Metabolomics reveals the perturbations in the metabolome of Caenorhabditis elegans exposed to titanium dioxide nanoparticles

References

• Behm CA. 2002. Metabolism. In: Lee DL, ed. Biology of Nematode. New York: Taylor and Francis Inc
   Google Scholar
• Berridge MJ. 1993. Inositol triphosphate and calcium signalling. Nature 361:315–25
   PubMed Web of Science ®Google Scholar
• Brayner R. 2008. The toxicological impact of nanoparticles. Nanotoday 3:48–55
   Web of Science ®Google Scholar
• Broadhurst DI, Kell DB. 2006. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2:171–96
   Web of Science ®Google Scholar
• Bruna E, Petit E, Beljean LM, Huynh S. Nouvelot A. 1989. Specific susceptibility of docosahexaenoic acid and eicosapentaenoic acid to peroxidation in aqueous solution. Lipids 24:970–5
   Web of Science ®Google Scholar
• Bujak R, García-Álvarez A, Rupérez FJ, Nuño-Ayala M, García A, Ruiz-Cabello J, et al. 2014. Metabolomics reveals metabolite changes in acute pulmonary metabolism. J Protome Res 13:805–16
   PubMed Web of Science ®Google Scholar
• Bundy JG, Davey MP, Viant MR. 2009. Environmental metabolomics: a critical review and future perspectives. Metabolomics 5:3–21
   Web of Science ®Google Scholar
• Butler JA, Mushur RJ, Bokov AF, Hakala KW, Weintraub ST, Rea SL. 2012. Profiling of anaerobic response of C. elegans using GC–MS. PLoS One 7:e46140
   PubMedGoogle Scholar
• Current Intelligence Bulletin 63: Occupational exposure to TiO2. 2011. Department of Health and Human Services, Centres for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOHS). 160:1–119
   Google Scholar
• Dettemer K, Aronov PA, Hammock BD. 2007. Mass spectrometry-based metabolomics. Mass Spectrum Rev 26:51–78
   PubMed Web of Science ®Google Scholar
• Donkin SG, Williams PL. 1995. Influence of developmental stage, salts and food presence on various end points using Caenorhabditis elegans for aquatic toxicity testing. Environ Toxicol Chem 14:2139–47
   Web of Science ®Google Scholar
• Downes CP, Macphee CH. 1990. Myo-inositol metabolites as cellular signals. Eur J Biochem 193:1–18
   PubMedGoogle Scholar
• Edwards CB, Copes N, Brito AG, Canfield J, Bradshaw PC. 2013. Malate and fumarate extend lifespan in Caenorhabditis elegans. PLoS One 8:e58345
   PubMedGoogle Scholar
• Firnhaber C, Hammarlund M. 2013. Neuron-specific feeding RNAi in C. elegans and its use in a screen for essential genes required for GABA neuron function. PLoS Genet 9:e1003921
   PubMedGoogle Scholar
• Föll RL, Pleyer A, Lewandovski GJ, Wermter C, Hegemann V, Paul RJ. 1999. Anaerobiosis in the nematode Caenorhabditis elegans. Comp Biochem Physiol B: Biochem Mol Biol 124:269–80
   PubMed Web of Science ®Google Scholar
• Geier FM, Want EJ, Leroi AM, Bundy JG. 2011. Cross-platform comparison of Caenorhabditis elegans tissue extraction strategies for comprehensive metabolome coverage. Anal Chem 83:3730–6
   PubMed Web of Science ®Google Scholar
• Gems D, Doonan R. 2008. The nematode Caenorhabditis elegans: oxidative stress and aging in the nematode Caenorhabditis elegans. In: Miwa S, Beckman KB, Muller FL, eds. Oxidative Stress in Aging: From Model Systems to Human Diseases. Totowa, NJ: Humana Press, 81–108
   Google Scholar
• Gordon AT, Lutz GE, Boninger ML, Cooper RA. 2007. Introduction to nanotechnology: potential applications in physical medicine and rehabilitation. Am J Phys Med Rehabil 86:225–41
   PubMed Web of Science ®Google Scholar
• Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, et al. 2010. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 466:383–7
   PubMed Web of Science ®Google Scholar
• Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev 19:1544–55
   PubMed Web of Science ®Google Scholar
• Hayauchi YA. 2005. Precise colour determination method for tablets – an application of instrumental colour measurement in the pharmaceutical development. Pharmeur Sci Notes 2005:21–6
   PubMedGoogle Scholar
• Hext PM, Tomenson JA, Thompson P. 2005. Titanium dioxide: inhalation toxicology and epidemiology. Ann Occup Hyg 49:461–72
   PubMed Web of Science ®Google Scholar
