Local drug delivery for inner ear therapy

References

• Konings A, Van Laer L, Van Camp G. Genetic studies on noise-induced hearing loss: a review. Ear Hear. 2009; 30:151–9.
   PubMed Web of Science ®Google Scholar
• Segal S, Harell M, Shahar A, Englender M. Acute acoustic trauma: dynamics of hearing loss following cessation of exposure. Am J Otol. 1988;9:293–8.
   PubMedGoogle Scholar
• Wang J, Ruel J, Ladrech S, Bonny C, van de Water TR, Puel JL. Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol. 2007;71:654–66.
   PubMed Web of Science ®Google Scholar
• Nordmann AS, Bohne BA, Harding GW. Histopathological differences between temporary and permanent threshold shift. Hear Res. 2000;139:13–30.
   PubMed Web of Science ®Google Scholar
• Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27:1–19.
   PubMed Web of Science ®Google Scholar
• Patuzzi R. Non-linear aspects of outer hair cell transduction and the temporary threshold shifts after acoustic trauma. Audiol Neurootol. 2002;7:17–20.
   PubMed Web of Science ®Google Scholar
• Liberman MC. Auditory Processing in Sensorineural Hearing Loss. Chapter 26 in Otolaryngology: Basic Science and Clinical Review. Van De Water T R, Staecker H (editors), Thieme Medical Publishers, NewYork, Stuttgart. 2005, 340–349.
   Google Scholar
• Hirose K, Discolo CM, Keasler JR, Ransohoff R. Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma. J Comp Neurol. 2005;22;489:180–94.
   Google Scholar
• Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H. Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res. 2006;83:575–83.
   PubMed Web of Science ®Google Scholar
• Haake SM, Dinh CT, Chen S, Eshraghi AA, Van De Water TR. Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling. Hear Res. 2009;255:22–32.
   PubMed Web of Science ®Google Scholar
• Abi-Hachem RN, Zine A, Van De Water TR. The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. Recent Pat CNS Drug Discov. 2010;5:147–63.
   PubMedGoogle Scholar
• Dinh C, Hoang K, Haake S, Chen S, Angeli S, Nong E . Biopolymer-released dexamethasone prevents tumor necrosis factor alpha-induced loss of auditory hair cells in vitro: implications toward the development of a drug-eluting cochlear implant electrode array. Otol Neurotol. 2008;29:1012–9.
   PubMed Web of Science ®Google Scholar
• Dinh CT, Haake S, Chen S, Hoang K, Nong E, Eshraghi AA . Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes. Neurosci. 2008;157:405–13.
   PubMed Web of Science ®Google Scholar
• Takemura K, Komeda M, Yagi M, Himeno C, Izumikawa M, Doi T . Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res. 2004;196:58–68.
   PubMed Web of Science ®Google Scholar
• Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, . Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci. 2000;20:43–50.
   PubMed Web of Science ®Google Scholar
• Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci. 2003;23:8596–607.
   PubMed Web of Science ®Google Scholar
• Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci. 2008;65:3525–44.
   PubMed Web of Science ®Google Scholar
• Manning AM, Davis RJ. Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov. 2003; 2:554–65.
   PubMed Web of Science ®Google Scholar
• Bonny C, Oberson A, Steinmann M, Schorderet DF, Nicod P, Waeber G. IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J Biol Chem. 2000; 275:16466–72.
   PubMed Web of Science ®Google Scholar
• Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes. 2001;50:77–82.
   PubMed Web of Science ®Google Scholar
• Zine A, van de Water TR. The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness. Curr Drug Targets CNS Neurol Disord. 2004;3:325–32.
   PubMedGoogle Scholar
• Coleman JK, Littlesunday C, Jackson R, Meyer T. AM-111 protects against permanent hearing loss from impulse noise trauma. Hear Res. 2007;226:70–78.
