486
Views
25
CrossRef citations to date
0
Altmetric
ORIGINAL INVESTIGATION

The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain

, , , , , , , & show all
Pages 45-56 | Received 19 Aug 2014, Accepted 03 Nov 2014, Published online: 06 Jan 2015

References

  • Achyut BR, Srivastava A, Bhattacharya S, Mittal B. 2007. Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. Clin Chim Acta 377:163–169.
  • Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, et al. 1999. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686–1696.
  • Amaral ME, Barbuio R, Milanski M, Romanatto T, Barbosa HC, Nadruz W, et al. 2006. Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem 98:203–212.
  • Angelucci F, Mathe AA, Aloe L. 2000. Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. J Neurosci Res 60:783–794.
  • Bariohay B, Lebrun B, Moyse E, Jean A. 2005. Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 146:5612–5620.
  • Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265.
  • Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, Tollefson GD. 2001. Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. J Clin Psychiatry 62:231–238.
  • Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M. 2012. An integrated encyclopedia of DNA elements in the human genome. Nature 489:57–74.
  • Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, et al. 2012. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 22:1790–1797.
  • Calle ML, Urrea V, Malats N, Van Steen K. 2010. mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits. Bioinformatics 26:2198–2199.
  • Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, et al.006. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 15:519–529.
  • Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC. 2009. Genotypic and functional roles of IL-1B and IL-1RN on the risk of gastroesophageal reflux disease: the presence of IL-1B-511*T/IL-1RN*1 (T1) haplotype may protect against the disease. Am J Gastroenterol 104:2704–2713.
  • De Hert M, Correll CU, Bobes J, Cetkovich-Bakmas M, Cohen D, Asai I, et al. 2011. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 10:52–77.
  • De Hert M, Detraux J, van Winkel R, Yu W, Correll CU. 2012. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nat Rev Endocrinol 8:114–126.
  • Dinarello CA. 2011. A clinical perspective of IL-1β as the gatekeeper of inflammation. Eur J Immunol 41:1203–1217.
  • Drzyzga L, Obuchowicz E, Marcinowska A, Herman ZS. 2006. Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun 20:532–545.
  • Dudbridge F. 2008. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66:87–98.
  • Ensom MH, Chang TK, Patel P. 2001. Pharmacogenetics: the therapeutic drug monitoring of the future? Clin Pharmacokinet 40:783–802.
  • Garcia MC, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, et al. 2006. Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes 55:1205–1213.
  • Gauderman WJ, Morrison JM. 2006. QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies.
  • Gebhardt S, Theisen FM, Haberhausen M, Heinzel-Gutenbrunner M, Wehmeier PM, Krieg JC, et al. 2010. Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study. J Clin Pharm Ther 35:207–211.
  • Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS. 2009. Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 70:1078–1090.
  • Guijarro A, Laviano A, Meguid MM. 2006. Hypothalamic integration of immune function and metabolism. Prog Brain Res 153:367–405.
  • Gunstad J, Schofield P, Paul RH, Spitznagel MB, Cohen RA, Williams LM, et al.BDNF Val66Met polymorphism is associated with body mass index in healthy adults. Neuropsychobiology 53:153–156.
  • Himmerich H, Schonherr J, Fulda S, Sheldrick AJ, Bauer K, Sack U. 2011. Impact of antipsychotics on cytokine production in-vitro. J Psychiatr Res 45:1358–1365.
  • Hong KW, Lim JE, Go MJ, Shin Cho Y, Ahn Y, Han BG, et al. 2012. Recapitulation of the association of the Val66Met polymorphism of BDNF gene with BMI in Koreans. Obesity (Silver Spring) 20:1871–1875.
  • International HapMap Consortium. 2005. A haplotype map of the human genome. Nature 437:1299–320.
  • Kent S, Rodriguez F, Kelley KW, Dantzer R. 1994. Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat. Physiol Behav 56:1031–1036.
  • Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, et al. 2002. The human genome browser at UCSC. Genome Res 12:996–1006.
  • Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, et al. 1999. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189:865–870.
  • Kerschensteiner M, Meinl E, Hohlfeld R. 2009. Neuro-immune crosstalk in CNS diseases. Neuroscience 158:1122–1132.
  • Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R. 2003. Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann Neurol 53:292–304.
  • Klemettila JP, Kampman O, Seppala N, Viikki M, Hamalainen M, Moilanen E, et al. 2014. Cytokine and adipokine alterations in patients with schizophrenia treated with clozapine. Psychiatry Res.
  • Kluge M, Schuld A, Schacht A, Himmerich H, Dalal MA, Wehmeier PM, et al. 2009. Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever. Psychoneuroendocrinology 34:118–128.
  • Lahiri DK, Nurnberger JI Jr. 1991. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444.
  • Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, et al. 2006. Risperidone-related weight gain: genetic and nongenetic predictors. J Clin Psychopharmacol 26:128–134.
  • Laviano A, Gleason JR, Meguid MM, Yang ZJ, Cangiano C, Rossi Fanelli F. 2000. Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. J Investig Med 48:40–48.
  • Lett TA, Wallace TJ, Chowdhury NI, Tiwari AK, Kennedy JL, Muller DJ. 2012. Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications. Mol Psychiatry 17:242–266.
  • Li J, Ji L. 2005. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) 95:221–227.
  • Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, et al. 2005. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353:1209–1223.
  • Lipska BK, Khaing ZZ, Weickert CS, Weinberger DR. 2001. BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs. Eur J Neurosci 14:135–144.
  • McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, et al. 2013. Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice. Am J Physiol Endocrinol Metab 305:E834–844.
  • Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TW, van Duijn CM, Slagboom PE. 2004. Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum 50:1179–1186.
  • Muller DJ, de Luca V, Sicard T, King N, Strauss J, Kennedy JL. 2006. Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study. Br J Psychiatry 189:317–23.
  • Nyholt DR. 2004. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765–769.
  • O'Brien SM, Fitzgerald P, Scully P, Landers A, Scott LV, Dinan TG. 2007. Impact of gender and menstrual cycle phase on plasma cytokine concentrations. Neuroimmunomodulation 14:84–90.
  • Pelleymounter MA, Cullen MJ, Wellman CL. 1995. Characteristics of BDNF-induced weight loss. Exp Neurol 131:229–238.
  • Pillai A, Terry AV Jr, Mahadik SP. 2006. Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus. Schizophr Res 82:95–106.
  • Plata-Salaman CR. 1994. Meal patterns in response to the intracerebroventricular administration of interleukin-1 beta in rats. Physiol Behav 55:727–733.
  • Reichenberg A, Kraus T, Haack M, Schuld A, Pollmacher T, Yirmiya R. 2002. Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion. Psychoneuroendocrinology 27:945–956.
  • Ribases M, Gratacos M, Armengol L, de Cid R, Badia A, Jimenez L, et al. 2003. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry 8:745–751.
  • Rizos EN, Papadopoulou A, Laskos E, Michalopoulou PG, Kastania A, Vasilopoulos D, et al. 2010. Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics. World J Biol Psychiatry 11(2 Pt 2):251–255.
  • Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, et al. 2007. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab 5:450–463.
  • Shugart YY, Chen L, Day IN, Lewis SJ, Timpson NJ, Yuan W, et al. 2009. Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Eur J Hum Genet 17:1050–1055.
  • Singh H, Sachan R, Goel H, Mittal B. 2008. Genetic variants of interleukin-1RN and interleukin-1beta genes and risk of cervical cancer. BJOG 115:633–638.
  • Song X, Fan X, Li X, Zhang W, Gao J, Zhao J, et al. 2014. Changes in pro-inflammatory cytokines and body weight during 6-month risperidone treatment in drug naive, first-episode schizophrenia. Psychopharmacology (Berl) 231:319–325.
