Neuroinflammation in suicide: Toward a comprehensive model

References

• Aliberti J, Bafica A. 2005. Anti-inflammatory pathways as a host evasion mechanism for pathogens. Prostaglandins Leukot Essent Fatty Acids 73:283–288.
   PubMed Web of Science ®Google Scholar
• Arling TA, Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA, et al. 2009. Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders. J Nerv Ment Dis 197:905–908.
   PubMed Web of Science ®Google Scholar
• Artero S, Astruc B, Courtet P, Ritchie K. 2006. Life-time history of suicide attempts and coronary artery disease in a community-dwelling elderly population. Int J Geriatr Psychiatry 21: 108–112.
   PubMed Web of Science ®Google Scholar
• Asano NM, Coriolano M, Asano BJ, Lins OG. 2013. Psychiatric comorbidities in patients with systemic lupus erythematosus: a systematic review of the last 10 years. Rev Bras Reumatol 53:431–437.
   PubMed Web of Science ®Google Scholar
• Ballard ED, Ionescu DF, Vande Voort JL, Niciu MJ, Richards EM, Luckenbaugh DA, et al. 2014. Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety. J Psychiatr Res 58:161–166.
   PubMed Web of Science ®Google Scholar
• Baron DA, Hardie T, Baron SH. 1993. Possible association of interleukin-2 treatment with depression and suicide. J Am Osteopath Assoc 93:799–800.
   PubMedGoogle Scholar
• Baumeister RF, Leary MR. 1995. The need to belong: desire for interpersonal attachments as a fundamental human motivation. Psychol Bull 117:497–529.
   PubMed Web of Science ®Google Scholar
• Bay-Richter C, Linderholm KR, Lim CK, Samuelsson M, Traskman-Bendz L, Guillemin GJ, et al. 2015. A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality. Brain Behav Immun 43:110–117.
   PubMed Web of Science ®Google Scholar
• Bayard-Burfield L, Alling C, Blennow K, Jonsson S, Traskman-Bendz L. 1996. Impairment of the blood-CSF barrier in suicide attempters. Eur Neuropsychopharmacol 6:195–199.
   PubMed Web of Science ®Google Scholar
• Bergen H, Hawton K, Waters K, Ness J, Cooper J, Steeg S, et al. 2012. Premature death after self-harm: a multicentre cohort study. Lancet 380:1568–1574.
   PubMed Web of Science ®Google Scholar
• Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, et al. 2000. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351–354.
   PubMed Web of Science ®Google Scholar
• Black C, Miller BJ. 2014. Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients. Biol Psychiatry 78:28–37.
   PubMed Web of Science ®Google Scholar
• Bronnum-Hansen H, Stenager E, Nylev Stenager E, Koch-Henriksen N. 2005. Suicide among Danes with multiple sclerosis. J Neurol Neurosurg Psychiatry 76:1457–1459.
   PubMed Web of Science ®Google Scholar
• Bryant PA, Trinder J, Curtis N. 2004. Sick and tired: Does sleep have a vital role in the immune system? Nat Rev Immunol 4:457–467.
   PubMed Web of Science ®Google Scholar
• Cacioppo JT, Hawkley LC. 2003. Social isolation and health, with an emphasis on underlying mechanisms. Perspect Biol Med 46, S39–52.
   PubMed Web of Science ®Google Scholar
• Cacioppo JT, Hawkley LC, Crawford LE, Ernst JM, Burleson MH, Kowalewski RB, et al. 2002. Loneliness and health: potential mechanisms. Psychosom Med 64:407–417.
   PubMed Web of Science ®Google Scholar
• Capuron L, Pagnoni G, Demetrashvili M, Woolwine BJ, Nemeroff CB, Berns GS, et al. 2005. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol Psychiatry 58:190–196.
   PubMed Web of Science ®Google Scholar
• Carlborg A, Jokinen J, Jonsson EG, Erhardt S, Nordstrom P. 2013. CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis. Psychiatry Res 205:165–167.
   PubMed Web of Science ®Google Scholar
• Carroll JE, Low CA, Prather AA, Cohen S, Fury JM, Ross DC, et al. 2011. Negative affective responses to a speech task predict changes in interleukin (IL)-6. Brain Behav Immun 25:232–238.
   PubMed Web of Science ®Google Scholar
• Christodoulou C, Douzenis A, Papadopoulos FC, Papadopoulou A, Bouras G, Gournellis R, et al. 2012. Suicide and seasonality. Acta Psychiatr Scand 125:127–146.
   PubMed Web of Science ®Google Scholar
• Cipriani A, Hawton K, Stockton S, Geddes JR. 2013. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. Br Med J 346:f3646.
   PubMed Web of Science ®Google Scholar
• Coccaro EF, Lee R, Coussons-Read M. 2014. Elevated plasma inflammatory markers in individuals with intermittent explosive disorder and correlation with aggression in humans. J Am Med Assoc Psychiatry 71:158–165.
