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Research Article

Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: Role of ROS-NFκB signaling pathway

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Pages 502-516 | Received 01 Aug 2010, Accepted 15 Nov 2010, Published online: 21 Mar 2011

References

  • Alt V, Bechert T, Steinrűcke P, Wagener M, Seidel P, Dingeldein E, Domann E, Schnettler R. 2004. An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials 25:4383–4391.
  • Baetz D, Shaw J, Kirshenbaum LA. 2005. Nuclear factor-κ B decoys suppress endotoxin-induced lung injury. Mol Pharmacol 67:977–979.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ana Biochem 72:248–254.
  • Braydich-Stolle L, Hussain SM, Schlager JJ, Hofmann MC. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88:412–419.
  • Brown DM, Donaldson K, Borm PJ, Schins RP, Dehnhardt M, Gilmour P, Jimenez LA, Stone V. 2004. Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol 286:L344–353.
  • Carmichael J, DeGraV WG, Gazdar AF, Minna JD, Mitchell JB. 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res 47:936–942.
  • Castranova V. 2004. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: Role of reactive oxygen/nitrogen species. Free Radic Biol Med 37:916–925.
  • Diaz A, Chepenik KP, Korn JH, Reginato AM, Jimenez SA. 1998. Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 Beta, tumor necrosis factor-Alpha, and transforming growth factor-Beta 1 in human lung fibroblasts. Exp Cell Res 241:222–229.
  • Dutta D, Sundaram SK, Teeguarden JG, Riley BJ, Fifield LS, Jacobs JM, Addleman SR, Kaysen GA, Moudgil BM, Weber TJ. 2007. Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials. Toxicol Sci 100:303–315.
  • Harris RE. 2009. Cyclooxygenase-2 blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology 17:55–67.
  • Hendel J, Nielsen OH. 1997. Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. Am J Gastroenterol 92:1170–1173.
  • Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price RE, Hazle JD, Halas NJ, West JL. 2003. Nanoshell mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 100:13549–13554.
  • Hiura TS, Kaszubowski MP, Li N, Nel AE. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582–5591.
  • Hussain SM, Frazier JM. 2002. Cellular toxicity of hydrazine in primary hepatocytes. Toxicol Sci 69:424–432.
  • Hussain SM, Hess KL, Gearhart JM, Geis KT, Schlager JJ. 2005. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19:975–983.
  • Janssen YM, Barchowsky A, Treadwell M, Driscoll KE, Mossman BT. 1995. Asbestos induces nuclear factor kappa B (NF-Kappa B) DNA-binding activity and NF-Kappa B-dependent gene expression in tracheal epithelial cells. Proc Natl Acad Sci USA 92:8458–8462.
  • Kaewamatawong T, Shimada A, Okajima M, Inoue H, Morita T, Inoue K, Takano H. 2006. Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol 34:958–965.
  • Koike E, Kobayashi T. 2006. Chemical and biological oxidative effects of carbon black nanoparticles. Chemosphere 65:946–951.
  • Lu Y, Wahl LM. 2005. Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-Kappa B activity in lipopolysaccharide-activated human primary monocytes. J Immunol 175:5423–5429.
  • Ma LL, Feldman MD, Tam JM, Paranjape AS, Cheruku KK, Larson TA, Tam JO, Ingram DR, Paramita V, Villard JW, 2009. Small multifunctional nanoclusters (nanoroses) for targeted cellular imaging and therapy. ACS Nano 3:2686–2696.
  • Magrez A, Kasas S, Salicio V, Pasquier N, Schwaller B, Forrò L. 2006. Cellular toxicity of carbon based nanomaterials. Nano Lett 6:1121–1125.
  • Medina C, Santos-Martinez MJ, Radomski A, Corrigan O I, Radomski MW. 2007. Nanoparticles: Pharmacological and toxicological significance. Br J Pharmacol 150:552–558.
  • Mroz RM, Schins RP, Li H, Drost EM, Macnee W, Donaldson K. 2007. Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappa B DNA binding in lung epithelial A549 cell line. J Physiol Pharmacol 58:461–470.
  • Nakao S, Ogtata Y, Shimizu E, Yamazaki M, Furuyama S, Sugiya H. 2002. Tumor necrosis factor alpha (TNF-α)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (Cox-2) transcription via NFκB in human gingival fibroblasts. Mol Cell Biochem 238:11–18.
  • Nam JM, Thaxton CS, Mirkin CA. 2003. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301:1884–1886.
  • Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–627.
  • Niwa Y, Hiura Y, Sawamura H, Iwai N. 2008. Inhalation exposure to carbon black induces inflammatory response in rats. Circ J 72:144–149.
  • Panyam J, Labhasetwar V. 2003. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55:329–347.
  • Park EJ, Park K. 2009. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184:18–25.
  • Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. 2007. Cell selective response to gold nanoparticles. Nanomedicine 3:111–119.
  • Pinkus R, Weiner LM, Daniel V. 1996. Role of oxidants and antioxidants in the induction of AP-1, NF-Kappa B, and glutathione S-transferase gene expression. J Biol Chem 271:13422–13429.
  • Pitsillides CM, Joe EK, Wei X, Anderson RR, Lin CP. 2003. Selective cell targeting with light absorbing microparticles and nanoparticles. Biophys J 84:4023–4032.
  • Reddy MC, Subhashini J, Mahipal SVK, Bhat VB, Reddy PS, Kiranmai G, Madyasatha KM, Reddanna P. 2003. C-phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochem Biophys Res Commun 304:385–392.
  • Rojanasakul Y, Ye J, Chen F, Wang L, Cheng N, Castranova V, Vallyathan V, Shi X. 1999. Dependence of NF-Kappa B activation and free radical generation on silica-induced TNF-alpha production in macrophages. Mol Cell Biochem 200:119–125.
  • Salata OV. 2004. Applications of nanoparticles in biology and medicine. J Nanobiotech 2:3.
  • Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde R, Sastry M. 2005. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview. Langmuir 21:10644–10654.
  • Stone V, Shaw J, Brown DM, Macnee W, Faux SP, Donaldson K. 1998. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol In Vitro 12:649–659.
  • Sutherland WS, Winefordner JD. 1992. Colloid filtration a novel substrate preparation method for surface-enhanced raman-spectroscopy. J Colloid Interface Sci 48:129–141.
  • Tian F, Cui D, Heinz SH, Gomez EG, Kobayashi H. 2006. Cytotoxicity of singlewall carbon nanotubes on human fibroblasts. Toxicol In Vitro 20:1202–1212.
  • Tkachenko AG, Xie H, Coleman D, Glomm W, Ryan J, Anderson MF, Franzen S, Feldheim DL. 2003. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 125:4700–4701.
  • Tzeng HP, Yang RS, Ueng TH, Liu SH. 2007. Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation. Chem Res Toxicol 20:1170–1176.
  • Walter JL, Maire EP, Theo PK. 2005. Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture. J Inorg Biochem 99:1895–1898.
  • Wang H, Joseph JA. 1999. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612–616.
  • Wu W, Li R, Bian X, Zhu Z, Ding D, Li X, Jia Z, Jiang X, Hu Y. 2009. Covalently combining carbon nanotubes with anticancer agent: Preparation and antitumor activity. ACS Nano 3:2740–2750.
  • Xu A, Chai Y, Nohmi T, Hei TK. 2009. Genotoxic responses to titanium dioxide nanoparticles and fullerene in GPT delta transgenic MEF cells. Part Fibre Toxicol 6:3.

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