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Review

Does exercise reduce the burden of fractures?

A review

Pages 691-705 | Received 25 Sep 2001, Accepted 25 Apr 2002, Published online: 22 Feb 2011

  • Bailey D A, McCulloch R G. Bone tissue and physical activity. Can J Sport Sci 1990; 15: 229–39
  • Bailey D A, McKay H A, Mirwald R L, Crocker P R, Faulkner R A. A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study. J Bone Miner Res 1999; 14: 1672–9
  • Bass S, Pearce G, Bradney M, Hendrich E, Delmas P D, Harding A, Seeman E. Exercise before puberty may confer residual benefits in bone density in adulthood: studies in active prepubertal and retired female gymnasts. J Bone Miner Res 1998; 13: 500–7
  • Bassey E J, Ramsdale S J. Weight-bearing exercise and ground reaction forces: a 12-month randomized controlled trial of effects on bone mineral density in healthy postmenopausal women. Bone 1995; 16: 469–76
  • Berard A, Bravo G, Gauthier P. Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women. Osteoporos Int 1997; 7: 331–7
  • Blimkie C J, Rice S, Webber C E, Martin J, Levy D, Gordon C. L. Effects of resistance training on bone mineral content and density in adolescent females. Can J Physiol Pharmacol 1996; 74: 1025–33
  • Bouxsein M L, Marcus R. Overview of exercise and bone mass. Rheum Dis Clin North Am 1994; 20: 787–802
  • Bradney M, Pearce G, Naughton G, Sullivan C, Bass S, Beck T, Carlson J, Seeman E. Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective study. J Bone Miner Res 1998; 13: 1814–21
  • Brahm H, Mallmin H, Michaelsson K, Strom H, Ljunghall S. Relationships between bone mass measurements and lifetime physical activity in a Swedish population. Calcif Tissue Int 1998; 62: 400–12
  • Bravo G, Gauthier P, Roy P M, Payette H, Gaulin P, Harvey M, Peloquin L, Dubois M F. Impact of a 12-month exercise program on the physical and psychological health of osteopenic women. J Am Geriatr Soc 1996; 44: 756–62
  • Buchner D M, Cress M E, de Lateur B J, Esselman P C, Mar-Gherita A, Price J. R, Wagner E H. The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol A Biol Sci Med Sci 1997; 52: M218–24
  • Campbell A, Borrie J. M J, Spears G F. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989; 44: M112–7
  • Campbell A J, Robertson M C, Gardner M M, Norton R N, Tilyard M W, Buchner D M. Randomised controlled trial of a general practice programme of home-based exercise to prevent falls in elderly women. BMJ 1997; 315: 1065–9
  • Campbell A, Robertson J. M C, Gardner M M, Norton R N, Buchner D M. Falls prevention over 2 years: a randomized controlled trial in women 80 years and older. Age Ageing 1999a; 28: 513–8
  • Campbell A J, Robertson M C, Gardner M M, Norton R N, Buchner D M. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 1999b; 47: 850–3
  • Center J R, Nguyen T V, Schneider D, Sambrook P N, Eisman J A. Mortality after all major types of osteopo-rotic fracture in men and women: an observational study. Lancet 1999; 353: 878–82
  • Chan H H, Lau E M, Woo J., Lin F., Sham A, Leung P C. Dietary calcium intake, physical activity and the risk of vertebral fracture in Chinese. Osteoporos Int 1996; 6: 228–32
  • Cooper C, Barker D, Wickham J. C. Physical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain. BMJ 1988; 297: 1443–6
  • Cooper C., Campion G, Melton L J D. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992; 2: 285–9
  • Cooper C, Atkinson E J, Jacobsen S J, O'Fallon W M, Melton L J D. Population-based study of survival after osteoporotic fractures. Am J Epidemiol 1993; 137: 1001–5
  • Cooper C, Cawley M, Bhalla A, Egger P, Ring F., Morton L, Barker D. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res 1995; 10: 940–7
  • Coupland C, Wood D, Cooper C. Physical inactivity is an independent risk factor for hip fracture in the elderly. J Epidemiol Community Health 1993; 47: 441–3