   Google Scholar
• Coelho R, Viola TW, Walss-Bass C, Brietzke E, Grassi-Oliveira R. 2014. Childhood maltreatment and inflammatory markers: a systematic review. Acta Psychiatr Scand 129:180–192.
   PubMed Web of Science ®Google Scholar
• Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT. 2007. Social regulation of gene expression in human leukocytes. Genome Biol 8:R189.
   PubMed Web of Science ®Google Scholar
• Courtet P, Gottesman, II, Jollant F, Gould, TD. 2011. The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Transl Psychiatry 1, pii:e7.
   PubMed Web of Science ®Google Scholar
• Courtet P. 2013. Suicide et environnement social. Paris: DUNOD.
   Google Scholar
• Couzin-Frankel J. 2010. Inflammation bares a dark side. Science 330:1621.
   PubMed Web of Science ®Google Scholar
• Danese A, McEwen BS. 2012. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav 106:29–39.
   PubMed Web of Science ®Google Scholar
• Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A. 2008. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 65:409–415.
   PubMed Web of Science ®Google Scholar
• Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, et al. 2000. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. Br Med J 321:199–204.
   PubMed Web of Science ®Google Scholar
• Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56.
   PubMed Web of Science ®Google Scholar
• DiazGranados N, Ibrahim LA, Brutsche NE, Ameli R, Henter ID, Luckenbaugh DA, et al. 2010. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry 71:1605–1611.
   PubMed Web of Science ®Google Scholar
• Dich N, Hansen AM, Avlund K, Lund R, Mortensen EL, Bruunsgaard H, et al. 2014. Early life adversity potentiates the effects of later life stress on cumulative physiological dysregulation. Anxiety Stress Coping 1–19.
   Google Scholar
• Dickerson SS, Gable SL, Irwin MR, Aziz N, Kemeny ME. 2009. Social-evaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychol Sci 20:1237–1244.
   PubMed Web of Science ®Google Scholar
• Dietz LJ, Stoyak S, Melhem N, Porta G, Matthews KA, Walker Payne M, et al. 2013. Cortisol response to social stress in parentally bereaved youth. Biol Psychiatry 73:379–387.
   PubMed Web of Science ®Google Scholar
• Dong H, Zhang X, Dai X, Lu S, Gui B, Jin, W, et al. 2014. Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation 11:140.
   PubMed Web of Science ®Google Scholar
• Dowlati Y, Herrmann N, Swardfager, W, Liu H, Sham L, Reim EK, et al. 2010. A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457.
   PubMed Web of Science ®Google Scholar
• Ducasse D, Olié E, Guillaume S, Artero S, Courtet P. 2015. A meta-analysis of cytokines in suicidal beahvior. Brain Behav Immun 46:203–211.
   PubMed Web of Science ®Google Scholar
• Ducasse D, Rene E, Beziat S, Guillaume S, Courtet P, Olie E. 2014. Acceptance and commitment therapy for management of suicidal patients: a pilot study. Psychother Psychosom 83:374–376.
   PubMed Web of Science ®Google Scholar
• Eisenberger NI. 2012. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nat Rev Neurosci 13:421–434.
   PubMed Web of Science ®Google Scholar
• Eisenberger NI, Lieberman MD. 2004. Why rejection hurts: a common neural alarm system for physical and social pain. Trends Cogn Sci 8:294–300.
   PubMed Web of Science ®Google Scholar
• Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, et al. 2013. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 38:743–752.
   PubMed Web of Science ®Google Scholar
• Falcone T, Fazio V, Lee C, Simon B, Franco K, Marchi N, et al. 2010. Serum SB100: a potential biomarker for suicidality in adolescents? PloS One 5:e11089.
   PubMed Web of Science ®Google Scholar
• Fardet L, Petersen I, Nazareth I. 2012. Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care. Am J Psychiatry 169:491–497.
   PubMed Web of Science ®Google Scholar
• Feinstein A. 2002. An examination of suicidal intent in patients with multiple sclerosis. Neurology 59:674–678.
   PubMed Web of Science ®Google Scholar
• Feinstein A. 2011. Multiple sclerosis and depression. Mult Scler 17:1276–1281.
   PubMed Web of Science ®Google Scholar
• Felger JC, Lotrich FE. 2013. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199–229.
   PubMed Web of Science ®Google Scholar
• Fragoso YD, Frota ER, Lopes JS, Noal JS, Giacomo MC, Gomes S, et al. 2010. Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis. Clin Neuropharmacol 33:312–316.
   PubMed Web of Science ®Google Scholar
• Fredrikson S, Cheng Q, Jiang G, Wasserman D. 2003. Elevated suicide risk among patients with multiple sclerosis in Sweden. Neuroepidemiology 22:146–152.
   PubMed Web of Science ®Google Scholar
• Fukunishi K, Tanaka H, Maruyama J, Takahashi H, Kitagishi H, Ueshima T, et al. 1998. Burns in a suicide attempt related to psychiatric side effects of interferon. Burns 24:581–583.
