The buccal mucosa as a route for TiO₂ nanoparticle uptake

References

• Asikainen P, Ruotsalainen TJ, Mikkonen JJ, Koistinen A, Ten Bruggenkate C, Kullaa AM. 2012. The defence architecture of the superficial cells of the oral mucosa. Med Hypotheses 78:790–2
   PubMed Web of Science ®Google Scholar
• Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Cogliano V. 2006. Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol 7:295–6
   PubMed Web of Science ®Google Scholar
• Barone F, Berardis BD, Bizzarri L, Degan P, Andreoli C, Zijno A, Angelis ID. 2011. Physico-chemical characteristics and cyto-genotoxic potential of ZnO and TiO2 nanoparticles on human colon carcinoma cells. J Phys Conf Ser 304:012047. doi: 10.1088/1742-6596/304/1/012047
   Google Scholar
• Brown DM, Donaldson K, Borm PJ, Schins RP, Dehnhardt M, Gilmour P, et al. 2004. Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol 286:L344–53
   PubMed Web of Science ®Google Scholar
• Brun E, Jugan M-L, Herlin-Boime N, Jaillard D, Fayard B, Flank A-M, et al. 2011. Investigation of TiO2 nanoparticles translocation through a Caco-2 monolayer. J Phys Conf Ser 304:012048. doi: 10.1088/1742-6596/304/1/012048
   Google Scholar
• Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, Ravenzwaay B. 2008. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch Toxicol 82:151–7
   PubMed Web of Science ®Google Scholar
• Fröhlich E, Roblegg E. 2012. Models for oral uptake of nanoparticles in consumer products. Toxicology 291:10–17
   PubMed Web of Science ®Google Scholar
• Galey WR, Lonsdale HK, Nacht S. 1976. The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. J Invest Dermatol 67:713–17
   PubMed Web of Science ®Google Scholar
• Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, et al. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555–60
   PubMed Web of Science ®Google Scholar
• Ghandi R, Robinson J. 1988. Bioadhesion in drug delivery. Ind J Pharm Sci 3:145–52
   Google Scholar
• Gottschalk F, Sonderer T, Scholz RW, Nowack B. 2009. Modeled environmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, Fullerenes) for different regions. Environ Sci Technol 43:9216–22
   PubMed Web of Science ®Google Scholar
• Harris AT, Bali R. 2008. On the formation and extent of uptake of silver nanoparticles by live plants. J Nanopart Res 10:691–5
   Web of Science ®Google Scholar
• Harris D, Robinson JR. 1992. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 81:1–10
   PubMed Web of Science ®Google Scholar
• Holm R, Meng-Lund E, Andersen MB, Jespersen ML, Karlsson J-J, Garmer M, et al. 2013. In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs. Eur J Pharm Sci 49:117–24
   PubMed Web of Science ®Google Scholar
• Jacobsen J, Van Deurs B, Pedersen M, Rassing MR. 1995. TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability. Int J Pharm 125:165–84
   Web of Science ®Google Scholar
• Jani PU, Mccarthy DE, Florence AT. 1994. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration. Int J Pharm 105:157–68
   Web of Science ®Google Scholar
• Khinast J, Baumgartner R, Roblegg E. 2013. Nano-extrusion: a one-step process for manufacturing of solid nanoparticle formulations directly from the liquid phase. AAPS Pharm Sci Tech 14:601–4
   PubMed Web of Science ®Google Scholar
• Koeneman B, Zhang Y, Westerhoff P, Chen Y, Crittenden J, Capco D. 2010. Toxicity and cellular responses of intestinal cells exposed to titanium dioxide. Cell Biol Toxicol 26:225–38
   PubMed Web of Science ®Google Scholar
• Lankveld DPK, Oomen AG, Krystek P, Neigh A, Troost-De Jong A, Noorlander CW, et al. 2010. The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials 31:8350–61
   PubMed Web of Science ®Google Scholar
• Leblanc AJ, Moseley AM, Chen BT, Frazer D, Castranova V, Nurkiewicz TR. 2010. Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism. Cardiovasc Toxicol 10:27–36
   PubMed Web of Science ®Google Scholar