   PubMed Web of Science ®Google Scholar
• Wang J, Ruel J, Ladrech S, Bonny C, van de Water TR, Puel JL. Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol. 2007;71: 654–66.
   PubMed Web of Science ®Google Scholar
• Swan EE, Mescher MJ, Sewell WF, Tao SL, Borenstein JT. Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev. 2008;60:1583–99.
   PubMed Web of Science ®Google Scholar
• Suckfuell M, Canis M, Strieth S, Scherer H, and Haisch A. Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study. Haisch Acta Otolaryngol. 2007;127: 938–942
   PubMed Web of Science ®Google Scholar
• Forge A, Van De Water TR. In: Salvi R, Popper (editors) Hair Cell Regeneration, Repair, and Protection. Protection and Repair of Inner Ear Sensory Cells. Springer Handbook in Auditory Research Series. USA 2008, 199–225.
   Google Scholar
• Miller JM, Brown JN, Schacht J. 8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow. Audiol Neurootol. 2003;8:207–21.
   PubMed Web of Science ®Google Scholar
• Wong AC, Guo CX, Gupta R, Housley GD, Thorne PR, Vlajkovic SM. Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss. Hear Res. 2010;260:81–88.
   PubMed Web of Science ®Google Scholar
• Hu BH, Zheng XY, McFadden SL, Kopke RD, Henderson D. R-phenylisopropyl-adenosine attenuates noise-induced hearing loss in the chinchilla. Hear Res. 1997;113:198–206.
   PubMed Web of Science ®Google Scholar
• Jacono AA, Hu B, Kopke R, Henderson D, Van De Water TR, Steinman HM. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res.1998;117:31–8.
   PubMed Web of Science ®Google Scholar
• Campbell KC, Meech RP, Klemens JJ, Gerberi MT, Dyrstad SSW, Larsen DL . Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res. 2007;226:94–103.
   Web of Science ®Google Scholar
• Kil J, Pierce C, Tran H, Gu R, Lynch ED. Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase. Hear Res. 2007;226: 44–51.
   PubMed Web of Science ®Google Scholar
• Campo P, Subramaniam M, Henderson D. The effect of ‘conditioning’ exposures on hearing loss from traumatic exposure. Hear Res. 1991;55:195–200.
   PubMed Web of Science ®Google Scholar
• Maggirwar SB, Dhanraj DN, Somani SM, Ramkumar V. Adenosine acts as an endogenous activator of the cellular antioxidant defense system. Biochem Biophys Res Commun. 1994;201:508–15.
   PubMed Web of Science ®Google Scholar
• Samson J, Wiktorek-Smagur A, Politanski P, Rajkowska E, Pawlaczyk-Luszczynska M, Dudarewicz A . Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by D-methionine. Neuroscience. 2008;152:146–50.
   PubMed Web of Science ®Google Scholar
• Kopke RD, Jackson RL, Coleman JK, Liu J, Bielefeld EC, Balough BJ. NAC for noise: from the bench top to the clinic. Hear Res. 2007;226:114–25.
   PubMed Web of Science ®Google Scholar
• Cheng PW, Liu SH, Young YH, Hsu CJ, Lin-Shiau SY. Protection from noise-induced temporary threshold shift by D-methionine is associated with preservation of ATPase activities. Ear Hear. 2008;29:65–75.
   PubMed Web of Science ®Google Scholar
• Yamasoba T, Pourbakht A, Sakamoto T, Suzuki M. Ebselen prevents noise-induced excitotoxicity and temporary threshold shift. Neurosci Lett. 2005;380:234–8.
   PubMed Web of Science ®Google Scholar
• Lynch ED, Gu R, Pierce C, Kil J. Ebselen-mediated protection from single and repeated noise exposure in rat. Laryngoscope. 2004;114:333–7.
   PubMed Web of Science ®Google Scholar
• Kramer S, Dreisbach L, Lockwood J, Baldwin K, Kopke R, Scranton S . Efficacy of the Antioxidant N-acetylcysteine (NAC) in Protecting Ears Exposed to Loud Music. J Am Acad Audiol. 2006;17:265–78.
