Advances in mechanisms and signaling pathways of carbon nanotube toxicity

References

• Adamson IY, Bakowska J, Bowden DH. 1993. Mesothelial cell proliferation after instillation of long or short asbestos fibers into mouse lung. Am J Pathol 142:1209–16
   PubMed Web of Science ®Google Scholar
• Aiso S, Yamazaki K, Umeda Y, Asakura M, Kasai T, Takaya M, et al. 2010. Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats. Ind Health 48:783–95
   PubMed Web of Science ®Google Scholar
• Alarifi S, Ali D, Verma A, Almajhdi FN, Al-Qahtani AA. 2014. Single-walled carbon nanotubes induce cytotoxicity and DNA damage via reactive oxygen species in human hepatocarcinoma cells. In Vitro Cell Dev Biol Anim 50:714–22
   PubMed Web of Science ®Google Scholar
• Arthur JS, Ley SC. 2013. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13:679–92
   PubMed Web of Science ®Google Scholar
• Azad N, Iyer AK, Wang L, Liu Y, Lu Y, Rojanasakul Y. 2013. Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses. Nanotoxicology 7:157–68
   PubMed Web of Science ®Google Scholar
• Bergsbaken T, Fink SL, Cookson BT. 2009. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 7:99–109
   PubMed Web of Science ®Google Scholar
• Borm PJ, Schins RP, Albrecht C. 2004. Inhaled particles and lung cancer, part B: paradigms and risk assessment. Int J Cancer, 110:3–14
   PubMed Web of Science ®Google Scholar
• Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, et al. 2006. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett 160:121–6
   PubMed Web of Science ®Google Scholar
• Brown DM, Dickson C, Duncan P, Al-Attili F, Stone V. 2010. Interaction between nanoparticles and cytokine proteins: impact on protein and particle functionality. Nanotechnology 21:215104
   PubMed Web of Science ®Google Scholar
• Brown DM, Kinloch IA, Bangert U, Windle AH, Walters DM, Walker GS, et al. 2007. An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammation mediators and frustrated phagocytosis. Carbon 45:1743–56
   Web of Science ®Google Scholar
• Carrero-Sanchez JC, Elias AL, Mancilla R, Arrellin G, Terrones H, Laclette JP, et al. 2006. Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen. Nano Lett 6:1609–16
   PubMed Web of Science ®Google Scholar
• Case BW, Abraham JL, Meeker G, Pooley FD, Pinkerton KE. 2011. Applying definitions of “asbestos” to environmental and “low-dose” exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B Crit Rev 14:3–39
   PubMed Web of Science ®Google Scholar
• Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, et al. 2008. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 105:9035–40
   PubMed Web of Science ®Google Scholar
• Chang CC, Tsai ML, Huang HC, Chen CY, Dai SX. 2012. Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis. Nanotoxicology 6:600–10
   PubMed Web of Science ®Google Scholar
• Chaudhury A, Howe PH. 2009. The tale of transforming growth factor-beta (TGFbeta) signaling: a soigne enigma. IUBMB Life 61:929–39
   PubMed Web of Science ®Google Scholar
• Chen T, Nie H, Gao X, Yang J, Pu J, Chen Z, et al. 2014. Epithelial-mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway. Toxicol Lett 226:150–62
   PubMed Web of Science ®Google Scholar
• Cheng WW, Lin ZQ, Wei BF, Zeng Q, Han B, Wei CX, et al. 2011. Single-walled carbon nanotube induction of rat aortic endothelial cell apoptosis: reactive oxygen species are involved in the mitochondrial pathway. Int J Biochem Cell Biol 43:564–72
   PubMed Web of Science ®Google Scholar
• Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW, et al. 2008. Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett 8:437–45
   PubMed Web of Science ®Google Scholar
• Council NR. 2012. A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials. Washington, DC: The National Academic Press
   Google Scholar
• Davis JM, Addison J, Bolton RE, Donaldson K, Jones AD, Smith T. 1986. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol 67:415–30
   PubMed Web of Science ®Google Scholar
• De Volder MF, Tawfick SH, Baughman RH, Hart AJ. 2013. Carbon nanotubes: present and future commercial applications. Science 339:535–9
   PubMed Web of Science ®Google Scholar
• Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. 1993. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103–11