   PubMed Web of Science ®Google Scholar
• Gabbay V, Klein RG, Guttman LE, Babb JS, Alonso CM, Nishawala M, et al. 2009. A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression. J Child Adolesc Psychopharmacol 19:423–430.
   PubMed Web of Science ®Google Scholar
• Galfalvy H, Mann JJ. 2011. Cerebrospinal fluid biomarkers in suicide attempters. Acta Psychiatr Scand 124:4–5.
   PubMed Web of Science ®Google Scholar
• Gettings L. 2010. Psychological well-being in rheumatoid arthritis: a review of the literature. Musculoskeletal Care 8:99–106.
   PubMedGoogle Scholar
• Goodin DS, Corwin M, Kaufman D, Golub H, Reshef S, Rametta MJ, et al. 2014. Causes of death among commercially insured multiple sclerosis patients in the United States. PloS One 9:e105207.
   PubMed Web of Science ®Google Scholar
• Goodwin RD, Eaton, WW. 2005. Asthma, suicidal ideation, and suicide attempts: findings from the Baltimore epidemiologic catchment area follow-up. Am J Public Health 95:717–722.
   PubMed Web of Science ®Google Scholar
• Goodwin RD, Messineo K, Bregante A, Hoven CW, Kairam R. 2005. Prevalence of probable mental disorders among pediatric asthma patients in an inner-city clinic. J Asthma 42:643–647.
   PubMed Web of Science ®Google Scholar
• Grassi-Oliveira R, Brieztke E, Teixeira A, Pezzi JC, Zanini M, Lopes RP, et al. 2012. Peripheral chemokine levels in women with recurrent major depression with suicidal ideation. Rev Bras Psiquiatr 34:71–75.
   PubMed Web of Science ®Google Scholar
• Greden JF. 2001. The burden of disease for treatment-resistant depression. J Clin Psychiatry 62(Suppl 16):26–31.
   PubMedGoogle Scholar
• Hackett RA, Hamer M, Endrighi R, Brydon L, Steptoe A. 2012. Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women. Psychoneuroendocrinology 37:1801–1809.
   PubMed Web of Science ®Google Scholar
• Hanke ML, Kielian T. 2011. Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (London) 121:367–387.
   PubMed Web of Science ®Google Scholar
• Haroon E, Raison CL, Miller AH. 2012. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37:137–162.
   PubMed Web of Science ®Google Scholar
• Harris EC, Barraclough BM. 1994. Suicide as an outcome for medical disorders. Medicine (Baltimore) 73:281–296.
   PubMed Web of Science ®Google Scholar
• Henningsson S, Baghaei F, Rosmond R, Holm G, Landen M, Anckarsater H, et al. 2008. Association between serum levels of C-reactive protein and personality traits in women. Behav Brain Funct 4:16.
   PubMed Web of Science ®Google Scholar
• Holsboer F. 2000. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477–501.
   PubMed Web of Science ®Google Scholar
• Hsu PC, Groer M, Beckie T. 2014. New findings: Depression, suicide, and Toxoplasma gondii infection. J Am Assoc Nurse Pract 26:629–637.
   PubMed Web of Science ®Google Scholar
• Huang TL, Lee CT. 2007. T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression. Psychiatry Clin Neurosci 61:415–420.
   PubMed Web of Science ®Google Scholar
• Irwin MR, Cole SW. 2011. Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11: 625–632.
   PubMed Web of Science ®Google Scholar
• Isometsa E, Heikkinen M, Henriksson M, Aro H, Lonnqvist J. 1995. Recent life events and completed suicide in bipolar affective disorder. A comparison with major depressive suicides . J Affect Disord 33:99–106.
   PubMed Web of Science ®Google Scholar
• Isung J, Aeinehband S, Mobarrez F, Martensson B, Nordstrom P, Asberg M, et al. 2012a. Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. Transl Psychiatry 2, e196.
   PubMed Web of Science ®Google Scholar
• Isung J, Mobarrez F, Nordstrom P, Asberg M, Jokinen J. 2012b. Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. World J Biol Psychiatry 13:468–473.
   PubMed Web of Science ®Google Scholar
• Janelidze S, Mattei D, Westrin A, Traskman-Bendz L, Brundin L. 2011. Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun 25:335–339.
   PubMed Web of Science ®Google Scholar
• Janelidze S, Ventorp F, Erhardt S, Hansson O, Minthon L, Flax J, et al. 2013. Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters. Psychoneuroendocrinology 38:853–862.
   PubMed Web of Science ®Google Scholar
• Janelidze S, Suchankova P, Ekman A, Erhardt S, Sellgren C, Samuelsson M, et al. 2014. Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels. Acta Psychiatr Scand 1–10.
   Google Scholar
• Janssen HL, Brouwer JT, van der Mast RC, Schalm SW. 1994. Suicide associated with alfa-interferon therapy for chronic viral hepatitis. J Hepatol 21:241–243.