   PubMed Web of Science ®Google Scholar
• Kopke RD, Weisskopf PA, Boone JL, Jackson RL, Wester DC, Hoffer ME . Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res. 2000;149:138–46.
   PubMed Web of Science ®Google Scholar
• Fetoni AR, Piacentini R, Fiorita A, Paludetti G, Troiani D. Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res. 2009; 1257:108–16.
   PubMed Web of Science ®Google Scholar
• Hirose Y, Sugahara K, Mikuriya T, Hashimoto M, Shimogori H, Yamashita H. Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs. Acta Otolaryngol. 2008;128:1071–6.
   PubMed Web of Science ®Google Scholar
• Sergi B, Fetoni AR, Paludetti G, Ferraresi A, Navarra P, Mordente A . Protective Properties of Idebenone in Noise-Induced Hearing Loss in the Guinea Pig. Neuro Report. 2006;17:857–61.
   PubMed Web of Science ®Google Scholar
• Le Prell CG, Hughes LF, Miller JM. Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma. Free Radic Biol Med. 2007;42:1454–63.
   PubMed Web of Science ®Google Scholar
• Minami SB, Yamashita D, Ogawa K, Schacht J, Miller JM. Creatine and tempol attenuate noise-induced hearing loss. Brain Res. 2007;1148:83–9.
   PubMed Web of Science ®Google Scholar
• Chapman HA, Riese RJ, Shi G. Emerging Roles for Cysteine Proteases in Human Biology. Ann Rev Physiol 1997;59: 63–88.
   PubMed Web of Science ®Google Scholar
• Van De Water TR, Lallemend F, Eshraghi AA, Ahsan S, He J, Guzman J . Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otol Neurotol. 2004;25:627–32.
   PubMed Web of Science ®Google Scholar
• Abaamrane L, Raffin F, Schmerber S, Sendowski I. Intracochlear perfusion of leupeptin and z-VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss. Eur Arch Otorhinolaryngol. 2011 Jan 19. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Sutinen P, Zou J, Hunter LL, Toppila E, Pyykkö I. Vibration-induced hearing loss: mechanical and physiological aspects. Otol Neurotol. 2007;28:171–7.
   PubMed Web of Science ®Google Scholar
• Pyykkö I, Starck J, Färkkilä M, Hoikkala M, Korhonen O, Nurminen M. Hand-arm vibration in the aetiology of hearing loss in lumberjacks. Br J Ind Med. 1981;38:281–9.
   PubMedGoogle Scholar
• Zou J, Pyykkö I, Sutinen P, Toppila E. Vibration induced hearing loss in guinea pig cochlea: expression of TNF-alpha and VEGF. Hear Res. 2005;202:13–20.
   PubMed Web of Science ®Google Scholar
• Zou J, Bretlau P, Pyykkö I, Toppila E, Olovius NP, Stephanson N . Comparison of the protective efficacy of neurotrophins and antioxidants for vibration-induced trauma. ORL J Otorhinolaryngol Relat Spec. 2003;65: 155–61.
   PubMed Web of Science ®Google Scholar
• Alderden RA, Hall MD, Hambley TW. The Discovery and Development of Cisplatin. J Chem Educ. 2006;83: 728–34.
   Web of Science ®Google Scholar
• Rybak LP, Mukherjea D, Sarvesh J, Ramkumar V. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med. 2009;219:177–86.
   PubMed Web of Science ®Google Scholar
• Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007;226:157–67.
   PubMed Web of Science ®Google Scholar
• Ulfendahl M, Flock Å. Outer Hair Cells Provide Active Tuning in the Organ of Corti. News Physiol Sci 1998; 13:107–111.
   PubMedGoogle Scholar
• More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM. Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity. J Neurosci. 2010;30:9500–9.