  • Stowe RP, Peek MK, Cutchin MP, Goodwin JS. 2010. Plasma cytokine levels in a population-based study: relation to age and ethnicity. J Gerontol A Biol Sci Med Sci 65:429–433.
  • Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C, et al. 2006. Interleukin-1 system gene polymorphisms are associated with fat mass in young men. J Clin Endocrinol Metab 91:2749–2754.
  • Strandberg L, Mellstrom D, Ljunggren O, Grundberg E, Karlsson MK, Holmberg AH, et al. 2008. IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden. Obesity (Silver Spring) 16:710–713.
  • Sudom K, Turrin NP, Hayley S, Anisman H. 2004. Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. Neuroimmunomodulation 11:341–350.
  • Tabakman R, Lecht S, Sephanova S, Arien-Zakay H, Lazarovici P. 2004. Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury. Prog Brain Res 146:387–401.
  • Tanaka K, Miyake Y, Hanioka T, Arakawa M. 2014. Relationship between IL1 gene polymorphisms and periodontal disease in Japanese women. DNA Cell Biol 33:227–233.
  • Theisen FM, Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M, Wehmeier PM, Krieg JC, et al. 2005. Clozapine-induced weight gain: a study in monozygotic twins and same-sex sib pairs. Psychiatr Genet 15:285–289.
  • Tsai A, Liou YJ, Hong CJ, Wu CL, Tsai SJ, Bai YM. 2011. Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment. Neuromolecular Med 13:328–333.
  • Um JY, Rim HK, Kim SJ, Kim HL, Hong SH. 2011. Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice. PLoS One 6:e29524.
  • van der Ploeg AH, Kumpf O, Seelow E, Almanza LC, Schlag PM, Schumann RR, et al. 2014. The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1beta. Gastric Cancer.
  • Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, et al. 2004. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89:2119–2126.
  • Volavka J, Czobor P, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, et al. 2002. Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder. Am J Psychiatry 159:255–262.
  • Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, et al. 2002. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75–79.
  • Wang C, Bomberg E, Billington CJ, Levine AS, Kotz CM. 2010a. Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res 1336:66–77.
  • Wang L, Basa NR, Shaikh A, Luckey A, Heber D, St-Pierre DH, et al. 2006. LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications. Am J Physiol Gastrointest Liver Physiol 291:G611–620.
  • Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. 2010b. Genetic association between TNF-alpha -308 G> A polymorphism and longitudinal weight change during clozapine treatment. Hum Psychopharmacol 25:303–309.
  • Ward LD, Kellis M. 2012. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40(Database issue):D930–934.
  • Wehmeier PM, Gebhardt S, Schmidtke J, Remschmidt H, Hebebrand J, Theisen FM. 2005. Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation. Psychiatry Res 133:273–276.
  • Wolford JK, Colligan PB, Gruber JD, Bogardus C. 2003. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol Genet Metab 80:338–343.
  • Wysokinski A, Kloszewska I. 2014. Mechanisms of increased appetite and weight gain induced by psychotropic medications. J Adv Clin Pharmacol 1:12–33.
  • Zai CC, Tiwari AK, De Luca V, Muller DJ, Bulgin N, Hwang R, et al. 2009. Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia. Eur Neuropsychopharmacol 19:317–328.
  • Zai G, Muller DJ, Volavka J, Czobor P, Lieberman JA, Meltzer HY, et al. 2006. Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication. Psychopharmacology (Berl) 188:171–182.
  • Zai GC, Zai CC, Chowdhury NI, Tiwari AK, Souza RP, Lieberman JA, et al. 2012. The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain. Prog Neuropsychopharmacol Biol Psychiatry 39:96–101.
  • Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q, et al. 2007. Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J Psychiatr Res 41:997–1004.
  • Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, et al. 2008. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology 33:2200–2205.
  • Zheng L, Yin J, Wang L, Wang X, Shi Y, Shao A, et al. 2013. Interleukin 1B rs16944 G> A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Clin Biochem 46:1469–1473.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.