, Heyser CJ, Maldonado-Irizarry C et al. 1998. Substance dependence as a compulsive behavior. J Psychopharmacol 12:39–48.
  • Kuo MF, Unger M, Liebetanz D, Lang N, Tergau F, Paulus W et al. 2008. Limited impact of homeostatic plasticity on motor learning in humans. Neuropsychologia 46:2122–2128.
  • Levasseur-Moreau J, Brunelin J, Fecteau S. 2013. Non-invasive brain stimulation can induce paradoxical facilitation. Are these neuroenhancements transferable and meaningful to security services?Front Hum Neurosci 7:449.
  • Loo CK, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi GS, et al. 2010. A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. Int J Neuropsychopharmacol 13:61–69.
  • Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P. 2012. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. Br J Psychiatry 200:52–59.
  • Martin DM, Alonzo A, Mitchell PB, Sachdev P, Galvez V, Loo CK. 2011. Fronto-extracephalic transcranial direct current stimulation as a treatment for major depression: an open-label pilot study. J Affect Disord 134:459–463.
  • Martin DM, Alonzo A, Ho KA, Player M, Mitchell PB, Sachdev P, et al. 2013. Continuation transcranial direct current stimulation for the prevention of relapse in major depression. J Affect Disord 144:274–278.
  • Mathers CD, Loncar D. 2006. Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine. 3:e442.
  • Mattai A, Miller R, Weisinger B, Greenstein D, Bakalar J, Tossell J, et al. 2011. Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. Brain Stimul 4:275–280.
  • Monte-Silva K, Kuo MF, Thirugnanasambandam N, Liebetanz D, Paulus W, Nitsche MA. 2009. Dose-dependent inverted U-shaped effect of dopamine (D2-like) receptor activation on focal and nonfocal plasticity in humans. J Neurosci 29: 6124–6131.
  • Monte-Silva K, Kuo M-F, Liebetanz D, Paulus W, Nitsche MA. 2010. Shaping the optimal repetition interval for cathodal transcranial direct current stimulation (tDCS). J Neurophysiol 103:1735–1740.
  • Monte-Silva K, Kuo MF, Hessenthaler S, Fresnoza S, Liebetanz D, Paulus W, et al. 2013. Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul 6:424–432.
  • Nakamura-Palacios EM, de Almeida Benevides MC, da Penha Zago-Gomes M, de Oliveira RW, de Vasconcellos VF, de Castro LN, et al. 2012. Auditory event-related potentials (P3) and cognitive changes induced by frontal direct current stimulation in alcoholics according to Lesch alcoholism typology. Int J Neuropsychopharmacol 15:601–616.
  • Nitsche MA, Paulus W. 2000. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 527:633–639.
  • Nitsche MA, Paulus W. 2001. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 57:1899–1901.
  • Nitsche MA, Liebetanz D, Antal A, Lang N, Tergau F, Paulus W. 2003a. Modulation of cortical excitability by weak direct current stimulation–technical, safety and functional aspects. Suppl Clin Neurophysiol 56:255–276.
  • Nitsche MA, Nitsche MS, Klein CC, Tergau F, Rothwell J, Paulus W. 2003b. Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. Clin Neurophysiol 114:600–604.
  • Nitsche MA, Niehaus L, Hoffmann KT, Hengst S, Liebetanz D, Paulus W, Meyer BU. 2004. MRI study of human brain exposed to weak direct current stimulation of the frontal cortex. Clin Neurophysiol 115:2419–23.
  • Nitsche MA, Doemkes S, Karakose T, Antal A, Liebetanz D, Lang N et al. 2007. Shaping the effects of transcranial direct current stimulation of the human motor cortex. J Neurophysiol 97:3109–3117.
  • Nitsche M, Cohen LG, Wassermann E, Priori A, Lang N, Antal A, et al. 2008. Transcranial direct current stimulation: state of the art. Brain Stimul 1:206–223.
  • Nitsche MA, Kuo MF, Karrasch R, Wächter B, Liebetanz D, Paulus W. 2009. Serotonin affects transcranial direct current-induced neuroplasticity in humans. Biol Psychiatry 66:503–508.
  • Oliveira JF, Zanao TA, Valiengo L, Lotufo PA, Bensenor IM, Fregni F, et al. 2013. Acute working memory improvement after tDCS in antidepressant-free patients with major depressive disorder. Neurosci Lett 14:60–64.