   PubMed Web of Science ®Google Scholar
• Joiner T. 2005. Why people die by suicide. Cambridge, MA: Harvard University Press.
   Google Scholar
• Jollant F, Lawrence NS, Giampietro V, Brammer MJ, Fullana MA, Drapier D, et al. 2011. Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. Am J Psychiatry 165:740–748.
   Web of Science ®Google Scholar
• Karlovic D, Serretti A, Vrkic N, Martinac M, Marcinko D. 2012. Serum concentrations of CRP, IL6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Res 198:74–80.
   PubMed Web of Science ®Google Scholar
• Kim YK, Lee SW, Kim SH, Shim SH, Han SW, Choi SH, et al. 2008. Differences in cytokines between non-suicidal patients and suicidal patients in major depression. Prog Neuropsychopharmacol Biol Psychiatry 32:356–361.
   PubMed Web of Science ®Google Scholar
• Knox KL, Litts DA, Talcott GW, Feig JC, Caine ED. 2003. Risk of suicide and related adverse outcomes after exposure to a suicide prevention programme in the US Air Force: cohort study. Br Med J 327:1376.
   PubMed Web of Science ®Google Scholar
• Kodaka M, Matsumoto T, Katsumata Y, Akazawa M, Tachimori H, Kawakami N, et al. 2014. Suicide risk among individuals with sleep disturbances in Japan: a case-control psychological autopsy study. Sleep Med 15:430–435.
   PubMed Web of Science ®Google Scholar
• Kraus MR, Schafer A, Faller H, Csef H, Scheurlen M. 2003. Psychiatric symptoms in patients with chronic hepatitis C receiving interferon alfa-2b therapy. J Clin Psychiatry 64:708–714.
   PubMed Web of Science ®Google Scholar
• Kudoh A, Takahira Y, Katagai H, Takazawa T. 2002. Small-dose ketamine improves the postoperative state of depressed patients. Anesth Analg 95:114–118, table of contents.
   PubMed Web of Science ®Google Scholar
• Labonte B, Yerko V, Gross J, Mechawar N, Meaney MJ, Szyf M, et al. 2012. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry 72:41–48.
   PubMed Web of Science ®Google Scholar
• Lana-Peixoto MA, Teixeira AL Jr, Haase VG. 2002. Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis. Arq Neuropsiquiatr 60:721–724.
   PubMed Web of Science ®Google Scholar
• Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H. 2000. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22:370–379.
   PubMed Web of Science ®Google Scholar
• Larkin GL, Beautrais AL. 2011. A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. Int J Neuropsychopharmacol 14:1127–1131.
   PubMed Web of Science ®Google Scholar
• Lee HY, Kim YK. 2010. Transforming growth factor-beta1 and major depressive disorder with and without attempted suicide: preliminary study. Psychiatry Res 178:92–96.
   PubMed Web of Science ®Google Scholar
• Leonard B 2000. Stress, depression and the activation of the immune system. World J Biol Psychiatry 1:17–25.
   PubMedGoogle Scholar
• Lester D. 1992. The dexamethasone suppression test as an indicator of suicide: a meta-analysis. Pharmacopsychiatry 25: 265–270.
   PubMed Web of Science ®Google Scholar
• Li H, Li Q, Du X, Sun Y, Wang X, Kroemer G, et al. 2011. Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J Cereb Blood Flow Metab 31:2106–2115.
   PubMed Web of Science ®Google Scholar
• Li Z, Qi D, Chen J, Zhang C, Yi Z, Yuan C, et al. 2013. Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-alpha) in the Chinese patients with major depressive disorder: a prospective longitudinal study. Psychoneuroendocrinology 38:107–114.
   PubMed Web of Science ®Google Scholar
• Lindqvist D, Janelidze S, Erhardt S, Traskman-Bendz L, Engstrom G, Brundin L. 2011. CSF biomarkers in suicide attempters–a principal component analysis. Acta Psychiatr Scand 124:52–61.
   PubMed Web of Science ®Google Scholar
• Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, et al. 2009. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol Psychiatry 66:287–292.
   PubMed Web of Science ®Google Scholar
• Ling VJ, Lester D, Mortensen PB, Langenberg PW, Postolache TT. 2011. Toxoplasma gondii seropositivity and suicide rates in women. J Nerv Ment Dis 199:440–444.
   PubMed Web of Science ®Google Scholar
• Lotrich FE, Ferrell RE, Rabinovitz M, Pollock BG. 2010. Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha. Clin Neuropharmacol 33:191–197.
   PubMed Web of Science ®Google Scholar
• Matsukawa Y, Sawada S, Hayama T, Usui H, Horie T. 1994. Suicide in patients with systemic lupus erythematosus: a clinical analysis of seven suicidal patients. Lupus 3:31–35.
   PubMed Web of Science ®Google Scholar
• McGirr A, Diaconu G, Berlim MT, Pruessner JC, Sable R, Cabot S, et al. 2010. Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J Psychiatry Neurosci 35:399–408.