   PubMed Web of Science ®Google Scholar
• Bánfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause K. NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear. J Biol Chem. 2004;279: 46065–72.
   PubMed Web of Science ®Google Scholar
• Mukherjea D, Jajoo S, Sheehan K, Kaur T, Sheth S, Bunch J . NOX3 NADPH Oxidase Couples Transient Receptor Potential Vanilloid 1 to Signal Transducer and Activator of Transcription 1-Mediated Inflammation and Hearing Loss. Antioxid Redox Sign. 2011;14:999–1010.
   PubMed Web of Science ®Google Scholar
• Chung W, Boo SH, Chung MK, Lee H, Cho Y, Hong SH. Proapoptotic effects of NF-kB on cisplatin-induced cell death in auditory cell line. Acta Oto-Laryngol. 2008;128:1063–70.
   PubMed Web of Science ®Google Scholar
• Jiang H, Sha S, Schacht J. NF-κB Pathway Protects Cochlear Hair Cells From Aminoglycoside-Induced Ototoxicity. J Neurosci Res. 2005;79:644–51.
   PubMed Web of Science ®Google Scholar
• Stanbury RM, Graham EM. Systemic corticosteroid therapy—side effects and their management. Br J Ophthalmol. 1998;82:704–8.
   PubMed Web of Science ®Google Scholar
• McCall AA, Swan EEL, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear 2010;31: 156–65.
   PubMed Web of Science ®Google Scholar
• Feghali JG, Liu W, Van De Water TR. L-N-Acetyl-Cysteine Protection Against Cisplatin-Induced Auditory Neuronal and Hair Cell Toxicity. Laryngoscope. 2001;111: 1147–55.
   PubMed Web of Science ®Google Scholar
• Saliba I, El Fata F, Ouelette V, Robitalle Y. Are intratympanic injections of N-acetylcysteine and methylprednisolone protective against Cisplatin-induced ototoxicity? J Otolaryngol Head Neck Surg. 2010;39:236–43.
   PubMed Web of Science ®Google Scholar
• Campbell KC, Rybak LP, Meech RP, Hughes L. D-methionine provides excellent protection from cisplatin ototoxicity in the rat. Hear Res. 1996;102:90–8.
   PubMed Web of Science ®Google Scholar
• Li G, Frenz DA, Brahmblatt S, Feghali JG, Ruben RJ, Berggren D, . Round window membrane delivery of L-methionine provides protection from cisplatin ototoxicity without compromising chemotherapeutic efficacy. Neurotoxicology. 2001;22:163–76.
   PubMed Web of Science ®Google Scholar
• Dickey DT, Wu YJ, Muldoon LL, Neuwelt EA. Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels. J Pharmacol Exp Ther. 2005; 314:1052–8.
   PubMed Web of Science ®Google Scholar
• Viallet NR, Blakley BB, Begleiter A, Leith MK. Sodium thiosulphate impairs the cytotoxic effects of FADU cells in culture. J Otolaryngol. 2006;35:19–21.
   PubMedGoogle Scholar
• Kim S, Park C, Han AL, Youn M, Lee J, Kim Y, . Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells. Hear Res. 2009; 251:70–82.
   PubMed Web of Science ®Google Scholar
• Mukherjea D, Jajoo S, Kaur T, Sheehan K, Ramkumar V, Rybak LP. Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat. Antioxid Redox Sign. 2010;13:589–98.
   PubMed Web of Science ®Google Scholar
• Hill GW, Morest DK, Parham K. Cisplatin-Induced Ototoxicity: Effect of Intratympanic Dexamethasone Injections. Otol Neurotol. 2008;29:1005–11.
   PubMed Web of Science ®Google Scholar
• Wang J, Ladrech S, Pujol R, Brabet P, Van De Water TR, Puel J. Caspase Inhibitors, but not c-Jun NH2-Terminal Kinase Inhibitor Treatment, Prevent Cisplatin-Induced Hearing Loss. Cancer Res. 2004;64:9217–24.