   PubMed Web of Science ®Google Scholar
• Dickinson BC, Chang CJ. 2011. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat Chem Biol 7:504–11
   PubMed Web of Science ®Google Scholar
• Ding L, Stilwell J, Zhang T, Elboudwarej O, Jiang H, Selegue JP, et al. 2005. Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast. Nano Lett 5:2448–64
   PubMed Web of Science ®Google Scholar
• Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forrest G, et al. 2006. Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92:5–22
   PubMed Web of Science ®Google Scholar
• Donaldson K, Murphy FA, Duffin R, Poland CA. 2010. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 7:5
   PubMed Web of Science ®Google Scholar
• Dong J, Porter DW, Battelli LA, Wolfarth MG, Richardson DL, Ma Q. 2014. Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes. Arch Toxicol [Epub ahead of print]. DOI: 10.1007/s00204-014-1428-y
   Google Scholar
• Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320:674–7
   PubMed Web of Science ®Google Scholar
• Fernandez IE, Eickelberg O. 2012. The impact of TGF-beta on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc 9:111–6
   PubMedGoogle Scholar
• Finkel T. 2005. Radical medicine: treating ageing to cure disease. Nat Rev Mol Cell Biol 6:971–6
   PubMed Web of Science ®Google Scholar
• Finkel T. 2011. Signal transduction by reactive oxygen species. J Cell Biol 194:7–15
   PubMed Web of Science ®Google Scholar
• Gebel T, Foth H, Damm G, Freyberger A, Kramer PJ, Lilienblum W, et al. 2014. Manufactured nanomaterials: categorization and approaches to hazard assessment. Arch Toxicol 88:2191–211
   PubMed Web of Science ®Google Scholar
• Hamilton RF, Jr Xiang C, Li M, Ka I, Yang F, Ma D, et al. 2013. Purification and sidewall functionalization of multiwalled carbon nanotubes and resulting bioactivity in two macrophage models. Inhal Toxicol 25:199–210
   PubMed Web of Science ®Google Scholar
• Han SG, Andrews R, Gairola CG. 2010. Acute pulmonary response of mice to multi-wall carbon nanotubes. Inhal Toxicol 22:340–7
   PubMed Web of Science ®Google Scholar
• Han YG, Xu J, Li ZG, Ren GG, Yang Z. 2012. In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology 33:1128–34
   PubMed Web of Science ®Google Scholar
• Hansen G, Mcintire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, et al. 2000. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest 105:61–70
   PubMed Web of Science ®Google Scholar
• He X, Young SH, Ferback JE, Ma Q. 2012. Single-walled carbon nanotubes induce fibrogenic effect by disturbing mitochondrial oxidative stress and activating NF-κB signaling. J Clin Toxicol S5:005
   Google Scholar
• He X, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q. 2011. Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-kappaB signaling, and promoting fibroblast-to-myofibroblast transformation. Chem Res Toxicol 24:2237–48
   PubMed Web of Science ®Google Scholar
• Hirano S, Fujitani Y, Furuyama A, Kanno S. 2010. Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells. Toxicol Appl Pharmacol 249:8–15
   PubMed Web of Science ®Google Scholar
• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9:847–56
   PubMed Web of Science ®Google Scholar
• Hsieh WY, Chou CC, Ho CC, Yu SL, Chen HY, Chou HY, et al. 2012. Single-walled carbon nanotubes induce airway hyperreactivity and parenchymal injury in mice. Am J Respir Cell Mol Biol 46:257–67
   PubMed Web of Science ®Google Scholar
• Huang X, Zhang F, Sun X, Choi KY, Niu G, Zhang G, et al. 2014. The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials 35:856–65
   PubMed Web of Science ®Google Scholar
• Hussain S, Sangtian S, Anderson SM, Snyder RJ, Marshburn JD, Rice AB, et al. 2014. Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts. Part Fibre Toxicol 11:28
   PubMed Web of Science ®Google Scholar
• Inoue K, Koike E, Yanagisawa R, Hirano S, Nishikawa M, Takano H. 2009. Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 237:306–16
   PubMed Web of Science ®Google Scholar
• Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. 2002. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341–50
   PubMed Web of Science ®Google Scholar