   PubMed Web of Science ®Google Scholar
• McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonte B, Szyf M, et al. 2009. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342–348.
   PubMed Web of Science ®Google Scholar
• McNally L, Bhagwagar Z, Hannestad J. 2008. Inflammation, glutamate, and glia in depression: a literature review. CNS Spectr 13:501–510.
   PubMed Web of Science ®Google Scholar
• Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, et al. 2004. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43:678–683.
   PubMed Web of Science ®Google Scholar
• Mendlovic S, Mozes E, Eilat E, Doron A, Lereya J, Zakuth V, et al. 1999. Immune activation in non-treated suicidal major depression. Immunol Lett 67:105–108.
   PubMed Web of Science ®Google Scholar
• Miller GE, Chen E, Parker KJ. 2011. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull 137:959–997.
   PubMed Web of Science ®Google Scholar
• Mitchell AM, Possel P, Sjogren E, Kristenson M. 2013. Hopelessness the “active ingredient”? Associations of hopelessness and depressive symptoms with interleukin-6. Int J Psychiatry Med 46:109–117.
   PubMed Web of Science ®Google Scholar
• Modabbernia A, Taslimi S, Brietzke E, Ashrafi M. 2013. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 74:15–25.
   PubMed Web of Science ®Google Scholar
• Mok CC, Chan KL, Cheung EF, Yip PS. 2014. Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors. Rheumatology (Oxford) 53:714–721.
   PubMed Web of Science ®Google Scholar
• Monfrim X, Gazal M, De Leon PB, Quevedo L, Souza LD. 2014. Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin-releasing hormone and interleukin-1b? Bipolar Disord 16: 741–747.
   PubMed Web of Science ®Google Scholar
• Motivala SJ, Sarfatti A, Olmos L, Irwin MR. 2005. Inflammatory markers and sleep disturbance in major depression. Psychosom Med 67:187–194.
   PubMed Web of Science ®Google Scholar
• Muller N, Schwartz MJ. 2007. The immune-mediated alteration of serotonin and glutamate: towards and integrated view of depression. Mol Psychiatry 12:988–1000.
   PubMed Web of Science ®Google Scholar
• Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. 2009.
   Google Scholar
• Cadiovascular, inflammatory and metabolic consequences of sleep deprivation. Progr Cardiovasc Dis 51:294–302.
   PubMed Web of Science ®Google Scholar
• Murphy ML, Slavich GM, Rohleder N, Miller GE. 2013. Targeted rejection triggers differential pro- and anti-inflammatory gene expression in adolescents as a function of social status. Clin Psychol Sci 1:30–40.
   PubMedGoogle Scholar
• Nowak G, Ordway GA, Paul IA. 1995. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res 675:157–164.
   PubMed Web of Science ®Google Scholar
• O’Donovan A, Lin J, Tillie J, Dhabhar FS, Wolkowitz OM, Blackburn EH, et al. 2009. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun 23:446–449.
   PubMed Web of Science ®Google Scholar
• O’Donovan A, Rush G, Hoatam G, Hughes BM, McCrohan A, Kelleher C, et al. 2013. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anx 30:307–314.
   PubMed Web of Science ®Google Scholar
• Okusaga O, Langenberg P, Sleemi A, Vaswani D, Giegling I, Hartmann AM, et al. 2011. Toxoplasma gondii antibody titers and history of suicide attempts in patients with schizophrenia. Schizophr Res 133:150–155.
   PubMed Web of Science ®Google Scholar
• Okusaga O, Postolache TT. 2012. Toxoplasma gondii, the immune system, and suicidal behavior. In: Dwivedi Y, editor. Source. The Neurobiological Basis of Suicide. Boca Raton, FL: CRC Press. Chapter 19. Frontiers in neuroscience.
   Google Scholar
• Omrani MD, Bagheri M, Bushehri B, Azizi F, Anoshae MR. 2012. The association of TGF-beta1 codon 10 polymorphism with suicide behavior. Am J Med Genet B Neuropsychiatr Genet 159B:772–775.
   PubMed Web of Science ®Google Scholar
• Omrani MD, Bushehri B, Bagheri M, Salaki-Lak S, Alipour A, Anoshae MR, et al. 2009. Role of IL-10 -1082, IFN-gamma + 874, and TNF-alpha -308 genes polymorphisms in suicidal behavior. Arch Suicide Res 13:330–339.
   PubMed Web of Science ®Google Scholar
• Opp MR, Born J, Irwin MR. 2007. Sleep and the immune system. In: Ader R, editor. Psychoneuroimmunology. New York, NY: Academic Press. p 570–618.
   Google Scholar
• Oquendo MA, Galfalvy H, Russo S, Ellis SP, Grunebaum MF, Burke A, et al. 2004. Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry 161:1433–1441.
   PubMed Web of Science ®Google Scholar
• Pace TW, Negi LT, Adame DD, Cole SP, Sivilli TI, Brown TD, et al. 2009. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology 34:87–98.