   PubMed Web of Science ®Google Scholar
• Zuur CL, Simis YJ, Lansdaal PE, Hart AA, Rasch CR, Schornagel JH . Risk Factors of Ototoxicity After Cisplatin-Based Chemoirradiation in Patients with Locally Advanced Head-and-Neck Cancer: A Multivariate Analysis. Int J Radiation Oncology Biol Phys. 2007;68: 1320–5.
   PubMed Web of Science ®Google Scholar
• Rizzi MD, Hirose K. Aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg. 2007;15:352–57.
   PubMedGoogle Scholar
• Warchol ME. Cellular mechanisms of aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg. 2010; 18:454–58.
   PubMed Web of Science ®Google Scholar
• Hashino E, Shero M. Endocytosis of aminoglycoside antibiotics in sensory hair cells. Brain Res. 1995;704:135–40.
   PubMed Web of Science ®Google Scholar
• Marcotti W, van Netten SM, Kros CJ. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005;567:505–21.
   PubMed Web of Science ®Google Scholar
• Goodyear RJ, Gale JE, Ranatunga KM, Kros CJ, Richardson GP. Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible. J Neurosci. 2008;28:9939–52.
   PubMed Web of Science ®Google Scholar
• Wang, Q, Steyger, P.S. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J Assoc Res Otolaryngol. 2009;10:205–19.
   PubMed Web of Science ®Google Scholar
• Hu D, Qiu W, Wu B, Fang L, Zhou F, Gu Y . Genetic aspects of antibiotic induced deafness: mitochondrial inheritance. J Med Genet. 1991;28:79–83.
   PubMed Web of Science ®Google Scholar
• Guan M. Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity. Mitochondrion. 2011; 11:237–45.
   PubMed Web of Science ®Google Scholar
• Yu L, Jiang XH, Zhou Z, Tsang LL, Yu MK, Chung YW, . A Protective Mechanism against Antibiotic-Induced Ototoxicity: Role of Prestin. PLoS One. 2011;6:1–8.
   Web of Science ®Google Scholar
• Ye LF, Tao ZZ, Hua QQ, Xiao BK, Zhou XH, Li J . Protective effect of melatonin against gentamicin ototoxicity. J Laryngol Otol. 2009;123:598–602.
   PubMed Web of Science ®Google Scholar
• Nakamagoe M, Tabuchi K, Uemaetomari I, Nishimura B, Hara A. Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway. Hear Res. 2010;261:67–74.
   PubMed Web of Science ®Google Scholar
• Cunningham LL, Brandon CS. Heat shock inhibits both aminoglycoside-and cisplatin-induced sensory hair cell death. J Assoc Res Otolaryngol. 2006;7:299–307.
   PubMed Web of Science ®Google Scholar
• Taleb M, Brandon CS, Lee F, Harris KC, Dillmann WH, Cunningham LL. Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death. Cell Stress Chaperon. 2009;14:427–37.
   PubMed Web of Science ®Google Scholar
• Salt AN, Plontke SK. Principles of local drug delivery to the inner ear. Audiol Neurotol. 2009;14:350–60.
   PubMed Web of Science ®Google Scholar
• Eshraghi AA, He J, Mou CH, Polak M, Zine A, Bonny C . D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma. Otol Neurotol. 2006;27:504–11.
   PubMed Web of Science ®Google Scholar
• Eshraghi AA, Adil E, He J, Graves R, Balkany TJ, Van De Water TR. Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss. Otol Neurotol. 2007;28:842–9.
   PubMed Web of Science ®Google Scholar
• Vivero RJ, Joseph DE, Angeli S, He J, Chen S, Eshraghi AA . Dexamethasone base conserves hearing from electrode trauma-induced hearing loss. Laryngoscope. 2008;118: 2028–35.
