In vivo effect of industrial titanium dioxide nanoparticles experimentally exposed to hairless rat skin

References

• Abe T, Mayuzumi J. 1979. The change and recovery of human skin barrier functions after ultraviolet light irradiation. Chem Pharm Bull 27:458–462.
   PubMedGoogle Scholar
• Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. 2004. Skin penetration and distribution of polymeric nanoparticles. J Control Release 99:53–62.
   PubMed Web of Science ®Google Scholar
• Bennat C, Muller-Goymann CC. 2000. Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter. Int J Cosmet Sci 22:271–283.
   PubMedGoogle Scholar
• Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. 2003. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 42:1–36.
   PubMed Web of Science ®Google Scholar
• Bronaugh RL, Stewart RF, Congdon ER. 1982. Methods for in vitro percutaneous absorption studies II. Animal models for human skin. Toxicol Appl Pharmacol 62:481–488.
   PubMed Web of Science ®Google Scholar
• Buzea C, Pacheco II, Robbie K. 2007. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases 2:MR17–71.
   PubMed Web of Science ®Google Scholar
• Catz P, Friend DR. 1990. Transdermal delivery of levonorgestrel VIII. Effects of enhancers on rat skin, hairless mouse skin, hairless guinea pig and human skin. Int J Pharm 58:93–102.
   Web of Science ®Google Scholar
• Dussert AS, Gooris E, Hemmerle J. 1997. Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum. Int J Cosmet Sci 19:119–129.
   PubMedGoogle Scholar
• Egawa M, Iwaki H. 2008. In vivo evaluation of the protective capacity of sunscreen by monitoring urocanic acid isomer in the stratum corneum using Raman spectroscopy. Skin Res Technol 14:410–417.
   PubMed Web of Science ®Google Scholar
• Gamer AO, Leibold E, van Ravenzwaay B. 2006. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol In Vitro 20:301–307.
   PubMed Web of Science ®Google Scholar
• Gilliam AC, Kremer IB, Yoshida Y, Stevens SR, Tootell E, Teunissen MB, Hammerberg C, Cooper KD. 1998. The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure. J Invest Dermatol. 110:422–427.
   PubMed Web of Science ®Google Scholar
• Gontier E, Ynsa MD, Bíró T, Hunyadi J, Kiss B, Gáspár K, Pinheiro T, Silva JN, Filipe P, Stachura J, Dabros W, Reinert T, Butz T, Moretto P, Surlève-Bazeille JE. 2008. Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicology 2:218–231.
   Web of Science ®Google Scholar
• International Organization for Standardization (ISO). 2008. ISO/TS 27687. Nanotechnologies – terminology and definitions for nanoobjects – nanoparticle, nanofibre and nanoplate.
   Google Scholar
• Kertész Z, Szikszai Z, Gontier E, Moretto P, Surlève-Bazeille JE, Kiss B, Juhász I, Hunyadi J, Kiss áZ. 2005. Nuclear microprobe study of TiO2-penetration in the epidermis of human skin xenografts. Interact Mater Atoms 231:280–285.
   Google Scholar
• Lademann J, Weigmann H, Rickmeyer C, Barthelmes H, Schaefer H, Mueller G, Sterry W. 1999. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol 12:247–256.
   PubMedGoogle Scholar
• Lansdown AB, Taylor A. 1997. Zinc and titanium oxides: Promising UV-absorbers but what influence do they have on the intact skin? Int J Cosmet Sci 19:167–172.
   PubMedGoogle Scholar
• Magnusson BM, Walters KA, Roberts MS. 2001. Veterinary drug delivery: Potential for skin penetration enhancement. Adv Drug Deliv Rev 50:205–227.
   PubMed Web of Science ®Google Scholar
• Mavon A, Miquel C, Lejeune O, Payre B, Moretto P. 2007. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol Physiol 20:10–20.
   PubMed Web of Science ®Google Scholar
• Menzel F, Reinert T, Vogt J, Butz T. 2004. Investigations of percutaneous uptake of ultrafine TiO2 particles at the high energy ion nanoprobe Lipsion. Interact Mater Atoms 219:82–86.
   Google Scholar
• Mortensen LJ, Oberdörster G, Pentland AP, DeLouise LA. 2008. In vivo skin penetration of quantum dot dot nanoparticles in the murine model: The effect of UVR. Nano Lett 8:2779–2787.
   PubMed Web of Science ®Google Scholar
• Newman MD, Stotland M, Ellis JI. 2009. The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol 61(4):685–692.
   PubMed Web of Science ®Google Scholar
• Nohynek GJ, Dufour EK, Roberts MS. 2008. Nanotechnology, cosmetics and the skin: Is there a health risk? Skin Pharmacol Physiol 21:136–149.
   PubMed Web of Science ®Google Scholar
• Nohynek GJ, Lademann J, Ribaud C, Roberts MS. 2007. Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit Rev Toxicol 37:251–277.
   PubMed Web of Science ®Google Scholar
• Pflücker F, Wendel V, Hohenberg H, Gärtner E, Will T, Pfeiffer S, Wepf R, Gers-Barlag H. 2001. The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacol Appl Skin Physiol 14(Suppl. 1):92–97.
   PubMedGoogle Scholar
• Schulz J, Hohenberg H, Pflücker F, Gärtner E, Will T, Pfeiffer S, Wepf R, Wendel V, Gers-Barlag H, Wittern KP. 2002. Distribution of sunscreens on skin. Adv Drug Deliv Rev 54(Suppl. 1):S157–163.
   Google Scholar
• Suschek CV, Opländer C, van Faassen EE. 2010. Non-enzymatic NO production in human skin: Effect of UVA on cutaneous NO stores. Nitric Oxide 22:120–135.
   Google Scholar
• Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL. 2006. Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92:174–185.
   PubMed Web of Science ®Google Scholar
• Tan MH, Commens CA, Burnett L, Snitch PJ. 1996. A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens. Australas J Dermatol 37:185–187.
   PubMedGoogle Scholar
• Tsuji JS, Maynard AD, Howard PC, James JT, Lam CW, Warheit DB, Santamaria AB. 2006. Research strategies for safety evaluation of nanomaterials. Part IV: Risk assessment of nanoparticles. Toxicol Sci 89:42–50.
   PubMed Web of Science ®Google Scholar
• van der Molen RG, Spies F, van't Noordende JM, Boelsma E, Mommaas AM, Koerten HK. 1997. Tape stripping of human stratum corneum yields cell layers that originate from various depths because of furrows in the skin. Arch Dermatol Res 289:514–518.
   PubMed Web of Science ®Google Scholar
• Wester RC, Noonnan PK. 1980. Relevance of animal models for percutaneous absorption. Int J Pharm 7:99–110.
   Web of Science ®Google Scholar
• Wu J, Liu W, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng FD. 2009. Toxicity and penetration of TiO(2) nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191:1–8.
   PubMed Web of Science ®Google Scholar