  • Cummings S, Nevitt R. M C, Browner W S, Stone K, Fox K, Ensrud M. K E, Cauley J, Black D, Vogt T M. Risk factors for hip fracture in white women. Study of Osteo-porotic Fractures Research Group. N Engl J Med 1995; 332: 767–73
  • Daly R M, Rich P, Klein A. R, Bass S L. Short stature in competitive prepubertal and early pubertal male gymnasts: the result of selection bias or intense training? (In Process Citation). J Pediatr 2000; 137: 510–6
  • Drinkwater B L. Exercise in the prevention of osteoporosis. Osteoporos Int 1993; 3: 169–71
  • Duppe H, Gardsell P, Johnell O, Ornstein E. Bone mineral density in female junior, senior and former football players. Osteoporos Int 1996; 6: 437–41
  • Dyson K, Blimkie C J, Davison K S, Webber C E, Adachi J D. Gymnastic training and bone density in pre-adolescent females. Med Sci Sports Exerc 1997; 29: 443–50
  • Ebrahim S, Thompson P W, Baskaran V, Evans K. Randomized placebo-controlled trial of brisk walking in the prevention of postmenopausal osteoporosis. Age Ageing 1997; 26: 253–60
  • Farmer M E, Harris T, Madans J H, Wallace R B, Cornoni-Huntley J, White L R. Anthropometric indicators and hip fracture. The NHANES I epidemiologic follow-up study. J Am Geriatr Soc 1989; 37: 9–16
  • Fiataronc M A, Marks E C, Ryan N D, Meredith C N, Lip-Sitz L A, Evans W J. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 1990; 263: 3029–34
  • Fiatarone M A, O'Neill E F, Ryan N D, Clements K M, Solares G R, Nelson M E, Roberts S B, Kehayias J J, Lipsitz L A, Evans W J. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769–75
  • Forwood M R, Burr D B. Physical activity and bone mass: exercises in futility?. Bone Miner 1993; 21: 89–112
  • Friedlander A L, Genant H K, Sadowsky S, Byl N N, Gluer C C. A two-year program of aerobics and weight training enhances bone mineral density of young women. J Bone Miner Res 1995; 10: 574–85
  • Fuchs R K, Bauer J J, Snow C. M. Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res 2001; 16: 148–56
  • Gillespie L D, Gillespie W J, Gumming R, Lamb S E, Rowe B H. Interventions for preventing falls in the elderly. Cochrane Database Syst Rev 2000; CD000340
  • Gleeson P B, Protas E J, LeBlanc A D, Schneider V S, Evans H J. Effects of weight lifting on bone mineral density in premenopausal women. J Bone Miner Res 1990; 5: 153–8
  • Graafmans W C, Ooms M E, Hofstee H M, Bezemer P D, Bouter L M, Lips P. Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 1996; 143: 1129–36
  • Grecndale G A, Barrett-Connor E, Edelstein S, Ingles S, Haile R. Lifetime leisure exercise and osteoporosis. The Rancho Bernardo study. Am J Epidemiol 1995; 141: 951–9
  • Greenspan S L, Myers E R, Maitland L A, Resnick N M, Hayes W C. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA 1994; 271: 128–33
  • Gregg E W, Cauley J A, Secley D G, Ensrud K E, Bauer D C. Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 1998; 129: 81–8
  • Gregg E W, Pereira M A, Caspersen C J. Physical activity, falls, and fractures among older adults: a review of the epidemiologic evidence. J Am Geriatr Soc 2000; 48: 883–93
  • Grisso J A, Kelsey J L, Strom B L, Chiu G Y, Maislin G, O'Brien L A, Hoffman S, Kaplan F. Risk factors for falls as a cause of hip fracture in women. The Northeast Hip Fracture Study Group. N Engl J Med 1991; 324: 1326–31
  • Grove K A, Londeree B R. Bone density in postmenopausal women: high impact vs low impact exercise. Med Sci Sports Exerc 1992; 24: 1190–4
  • Gutin B, Kasper M J. Can vigorous exercise play a role in osteoporosis prevention? A review. Osteoporos Int 1992; 2: 55–69
  • Haapasalo H, Sievanen H, Kannus P, Heinonen A, Oja P, Vuori I. Dimensions and estimated mechanical characteristics of the humerus after long-term tennis loading. J Bone Miner Res 1996; 11: 864–72
