660
Views
52
CrossRef citations to date
0
Altmetric
Original Article

Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats

, , , &
Pages 643-653 | Received 12 Apr 2013, Accepted 12 Jun 2013, Published online: 08 Jul 2013

References

  • Bio-Research Laboratories (BRL). 1994. Final report for a 90-day inhalation neurotoxicity and toxicity study by exposure to a dry powder aerosol of ceric oxide in the albino rat with cover letter dated 013095. Produced by Bio-Research Laboratories, Montreal, Canada for Rhone-Poulenc Inc. Submitted under TSCA Section 8E; EPA Doc. No. 89-950000107; NTIS No. OTS0556254.
  • Carvalho TC, Peters JI, Williams RO; 3RD. 2011. Influence of particle size on regional lung deposition–what evidence is there? Int J Pharm 406:1–10.
  • Cassee FR, Campbell A, Boere AJ, Mclean SG, Duffin R, Krystek P, et al. 2012. The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice. Environ Res 115:1–10.
  • Cassee FR, Muijser H, Duistermaat E, Freijer JJ, Geerse KB, Marijnissen JC, et al. 2002. Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model. Arch Toxicol 76:277–286.
  • Cassee FR, Van Balen EC, Singh C, Green D, Muijser H, Weinstein J, et al. 2011. Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive. Crit Rev Toxicol 41:213–229.
  • Cheng YS, Barr EB, Yey HC. 1989. A venturi dispenser as a dry powder generator for inhalation studies. Inhal Toxicol 1:365–371.
  • Cheng YS, Marshall TC, Henderson RF, Newton GJ. 1985. Use of a jet mill for dispersing dry powder for inhalation studies. Am Ind Hyg Assoc J 46:449–454.
  • Cho WS, Duffin R, Poland CA, Howie SE, Macnee W, Bradley M, et al. 2010. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118:1699–1706.
  • Cobben NA, Jacobs JA, Dieijen-Visser MP, Mulder PG, Wouters EF, Drent M. 1999. Diagnostic value of BAL fluid cellular profile and enzymes in infectious pulmonary disorders. Eur Respir J 14:496–502.
  • Duffin R, Tran L, Brown D, Stone V, Donaldson K. 2007. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849–856.
  • Eom HJ, Choi J. 2009. Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicol Lett 187:77–83.
  • Geraets L, Oomen AG, Schroeter JD, Coleman VA, Cassee FR. 2012. Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci 127:463–473.
  • Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, Leseman DL, John A, Boere F, et al. 2007. Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol 19:1055–1069.
  • Health Effects Institute. 2001. Communication 9. Evaluation of human health risk from cerium added to diesel fuel. Cambridge, MA: HEI.
  • Heckert E, Karakoti A, Seal S, Self WT. 2008. The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials 29:2705–2709.
  • Henderson RF, Scott GG, Waide JJ. 1995. Source of alkaline phosphatase activity in epithelial lining fluid of normal and injured F344 rat lungs. Toxicol Appl Pharmacol 134:170–174.
  • Hirst SM, Karakoti AS, Tyler RD, Sriranganathan N, Seal S, Reilly CM. 2009. Anti-inflammatory properties of cerium oxide nanoparticles. Small 5:2848–2856.
  • Horie M, Nishio K, Kato H, Fujita K, Endoh S, Nakamura A, et al. 2011. Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells. J Biochem 150:461–471.
  • Hristozov DR, Gottardo S, Critto A, Marcomini A. 2012. Risk assessment of engineered nanomaterials: a review of available data and approaches from a regulatory perspective. Nanotoxicology 6:880–898.
  • Li N, Xia T, Nel AE. 2008. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44:1689–1699.
  • Lin W, Huang YW, Zhou XD, Ma Y. 2006. Toxicity of cerium oxide nanoparticles in human lung cancer cells. Int J Toxicol 25:451–457.
  • Lippmann M, Yeates DB, Albert RE. 1980. Deposition, retention, and clearance of inhaled particles. Br J Ind Med 37:337–362.