• IWGN. 1999. Nanotechnology Research Directions: IWGN Workshopreport. Vision for Nanotechnology R&D in the Next Decade. Washington, DC: National Science and Technology Council Committee on Technology Interagency Working Group on Nanoscience, Engineering and Technology (IWGN)
   Google Scholar
• Jeffrey KL, Camps M, Rommel C, Mackay CR. 2007. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov 6:391–403
   PubMed Web of Science ®Google Scholar
• Jia G, Wang H, Yan L, Wang X, Pei R, Yan T, et al. 2005. Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39:1378–83
   PubMed Web of Science ®Google Scholar
• Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, et al. 2010. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physico-chemical characteristics. Nanotoxicology 4:207–46
   PubMed Web of Science ®Google Scholar
• Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, et al. 2010. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol 5:354–9
   PubMed Web of Science ®Google Scholar
• Kagan VE, Tyurina YY, Tyurin VA, Konduru NV, Potapovich AI, Osipov AN, et al. 2006. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165:88–100
   PubMed Web of Science ®Google Scholar
• Kalluri R, Neilson EG. 2003. Epithelial–mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776–84
   PubMed Web of Science ®Google Scholar
• Kang JL, Lee K, Castranova V. 2000. Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants. Mol Cell Biochem 215:1–9
   PubMed Web of Science ®Google Scholar
• Kanno S, Hirano S, Chiba S, Takeshita H, Nagai T, Takada M, et al. 2014. The role of Rho-kinases in IL-1beta release through phagocytosis of fibrous particles in human monocytes. Arch Toxicol 89:73–85
   Google Scholar
• Kato T, Totsuka Y, Ishino K, Matsumoto Y, Tada Y, Nakae D, et al. 2013. Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems. Nanotoxicology 7:452–61
   PubMed Web of Science ®Google Scholar
• Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W. 2003. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med 198:1179–88
   PubMed Web of Science ®Google Scholar
• Kool M, Petrilli V, De Smedt T, Rolaz A, Hammad H, Van Nimwegen M, et al. 2008. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 181:3755–9
   PubMed Web of Science ®Google Scholar
• Lacerda L, Ali-Boucetta H, Herrero MA, Pastorin G, Bianco A, Prato M, et al. 2008. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine (London) 3:149–61
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, Mccluskey R, Hunter RL. 2004. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126–34
   PubMed Web of Science ®Google Scholar
• Lamkanfi M, Dixit VM. 2014. Mechanisms and functions of inflammasomes. Cell 157:1013–22
   PubMed Web of Science ®Google Scholar
• Lee JK, Sayers BC, Chun KS, Lao HC, Shipley-Phillips JK, Bonner JC, et al. 2012. Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages. Part Fibre Toxicol 9:14
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhao Y, Sun B, Chen C. 2013. Understanding the toxicity of carbon nanotubes. Acc Chem Res 46:702–13
   PubMed Web of Science ®Google Scholar
• Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, et al. 2008. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 68:6652–60
   PubMed Web of Science ®Google Scholar
• Lohcharoenkal W, Wang L, Stueckle TA, Park J, Tse W, Dinu CZ, et al. 2014. Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells. Front Physiol 5:222
   PubMed Web of Science ®Google Scholar
• Luanpitpong S, Wang L, Stueckle TA, Tse W, Chen YC, Rojanasakul Y. 2014. Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget 5:3541–54
   Google Scholar
• Ma Q. 2010. Transcriptional responses to oxidative stress: pathological and toxicological implications. Pharmacol Ther 125:376–93
   PubMed Web of Science ®Google Scholar
• Ma Q. 2013. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401–26
   PubMed Web of Science ®Google Scholar
• Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. 2006. Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol 3:15
   PubMed Web of Science ®Google Scholar
• Manke A, Luanpitpong S, Dong C, Wang L, He X, Battelli L, et al. 2014. Effect of fiber length on carbon nanotube-induced fibrogenesis. Int J Mol Sci 15:7444–61
   PubMed Web of Science ®Google Scholar