  • Hakkinen K, Komi P V. Alterations of mechanical characteristics of human skeletal muscle during strength training. Eur J Appl Physiol 1983; 50: 161–72
  • Hakkinen K, Hakkinen A. Neuromuscular adaptations during intensive strength training in middle-aged and elderly males and females. Electromyogr Clin Neuro-physiol 1995; 35: 137–47
  • Hakkinen K, Kallinen M, Izquierdo M, Jokelainen K, Lassila H, Malkia E, Kraemer W J, Newton R U, Alen M. Changes in agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people. J Appl Physiol 1998; 84: 1341–9
  • Hartard M, Haber P, Ilieva D, Preisinger E, Seidl G, Huber J. Systematic strength training as a model of therapeutic intervention. A controlled trial in postmenopausal women with osteopenia. Am J Phys Med Rehabil 1996; 75: 21–8
  • Hatori M, Hasegawa A, Adachi H, Shinozaki A, Hayashi R, Okano H, Mizunuma H, Murata K. The effects of walking at the anaerobic threshold level on vertebral bone loss in postmenopausal women. Calcif Tissue Int 1993; 52: 411–4
  • Hayes W C, Myers E R, Morris J N, Gerhart T N, Yett H S, Lipsitz L A. Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tissue Int 1993; 52: 192–8
  • Heinonen A, Kannus P, Sievanen H, Oja P, Pasanen M, Rinne M, Uusi-Rasi K, Vuori I. Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures. Lancet 1996; 348: 1343–7
  • Hornbrook M C, Stevens V J, Wingnfield D J, Hollis J F, Greenlick M R, Ory M G. Preventing falls among community-dwelling older persons: results from a randomized trial. Gerontologist 1994; 34: 16–23
  • Hu M H, Woollacott M H. Multisensory training of standing balance in older adults: II. Kinematic and electro-myographic postural responses. J Gerontol 1994; 49: M62–71
  • Huddleston A L, Rockwell D, Kulund D N, Harrison R B. Bone mass in lifetime tennis athletes. JAMA 1980; 244: 1107–9
  • Hyakutake S, Goto S, Yamagata M, Moriya H. Relationship between bone mineral density of the proximal femur and lumbar spine and quadriceps and hamstrings torque in healthy Japanese subjects. Calcif Tissue Int 1994; 55: 23–9
  • Joakimsen R M, Fonnebo V, Magnus J H, Stormer J, Tollan A, Sogaard A J. The Tromso Study: physical activity and the incidence of fractures in a middle-aged population. J Bone Miner Res 1998; 13: 1149–57
  • Johnell O, Gullberg B, Kanis J A, Allander E, Elffors L, Dequeker J, Dilsen G, Gennari C, Lopes A Vaz, Lyritis G, et al. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res 1995; 10: 1802–15
  • Jones H H, Priest J D, Hayes W C, Tichenor C C, Nagel D A. Humeral hypertrophy in response to exercise. J Bone Joint Surg (Am) 1977; 59: 204–8
  • Kannus P, Haapasalo H, Sievanen H, Oja P, Vuori I. The site-specific effects of long-term unilateral activity on bone mineral density and content. Bone 1994; 15: 279–84
  • Kannus P, Parkkari J, Sievanen H, Heinonen A, Vuori I, Jarvinen M. Epidemiology of hip fractures. Bone 1996; 18: 57S–63S
  • Karlsson M K, Johnell O, Obrant K J. Bone mineral density in professional ballet dancers. Bone Miner 1993a; 21: 163–9
  • Karlsson M K, Johnell O, Obrant K J. Bone mineral density in weight lifters. Calcif Tissue Int 1993b; 52: 212–5
  • Karlsson M K, Johnell O, Obrant K. J. Is bone mineral density advantage maintained long-term in previous weight lifters?. Calcif Tissue Int 1995; 57: 325–8
  • Karlsson M K, Hasserius R, Obrant K J. Bone mineral density in athletes during and after career: a comparison between loaded and unloaded skeletal regions. Calcif Tissue Int 1996; 59: 245–8
  • Karlsson M K, Linden C, Karlsson C, Johnell O, Obrant K, Seeman E. Exercise during growth and bone mineral density and fractures in old age. Lancet 2000; 355: 469–70
  • Karlsson M K, Magnusson H, Karlsson C, Seeman E. The duration of exercise as a regulator of bone mass. Bone 2001; 28: 128–32