  • Palm U, Schiller C, Fintescu Z, Obermeier M, Keeser D, Reisinger E, et al. 2012. Transcranial direct current stimulation in treatment resistant depression: a randomized double-blind, placebo-controlled study. Brain Stimul 5:242–251.
  • Poreisz C, Boros K, Antal A, Paulus W. 2007. Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain Res Bull 72:208–214.
  • Priori A, Berardelli A, Rona S, Accornero N, Manfredi M. 1998. Polarization of the human motor cortex through the scalp. Neuroreport 9:2257–2260.
  • Priori A, Hallett M, Rothwell JC. 2009. Repetitive transcranial magnetic stimulation or transcranial direct current stimulation?Brain Stimul 2:241–245.
  • Rakesh G, Shivakumar V, Subramaniam A, Nawani H, Amaresha AC, Narayanaswamy JC, et al. 2013. Monotherapy with tDCS for schizophrenia: a case report. Brain Stimul 6:708–709.
  • Ramsay JC, Schlagenhauf G. 1966. Treatment of depression with low voltage direct current. South Med J 59:932–934.
  • Redfearn JW, Lippold OC, Costain R. 1964. A preliminary account of the clinical effects of polarizing the brain in certain psychiatric disorders. Br J Psychiatry 110:773–785.
  • Ribolsi M, Lisi G, Di Lorenzo G, Koch G, Oliveri M, Magni V, et al. 2013. Perceptual pseudoneglect in schizophrenia: candidate endophenotype and the role of the right parietal cortex. Schizophr Bull 39:601–607.
  • Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, et al. 2008. Transcranial direct stimulation and fluoxetine for the treatment of depression. Eur Psychiatry 23:74–76.
  • Rogers RD, Moeller FG, Swann AC, Clark L. 2010. Recent research on impulsivity in individuals with drug use and mental health disorders: implications for alcoholism. Alcohol Clin Exp Res 34:1319–1333.
  • Schestatsky P, Janovik N, Lobato MI, Belmonte-de-Abreu P, Schestatsky S, Shiozawa P, et al. 2013. Rapid therapeutic response to anodal tdcs of right dorsolateral prefrontal cortex in acute mania. Brain Stimul 6:701–703.
  • Shergill SS, Murray R, McGuire P. 1998. Auditory hallucinations: a review of psychological treatments. Schizophr Res 32: 137–150.
  • Shiffman S, West R, Gilbert D;SRNT Work Group on the Assessment of Craving and Withdrawal in Clinical Trials.2004. Recommendation for the assessment of tobacco craving and withdrawal in smoking cessation trials.Nicotine Tob Res 6: 599–614.
  • Shiozawa P, da Silva ME, Cordeiro Q, Fregni F, Brunoni AR. 2013. Transcranial direct current stimulation (tDCS) for catatonic schizophrenia: a case study. Schizophr Res 146: 374–375.
  • Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. 2006. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63:324–331.
  • Stagg CJ, Nitsche MA. 2011. Physiological basis of transcranial direct current stimulation. Neuroscientist 17:37–53.
  • Thirugnanasambandam N, Grundey J, Adam K, Drees A, Skwirba AC, Lang N, et al. 2011. Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans. Neuropsychopharmacology 36:879–886.
  • Trivedi MH, Hollander E, Nutt D, Blier P. 2008. Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depression. J Clin Psychiatry 69:246–258.
  • Utz KS, Dimova V, Oppenländer K, Kerkhoff G. 2010. Electrified minds: transcranial direct current stimulation (tDCS) and galvanic vestibular stimulation (GVS) as methods of non-invasive brain stimulation in neuropsychology – a review of current data and future implications. Neuropsychologia 48:2789–2810.
  • Vercammen A, Rushby JA, Loo C, Short B, Weickert CS, Weickert TW. 2011. Transcranial direct current stimulation influences probabilistic association learning in schizophrenia. Schizophr Res 131:198–205.
  • Volpato C, Piccione F, Cavinato M, Duzzi D, Schiff S, Foscolo L et al. 2013. Modulation of affective symptoms and resting state activity by brain stimulation in a treatment-resistant case of obsessive-compulsive disorder. Neurocase 19:360–370.
  • Wolkenstein L, Plewnia C. 2013. Amelioration of cognitive control in depression by transcranial direct current stimulation. Biol Psychiatry 73:646–651.
  • Wray JM, Gass JC, Tiffany ST. 2013. A systematic review of the relationships between craving and smoking cessation. Nicotine Tob Res 15:1167–1182.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.