   PubMed Web of Science ®Google Scholar
• Pandey GN, Rizavi HS, Ren X, Bhaumik R, Dwivedi Y. 2014. Toll-like receptors in the depressed and suicide brain. J Psychiatr Res 53:62–68.
   PubMed Web of Science ®Google Scholar
• Pandey GN, Rizavi HS, Ren X, Dwivedi Y, Palkovits M. 2013. Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims. Psychoneuroendocrinology 38:2628–2639.
   PubMed Web of Science ®Google Scholar
• Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, et al. 2012. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res 46:57–63.
   PubMed Web of Science ®Google Scholar
• Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT. 2012. Toxoplasma gondii infection and self-directed violence in mothers. Arch Gen Psychiatry 69: 1123–1130.
   PubMed Web of Science ®Google Scholar
• Perez-Ortiz JM, Garcia-Gutierrez MS, Navarrete F, Giner S, Manzanares J. 2013. Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims. Psychoneuroendocrinology 38:1251–1258.
   PubMed Web of Science ®Google Scholar
• Perroud N, Baud P, Ardu S, Krejci I, Mouthon D, Vessaz M, et al. 2013. Temperament personality profiles in suicidal behaviour: an investigation of associated demographic, clinical and genetic factors. J Affect Disord 146:246–253.
   PubMed Web of Science ®Google Scholar
• Perroud N, Baud P, Mouthon D, Courtet P, Malafosse A. 2011. Impulsivity, aggression and suicidal behavior in unipolar and bipolar disorders. J Affect Disord 134:112–118.
   PubMed Web of Science ®Google Scholar
• Perroud N, Courtet P, Vincze I, Jaussent I, Jollant F, Bellivier F, et al. 2008. Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt. Genes Brain Behav 7:314–322.
   PubMed Web of Science ®Google Scholar
• Pinho de Oliveira Ribeiro N, Rafael de Mello Schier A, Ornelas AC, Pinho de Oliveira CM, Nardi AE, Silva AC. 2013. Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Compr Psychiatry 54:1185–1189.
   PubMed Web of Science ®Google Scholar
• Postolache TT, Mortensen PB, Tonelli LH, Jiao X, Frangakis C, Soriano JJ, et al. 2010. Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders. J Affect Disord 121:88–93.
   PubMed Web of Science ®Google Scholar
• Postolache TT, Stiller JW, Herrell R, Goldstein MA, Shreeram SS, Zebrak R, et al. 2005. Tree pollen peaks are associated with increased nonviolent suicide in women. Mol Psychiatry 10: 232–235.
   PubMed Web of Science ®Google Scholar
• Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E. 2008. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63:801–808.
   PubMed Web of Science ®Google Scholar
• Price RB, Iosifescu DV, Murrough JW, Chang LC, Al Jurdi RK, Iqbal SZ, et al. 2014. Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression. Depress Anx 31:335–343.
   PubMed Web of Science ®Google Scholar
• Price RB, Nock MK, Charney DS, Mathew SJ. 2009. Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry 66:522–526.
   PubMed Web of Science ®Google Scholar
• Qin P, Mortensen PB, Waltoft BL, Postolache TT. 2011. Allergy is associated with suicide completion with a possible mediating role of mood disorder – a population-based study. Allergy 66:658–664.
   PubMed Web of Science ®Google Scholar
• Raison CL, Miller AH. 2003. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 160:1554–1565.
   PubMed Web of Science ®Google Scholar
• Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, et al. 2013. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment- resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31–41.
   PubMed Web of Science ®Google Scholar
• Ribeiro JD, Joiner TE. 2009. The interpersonal-psychological theory of suicidal behavior: current status and future directions. J Clin Psychol 65:1291–1299.
   PubMed Web of Science ®Google Scholar
• Roy B, Diez-Roux AV, Seeman T, Ranjit N, Shea S, Cushman M. 2010. Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA). Psychosom Med 72:134–140.
   PubMed Web of Science ®Google Scholar
• Rujescu D, Giegling I. 2010. The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin. Eur Psychiatry 25:272–274.
   PubMed Web of Science ®Google Scholar
• Sadovnick AD, Eisen K, Ebers GC, Paty DW. 1991. Cause of death in patients attending multiple sclerosis clinics. Neurology 41:1193–1196.
   PubMed Web of Science ®Google Scholar
• Saiz PA, Garcia-Portilla P, Paredes B, Arango C, Morales B, Alvarez V, et al. 2008. Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts. Psychiatr Genet 18:147–150.
   PubMed Web of Science ®Google Scholar
• Saiz PA, Garcia-Portilla P, Paredes B, Corcoran P, Arango C, Morales B, et al. 2011. Role of serotonergic-related systems in suicidal behavior: data from a case-control association study. Prog Neuropsychopharmacol Biol Psychiatry 35:1518–1524.
   PubMed Web of Science ®Google Scholar
• Schnieder TP, Trencevska I, Rosoklija G, Stankov A, Mann JJ, Smiley J, et al. 2014. Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol 73:880–890.