   PubMed Web of Science ®Google Scholar
• Kiefer J, Gstoettner W, Baumgartner W, Pok SM, Tillein J, Ye Q . Conservation of low-frequency hearing in cochlear implantation. Acta Otolaryngol. 2004;124:272–80.
   PubMed Web of Science ®Google Scholar
• Gantz BJ, Turner C, Gfeller K. Expanding cochlear implant technology: Combined electrical and acoustical speech processing. Cochlear Implants Int. 2004 Sep; 5 Suppl 1:8–14.
   PubMedGoogle Scholar
• Roland PS, Wright CG. Surgical aspects of cochlear implantation: mechanisms of insertional trauma. Adv Otorhinolaryngol. 2006;64:11–30.
   PubMedGoogle Scholar
• Adunka OF, Pillsbury HC, Kiefer J. Combining perimodiolar electrode placement and atraumatic insertion properties in cochlear implantation—fact or fantasy? Acta Otolaryngol. 2006;126:475–82.
   PubMed Web of Science ®Google Scholar
• De Ceulaer G, Johnson S, Yperman M, Daemers K, Offeciers FE, O'Donoghue GM, Govaerts PJ. Long-term evaluation of the effect of intracochlear steroid deposition on electrode impedance in cochlear implant patients. Otol Neurotol. 2003;24:769–74.
   PubMed Web of Science ®Google Scholar
• Guzman J, Ruiz J, Eshraghi AA, Polak M, Garnham C, Balkany TJ . Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) ototoxicity in vitro. Acta Otolaryngol. 2006;126:685–90.
   PubMed Web of Science ®Google Scholar
• Ye Q, Tillein J, Hartmann R, Gstoettner W, Kiefer J. Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention. Ear Hear. 2007;28:361–9.
   PubMed Web of Science ®Google Scholar
• James DP, Eastwood H, Richardson RT, O'Leary SJ. Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation. Audiol Neurootol. 2008;13:86–96.
   PubMed Web of Science ®Google Scholar
• Chang A, Eastwood H, Sly D, James D, Richardson R, O'Leary S. Factors influencing the efficacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery. Hear Res. 2009;255:67–72.
   PubMed Web of Science ®Google Scholar
• Eastwood H, Chang A, Kel G, Sly D, Richardson R, O'Leary SJ. Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea. Hear Res. 2010;265:25–9.
   PubMed Web of Science ®Google Scholar
• Staecker H, Jolly C, Garnham C. Cochlear implantation: an opportunity for drug development. Drug Discov Today. 2010;15:314–21.
   PubMed Web of Science ®Google Scholar
• Jolly C, Garnham C, Mirzadeh H, Truy E, Martini A, Kiefer J . Electrode features for hearing preservation and drug delivery strategies. Adv Otorhinolaryngol. 2010; 67:28–42.
   PubMedGoogle Scholar
• Staecker H, Kopke R, Malgrange B, Lefebvre P, Van de Water TR. NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells. Neuroreport. 1996;7:889–94.
   PubMed Web of Science ®Google Scholar
• Ernfors P, Duan ML, ElShamy WM, Canlon B. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Nat Med. 1996;2:463–7.
   PubMed Web of Science ®Google Scholar
• Nadol JB Jr. Patterns of neural degeneration in the human cochlea and auditory nerve: implications for cochlear implantation. Otolaryngol Head Neck Surg. 1997;117(3 Pt 1): 220–8.
   PubMed Web of Science ®Google Scholar
• Linthicum FH Jr, Fayad JN. Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans. Otol Neurotol. 2009;30:418–422.
   PubMed Web of Science ®Google Scholar
• Shepherd RK, Coco A, Epp SB. Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss. Hear Res. 2008;242:100–9.
   PubMed Web of Science ®Google Scholar
• Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 1998;119:7–13.
   PubMed Web of Science ®Google Scholar
• Chikar JA, Colesa DJ, Swiderski DL, Di Polo A, Raphael Y, Pfingst BE. Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons. Hear Res. 2008;245:24–34.