  • Kelley G A. Aerobic exercise and bone density at the hip in postmenopausal women: a meta-analysis. Prev Med 1998; 27: 798–807
  • Kelsey J L, Browner W S, Seeley D G, Nevitt M C, Cummings S R. Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group (published erratum appears in Am J Epidemiol 1992 May 15; 135 (10): 1183). Am J Epide-miol 1992; 135: 477–89
  • Khan K M, Green R M, Saul A, Bennell K L, Crichton K J, Hopper J L, Wark J D. Retired elite female ballet dancers and nonathletic controls have similar bone mineral density at weightbearing sites. J Bone Miner Res 1996; 11: 1566–74
  • Kontulainen S, Kannus P, Haapasalo H, Heinonen A, Sievanen H, Oja P, Vuori I. Changes in bone mineral content with decreased training in competitive young adult tennis players and controls: a prospective 4-year follow-up. Med Sci Sports Exerc 1999; 31: 646–52
  • Kritz-Silverstein D, Barrett-Connor E. Grip strength and bone mineral density in older women. J Bone Miner Res 1994; 9: 45–51
  • Kujala U M, Kaprio J, Kannus P, Sarna S, Koskenvuo M. Physical activity and osteoporotic hip fracture risk in men. Arch Intern Med 2000; 160: 705–8
  • Lau E M, Woo J, Leung P C, Swaminathan R, Leung D. The effects of calcium supplementation and exercise on bone density in elderly Chinese women. Osteoporos Int 1992; 2: 168–73
  • Lehtola S, Hanninen L, Paatalo M. The incidence of falls during a six-month exercise trial and four-month follow-up among home dwelling persons aged 70–75 years (Finnish). Liikunta Tiede 2000; 6: 41–7
  • Lipsitz L A, Nakajima I, Gagnon M, Hirayama T, Connelly C M, Izumo H. Muscle strength and fall rates among residents of Japanese and American nursing homes: an international cross-cultural study. J Am Geriatr Soc 1994; 42: 953–9
  • Lohman T, Going S, Pamenter R, Hall M, Boyden T, Houtkooper L, Ritenbaugh C, Bare L, Hill A, Aickin M. Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 1995; 10: 1015–24
  • Lord S R, Ward J A. Age-associated differences in sensorim-otor function and balance in community dwelling women. Age Ageing 1994; 23: 452–60
  • Lord S R, Ward J A, Williams P, Strudwick M. The effect of a 12-month exercise trial on balance, strength, and falls in older women: a randomized controlled trial. J Am Geriatr Soc 1995; 43: 1198–206
  • Magnusson H, Linden C, Karlsson C, Obrant K, Karlsson M. Exercise may induce reversible bone mass shift from unloaded to weight-loaded skeletal regions. Submitted Osteoporos Int 2001a
  • Magnusson H, Linden C, Obrant K, Johnell O, Karlsson M. Bone mass changes in loaded and unloaded skeletal regions following a fracture of the hip. Submitted Calcif Tissue Int, 200: Ib
  • Mallmin H, Ljunghall S, Persson I, Bergstrom R. Risk factors for fractures of the distal forearm: a population-based case-control study. Osteoporos Int 1994; 4: 298–304
  • McKay H A, Petit M A, Schutz R W, Prior J C, Barr S I, Khan K. M. Augmented trochanteric bone mineral density after modified physical education classes: a randomized school-based exercise intervention study in prepubescent and early pubescent children. J Pediatr 2000; 136: 156–62
  • McMurdo M E, Mole P A, Paterson C R. Controlled trial of weight bearing exercise in older women in relation to bone density and falls. BMJ 1997; 314: 569
  • Meyer H E, Tverdal A, Falch J A. Risk factors for hip fracture in middle-aged Norwegian women and men. Am J Epidemiol 1993; 137: 1203–11
  • Michel B A, Lane N E, Bjorkengren A, Bloch D A, Fries J F. Impact of running on lumbar bone density: a 5-year longitudinal study. J Rheumatol 1992; 19: 1759–63
  • Morris F L, Naughton G A, Gibbs J L, Carlson J S, Wark J D. Prospective ten-month exercise intervention in premenar-cheal girls: positive effects on bone and lean mass. J Bone Miner Res 1997; 12: 1453–62
