1,208
Views
150
CrossRef citations to date
0
Altmetric
Original Article

Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen

, , , , , , , , , , & show all
Pages 654-662 | Received 16 Oct 2012, Accepted 01 Jul 2013, Published online: 25 Jul 2013

References

  • Boraschi D, Costantino L, Italiani P. 2012. Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. Nanomedicine (Lond) 7:121–131.
  • Cesta MF. 2006. Normal structure, function, and histology of the spleen. Toxicol Pathol 34:455–465.
  • Chen J, Dong X, Zhao J, Tang G. 2009. In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitoneal injection. J Appl Toxicol 29:330–337.
  • De Angelis S, Tassinari R, Maranghi F, Eusepi A, Di Virgilio A, Chiarotti F, et al. 2009. Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicol Sci 108:311–319.
  • Dong MS, Choi JY, Sung JH, Kim JS, Song KS, Ryu HR, et al. 2013. Gene expression profiling of kidneys from Sprague-Dawley rats following 12-week inhalation exposure to silver nanoparticles. Toxicol Mech Methods; Epub ahead of print.
  • Douglas SA, Sreenivasan D, Carman FH, Bunn SJ. 2010. Cytokine interactions with adrenal medullary chromaffin cells. Cell Mol Neurobiol 30:1467–1475.
  • EEC. 1986. Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. O J L 358:1-28.
  • EFSA. 2004. Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on Titanium dioxide. EFSA J 163:1-12
  • EFSA. 2009. The Potential Risks Arising from Nanoscience and Nanotechnologies on Food and Feed Safety. EFSA J 958:1-39.
  • EFSA. 2011. Guidance on the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain. EFSA J 9:2140.
  • Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, van Ravenzwaay B. 2008. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch Toxicol 82:151–157.
  • FAO/WHO. 2010. Expert meeting on the application of nanotechnologies in the food and agriculture sectors: potential food safety implications. Meeting report. http://whqlibdoc.who.int/publications/2010/9789241563932_eng.pdf.
  • Fijak M, Bhushan S, Meinhardt A. 2011. Immunoprivileged sites: the testis. Methods Mol Biol 677:459–470.
  • Fortune JE. 2003. The early stages of follicular development: activation of primordial follicles and growth of preantral follicles. Anim Reprod Sci 78:135–163.
  • Gao G, Ze Y, Li B, Zhao X, Zhang T, Sheng L, et al. 2012. Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles. J Hazard Mater 243:19–27.
  • Gao G, Ze Y, Zhao X, Sang X, Zheng L, Ze X, et al. 2013. Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice. J Hazard Mater 258-259:133–143.
  • Hermo L, Pelletier RM, Cyr DG, Smith CE. 2010. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes. Microsc Res Tech 73:241–278.
  • Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Löschner K, Larsen EH, et al. 2010. Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 14:7–16.
  • IARC. 2009. Identification of research needs to resolve the carcinogenicity of high priority IARC carcinogens. Technical Publication No. 42.
  • IARC. 2010. Monographs on the Evaluation of Carcinogenic Risks to Humans. Carbon Black, Titanium Dioxide, and Talc. Volume 93.
  • Kim WY, Kim J, Park JD, Ryu HY, Yu IJ. 2009. Histological study of gender differences in accumulation of silver nanoparticles in kidneys of Fischer 344 rats. J Toxicol Environ Health A 72:1279–1284.
  • Maranghi F, Tassinari R, Lagatta V, Moracci G, Macrì C, Eusepi A, et al. 2009. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol 47:472–479.
  • Rosol TJ, Yarrington JT, Latendresse J, Capen CC. 2001. Adrenal gland: structure, function, and mechanisms of toxicity. Toxicol Pathol 29:41–48.
  • Sang X, Zheng L, Sun Q, Li N, Cui Y, Hu R, et al. 2012. The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles. J Biomed Mater Res A 100:894–902.
  • Takeda K, Suzuki KI, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, et al. 2009. Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55:95–102.
  • Tan SW, Zoeller RT. 2007. Integrating basic research on thyroid hormone action into screening and testing programs for thyroid disruptors. Crit Rev Toxicol 37:5–10.
  • Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, et al. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–185.
  • Weir A, Westerhoff P, Fabricius L, Hristovski K, von Goetz N. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–2250.
  • Xie G, Wang C, Sun J, Zhong G. 2011. Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles. Toxicol Lett 205:55–61.
  • Xue Y, Zhang S, Huang Y, Zhang T, Liu X, Hu Y, et al. 2012. Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice. J Appl Toxicol 32:890–899.
  • Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, et al. 2011. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 6:321–328.
  • Zhao X, Ze Y, Gao G, Sang X, Li B, Gui S, et al. 2013. Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS One 8:e59378.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.