• Lesch CA, Squier CA, Cruchley A, Williams DM, Speight P. 1989. The permeability of human oral mucosa and skin to water. J Dent Res 68:1345–9
   PubMed Web of Science ®Google Scholar
• Li S, Zhu H, Zhu R, Sun X, Yao S, Wang S. 2008. Impact and mechanism of TiO2 nanoparticles on DNA synthesis in vitro. Sci China Ser B 51:367–72
   Google Scholar
• Lomer MC, Hutchinson C, Volkert S, Greenfield SM, Catterall A, Thompson RP, Powell JJ. 2004. Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease. Br J Nutr 92:947–55
   PubMed Web of Science ®Google Scholar
• Lomer MC, Thompson RP, Commisso J, Keen CL, Powell JJ. 2000. Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst 125:2339–43
   PubMed Web of Science ®Google Scholar
• Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B. 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ Sci Technol 40:4346–52
   PubMed Web of Science ®Google Scholar
• Long TC, Tajuba J, Sama P, Saleh N, Swartz C, Parker J, et al. 2007. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ Health Perspect 115:1631–7
   PubMed Web of Science ®Google Scholar
• Müller RH. 1991. Surface Hydrophobicity-Determination by Rose Bengal (RB) Adsorption Methods. Colloidal Carriers for Controlled Drug Delivery and Targeting. 1st ed. Stuttgart: CRC Press
   Google Scholar
• Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–7
   PubMed Web of Science ®Google Scholar
• Nielsen HM, Rassing MR. 2000. TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and β-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. Int J Pharm 194:155–67
   PubMedGoogle Scholar
• Phenrat T, Saleh N, Sirk K, Tilton RD, Lowry GV. 2007. Aggregation and sedimentation of aqueous nanoscale zerovalent iron dispersions. Environ Sci Technol 41:284–90
   PubMed Web of Science ®Google Scholar
• Powell JJ, Faria N, Thomas-Mckay E, Pele LC. 2010. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 34:J226–33
   PubMed Web of Science ®Google Scholar
• Ramirez-Garcia S, Chen L, Morris MA, Dawson KA. 2011. A new methodology for studying nanoparticle interactions in biological systems: dispersing titania in biocompatible media using chemical stabilisers. Nanoscale 3:4617–24
   PubMed Web of Science ®Google Scholar
• Roblegg E, Fröhlich E, Meindl C, Teubl B, Zaversky M, Zimmer A. 2012. Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa. Nanotoxicology 6:399–413
   PubMed Web of Science ®Google Scholar
• Salvati A, Aberg C, Dos Santos T, Varela J, Pinto P, Lynch I, Dawson KA. 2011. Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics. Nanomedicine 7:818–26
   PubMed Web of Science ®Google Scholar
• Seo J-W, Chung H, Kim M-Y, Lee J, Choi I-H, Cheon J. 2007. Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment. Small 3:850–3
   PubMed Web of Science ®Google Scholar
• Singh S, Shi T, Duffin R, Albrecht C, Van Berlo D, Höhr D, et al. 2007. Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicol Appl Pharmacol 222:141–51
   PubMed Web of Science ®Google Scholar
• Stearns RC, Paulauskis JD, Godleski JJ. 2001. Endocytosis of ultrafine particles by A549 cells. Am J Respir Cell Mol Biol 24:108–15
   PubMed Web of Science ®Google Scholar
• Teubl BJ, Meindl C, Eitzlmayr A, Zimmer A, Fröhlich E, Roblegg E. 2013. In-vitro permeability of neutral polystyrene particles via buccal mucosa. Small 9:457–66
   PubMed Web of Science ®Google Scholar
• Thurn KT, Paunesku T, Wu A, Brown EMB, Lai B, Vogt S, et al. 2009. Labeling TiO2 nanoparticles with dyes for optical fluorescence microscopy and determination of TiO2–DNA nanoconjugate stability. Small 5:1318–25
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, et al. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–85
   PubMed Web of Science ®Google Scholar
• Weir A, Westerhoff P, Fabricius L, Hristovski K, Von Goetz N. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–50
   PubMed Web of Science ®Google Scholar
• Wertz PW, Squier CA. 1991. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Ther Drug Carrier Syst 8:237–69
   PubMed Web of Science ®Google Scholar