   PubMed Web of Science ®Google Scholar
• Schwarcz R, Guidetti P, Sathyasaikumar KV, Muchowski PJ. 2010. Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Prog Neurobiol 90: 230–245.
   PubMed Web of Science ®Google Scholar
• Sequeira A, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, et al. 2012. Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. PloS One 7, e35367.
   PubMed Web of Science ®Google Scholar
• Slavich GM, Cole SW. 2013. The emerging field of human social genomics. Clin Psychol Sci 1:331–348.
   PubMedGoogle Scholar
• Slavich GM, Thornton T, Torres LD, Monroe SM, Gotlib IH. 2009. Targeted rejection predicts hastened onset of major depression. J Soc Clin Psychol 28:223–243.
   PubMed Web of Science ®Google Scholar
• Sockalingam S, Links PS, Abbey SE. 2011. Suicide risk in hepatitis C and during interferon-alpha therapy: a review and clinical update. J Viral Hepat 18:153–160.
   PubMed Web of Science ®Google Scholar
• Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, et al. 2008. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res 42:151–157.
   PubMed Web of Science ®Google Scholar
• Steiner J, Mawrin C, Ziegeler A, Bielau H, Ullrich O, Bernstein HG, et al. 2006. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathol 112:305–316.
   PubMed Web of Science ®Google Scholar
• Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, et al. 2011. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation 8:94.
   PubMed Web of Science ®Google Scholar
• Stenager EN, Stenager E, Koch-Henriksen N, Bronnum-Hansen H, Hyllested K, Jensen K, et al. 1992. Suicide and multiple sclerosis: an epidemiological investigation. J Neurol Neurosurg Psychiatry 55:542–545.
   PubMed Web of Science ®Google Scholar
• Stuart MJ, Baune BT. 2014. Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies. Neurosci Biobehav Rev 42:93–115.
   PubMed Web of Science ®Google Scholar
• Suarez EC. 2008. Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav Immun 22:960–968.
   PubMed Web of Science ®Google Scholar
• Sublette ME, Galfalvy HC, Fuchs D, Lapidus M, Grunebaum MF, Oquendo MA, et al. 2011. Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun 25:1272–1278.
   PubMed Web of Science ®Google Scholar
• Suchankova P, Henningsson S, Baghaei F, Rosmond R, Holm G, Ekman A. 2009. Genetic variability within the innate immune system influences personality traits in women. Genes Brain Behav 8:212–217.
   PubMed Web of Science ®Google Scholar
• Suchankova P, Holm G, Traskman-Bendz L, Brundin L, Ekman A. 2013. The + 1444C> T polymorphism in the CRP gene: a study on personality traits and suicidal behaviour. Psychiatr Genet 23:70–76.
   PubMed Web of Science ®Google Scholar
• Sutin AR, Terracciano A, Deiana B, Naitza S, Ferrucci L, Uda M, et al. 2010. High neuroticism and low conscientiousness are associated with interleukin-6. Psychol Med 40:1485–1493.
   PubMed Web of Science ®Google Scholar
• Thakurta RG, Das R, Bhattacharya AK, Saha D, Sen S, Singh OP, et al. 2012. Rapid response with ketamine on suicidal cognition in resistant depression. Indian J Psychol Med 34:170–175.
   PubMedGoogle Scholar
• Tiihonen J, Virkkunen M, Rasanen P, Pennanen S, Sainio EL, Callaway J, et al. 2001. Free L-tryptophan plasma levels in antisocial violent offenders. Psychopharmacology (Berlin) 157:395–400.
   PubMed Web of Science ®Google Scholar
• Timonen M, Viilo K, Hakko H, Sarkioja T, Meyer-Rochow VB, Vaisanen E, et al. 2004. Is seasonality of suicides stronger in victims with hospital-treated atopic disorders? Psychiatry Res 126:167–175.
   PubMed Web of Science ®Google Scholar
• Timonen M, Viilo K, Hakko H, Sarkioja T, Ylikulju M, Meyer-Rochow VB, et al. 2003. Suicides in persons suffering from rheumatoid arthritis. Rheumatology (Oxford) 42:287–291.
   PubMed Web of Science ®Google Scholar
• Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K, et al. 2008. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand 117:198–206.
   PubMed Web of Science ®Google Scholar
• Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. 2014. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 42:50–59.
   PubMed Web of Science ®Google Scholar
• Torres-Platas SG, Hercher C, Davoli MA, Maussion G, Labonte B, Turecki G, et al. 2011. Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology 36:2650–2658.
   PubMed Web of Science ®Google Scholar
• Treharne GJ, Lyons AC, Kitas GD. 2000. Suicidal ideation in patients with rheumatoid arthritis. Research may help identify patients at high risk. Br Med J 321:1290.
   Google Scholar
• Turiano NA, Mroczek DK, Moynihan J, Chapman BP. 2013. Big 5 personality traits and interleukin-6: evidence for “healthy Neuroticism” in a US population sample. Brain Behav Immun 28:83–89.