• Manna SK, Sarkar S, Barr J, Wise K, Barrera EV, Jejelowo O, et al. 2005. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes. Nano Lett 5:1676–84
   PubMed Web of Science ®Google Scholar
• Maynard AD, Kuempel ED. 2005. Airborne nanostructured particles and occupational health. J Nanopart Res 7:587–614
   Web of Science ®Google Scholar
• Maynard AD, Warheit DB, Philbert MA. 2011. The new toxicology of sophisticated materials: nanotoxicology and beyond. Toxicol Sci 120:S109–29
   Web of Science ®Google Scholar
• Mercer RR, Hubbs AF, Scabilloni JF, Wang L, Battelli LA, Friend S, et al. 2011. Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Part Fibre Toxicol 8:21
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni J, Wang L, Kisin E, Murray AR, Schwegler-Berry D, et al. 2008. Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physiol 294:L87–97
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni JF, Hubbs AF, Battelli LA, Mckinney W, Friend S, et al. 2013a. Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 10:33
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni JF, Hubbs AF, Wang L, Battelli LA, Mckinney W, et al. 2013b. Extrapulmonary transport of MWCNT following inhalation exposure. Part Fibre Toxicol 10:38
   PubMed Web of Science ®Google Scholar
• Meunier E, Coste A, Olagnier D, Authier H, Lefevre L, Dardenne C, et al. 2012. Double-walled carbon nanotubes trigger IL-1beta release in human monocytes through Nlrp3 inflammasome activation. Nanomedicine 8:987–95
   PubMed Web of Science ®Google Scholar
• Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, Mcdonald JD. 2007. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci 100:203–14
   PubMed Web of Science ®Google Scholar
• Mitchell LA, Lauer FT, Burchiel SW, Mcdonald JD. 2009. Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice. Nat Nanotechnol 4:451–6
   PubMed Web of Science ®Google Scholar
• Morgan W.K.C., Gee J.B.L. 1995. Asbestos-related diseases. In: Morgan W.K.C., Seaton A, eds. Occupational Lung Diseases, 3rd ed. Philadelphia: W.B. Saunders Company
   Google Scholar
• Muller J, Decordier I, Hoet PH, Lombaert N, Thomassen L, Huaux F, et al. 2008. Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 29:427–33
   PubMed Web of Science ®Google Scholar
• Muller J, Delos M, Panin N, Rabolli V, Huaux F, Lison D. 2009. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci 110:442–8
   PubMed Web of Science ®Google Scholar
• Muller J, Huaux F, Moreau N, Misson P, Heilier JF, Delos M, et al. 2005. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 207:221–31
   PubMed Web of Science ®Google Scholar
• Munshi A, Ramesh R. 2013. Mitogen-activated protein kinases and their role in radiation response. Genes Cancer 4:401–8
   PubMedGoogle Scholar
• Murphy FA, Poland CA, Duffin R, Al-Jamal KT, Ali-Boucetta H, Nunes A, et al. 2011. Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. Am J Pathol 178:2587–600
   PubMed Web of Science ®Google Scholar
• Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, et al. 2009. Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. Toxicology 257:161–71
   PubMed Web of Science ®Google Scholar
• Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, et al. 2011. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci USA 108:E1330–8
   PubMed Web of Science ®Google Scholar
• Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, et al. 2000. Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 192:151–8
   PubMed Web of Science ®Google Scholar
• Nerl HC, Cheng C, Goode AE, Bergin SD, Lich B, Gass M, et al. 2011. Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo. Nanomedicine (London) 6:849–65
   Google Scholar
• NIOSH. 2013a. Current Intelligence Bulletin 65: occupational exposure to carbon naotubes and nanofibers
   Google Scholar
• NIOSH. 2013b. Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes. Cincinnati: Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health
   Google Scholar
• NSF. 2011. Nanotechnology research directions for societal needs in 2020: retrospective and outlook summary. National Science Foundation. In: Roco M, Mirkin C, Hersan M, eds. Science Policy Reports. New York: Springer
   Google Scholar
