446
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Intratracheal exposure to multi-walled carbon nanotubes induces a nonalcoholic steatohepatitis-like phenotype in C57BL/6J mice

, , , , &
Pages 613-623 | Received 03 Feb 2014, Accepted 04 Sep 2014, Published online: 29 Sep 2014

References

  • Arndt PG, Young SK, Worthen GS. 2005. Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator inhibitor-1 through a JNK-mediated pathway. J Immunol 175:4049–59
  • Bates DV, Fish BR, Hatch TF, Mercer TT, Morrow PE. 1966. Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics. Health Phys 12:173–207
  • Berber S, Kwon YK, Tomanek D. 2000. Unusually high thermal conductivity of carbon nanotubes. Phys Rev Lett 84:4613–16
  • Bourdon JA, Halappanavar S, Saber AT, Jacobsen NR, Williams A, Wallin H, et al. 2012. Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis. Toxicol Sci 127:474–84
  • Brunt EM. 2001. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 21:3–16
  • Chen JC, Schwartz J. 2008. Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environ Health Perspect 116:612–17
  • Czarny B, Georgin D, Berthon F, Plastow G, Pinault M, Patriarche G, et al. 2014. Carbon nanotube translocation to distant organs after pulmonary exposure: insights from in situ 14c-radiolabelling and tissue radioimaging. ACS Nano 8:5715–24
  • Day CP, James OF. 1998. Steatohepatitis: a tale of two “hits”? Gastroenterology 114:842–5
  • De Volder MF, Tawfick SH, Baughman RH, Hart AJ. 2013. Carbon nanotubes: present and future commercial applications. Science 339:535–9
  • Della Corte C, Liccardo D, Mosca A, Vania A, Nobili V. 2013. Non-alcoholic fatty liver disease. Paediatr Child Health, 23:529–34
  • Deng X, Jia G, Wang H, Sun H, Wang X, Yang S, et al. 2007. Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon 45:1419–24
  • Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55:24–35
  • Erdely A, Hulderman T, Salmen R, Liston A, Zeidler-Erdely PC, Schwegler-Berry D, et al. 2009. Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers. Nano Lett 9:36–43
  • Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. 2006. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 45:120–59
  • Galer DM, Leung HW, Sussman RG, Trzos RJ. 1992. Scientific and practical considerations for the development of occupational exposure limits (oels) for chemical substances. Regul Toxicol Pharmacol 15:291–306
  • Hu L, Hecht DS, Gruner G. 2010. Carbon nanotube thin films: fabrication, properties, and applications. Chem Rev 110:5790–844
  • Hui E, Xu A, Yang BH, Lam KS. 2013. Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: role of adipokines. J Diabetes Investig 4:413–25
  • Jain S, Thakare VS, Das M, Godugu C, Jain AK, Mathur R, et al. 2011. Toxicity of multiwalled carbon nanotubes with end defects critically depends on their functionalization density. Chem Res Toxicol 24:2028–39
  • Ji Z, Zhang D, Li L, Shen X, Deng X, Dong L, et al. 2009. The hepatotoxicity of multi-walled carbon nanotubes in mice. Nanotechnology 20:445101. doi:10.1088/0957-4484/20/44/445101
  • Kim JE, Lim HT, Minai-Tehrani A, Kwon JT, Shin JY, Woo CG, et al. 2010. Toxicity and clearance of intratracheally administered multiwalled carbon nanotubes from murine lung. J Toxicol Environ Health A 73:1530–43
  • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. 2005. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313–21
  • Kramer U, Herder C, Sugiri D, Strassburger K, Schikowski T, Ranft U, Rathmann W. 2010. Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study. Environ Health Perspect 118:1273–9
  • Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, et al. 2010. Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol 299:C736–49
  • Mercer RR, Scabilloni JF, Hubbs AF, Wang L, Battelli LA, Mckinney W, et al. 2013. Extrapulmonary transport of MWCNT following inhalation exposure. Part Fibre Toxicol 10:38. doi: 10.1186/1743-8977-10-38
  • NIOSH. 2010. Current Intelligence Bulletin: occupational exposure to carbon nanotubes and nanofibers. Cincinnati, Ohio: US Department of Health and Human Services Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; draft document
  • Osorio A, Silveira I, Bueno V, Bergmann C. 2008. H2SO4/HNO3/HCl-Functionalization and its effect on dispersion of carbon nanotubes in aqueous media. Appl Surf Sci 255:2485–9
  • Park EJ, Lee JH, Yu G-Y, He G, Ali SR, Holzer RG, et al. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140:197–208
  • Patlolla AK, Berry A, Tchounwou PB. 2011. Study of hepatotoxicity and oxidative stress in male Swiss-Webster mice exposed to functionalized multi-walled carbon nanotubes. Mol Cell Biochem 358:189–99
  • Reddy AR, Krishna DR, Reddy YN, Himabindu V. 2010. Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats. Toxicol Mech Methods 20:267–72
  • Reeves HL, Burt AD, Wood S, Day CP. 1996. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 25:677–83
  • Saber AT, Lamson JS, Jacobsen NR, Ravn-Haren G, Hougaard KS, Nyendi AN, et al. 2013. Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk. PLoS One 8:e69020
  • Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, et al. 2006. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 103:3357–62
  • Spoelstra EN, Ince C, Koeman A, Emons VM, Brouwer LA, van Luyn MJ, et al. 2007. A novel and simple method for endotracheal intubation of mice. Lab Anim 41:128–35
  • Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. 1992. Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6:235–43
  • Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, et al. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–46
  • Tan HH, Fiel MI, Sun Q, Guo J, Gordon RE, Chen LC, et al. 2009. Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease. J Immunotoxicol 6:266–75
  • Targher G, Bertolini L, Scala L, Zenari L, Lippi G, Franchini M, Arcaro G. 2007. Plasma PAI-1 levels are increased in patients with nonalcoholic steatohepatitis. Diabetes Care 30:e31–2
  • Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, Kadowaki T. 2005. Peroxisome proliferator–activated receptor (PPAR) α activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue comparison of activation of PPARα, PPARγ, and their combination. Diabetes 54:3358–70
  • Vaisman BL, Demosky SJ, Stonik JA, Ghias M, Knapper CL, Sampson ML, et al. 2012. Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis. J Lipid Res 53:158–67
  • Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. 2008. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. The Am J Gastroenterol 103:1372–9
  • Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. 2002. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288–95
  • Zhao GJ, Tang SL, Lv YC, Ouyang XP, He PP, Yao F, et al. 2013. Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression. PLoS One 8:e74782
  • Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Huttemann M, et al. 2013. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. J Hepatol 58:148–54

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.