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Audiological Medicine Volume 9, 2011 - Issue 2
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Original Article

Presynaptic and postsynaptic mechanisms underlying auditory neuropathy in patients with mutations in the OTOF or OPA1 gene

Rosamaria Santarelli Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padova, Padua, ItalyCorrespondence[email protected]
,
Arnold Starr Department of Neurology, University of California, Irvine, California, USA
,
Ignacio del Castillo Unidad de Genética Molecular, Hospital Ramón y Cajal, Carretera de Colmenar, Madrid, Spain
,
Taosheng Huang Department of Pediatrics, Division of Human Genetics, University of California, Irvine, California, USA
,
Pietro Scimemi Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padova, Padua, Italy
,
Elona Cama Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padova, Padua, Italy
,
Roberta Rossi Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padova, Padua, Italy
&
Edoardo Arslan Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padova, Padua, Italy
 show all
Pages 59-66 | Accepted 25 Jan 2011, Published online: 01 Mar 2011

References

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  • Santarelli R. Genetic mutations underlie pre- or post-synaptic auditory neuropathy: correlation with cochlear potentials helps to localize the site of lesion. Genome Medicine (in press).
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  • Santarelli R, Starr A, Michalewski HJ, Arslan E. Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy. Clin Neurophysiol. 2008;119:1028–41.
  • Santarelli R, del Castillo I, Rodríguez-Ballesteros M, Scimemi P, Cama E, Arslan E, . Abnormal cochlear potentials from deaf patients with mutations in the otoferlin gene. J Assoc Res Otolaryngol. 2009;10:545–56.
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  • Sellick P, Patuzzi R, Robertson D. Primary afferent and cochlear nucleus contributions to extracellular potentials during tone-bursts. Hear Res. 2003;176:42–58.

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