   PubMed Web of Science ®Google Scholar
• Turner AP, Williams RM, Bowen JD, Rivlahan DR, Haselkorn JK. 2006. Suicidal ideation in multiple sclerosis. Arch Phys Med Rehabil 87:1073–1078.
   PubMed Web of Science ®Google Scholar
• Tursich M, Neufeld RW, Frewen PA, Harricharan S, Kibler JL, Rhind SG, et al. 2014. Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis. Transl Psychiatry 4, e413.
   PubMed Web of Science ®Google Scholar
• Tyrka AR, Burgers DE, Philip NS, Price LH, Carpenter LL. 2013. The neurobiological correlates of childhood adversity and implications for treatment. Acta Psychiatr Scand 128:434–447.
   PubMed Web of Science ®Google Scholar
• Uher R, Tansey KE, Dew T, Maier, W, Mors O, Hauser J, et al. 2014. An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am J Psychiatry.
   PubMed Web of Science ®Google Scholar
• Vaiva G, Ducrocq F, Meyer P, Mathieu D, Philippe A, Libersa C, et al. 2006. Effect of telephone contact on further suicide attempts in patients discharged from an emergency department: randomised controlled study. BMJ 332:1241–1245.
   PubMed Web of Science ®Google Scholar
• Valkanova V, Ebmeier KP, Allan CL. 2013. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150:736–744.
   PubMed Web of Science ®Google Scholar
• Van Orden KA, Witte TK, Cukrowicz KC, Braithwaite SR, Selby EA, Joiner TE. 2010. The interpersonal theory of suicide. Psychol Rev 117:575–600.
   PubMed Web of Science ®Google Scholar
• Vargas HO, Nunes SO, Pizzo de Castro M, Bortolasci CC, Sabbatini Barbosa D, Kaminami Morimoto H, et al. 2013. Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts. J Affect Disord 150:923–930.
   PubMed Web of Science ®Google Scholar
• Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, et al. 1999. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 84:2603–2607.
   PubMed Web of Science ®Google Scholar
• Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, et al. 2004. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89:2119–2126.
   PubMed Web of Science ®Google Scholar
• Vignau J, Soichot M, Imbenotte M, Jacquemont MC, Danel T, Vandamme M, et al. 2010. Impact of tryptophan metabolism on the vulnerability to alcohol-related blackouts and violent impulsive behaviours. Alcohol Alcohol 45:79–88.
   PubMed Web of Science ®Google Scholar
• Viner R, Patten SB, Berzins S, Bulloch AG, Fiest KM. 2014. Prevalence and risk factors for suicidal ideation in a multiple sclerosis population. J Psychosom Res 76:312–316.
   PubMed Web of Science ®Google Scholar
• Williams KD. 2007. Ostracism. Annu Rev Psychol 58:425–452.
   PubMed Web of Science ®Google Scholar
• Woo JM, Gibbons RD, Qin P, Komarow H, Kim JB, Rogers CA, et al. 2011. Suicide and prescription rates of intranasal corticosteroids and nonsedating antihistamines for allergic rhinitis: an ecological study. J Clin Psychiatry 72:1423–1428.
   PubMed Web of Science ®Google Scholar
• Woo JM, Okusaga O, Postolache TT. 2012. Seasonality of suicidal behavior. Int J Environ Res Public Health 9:531–547.
   PubMed Web of Science ®Google Scholar
• Xie LF, Chen PL, Pan HF, Tao JH, Li XP, Zhang YJ, et al. 2012. Prevalence and correlates of suicidal ideation in SLE inpatients: Chinese experience. Rheumatol Int 32: 2707–2714.
   PubMed Web of Science ®Google Scholar
• Yagmur F, Yazar S, Temel HO, Cavusoglu M. 2010. May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects? Forensic Sci Int 199:15–17.
   PubMed Web of Science ®Google Scholar
• Yamakawa K, Matsunaga M, Isowa T, Kimura K, Kasugai K, Yoneda M, et al. 2009. Transient responses of inflammatory cytokines in acute stress. Biol Psychol 82:25–32.
   PubMed Web of Science ®Google Scholar
• Yang JJ, Wang N, Yang C, Shi JY, Yu HY, Hashimoto K. 2015. Serum Interleukin-6 is a predictive biomarker for ketamine's antidepressant effect in treatment-resistant patients with major depression. Biol Psychiatry 77:e19–20.
   PubMed Web of Science ®Google Scholar
• Yirmiya R, Goshen I. 2011. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25:181–213.
   PubMed Web of Science ®Google Scholar
• Zarate CA Jr, Brutsche NE, Ibrahim L, Franco-Chaves J, Diazgranados N, Cravchik A, et al. 2012. Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry 71: 939–946.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Traskman-Bendz L, Janelidze S, Langenberg P, Saleh A, Constantine N, et al. 2012. Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence. J Clin Psychiatry 73:1069–1076.
   PubMed Web of Science ®Google Scholar