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Research Article

The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

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Pages 562-575 | Received 04 Oct 2010, Accepted 17 May 2011, Published online: 10 Jun 2011

References

  • Barnham KJ, Masters CL, Bush AI. 2004. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 3(3):205–214.
  • Block ML, Wu X, Pei Z, Li G, Wang T, Qin L, Wilson B, Yang J, Hong JS, Veronesi B. 2004. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: The role of microglia, phagocytosis, and NADPH oxidase. FASEB J 18:1618–1620.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.
  • Byrne JH. 2003. Neural computation: Olfactory cortex as a model for telencephalic processing. In: Learning & Memory. 2nd ed. New York, NY: Macmillan Reference USA. pp 445–450.
  • Caviedes P, Segura-Aguilar J. 2001. The price of development in Chile: Overcoming environmental hazards produced by heavy industrial exploitation. Neuroreport 12(4):A25–A29.
  • Chen Z, Meng H, Xing GM, Chen CY, Zhao YL, Jia G, Wang TC, Yuan H, Ye C, Zhao F, 2006. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett 163(2):109–120.
  • Cioffi N, Ditaranto N, Torsi L, Picca RA, De Giglio E, Sabbatini L, Novello L, Tantillo G, Bleve-Zacheo T, Zambonin PG. 2005. Synthesis, analytical characterization and bioactivity of Ag and Cu nanoparticles embedded in poly-vinyl-methylketone films. Anal Bioanal Chem 382:1912–1918.
  • Colvin VL. 2003. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21:1166–1170.
  • Cooper JR, Bloom FE, Roth RH. 1996. The biochemical basis of neuropharmacology. New York, NY: Oxford University Press.
  • Corsini GU, Zuddas A, Bonuccelli U, Schinelli S, Kopin IJ. 1987. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice enhanced by ethanol and acetaldehyde. Life Sci 40:827–832.
  • Costa E. 1970. Simple neuronal models to estimate turnover rate of noradrenergic transmitters in vivo. Adv Biochem Psychopharmacol 2:169–204.
  • De Lorenzo A, Darin J. 1970. The olfactory neuron and the blood-brain barrier. In: Taste and smell in vertebrates. London: Churchill. pp 151–176.
  • Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Finkelstein J, Oberdörster G. 2006. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114(8):1172–1178.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2):88–95.
  • Fuster JM. 2008. Chemical neurotransmission. In: The prefrontal cortex. 4th ed. San Diego: Academic Press. pp 62.
  • Gaetke LM, Chow CK. 2003. Copper toxicity, oxidative stress and antioxidant nutrients. Toxicology 189(1–2):147–163.
  • Garg BD, Cadle SH, Mulawa PA, Groblichi PJ. 2000. Brake wear particulate matter emissions. Environ Sci Technol 34:4463–4469.
  • Goldhaber SB. 2003. Trace element risk assessment: Essentiality vs. toxicity. Regul Toxicol Pharm 38:232–242.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analysis of nitrate, nitrite, and [15N]nitrite in biological fluids. Anal Biochem 126:131–138.
  • Griffitt RJ, Luo J, Gao J, Bonzongo JC, Barber DS. 2008. Effects of particle composition and species on toxicity of metallic nanomaterials in aquatic organisms. Environ Toxicol Chem 27:1972–1978.
  • Haxhiu MA, Tolentino-Silva F, Pete G, Kc P, Mack SO. 2001. Monoaminergic neurons, chemosensation and arousal. Respir Physiol 129:191–209.
  • Honma T, Miyagawa M, Sato M. 1987. Methyl bromide alters catecholamine and metabolite concentrations in rat brain. Neurotoxicol Teratol 9:369–375.
  • Hulskotte JHJ, Schaap M, Visschedijk AJH. 2006. Brake wear from vehicles as an important source of diffuse copper pollution. Water Sci Technol 56(1):223–231.
  • Illum L. 2000. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 11(1):1–18.
  • International Programme on Chemical Safety (IPCS). 1982. The 26th Report of the Joint FAO/WHO Expert Committee on Food Additives. 1982. Toxicological evaluation of certain food additives and contaminants. WHO Food Additive Series:17.
  • Jose GP, Santra S, Mandal SK, Sengupta TK. 2011. Singlet oxygen mediated DNA degradation by copper nanoparticles: Potential towards cytotoxic effect on cancer cells. J Nanobiotechnol 9:9.
  • Landner L, Lindeström L. 1999. Copper in society and in the environment: An account of the facts on fluxes, amounts, and effects of copper in Sweden. 2nd ed. Västerås, Sweden: Swedish Environmental Research Group.
  • Lee WM, An YJ, Yoon H, Kweon HS. 2008. Toxicity and bioavailability of copper nanoparticles to the terrestrial plants mung bean (Phaseolus radiatus) and wheat (Triticum aestivum): Plant agar test for water-insoluble nanoparticles, Environ Sci Technol 27(9):1915–1921.
  • Lei RH, Wu CQ, Yang BH, Ma HZ, Shi C, Wang QJ, Wang QX, Yuan Y, Liao MY. 2008. Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid in vivo screening method for nanotoxicity. Toxicol Appl Pharm 232:292–301.
  • Linder MC, Hazegh-Azam M. 1996. Copper biochemistry and molecular biology. Am J Clin Nutr 63:797–811.
