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Original Investigation

Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review

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Pages 622-633 | Received 17 Feb 2015, Accepted 18 Jun 2015, Published online: 30 Jul 2015

References

  • Alzheimer's Disease International. 2010. World Alzheimer Report 2010. The Global Economic Impact of Dementia. London: Alzheimer's Disease International.
  • APA American Psychiatric Association. 1987. Diagnostic and statistical manual of mental disorders. 3rd ed. Revised. Washington, DC: American Psychiatric Association.
  • APA American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association.
  • Banerjee S, Samsi K, Petrie CD, Alvir J, Treglia M, Schwam EM, del Valle M. 2009. What do we know about quality of life in dementia? A review of the emerging evidence on the predictive and explanatory value of disease specific measures of health related quality of life in people with dementia. Int J Geriatr Psychiatry 24:15–24.
  • Beesdo K, Hartford J, Russell J, Spann M, Ball S, Wittchen HU. 2009. The short- and long-term effect of duloxetine on painful physical symptoms in patients with generalized anxiety disorder: results from three clinical trials. J Anxiety Disord 23:1064–1071.
  • Birks J, Grimley Evans J. 2009. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2009:1. Art. No.: CD003120. DOI: 10.1002/14651858.CD003120.pub3.
  • Bråne G, Gottfries CG, Winblad B. 2001. The Gottfries- Bråne-Steen Scale: Validity, reliability and application in anti-dementia drug trials. Dement Geriatr Cogn Disord 12:1–14.
  • Citrome L. 2014. Quantifying clinical relevance. Innov Clin Neurosci 11:26–30.
  • Cohen J. 1988. Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Lawrence Erlbaum Associates. 567 p.
  • Cummings JL. 1997. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 48(Suppl 6): S10–16.
  • de Vugt ME, Stevens F, Aalten P, Lousberg R, Jaspers N, Verhey FRJ. 2005. A prospective study of the effects of behavioral symptoms on the institutionalization of patients with dementia. Int Psychogeriatr 17:1–13.
  • Di Iulio F, Palmer K, Blundo C, Casini AR, Gianni W, Caltagirone C, et al. 2010. Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes. Int Psychogeriatr 22:629–640.
  • Erzigkeit H. 1992. SKT Manual. A short cognitive performance test for assessing memory and attention. Weinheim: Beltz Test.
  • Gauthier S, Loft H, Cummings JL. 2008. Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis. Int J Geriatr Psychiatry 23:537–545.
  • Gilley DW, Bienias JL, Wilson RS, Bennett DA, Beck TL, Evans DA. 2004. Influence of behavioral symptoms on rates of institutionalization for persons with Alzheimer's disease. Psychol Med 34:1129–1135.
  • Hamilton M. 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62.
  • Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, Schlaefke S. 2012. Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res. 46:716–723.
  • Higgins JPT, Whitehead A, Turner RM, Omar RZ, Thompson SG. 2001. Meta-analysis of continuous outcome data from individual patients. Stat Med 20:2219–2241.
  • Ihl R, Grass-Kapanke B, Jänner M, Weyer G. 1999. Neuropsychometric tests in cross sectional and longitudinal studies – a regression analysis of ADAS-Cog, SKT and MMSE. Pharmacopsychiatry 32:248–254.
  • Ihl R, Tribanek M, Bachinskaya N. 2010. Baseline neuropsychiatric symptoms are effect modifiers in Ginkgo biloba extract (EGb 761®) treatment of dementia with neuropsychiatric features. Retrospective data analyses of a randomized controlled trial. J Neurol Sci 299:184–187.
  • Ihl R, Bachinskaya N, Korczyn A, Vakhapova V, Tribanek M, Hoerr R, et al. 2011a. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features. A randomized controlled trial. Int J Geriatr Psychiatry 26:1186–1194.
  • Ihl R, Frölich L, Winblad B, Schneider L, Burns A, Möller HJ, et al. 2011b. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of Alzheimer's disease and other dementias. World J Biol Psychiatry 12:2–32.
  • Janssen IM, Sturtz S, Skipka G, Zentner A, Garrido MV, Busse R. 2010. Ginkgo biloba in Alzheimer's disease: a systematic review. Wien Med Wochenschr 160:539–546.
  • Kanowski S, Hoerr R. 2003. Ginkgo biloba extract EGb 761® in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial. Pharmacopsychiatry 36:297–303.
  • Karttunen K, Karppi P, Hiltunen A, Vanhanen M, Välimäki T, Martikainen J, et al. 2011. Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease. Int J Geriatr Psychiatry 26:473–482.
  • Kim YS, Nibbelink DW, Overall JE. 1993. Factor structure and scoring of the SKT test battery. J Clin Psychol 49:61–71.
  • Lanctôt KL, Herrmann N, Yau KK, Khan LR, Liu BA, LouLou MM, Einarson TR. 2003. Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis. Can Med Assoc J 169:557–564.
  • Lang F, Hoerr R, Noeldner M, Koch E. 2013. Ginkgo biloba extract EGb 761®: From an ancient Asian plant to a modern European herbal medicinal product. In: Wagner H, Ulrich-Merzenich G, editors. Evidence and rational based research on Chinese drugs. Wien: Springer. p 431–470.
  • Le Bars PL, Kieser M, Itil KZ. 2000. A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761® in dementia. Dement Geriatr Cogn Disord 11:230–237.