• Pacher P, Beckman JS, Liaudet L. 2007. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87:315–424
   PubMed Web of Science ®Google Scholar
• Pacurari M, Yin XJ, Zhao J, Ding M, Leonard SS, Schwegler-Berry D, et al. 2008. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells. Environ Health Perspect 116:1211–17
   PubMed Web of Science ®Google Scholar
• Palomaki J, Valimaki E, Sund J, Vippola M, Clausen PA, Jensen KA, et al. 2011. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5:6861–70
   PubMed Web of Science ®Google Scholar
• Park EJ, Cho WS, Jeong J, Yi J, Choi K, Park K. 2009. Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology 259:113–21
   PubMed Web of Science ®Google Scholar
• Park EJ, Roh J, Kim SN, Kang MS, Han YA, Kim Y, et al. 2011. A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice. Arch Toxicol 85:1121–31
   PubMed Web of Science ®Google Scholar
• Park EJ, Zahari NE, Lee EW, Song J, Lee JH, Cho MH, et al. 2014. SWCNTs induced autophagic cell death in human bronchial epithelial cells. Toxicol In Vitro 28:442–50
   PubMed Web of Science ®Google Scholar
• Patlolla AK, Hussain SM, Schlager JJ, Patlolla S, Tchounwou PB. 2010. Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss–Webster mice. Environ Toxicol 25:608–21
   PubMed Web of Science ®Google Scholar
• Peeters PM, Perkins TN, Wouters EF, Mossman BT, Reynaert NL. 2013. Silica induces NLRP3 inflammasome activation in human lung epithelial cells. Part Fibre Toxicol 10:3
   PubMed Web of Science ®Google Scholar
• Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. 2008. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423–8
   PubMed Web of Science ®Google Scholar
• Porter DW, Hubbs AF, Chen BT, Mckinney W, Mercer RR, Wolfarth MG, et al. 2013. Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes. Nanotoxicology 7:1179–94
   PubMed Web of Science ®Google Scholar
• Porter DW, Hubbs AF, Mercer RR, Wu N, Wolfarth MG, Sriram K, et al. 2010. Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136–47
   PubMed Web of Science ®Google Scholar
• Pulskamp K, Diabate S, Krug HF. 2007. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
   PubMed Web of Science ®Google Scholar
• Ravichandran P, Baluchamy S, Sadanandan B, Gopikrishnan R, Biradar S, Ramesh V, et al. 2010. Multiwalled carbon nanotubes activate NF-kappaB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells. Apoptosis 15:1507–16
   PubMed Web of Science ®Google Scholar
• Reddy AR, Reddy YN, Krishna DR, Himabindu V. 2012. Pulmonary toxicity assessment of multiwalled carbon nanotubes in rats following intratracheal instillation. Environ Toxicol 27:211–19
   PubMed Web of Science ®Google Scholar
• Rose BA, Force T, Wang Y. 2010. Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev 90:1507–46
   PubMed Web of Science ®Google Scholar
• Rothen-Rutishauser B, Brown DM, Piallier-Boyles M, Kinloch IA, Windle AH, Gehr P, et al. 2010. Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo. Nanotoxicology 4:331–42
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, et al. 2009a. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol 4:747–51
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC. 2009b. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. Am J Respir Cell Mol Biol 40:349–58
   PubMed Web of Science ®Google Scholar
• Sager TM, Wolfarth MW, Andrew M, Hubbs A, Friend S, Chen TH, et al. 2014. Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model. Nanotoxicology 8:317–27
   PubMed Web of Science ®Google Scholar
• Sakamoto Y, Nakae D, Fukumori N, Tayama K, Maekawa A, Imai K, et al. 2009. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 34:65–76
   PubMed Web of Science ®Google Scholar
• Sargent LM, Hubbs AF, Young SH, Kashon ML, Dinu CZ, Salisbury JL, et al. 2012. Single-walled carbon nanotube-induced mitotic disruption. Mutat Res 745:28–37
   PubMed Web of Science ®Google Scholar
• Sargent LM, Porter DW, Staska LM, Hubbs AF, Lowry DT, Battelli L, et al. 2014. Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 11:3
   PubMed Web of Science ®Google Scholar
• Sargent LM, Reynolds SH, Castranova V. 2010. Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects. Nanotoxicology 4:396–408
   PubMed Web of Science ®Google Scholar