  • Narici M V, Roi G S, Landoni L, Minetti A E, Cerretelli P. Changes in force, cross-sectional area and neural activation during strength training and detraining of the human quadriceps. Eur J Appl Physiol 1989; 59: 310–9
  • Nelson M E, Fiatarone M A, Morganti C M, Trice I, Greenberg R A, Evans W J. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA 1994; 272: 1909–14
  • Nevitt M C, Cummings S R, Kidd S, Black D. Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA 1989; 261: 2663–8
  • Nevitt M C, Cummings S R, Hudes E S. Risk factors for injurious falls: a prospective study. J Gerontol 1991; 46: Ml64–70
  • Nguyen T V, Eisman J A, Kelly P J, Sambrook P N. Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 1996; 144: 255–63
  • O'Loughlin J L, Robitaille Y, Boivin J F, Suissa S. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol 1993; 137: 342–54
  • O'Neill T W, Marsden D, Adams J E, Silman A J. Risk factors, falls, and fracture of the distal forearm in Manchester, UK. J Epidemiol Community Health 1996; 50: 288–92
  • Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, Adami S, Weber K, Lorenc R, Pietschmann P, Vandormael K, Lombardi A. Alendronate for the treatment of osteoporosis in men. N Engl J Med 2000; 343: 604–10
  • Overstall P W, Johnson A L, Exton-Smith A N. Instability and falls in the elderly. Age Ageing (Suppl) 1978; 92–6
  • Paganini-Hill A, Chao A, Ross R K, Henderson B E. Exercise and other factors in the prevention of hip fracture: the Leisure World study. Epidemiology 1991; 2: 16–25
  • Pocock N, Eisman J, Gwinn T, Sambrook P, Kelly P, Freund J, Yeates M. Muscle strength, physical fitness, and weight, but not age predict femoral neck bone mass. J Bone Miner Res 1989; 4: 441–8
  • Poor G, Atkinson E J, O'Fallon W M, Melton L J, 3rd. Determinants of reduced survival following hip fractures in men. Clin Orthop 1995; 319: 260–5
  • Preisinger E, Alacamlioglu Y, Pils K, Saradeth T, Schneider B. Therapeutic exercise in the prevention of bone loss. A controlled trial with women after menopause. Am J Phys Med Rehabil 1995; 74: 120–3
  • Prince R, Devine A, Dick I, Criddle A, Kerr D, Kent N, Price R, Randell A. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res 1995; 10: 1068–75
  • Province M A, Hadley E C, Hornbrook M C, Lipsitz L A, Miller J P, Mulrow C D, Ory M G, Sattin R W, Tinetti M E, Wolf S L. The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and Injuries: Cooperative Studies of Intervention Techniques. JAMA 1995; 273: 1341–7
  • Pruitt L A, Taaffe D R, Marcus R. Effects of a one-year high-intensity versus low-intensity resistance training program on bone mineral density in older women. J Bone Miner Res 1995; 10: 1788–95
  • Pyka G, Lindenberger E, Charette S, Marcus R. Muscle strength and fiber adaptations to a year-long resistance training program in elderly men and women. J Gerontol 1994; 49: M22–7
  • Ramnemark A, Nyberg L, Lorentzon R, Englund U, Gustafson Y. Progressive hemiosteoporosis on the paretic side and increased bone mineral density in the nonpa-retic arm the first year after severe stroke. Osteoporos Int 1999; 9: 269–75
  • Ray N F, Chan J K, Thamer M, Melton L J, 3rd. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 1997; 12: 24–35
  • Revel M. Mayoux-Benhamou M A, Rabourdin J P. Bagheri F, Roux C. One-year psoas training can prevent lumbar bone loss in postmenopausal women: a randomized controlled trial. Calcif Tissue Int 1993; 53: 307–11
  • Rockwell J C, Sorensen A M, Baker S, Leahey D, Stock J L, Michaels J, Baran D T. Weight training decreases vertebral bone density in premenopausal women: a prospective study. J Clin Endocrinol Metab 1990; 71: 988–93
  • Roman W J, Fleckenstein J, Stray-Gundersen J, Alway S E, Peshock R, Gonyea W J. Adaptations in the elbow flexors of elderly males after heavy-resistance training. J Appl Physiol 1993; 74: 750–4