  • Leber P. 1990 (US Food and Drug Administration). Guidelines for the clinical evaluation of antidementia drugs. First Draft 8 November 1990. Rockville (MD): Food and Drug Administration.
  • Livingston G, Katona C. 2000. How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis. Int J Geriatr Psychiatry 15: 203–207.
  • Lockhart IA, Orme ME, Mitchell SA. 2011. The efficacy of licensed-indication use of donepezil and memantine monotherapies for treating behavioural and psychological symptoms of dementia in patients with Alzheimer's disease: Systematic review and meta-analysis. Dement Geriatr Cogn Disord Extra 1:212–227.
  • Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JCS. 2000. Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging. Am J Psychiatry 157:708–714.
  • Mahoney R, Johnston K, Katona C, Maxmin K, Livingston G. 2005. The TE4D-Cog: a new test for detecting early dementia in English-speaking populations. Int J Geriatr Psychiatry 20:1172–1179.
  • Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P. 2009. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med 6:e1000180.
  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939–944.
  • Mega MS, Masterman DM, O'Connor SM, Barclay TR, Cummings JL. 1999. The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease. Arch Neurol 56:1388–1393.
  • Müller WE, Heiser J, Leuner K. 2012. Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity. Int Psychogeratr 24(Suppl 1):S21–24.
  • Napryeyenko O, Borzenko I, GINDEM-NP Study Group. 2007. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung 57:4–11.
  • Nikolova G, Yancheva S, Raychev I, Hoerr R, for the PLAGIN Study Group. 2013. Ginkgo biloba extract in dementia: A 22-week randomised, placebo-controlled, double-blind trial. Bulgarian Neurology 14:139–143.
  • Petrovic M, Hurt C, Collins D, Burns A, Camus V, Liperoti R, et al. 2007. Clustering of behavioural and psychological symptoms in dementia (BPSD): A European Alzheimer's Disease Consortium (EADC) study. Acta Clin Belg 62:426–432.
  • Powlishta KK, Storandt M, Mandernach TA, Hogan E, Grant EA, Morris JC. 2004. Absence of effect of depression on cognitive performance in early-stage Alzheimer Disease. Arch Neurol 61:1265–1268.
  • Rabins PV, Schwartz S, Black BS, Corcoran C, Fauth E, Mielke M, et al. 2013. Predictors of progression to severe Alzheimer's disease in an incidence sample. Alzheimers Dement 9: 204–207.
  • Reisberg B, Finkel S, Overall J, Schmidt-Gollas N, Kanowski S, Lehfeld H, et al. 2001. The Alzheimer's Disease Activities of Daily Living International Scale (ADL-IS). Int Psychogeriatr 13:163–181.
  • Rodda J, Morgan S, Walker Z. 2009. Are cholinesterase inhibitors effective in the management of the behavioural and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr 21:813–824.
  • Rogers Sl, Farlow MR, Doody RS, Mohs R, Friedhoff LT and the Donepezil Study Group. 1998. A 24 week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Neurology 50:136–145.
  • Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. 1993. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43:250–260.
  • Schneider LS, Olin JT, Lyness SA, Chui HC. 1997a. Eligibility of Alzheimer's disease clinic patients for clinical trials. J Am Geriatr Soc 45:923–928.
  • Schneider LS, Olin JT, Doody RS, Clark CM, Morris JC, Reisberg B, et al. 1997b. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. Alzheimer Dis Assoc Disord 11(Suppl 2): S22–32.
  • Schneider LS, DeKosky ST, Farlow MR, Tariot PN, Hoerr R, Kieser M. 2005. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr Alzheimer Res 2:541–551.
  • Schneider JA, Arvanitakis Z, Bang W, Bennett DA. 2007. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69:2197–2204.
  • Smith SC, Lamping DL, Banerjee S, Harwood R, Foley B, Smith P, et al. 2005. Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology. Health Technol Assess 9(10).
  • Stacey B, Parsons B, Huang S, Peyser S, Dukes E. 2004. Gabapentin and improved health status in elderly patients with postherpetic neuralgia: A pooled analysis of three clinical studies. Pharmacy and Therapeutics 29:646–651.
  • Steinberg M, Shao H, Zandi P, Lyketsos CG, Welsh-Bohmer KA, Norton MC, et al. 2008. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry 23:170–177.
  • Tatsch MF, Bottino CM, Azevedo D, Hototian SR, Moscoso MA, Folquitto JC, et al. 2006. Neuropsychiatric symptoms in Alzheimer disease and cognitively impaired, nondemented elderly from a community-based sample in Brazil: Prevalence and relationship with dementia severity. Am J Geriatr Psychiatry 14:438–445.
  • Treiber KA, Lyketsos CG, Corcoran C, Steinberg M, Norton M, Green RC, et al. 2008. Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. Int Psychogeriatr 20:538–553.
  • Van der Mussele S, Le Bastard N, Vermeiren Y, Saerens J, Somers N, Mariën P, et al. 2013. Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults. Int J Geriatr Psychiatry 28:265–275.
  • Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. 2010. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr 10:14–26.
  • WHO World Health Organization. 1992. International Statistical Classification of Diseases and Related Health Problems. 10th revision. Geneva: World Health Organization.