Toxicity of gold-nanoparticles: Synergistic effects of shape and surface functionalization on micromotility of epithelial cells

References

• Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD. 2009. Cellular uptake and cytotoxicity of gold nanorods: Molecular origin of cytotoxicity and surface effects. Small 5:701–708.
   PubMed Web of Science ®Google Scholar
• Arnida, Malugin A, Ghandehari H. 2010. Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: A comparative study of rods and spheres. J Appl Toxicol 30:212–217.
   PubMed Web of Science ®Google Scholar
• Barz M, Tarantola M, Fischer K, Schmidt M, Luxenhofer R, Janshoff A, Theato P, Zentel R. 2008. From defined reactive Diblock copolymers to functional HPMA-based self-assembled nanoaggregates. Biomacromolecules 9:3114–3118.
   PubMed Web of Science ®Google Scholar
• Basu S, Harfouche R, Soni S, Chimote G, Mashelkar RA, Sengupta S. 2009. Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. PNAS 106:7957–7961.
   PubMed Web of Science ®Google Scholar
• Cans AS, Hook F, Shupliakov O, Ewing AG, Eriksson PS, Brodin L, Orwar O. 2001. Measurement of the dynamics of exocytosis and vesicle retrieval at cell populations using a quartz crystal microbalance. Anal Chem 73:5805–5811.
   PubMed Web of Science ®Google Scholar
• Cedervall T, Lynch I, Foy M, Berggad T, Donnelly SC, Cagney G, Linse S, Dawson KA. 2007. Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angewandte Chemie-Int Ed 46:5754–5756.
   PubMed Web of Science ®Google Scholar
• Chanana M, Gliozzi A, Diaspro A, Chodnevskaja I, Huewel S, Moskalenko V, Ulrichs K, Galla HJ, Krol S. 2005. Interaction of polyelectrolytes and their composites with living cells. Nano Lett 5:2605–2612.
   PubMed Web of Science ®Google Scholar
• Chithrani BD, Chan WCW. 2007. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 7:1542–1550.
   PubMed Web of Science ®Google Scholar
• Chithrani BD, Ghazani AA, Chan WCW. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6:662–668.
   PubMed Web of Science ®Google Scholar
• Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. 2005. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1:325–327.
   PubMed Web of Science ®Google Scholar
• Cooper MA, Singleton VT. 2007. A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: Applications of acoustic physics to the analysis of biomolecular interactions. J Mol Recognit 20:154–184.
   PubMed Web of Science ®Google Scholar
• de la Fuente JM, Berry CC, Riehle MO, Curtis ASG. 2006. Nanoparticle targeting at cells. Langmuir 22:3286–3293.
   PubMed Web of Science ®Google Scholar
• Ferrari M. 2008. Beyond drug delivery. Nat Nanotechnol 3:131–132.
   PubMed Web of Science ®Google Scholar
• Giaever I, Keese CR. 1986. Use of electric-fields to monitor the dynamic aspect of cell behavior in tissue-culture. IEEE T Bio-med Eng 33:242–247.
   PubMed Web of Science ®Google Scholar
• Giaever I, Keese CR. 1993. A morphological biosensor for mammalian-cells. Nature 366:591–592.
   PubMed Web of Science ®Google Scholar
• Grenha A, Grainger CI, Dailey LA, Seijo B, Martin GP, Remunan-Lopez C, Forbes B. 2007. Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro. Eur J Pharm Sci 31:73–84.
   PubMed Web of Science ®Google Scholar
• Hanaichi T, Sato T, Iwamoto T, Malavasiyamashiro J, Hoshino M, Mizuno N. 1986. A stable lead by modification of Sato method. J Electron Microsc 35:304–306.
   PubMed Web of Science ®Google Scholar
• Hanauer M, Pierrat S, Zins I, Lotz A, Soennichsen C. 2007. Separation of nanoparticles by gel electrophoresis according to shape and size. Nano Lett 7:2881–2885.
   PubMed Web of Science ®Google Scholar
• Hayat MA. 2000. Principles and techniques of electron microscopy: Biological application 4th ed. Cambridge: Cambridge University Press.
   Google Scholar
• Hug TS. 2003. Biophysical methods for monitoring cell-substrate interactions in drug discovery. Assay Drug Dev Technol 1:479–488.
   PubMed Web of Science ®Google Scholar
• Jana NR, Gearheart L, Murphy CJ. 2001. Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template. Adv Mater 13:1389–1393.
   Web of Science ®Google Scholar
• Jiang W, Kim BYS, Rutka JT, Chan WCW. 2008. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 3:145–150.
   PubMed Web of Science ®Google Scholar
• Khan JA, Pillai B, Das TK, Singh Y, Maiti S. 2007. Molecular effects of uptake of gold nanoparticles in HeLa cells. Chembiochem 8:1237–1240.
   PubMed Web of Science ®Google Scholar
• Kumar CSSR. 2006. Nanomaterials for cancer diagnosis. Weinheim, Germany: Wiley-VHC.
   Google Scholar
• Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4:26–49.
   PubMed Web of Science ®Google Scholar
• Lo CM, Keese CR, Giaever I. 1993. Monitoring motion of confluent cells in tissue-culture. Exp Cell Res 204:102–109.
   PubMed Web of Science ®Google Scholar
• Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA. 2008. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. PNAS 105:14265–14270.
