323
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549

, , , , &
Pages 186-195 | Received 26 Jul 2009, Accepted 21 Dec 2009, Published online: 29 Jan 2010

References

  • Arora S, Jain J, Rajwade JM, Paknikar KM. 2008. Cellular responses induced by silver nanoparticles: In vitro studies. Toxicol Lett 179:93–100.
  • AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S. 2009. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279–290.
  • Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann A, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. 2009. Nanoparticles can cause DNA damage across a cellular barrier. Nature Nanotechnol 4:876–883.
  • Chen S, Pelletier D, Ao P, Boynton A. 1995. Connexin43 reverse the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinase. Cell Growth Differentiation 6:681–690.
  • Chen X, Schluesener HJ. 2008. Ag NPs: A nanoproduct in medical application. Toxicol Lett 176:1–12.
  • Cheng D, Yang J, Zhao Y. 2004. Antibacterial materials of silver nanoparticles application in medical appliances and appliances for daily use. Chin Med Equip 4:26–32.
  • Chipman J, Mally A, Edwards G. 2003. Disruption of gap junctions in toxicity and carcinogenicity. Toxicol Sci 71:146–153.
  • Cronier L, Crespin S, Strale PO, Defamie N, Mesnil M. 2009. Gap junctions and cancer: New functions for an old story. Antioxid Redox Sign 11:323–338.
  • Deng FR, Guo XB, Liu H, Fang X, Yang MJ, Chen W. 2007. Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts. Toxicol in vitro 21:632–638.
  • Foldbjerg R, Olesen P, Hougaard M, Anh Dang D, Jurgen Hoffmann H, Autrup H. 2009. PVP coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol Lett 190:156–162.
  • Harada K, Nonaka T, Hamada N, Sakurai H, Hasegawa M, Funayama T, Kakizaki T, Kobayashi Y, Nakano T. 2009. Heavy-ion-induced bystander killing of human lung cancer cells: Role of gap junctional intercellular communication. Cancer Sci 100(4):684–688.
  • Heid CA, Steven, J, Livak KJ, Williams PM. 1996. Genome methods: Real time quantitative PCR. Genome Res 6:986–994.
  • Hossain MZ, Wilkens LR, Mehta PP, Loewenstein W, Bertram JS. 1989. Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation. Carcinogenesis 10:1743–1748.
  • Jia G, Wang HF, Yan L, Wang X, Pei RJ, Yan T, Zhao YL, Guo XB. 2005. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39(5):1378–1383.
  • Kamibayashi Y, Oyamada Y, Mori M, Oyamada M. 1995. Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. Carcinogenesis 16:1287–1297.
  • Kim JH, Kang NJ, Lee BK, Lee KW, Lee HJ. 2008. Gallic acid, a metabolite of the antioxidant propyl gallate, inhibits gap junctional intercellular communication via phosphorylation of connexin43 and extracellular-signal-regulated kinase1/2 in rat liver epithelial cells. Mutat Res 638:175–183.
  • Koffler L, Roshong S, Park IK, Cesen-Cummings K, Thompson DC, Dwyer-Nield LD, Rice P, Mamay C, Malkinson AM, Ruch RJ. 2000. Growth inhibition in G1 and altered expression of Cyclin D1 and p27kip-1 after forced connexin expression in lung and liver carcinoma cells. J Cell Biochem 79:347–354.
  • Kuroki T, Inoguchi T, Umeda F, Ueda F, Nawata H. 1998. High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells. Diabetes 47:931–936.
  • Laird DW. 2005. Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochem Biophy Acta 1711:172–182.
  • Lau AF, Kanemitsu MY, Kurata WE. 1992. Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. Mol Biol Cell 3:865–874.
  • Leithe E, Crucian, V, Sanner T, Mikalsen SO. Rivedal E. 2003. Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C. Carcinogenesis 24:1239–1245.
  • Li HY, Li Y, Yan CH, Li LN, Chen XG. 2002. Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. J Asian Nat Prod Res 4(4):271–280.
  • Opsahl H, Rivedal E. 2000. Quantitative determination of gap junction intercellular communication by scrape loading and image analysis. Cell Adhes Commun 7:367–375.
  • Qi K, Deng F, Guo X. 2009. Effects of nanoscale titanium dioxide on gap junctional intercellular communication in human lung fibroblasts. J Peking University (Health Sci) 41:297–301 [in Chinese].
  • Quist AP, Rhee SK, Lin H, Lal R. 2000. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 148:1063–1074.
  • Rivedal E, Opsahl H. 2001. Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells. Carcinogesis 22:1543–1550.
  • Rivedal E, Leithe E. 2005. Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells. Exp Cell Res 302:143–152.
  • Shao Q, Wang H, McLachlan E, Veitch G, Laird D. 2005. Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res 65:2705–2711.
  • Sigler K, Ruch RJ. 1993. Enhancement of gap junctional intercellular communication in tumor promoter-treated cells by components of green tea. Cancer Lett 69:15–19.
  • Sirnes S, Kjenseth A, Leithe E, Rivedal E. 2009. Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication. Biochem Biophys Res Commun 382:41–45.
  • Stratmeyer ME, Goering PL, Hitchins VM, Umbreit TH. 2008. What we know and don't know about the bioeffects of nanoparticles: Developing experimental approaches for safety assessment. Biomed Microdevices 9261–9269.
  • Trosko JE. 2003. The role of stem cells and gap junctional intercellular communication in carcinogenesis. J Biochem Mol Biol 36:43–48.
  • Vigneshwaran N, Kathe AA, Varadarajan PV, Nachane RP, Balasubramanya RHJ. 2007. Functional finishing of cotton fabrics using silver nanoparticles. Nanosci Nanotechnol 7:1893–1897.
  • Yeh SL, Hu ML. 2003. Oxidized β-carotene inhibits gap junction intercellular communication in the human lung adenocarcinoma cell line A549. Food Chem Toxicol 41:1677–1684.
  • Zhang LX, Cooney RV, Bertram JS. 1991. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action. Carcinogenesis 12:2109–2114.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.