• Sayers BC, Taylor AJ, Glista-Baker EE, Shipley-Phillips JK, Dackor RT, Edin ML, et al. 2013. Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. Am J Respir Cell Mol Biol 49:525–35
   Google Scholar
• Schins RP, Knaapen AM. 2007. Genotoxicity of poorly soluble particles. Inhal Toxicol 19:189–98
   PubMed Web of Science ®Google Scholar
• Schmierer B, Hill CS. 2007. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8:970–82
   PubMed Web of Science ®Google Scholar
• Schroder K, Tschopp J. 2010. The inflammasomes. Cell 140:821–32
   PubMed Web of Science ®Google Scholar
• Seaton A, Tran L, Aitken R, Donaldson K. 2010. Nanoparticles, human health hazard and regulation. J R Soc Interface 7:S119–29
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, et al. 2012a. Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One 7:e30923
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, et al. 2008a. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 295:L552–65
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, et al. 2005. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–708
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, et al. 2007. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicol Appl Pharmacol 221:339–48
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, et al. 2008b. Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes. Toxicol Appl Pharmacol 231:235–40
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Pietroiusti A, Fadeel B, Kagan VE. 2012b. Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicol Appl Pharmacol 261:121–33
   PubMed Web of Science ®Google Scholar
• Siegrist KJ, Reynolds SH, Kashon ML, Lowry DT, Dong C, Hubbs AF, et al. 2014. Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses. Part Fibre Toxicol 11:6
   PubMed Web of Science ®Google Scholar
• Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. 1997. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100:768–76
   PubMed Web of Science ®Google Scholar
• Snyder-Talkington BN, Schwegler-Berry D, Castranova V, Qian Y, Guo NL. 2013. Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells. Part Fibre Toxicol 10:35
   PubMed Web of Science ®Google Scholar
• Stanton MF. 1973. Some etiological considerations of fibre carcinogenesis. In: Bogovski P, Gilson JC, Timbrell V, Wagner JC, eds. Biological Effects of Asbestos. Lyon, France: WHO IARC
   Google Scholar
• Stone V, Donaldson K. 2006. Nanotoxicology: signs of stress. Nat Nanotechnol 1:23–4
   PubMed Web of Science ®Google Scholar
• Subramanian V, Youtie J, Porter AL, Shapira P. 2010. Is there a shift to “active nanostructures"? J Nanopart Res 12:1–10
   PubMed Web of Science ®Google Scholar
• Sutterwala FS, Haasken S, Cassel SL. 2014. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci 1319:82–95
   PubMed Web of Science ®Google Scholar
• Takagi A, Hirose A, Futakuchi M, Tsuda H, Kanno J. 2012. Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice. Cancer Sci 103:1440–4
   PubMed Web of Science ®Google Scholar
• Takagi A, Hirose A, Nishimura T, Fukumori N, Ogata A, Ohashi N, et al. 2008. Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33:105–16
   PubMed Web of Science ®Google Scholar
• Taylor AJ, Mcclure CD, Shipkowski KA, Thompson EA, Hussain S, Garantziotis S, et al. 2014. Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo. PLoS One 9:e106870
   Google Scholar
• Thurnherr T, Brandenberger C, Fischer K, Diener L, Manser P, Maeder-Althaus X, et al. 2011. A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro. Toxicol Lett 200:176–86
   PubMed Web of Science ®Google Scholar
• Tschopp J, Schroder K. 2010. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10:210–15
   PubMed Web of Science ®Google Scholar
• Ursini CL, Cavallo D, Fresegna AM, Ciervo A, Maiello R, Buresti G, et al. 2014. Differences in cytotoxic, genotoxic, and inflammatory response of bronchial and alveolar human lung epithelial cells to pristine and COOH-functionalized multiwalled carbon nanotubes. Biomed Res Int 2014:359506
   PubMed Web of Science ®Google Scholar
• Van Berlo D, Clift MJ, Albrecht C, Schins RP. 2012. Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity. Swiss Med Wkly 142:w13698
   PubMed Web of Science ®Google Scholar