   PubMed Web of Science ®Google Scholar
• Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA. 2007. The nanoparticle – protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Adv Colloid Interface Sci 134–35: 167–174.
   Web of Science ®Google Scholar
• Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdörster G, Philbert MA, Ryan J, Seaton A, Stone V, Tinkle SS, Tran L, Walker NJ, Warheit DB. 2006. Safe handling of nanotechnology. Nature 444:267–269.
   PubMed Web of Science ®Google Scholar
• Moyes SM, Smyth SH, Shipman A, Long S, Morris JF, Carr KE. 2007. Parameters influencing intestinal epithelial permeability and microparticle uptake in vitro. Int J Pharm 337:133–141.
   PubMed Web of Science ®Google Scholar
• Nativo P, Prior IA, Brust M. 2008. Uptake and intracellular fate of surface-modified gold nanoparticles. Acs Nano 2:1639–1644.
   PubMed Web of Science ®Google Scholar
• Nikoobakht B, El-Sayed MA. 2003. Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem.Mat 15:1957–1962.
   Web of Science ®Google Scholar
• Oberdörster G, Stone V, Donaldson K. 2007. Toxicology of nanoparticles: A historical perspective. Nanotoxicology 1:2–25.
   Web of Science ®Google Scholar
• Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W. 2007. Size-dependent cytotoxicity of gold nanoparticles. Small 3:1941–1949.
   PubMed Web of Science ®Google Scholar
• Pax M, Rieger J, Eibl RH, Thielemann C, Johannsmann D. 2005. Measurements of fast fluctuations of viscoelastic properties with the quartz crystal microbalance. Analyst 130:1474–1477.
   PubMed Web of Science ®Google Scholar
• Prescott SW, Mulvaney P. 2006. Gold nanorod extinction spectra. J Appl Phys 99:123504.
   Web of Science ®Google Scholar
• Prescott SW, Mulvaney P. 2008. Erratum: Gold nanorod extinction spectra. J App Phys 103:119901.
   Web of Science ®Google Scholar
• Rayavarapu RG, Petersen W, Hartsuiker L, Chin P, Janssen H, van Leeuwen FWB, Otto C, Manohar S, van Leeuwen TG. 2010. In vitro toxicity studies of polymer-coated gold nanorods. Nanotechnology 21:145101.
   PubMed Web of Science ®Google Scholar
• Reiss B, Janshoff A, Steinem C, Seebach J, Wegener J. 2003. Adhesion kinetics of functionalized vesicles and mammalian cells: A comparative study. Langmuir 19:1816–1823.
   Web of Science ®Google Scholar
• Rothen-Rutishauser B, Grass RN, Blank F, Limbach LK, Muehlfeld C, Brandenberger C, Raemy DO, Gehr P, Stark WJ. 2009. Direct combination of nanoparticle fabrication and exposure to lung cell cultures in a closed setup as a method to simulate accidental nanoparticle exposure of humans. Environ Sci Technol 43:2634–2640.
   PubMed Web of Science ®Google Scholar
• Sapper A, Wegener J, Janshoff A. 2006. Cell motility probed by noise analysis of thickness shear mode resonators. Anal Chem 78:5184–5191.
   PubMed Web of Science ®Google Scholar
• Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. 2005. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview. Langmuir 21:10644–10654.
   PubMed Web of Science ®Google Scholar
• Shukoor MI, Natalio F, Tahir MN, Wiens M, Tarantola M, Therese HA, Barz M, Weber S, Terekhov M, Schroder HC, Muller WEG, Janshoff A, Theato P, Zentel R, Schreiber LM, Tremel W. 2009. Pathogen-mimicking MnO nanoparticles for selective activation of the TLR9 pathway and imaging of cancer cells. Adv Funct Mater 19:3717–3725.
   Web of Science ®Google Scholar
• Takahashi H, Niidome Y, Niidome T, Kaneko K, Kawasaki H, Yamada S. 2006. Modification of gold nanorods using phospatidylcholine to reduce cytotoxicity. Langmuir 22:2–5.
   PubMed Web of Science ®Google Scholar
• Tarantola M, Marel AK, Sunnick E, Adam H, Wegener J, Janshoff A. 2010. Dynamics of human cancer cell lines monitored by electrical and acoustic fluctuation analysis. Integr Biol 2:139–150.
   Google Scholar
• Tarantola M, Schneider D, Sunnick E, Adam H, Pierrat S, Rosman C, Breus V, Sonnichsen C, Basche T, Wegener J, Janshoff A. 2009. Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. Acs Nano 3:213–222.
   PubMed Web of Science ®Google Scholar
• Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. 2006. Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300–312.
   PubMed Web of Science ®Google Scholar
• Wang SG, Lu WT, Tovmachenko O, Rai US, Yu HT, Ray PC. 2008. Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes. Chem Phys Lett 463:145–149.
   PubMed Web of Science ®Google Scholar
• Wegener J, Janshoff A, Steinem C. 2001. The quartz crystal microbalance as a novel means to study cell-substrate interactions in situ. Cell Biochem Biophys 34:121–151.
   PubMed Web of Science ®Google Scholar
• Wegener J, Sieber M, Galla HJ. 1996. Impedance analysis of epithelial and endothelial cell monolayers cultured on gold surfaces. J Biochem Biophys Methods 32:151–170.
   PubMedGoogle Scholar
• Yen HJ, Hsu SH, Tsai CL. 2009. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 5:1553–1561.
   PubMed Web of Science ®Google Scholar