  • Lizon C, Fritsch P. 1999. Chemical toxicity of some actinides and lanthanides towards alveolar macrophages: an in vitro study. Int J Radiat Biol 75:1459–1471.
  • Ma JY, Mercer RR, Barger M, Schwegler-Berry D, Scabilloni J, Ma JK, et al. 2012. Induction of pulmonary fibrosis by cerium oxide nanoparticles. Toxicol Appl Pharmacol 262:255–264.
  • MA JY, Zhao H, Mercer RR, Barger M, Rao M, Meighan T, et al. 2011. Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats. Nanotoxicology 5:312–325.
  • Mcdonald JW, Ghio AJ, Sheehan CE, Bernhardt PF, Roggli VL. 1995. Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review. Mod Pathol 8:859–865.
  • Morrow PE. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam Appl Toxicol 10:369–384.
  • Nalabotu SK, Kolli MB, Triest WE, Ma JY, Manne ND, Katta A, et al. 2011. Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats. Int J Nanomedicine 6:2327–2335.
  • Oberdorster G, Ferin J, Lehnert BE. 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl 5):173–179.
  • Oberdorster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839.
  • Pairon JC, Roos F, Sebastien P, Chamak B, Abd-Alsamad I, Bernaudin JF, et al. 1995. Biopersistence of cerium in the human respiratory tract and ultrastructural findings. Am J Ind Med 27. 349:58.
  • Park B, Donaldson K, Duffin R, Tran L, Kelly F, Mudway I, et al. 2008a. Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive - a case study. Inhal Toxicol 20:547–566.
  • Park EJ, Choi J, Park YK, Park K. 2008b. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology 245:90–100.
  • Pauluhn J. 2011. Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Toxicology 279:176–188.
  • Reist PC, Taylor L. 2000. Development and operation of an improved turntable dust feeder. Powder Technol 107:36–42.
  • Rothen-Rutishauser B, Grass RN, Blank F, Limbach LK, Muhlfeld C, Brandenberger C, et al. 2009. Direct combination of nanoparticle fabrication and exposure to lung cell cultures in a closed setup as a method to simulate accidental nanoparticle exposure of humans. Environ Sci Technol 43:2634–2640.
  • Sabbioni E, Pietra R, Gaglione P, Vocaturo G, Colombo F, Zanoni M, et al. 1982. Long-term occupational risk of rare-earth pneumoconiosis. A case report as investigated by neutron activation analysis. Sci Total Environ 26:19–32.
  • Slob W, Moerbeek M, Rauniomaa E, Piersma AH. 2005. A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints. Toxicol Sci 84:167–185.
  • Slob W. 2002. Dose-response modeling of continuous endpoints. Toxicol Sci 66:298–312.
  • Srinivas A, Rao PJ, Selvam G, Murthy PB, Reddy PN. 2011. Acute inhalation toxicity of cerium oxide nanoparticles in rats. Toxicol Lett 205:105–115.
  • Stoeger T, Takenaka S, Frankenberger B, Ritter B, Karg E, Maier K, et al. 2009. Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds. Environ Health Perspect 117:54–60.
  • Stoeger T, Reinhard C, Takenaka S, Schroeppel A, Karg E, Ritter B, et al. 2006. Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect 114:328–333.
  • Thill A, Zeyons O, Spalla O, Chauvat F, Rose J, Auffan M, et al. 2006. Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism. Environ Sci Technol 40:6151–6156.
  • Toya T, Takata A, Otaki N, Takaya M, Serita F, Yoshida K, et al. 2010. Pulmonary toxicity induced by intratracheal instillation of coarse and fine particles of cerium dioxide in male rats. Ind Health 48:3–11.
  • Vocaturo G, Colombo F, Zanoni M, Rodi F, Sabbioni E, Pietra R. 1983. Human exposure to heavy metals. Rare earth pneumoconiosis in occupational workers. Chest 83:780–783.
  • Warheit DB, Reed KL, Sayes CM. 2009. A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management. Inhal Toxicol 21(Suppl 1):61–67.
  • Wittmaack K. 2007. In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ Health Perspect 115:187–194.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.