  • Liu G, Li X, Qin B, Xing D, Guo Y, Fan R. 2004. Investigation of the mending effect and mechanism of copper nano-particles on a tribologically stressed surface. Tribol Lett 17:961–966.
  • Liu Y, Gao YX, Zhang LL, Wang TC, Wang JX, Jiao F, Li W, Liu Y, Li YF, Li B, 2009. Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. J Nanosci Nanotechnol 9(11):6335–6343.
  • Loeffler DA, LeWitt PA, Juneau PL, Sima AAF, Nguyen HU, DeMaggio AJ, Brickman CM, Brewer GJ, Dick RD, Troyer MD, 1996. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders. Brain Res 738(2):265–274.
  • MacPherson IS, Murphy ME. 2007. Type-2 copper-containing enzymes. Cell Mol Life Sci 64(22):2887–2899.
  • Maurer I, Zierz S, Möller HJ. 2000. A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol Aging 21(3):455–462.
  • Maynard CJ, Bush AI, Masters CL, Cappai R, Li QX. 2005. Metals and amyloid-β in Alzheimer's disease. Int J Exp Pathol 86(3):147–159.
  • Midander M, Cronholm P, Karlsson HL, Elihn K, Moller L, Leygraf C, Wallinder IO. 2009. Surface characteristics, copper release, and toxicity of nano- and micrometer-sized copper and copper(II) oxide particles: A cross-disciplinary study. Small 5:389–399.
  • Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–627.
  • Nemmar A, Vanbilloen H, Hoylaerts MF, Hoet PHM, Verbruggen A, Nemery B. 2001. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am J Respir Crit Care Med 164:1665–1668.
  • Nemmar A, Hoet PHM, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411–414.
  • O'Kusky JR, Boyers BE, McGeer EG. 1988. Methylmercury-induced movement and postural disorders in developing rat: Regional analysis of brain catecholamines and indoleamines. Brain Res 439:138–146.
  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16(6–7):437–445.
  • Panessa-Warren BJ, Warren JB, Wong SS, Misewich JA. 2006. Biological cellular response to carbon nanoparticle toxicity. J Phys-Condens Mat 18:S2185–S2201.
  • Peters A, Veronesi B, Calderón-Garcidueñas L, Gehr P, Chen LC, Geiser M, Reed W, Rothen-Rutishauser B, Schürch S, Schulz H. 2006. Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol 3:13.
  • Prabhu BM, Ali SF, Murdock RC, Hussain SM, Srivatsan M. 2010. Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of rat. Nanotoxicology 4(2):150–160.
  • Sarter M, Bruno JP, Parikh V. 2006. Abnormal neurotransmitter release underlying behavioral and cognitive disorders: Toward concepts of dynamic and function-specific dysregulation. Neuropsychopharmacology 32(7):1452–1461.
  • Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdörster G, Kreyling WG. 2004. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal Toxicol 16(6–7):453–459.
  • Sharma HS, Hussain S, Schlager J, Ali SF, Sharma A. 2010. Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats. Acta Neurochir Suppl 106:359–364.
  • Sharma RP, Coulombe RA, Srisuchart B. 1986. Effects of dietary vanadium exposure on levels of regional brain neurotransmitters and their metabolites. Biochem Pharmacol 35:461–465.
  • Squitti R, Bressi F, Pasqualetti P, Bonomini C, Ghidoni R, Binetti G, Cassetta E, Moffa F, Ventriglia M, Vernieri F, 2009. Longitudinal prognostic value of serum “free” copper in patients with Alzheimer's disease. Neurology 72:50–55.
  • Stone V, Donaldson K. 2006. Nanotoxicology: Signs of stress. Nat Nanotechnol 1:23–24.
  • Tsuji JS, Maynard AD, Howard PC, James JT, Lam CW, Warheit DB, Santamaria AB. 2006. Research strategies for safety evaluation of nanomaterials, part IV: Risk assessment of nanoparticles. Toxicol Sci 89:42–50.
  • Tsunoda M, Dugyala RR, Sharma RP. 1998. Fumonisin B1-induced increases in neurotransmitter metabolite levels in different brain regions of BALB/c mice. Comp Biochem Physiol 120C:457–465.
  • Wang B, Feng WY, Wang M, Shi JW, Zhang F, Ouyang H, Zhao YL, Chai ZF, Huang YY, Xie YN, 2007a. Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 118:233–243.
  • Wang B, Feng WY, Zhu MT, Wang Y, Wang M, Gu YQ, Ouyang H, Wang HJ, Li M, Zhao YL, 2009. Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice. J Nanopart Res 11:41–53.
  • Wang JX, Zhou GQ, Chen CY, Yu HW, Wang TC, Ma YM, Jia G, Gao YX, Li B, Sun J, 2007b. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–185.
  • Wang JX, Chen CY, Liu Y, Jiao F, Li W, Lao F, Li YF, Li B, Ge CC, Zhou GQ, 2008a. Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183:72–80.
  • Wang JX, Liu Y, Jiao F, Lao F, Li W, Gu YQ, Li YF, Ge CC, Zhou GQ, Li B, 2008b. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology 254:82–90.
  • Win-Shwe TT, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H. 2008. Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure. Toxicol Appl Pharm 226:192–198.
  • Yamamoto A, Honma R, Sumita M, Hanawa T. 2004. Cytotoxicity evaluation of ceramic particles of different sizes and shapes. J Biomed Mater Res A 68A(2):244–256.
  • Zhao YL, Xing GM, Chai ZF. 2008. Nanotoxicology: Are carbon nanotubes safe? Nat Nanotechnol 3:191–192.

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