• Horton HR, Moran LA, Scrimgeour KG, Perry MD, Rawn JD. 2006. Principles of Biochemistry. 4th ed. Upper Saddle river, NJ: Pearson Prentice Hall
   Google Scholar
• Hu ZP, Browne ER, Liu T, Angel TE, Ho PC, Chan EC. 2012. Metabolomic profiling of TASTPM transgenic Alzheimer’s disease mouse model. J Proteome Res 11:5903–13
   PubMed Web of Science ®Google Scholar
• Hughes SL, Bundy JG, Want EJ, Kille P, Stuürzenbaum SR. 2009. The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. J Proteome Res 8:3512–19
   PubMed Web of Science ®Google Scholar
• IARC. 2010. 93. IARC monographs on the evaluation of carcinogenic risks to humans: carbon black, titanium dioxide, and talc. Lyon, France: World Health Organization, International Agency for Research on Cancer. [http://monographs.iarc.fr/ENG/Monographs/vol93/index.php]
   Google Scholar
• Izrayelit Y, Robinette SL, Bose N, von Reuss SH, Schroeder FC. 2013. 2D NMR-based metabolomics uncovers interactions between conserved biochemical pathways in the model organism Caenorhabditis elegans. ACS Chem Biol 8:314–19
   PubMed Web of Science ®Google Scholar
• Jin Y, Jorgensen E, Hartwieg E, Horvitz HR. 1999. The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J Neurosci 19:539–48
   PubMed Web of Science ®Google Scholar
• Jones OA, Swain SC, Svendsen C, Griffin JL, Sturzenbaum SR, Spurgeon DJ. 2012. Potential new method of mixture effects testing using metabolomics and Caenorhabditis elegans. J Proteome Res 11:1446−53
   PubMedGoogle Scholar
• Khare P, Sonane M, Nagar Y, Moin N, Ali S, Gupta KC, et al. 2014. Size dependent toxicity of zinc oxide nanoparticles in soil nematode Caenorhabditis elegans. Nanotoxicology. doi:10.3109/17435390.2014.940403
   Google Scholar
• Khare P, Sonane M, Pandey R, Ali S, Gupta KC, Satish A. 2011. Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans. J Biomed Nanotechnol 7:116–17
   PubMed Web of Science ®Google Scholar
• Kimata T, Tanizawa Y, Can Y, Ikeda S, Kuhara A, Mori I. 2012. Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans. Genetics 191:509–21
   PubMed Web of Science ®Google Scholar
• Koek MM, Jellema RH, Greef JVD, Tas AC, Hankemeier T. 2011. Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics 7:307–28
   PubMed Web of Science ®Google Scholar
• Koek MM, Muilwijk B, Vanderwerf MJ, Hankemeier T. 2006. Microbial metabolomics with gas chromatography/mass spectrometry. Anal Chem 78:1272–81
   PubMed Web of Science ®Google Scholar
• Kuehnbaum NL, Britz-McKibbin P. 2013. New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era. Chem Rev 113:2437–68
   PubMed Web of Science ®Google Scholar
• Lei Z, Huhman D, Sumner LW. 2011. Mass spectrometry strategies in metabolomics. J Biol Chem 286:25435–42
   PubMed Web of Science ®Google Scholar
• Lesa GM, Palfreyman M, Hall DH, Clandinin MT, Rudolph C, Jorgensen EM, Schiavo G. 2003. Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans. J Cell Sci 116:4965–75
   PubMed Web of Science ®Google Scholar
• Leung MC, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M, et al. 2008. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 106:5–28
   PubMed Web of Science ®Google Scholar
• Lindon JC, Nicholson JK, Holmes E, Everett JR. 2006. Metabonomics: metabolic process studied by NMR spectroscopy of biofluids. Concepts Magn Reson 12:289–320
   Google Scholar
• Lokesh BR, Mathur SN, Spector AA. 1981. Effect of fatty acid saturation on NADPH-dependent lipid peroxidation in rat liver microsomes. J Lipid Res 22:905–15
   PubMed Web of Science ®Google Scholar
• Lundstedt T, Seifert E, Abramo L, Thelin B, Nystrom A, Pattersen J, et al. 1998. Experimental design and optimization. Chemometr Intell Lab 42:3–40
   Web of Science ®Google Scholar
• Maurer-Jones MA, Gunsolus IL, Murphy CJ, Haynes CL. 2013. Toxicity of engineered nanoparticles in the environment. Anal Chem 85:3036–49
   PubMed Web of Science ®Google Scholar
• Montiel-Dávalos A, Ventura-Gallegos JL, Alfaro-Moreno E, Soria-Castro E, García-Latorre E, Cabañas-Moreno JG, et al. 2012. TiO2 nanoparticles induce dysfunction and activation of human endothelial cells. Chem Res Toxicol 25:920−30
   PubMedGoogle Scholar