   PubMed Web of Science ®Google Scholar
• Shinohara T, Bredberg G, Ulfendahl M, Pyykkö I, Olivius NP, Kaksonen R . Neurotrophic factor intervention restores auditory function in deafened animals. Proc Natl Acad Sci USA. 2002;99:1657–60.
   PubMed Web of Science ®Google Scholar
• Shibata SB, Cortez SR, Beyer LA, Wiler JA, Di Polo A, Pfingst BE, . Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae. Exp Neurol. 2010;223:464–72.
   PubMed Web of Science ®Google Scholar
• Linthicum FH Jr, Fayad J, Otto SR, Galey FR, House WF. Cochlear implant histopathology. Am J Otol. 1991;12: 245–311.
   PubMedGoogle Scholar
• Fayad JN, Linthicum FH Jr. Multichannel cochlear implants: relation of histopathology to performance. Laryngoscope. 2006;116:1310–20.
   PubMed Web of Science ®Google Scholar
• Cheng AG, Cunningham LL, Rubel EW. Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg. 2005;13:343–8.
   PubMedGoogle Scholar
• Do K, Baker K, Praetorius M and Staecker H. A mouse model of implantation trauma. International Congress Series Volume 1273, November 2004, 167–70.
   Google Scholar
• Shibata SB, Raphael Y. Future approaches for inner ear protection and repair. J Commun Disord. 2010;43: 295–310.
   PubMed Web of Science ®Google Scholar
• McCall AA, Swan EEL, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug Delivery for Treatment of Inner Ear Disease: Current State of Knowledge. Ear Hear. 2010; 31:156–65.
   PubMed Web of Science ®Google Scholar
• Piu F, Wang X, Fernandez R, Dellamary L, Harrop A, Ye, Q . OTO-104: A Sustained-Release Dexamethasone Hydrogel for the Treatment of Otic Disorders. Otol Neurotol. 2010;32:171–9.
   Web of Science ®Google Scholar
• Paulson DP, Abuzeid W, Jiang H, Oe T, O'Malley BW, Li D. A novel controlled local drug delivery system for inner ear disease. Laryngoscope. 2008;118:706–11.
   PubMed Web of Science ®Google Scholar
• Li H, Liu H, Heller S. Pluripotent stem cells from the adult mouse inner ear. Nat Med. 2003;9:1293–9.
   PubMed Web of Science ®Google Scholar
• Lopez IA, Zhao PM, Yamaguchi M, de Vellis J, Espinosa-Jeffery A. Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouse. Int J Dev Neurosci. 2004;22:205–13.
   PubMed Web of Science ®Google Scholar
• Oshima K, Grimm CM, Corrales CE, Senn P, Monedero RM, Géléoc GSG, . Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear. J Assoc Res Otolaryngol. 2007;8:18–31.
   PubMed Web of Science ®Google Scholar
• Malgrange B, Belachew S, Thiry M, Nguyen L, Rogister B, Alvarez ML, . Proliferative generation of mammalian auditory hair cells in culture. Mech Dev. 2002;112: 79–88.
   PubMed Web of Science ®Google Scholar
• Savary E, Hugnot JP, Chassigneux Y, Travo C, Duperray C, Van De Water T, . Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysis. Stem Cells. 2007;25:332–9.
   PubMed Web of Science ®Google Scholar
• Batts SA, Raphael Y. Transdifferentiation and its applicability for inner ear therapy. Hear Res. 2007;227:41–7.
   PubMed Web of Science ®Google Scholar
• Baker K, Brough DE, Staecker H. Repair of the vestibular system via adenovector delivery of Atoh1: a potential treatment for balance disorders. Adv Otorhinolaryngol. 2009; 66:52–63.
   PubMedGoogle Scholar
• Staecker H, Praetorius M, Brough DE. Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. Hear Res. 2011;276:44–51
   PubMed Web of Science ®Google Scholar