• Vietti G, Ibouraadaten S, Palmai-Pallag M, Yakoub Y, Bailly C, Fenoglio I, et al. 2013. Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay. Part Fibre Toxicol 10:52
   PubMed Web of Science ®Google Scholar
• Wagner EF, Nebreda AR. 2009. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9:537–49
   PubMed Web of Science ®Google Scholar
• Wang J, Sun P, Bao Y, Liu J, An L. 2011a. Cytotoxicity of single-walled carbon nanotubes on PC12 cells. Toxicol In Vitro 25:242–50
   PubMed Web of Science ®Google Scholar
• Wang L, Luanpitpong S, Castranova V, Tse W, Lu Y, Pongrakhananon V, et al. 2011b. Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. Nano Lett 11:2796–803
   PubMed Web of Science ®Google Scholar
• Wang L, Mercer RR, Rojanasakul Y, Qiu A, Lu Y, Scabilloni JF, et al. 2010a. Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts. J Toxicol Environ Health A 73:410–22
   PubMed Web of Science ®Google Scholar
• Wang P, Nie X, Wang Y, Li Y, Ge C, Zhang L, et al. 2013. Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-beta/Smad signaling pathway. Small 9:3799–811
   PubMed Web of Science ®Google Scholar
• Wang X, Xia T, Ntim SA, Ji Z, George S, Meng H, et al. 2010b. Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells. ACS Nano 4:7241–52
   PubMed Web of Science ®Google Scholar
• Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GA, Webb TR. 2004. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77:117–25
   PubMed Web of Science ®Google Scholar
• Wick P, Manser P, Limbach LK, Dettlaff-Weglikowska U, Krumeich F, Roth S, et al. 2007. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 168:121–31
   PubMed Web of Science ®Google Scholar
• Winter M, Beer HD, Hornung V, Kramer U, Schins RP, Forster I. 2011. Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells. Nanotoxicology 5:326–40
   PubMed Web of Science ®Google Scholar
• Wu L, Zhang Y, Zhang C, Cui X, Zhai S, Liu Y, et al. 2014. Tuning cell autophagy by diversifying carbon nanotube surface chemistry. ACS Nano 8:2087–99
   Google Scholar
• Wu W, Li R, Bian X, Zhu Z, Ding D, Li X, et al. 2009. Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS Nano 3:2740–50
   PubMed Web of Science ®Google Scholar
• Wynn TA. 2011. Integrating mechanisms of pulmonary fibrosis. J Exp Med 208:1339–50
   PubMed Web of Science ®Google Scholar
• Xu J, Futakuchi M, Shimizu H, Alexander DB, Yanagihara K, Fukamachi K, et al. 2012. Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats. Cancer Sci 103:2045–50
   PubMed Web of Science ®Google Scholar
• Yamaguchi A, Fujitani T, Ohyama K, Nakae D, Hirose A, Nishimura T, et al. 2012. Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice. J Toxicol Sci 37:177–89
   PubMed Web of Science ®Google Scholar
• Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, et al. 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta. Proc Natl Acad Sci USA 107:19449–54
   PubMed Web of Science ®Google Scholar
• Ye S, Jiang Y, Zhang H, Wang Y, Wu Y, Hou Z, et al. 2012. Multi-walled carbon nanotubes induce apoptosis in RAW 264.7 cell-derived osteoclasts through mitochondria-mediated death pathway. J Nanosci Nanotechnol 12:2101–12
   PubMed Web of Science ®Google Scholar
• Ye SF, Wu YH, Hou ZQ, Zhang QQ. 2009. ROS and NF-kappaB are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes. Biochem Biophys Res Commun 379:643–8
   PubMed Web of Science ®Google Scholar
• Zhang Q, Huang JQ, Qian WZ, Zhang YY, Wei F. 2013. The road for nanomaterials industry: a review of carbon nanotube production, post-treatment, and bulk applications for composites and energy storage. Small 9:1237–65
   PubMed Web of Science ®Google Scholar
• Zhang YE. 2009. Non-Smad pathways in TGF-beta signaling. Cell Res 19:128–39
   PubMed Web of Science ®Google Scholar
• Zhao X, Liu R. 2012. Recent progress and perspectives on the toxicity of carbon nanotubes at organism, organ, cell, and biomacromolecule levels. Environ Int 40:244–55
   PubMed Web of Science ®Google Scholar
• Zhiqing L, Zhuge X, Fuhuan C, Danfeng Y, Huashan Z, Bencheng L, et al. 2010. ICAM-1 and VCAM-1 expression in rat aortic endothelial cells after single-walled carbon nanotube exposure. J Nanosci Nanotechnol 10:8562–74
   PubMed Web of Science ®Google Scholar