• Mudiam MKR, Ratnasekhar C, Saxena PN. 2013. Gas chromatography mass spectrometry based metabolomic approach for optimization and toxicity evaluation of earthworm sub-lethal responses to carbofuran. PLoS One 8:e81077
   PubMedGoogle Scholar
• Pun PB, Murphy MP. 2012. Pathological significance of mitochondrial glycation. Int J Cell Biol 2012:1–13
   Google Scholar
• Reddy LH, Arias JL, Nicolas J, Couvreur P. 2012. Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev 112:5818−78
   PubMedGoogle Scholar
• Rubingh CM, Bijlsma S, Derks EPPA, Bobeldijk I, Verheij ER, Kochhar S, et al. 2006. Assessing the performance of statistical validation tools for megavariate metabolomics data. Metabolomics 2:53–61
   PubMed Web of Science ®Google Scholar
• Ryan D, Robards K. 2006. Metabolomics: the greatest omics of them all? Anal Chem 78:7954–8
   PubMed Web of Science ®Google Scholar
• Saji VS, Choe HC, Kelvin Yeung WK. 2010. Nanotechnology in biomedical applications: a review. Int J Nano Biomater 3:119–39
   Google Scholar
• Salthammer T, Fuhrmann F. 2007. Photocatalytic surface reactions on indoor wall paint. Environ Sci Technol 41:6573–8
   PubMed Web of Science ®Google Scholar
• Shi H, Magaye R, Castranova V, Zhao J. 2013. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:1–33
   PubMed Web of Science ®Google Scholar
• Taylor NS, Weber RJM, White TA, Viant MR. 2010. Discriminating between different acute chemical toxicities via changes in the daphnid metabolome. Toxicol Sci 118:307–17
   PubMed Web of Science ®Google Scholar
• Tissenbaum HA, Ruvkun G. 1998. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148:703–17
   PubMed Web of Science ®Google Scholar
• Tucci P, Porta G, Aqostini M, Dinsdale D, Lavicoli I, Cain K, et al. 2013. Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes. Cell Death Dis 4:e549
   PubMed Web of Science ®Google Scholar
• USFDA, 2012: Code of Federal Regulations Title 21. Part 73 – Listing of color additives exempt from certification
   Google Scholar
• Varmuza K, Filzmoser P. 2009. Introduction to Multivariate Statistical Analysis in Chemometrics. Boca Raton, FL: CRC Press
   Google Scholar
• Wan R, Mo Y, Feng L, Chien S, Tollerud DJ, Zhang Q. 2012. DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM. Chem Res Toxicol 25:1402–11
   PubMed Web of Science ®Google Scholar
• Watts JL, Browse J. 2002. Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. PNAS 99:5854–9
   PubMed Web of Science ®Google Scholar
• Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, van Velzen EJJ, et al. 2008. Assessment of PLS-DA cross validation. Metabolomics 4:81–9
   Web of Science ®Google Scholar
• Whitfield Aslund ML, McShane H, Simpson MJ, Simpson AJ, Whalen JK, Hendershot WH, et al. 2012. Earthworm sublethal responses to titanium dioxide nanomaterial in soil detected by 1H NMR metabolomics. Environ Sci Technol 46:1111–18
   PubMed Web of Science ®Google Scholar
• Wiesner MR, Lowry GV, Alvarez P, Dionysiou D, Biswas P. 2006. Assessing the risks of manufactured nanomaterials. Environ Sci Technol 40:4336–45
   PubMed Web of Science ®Google Scholar
• Wolkow CA, Kimura KD, Lee MS, Ruvkun G. 2000. Regulation of C. elegans life-span by insulin-like signalling in the nervous system. Science 290:147–50
   PubMed Web of Science ®Google Scholar
• Xia J, Mandal R, Sinelnikov I, Broadhurst D, Wishart DS. 2012. Metaboanalyst 2.0. A comprehensive server for metabolomic data analysis. Nucl Acids Res 40:127–33
   PubMed Web of Science ®Google Scholar
• Xia J, Wishart DS. 2010. MetPa: a web based metabolomics tool for pathway analysis and visualization. Bioinformatics 26:2342–4
   PubMed Web of Science ®Google Scholar
• Xuan J, Pan G, Qiu Y, Yang L, Su M, Chen J, et al. 2011. Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res 10:5433–43
   PubMed Web of Science ®Google Scholar
• Yinxia Li, Wei W, Qiuli Wu, Yiping Li, Meng T, Boping Ye, et al. 2012. Molecular control of TiO2-NPs toxicity formation at predicted environmental relevant concentrations by Mn-SODs proteins. PLoS One 7:e44688
   PubMedGoogle Scholar
• Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, et al. 2003. l-glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Car 6:229–40
   PubMed Web of Science ®Google Scholar