  • Rubenstein L Z, Josephson K R, Trueblood P R, Loy S, Harker J O, Pietruszka F M, Robbins A S. Effects of a group exercise program on strength, mobility, and falls among fall-prone elderly men. J Gerontol A Biol Sci Med Sci 2000; 55: M317–21
  • Rubin C T, Bain S D, McLeod K J. Suppression of the osteogcnic response in the aging skeleton. Calcif Tissue Int 1992; 50: 306–13
  • Ryan A S, Treuth M S, Rubin M A, Miller J P, Nicklas B J, Landis D M, Pratley R E, Libanati C R, Gundberg C M, Hurley B F. Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 1994; 77: 1678–84
  • Ryan A S, Treuth M S, Hunter G R, Elahi D. Resistive training maintains bone mineral density in postmenopausal women. Calcif Tissue Int 1998; 62: 295–9
  • Sarkar S, Mitlak B H, Wong M, Stock J L, Black D M, Harper K. D. Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 2002; 17: 1–10
  • SBU95. The Swedish council on technology assessment in health care: Measurement of bone density. StockholmSweden 1995, SBU report no. 127
  • Seeman E. The dilemma of osteoporosis in men. Am J Med 1995; 98: 76S–88S
  • Seeman E, Hopper J L, Young N R, Formica C, Goss P, Tsalamandris C. Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. Am J Physiol 1996; 270: E320–7
  • Silman A J, O'Neill T W, Cooper C, Kanis J, Felsenberg D. Influence of physical activity on vertebral deformity in men and women: results from the European Vertebral Osteoporosis Study. J Bone Miner Res 1997; 12: 813–9
  • Slemenda C W, Reister T K., Hui S L, Miller J Z, Christian J C, Johnston C C, Jr. Influences on skeletal mineralization in children and adolescents: evidence for varying effects of sexual maturation and physical activity. J Pediatr 1994; 125: 201–7
  • Snow-Harter C., Bouxsein M., Lewis B, Charette S, Weinstein P, Marcus R. Muscle strength as a predictor of bone mineral density in young women. J Bone Miner Res 1990; 5: 589–95
  • Snow-Harter C, Bouxsein M L, Lewis B T, Carter D, Marcus R. R. Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res 1992; 7: 761–9
  • Steinberg M., Cartwright C., Peel N, Williams G. A sustainable programme to prevent falls and near falls in community dwelling older people: results of a randomised trial. J Epidemiol Community Health 2000; 54: 227–32
  • Tinetti M E, Williams T, Mayewski F. R. Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 1986; 80: 429–34
  • Tinetti M E, Speechley M, Ginter S F. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988; 319: 1701–7
  • Tinetti M E, Baker D I, McAvay G, Claus E B, Garrett P, Gottschalk M. Koch M L, Trainor K, Horwitz R I. A multi-factorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 1994; 331: 821–7
  • Tinetti M E, Inouye S K, Gill T M, Doucette J. T. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995; 273: 1348–53
  • Tracy B L, Ivey F M, Hurlbut D, Martel G F, Lemmer J T, Siegel E L, Metter E, Fozard J. J, Fleg L. J L, Hurley B F. Muscle quality. II. Effects of strength training in 65- to 75-yr-old men and women. J Appl Physiol 1999; 86: 195–201
  • Turner C H, Forwood M R, Rho J Y, Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res 1994; 9: 87–97
  • Turner C H, Takano Y, Owan I. Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res 1995; 10: 1544–9
  • Vuori I., Heinonen A, Sievanen H, Kannus P, Pasanen M, Oja P. Effects of unilateral strength training and detraining on bone mineral density and content in young women: a study of mechanical loading and deloading on human bones. Calcif Tissue Int 1994; 55: 59–67
  • Wallace B A, Cumming R G. Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women. Calcif Tissue Int 2000; 67: 10–8
  • WH Assessment O. of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva 1994, WHO Technical Report Series 843
  • Wickham C A, Walsh K, Cooper C., Barker D J, Margetts B M, Morris J, Bruce S A. Dietary calcium, physical activity, and risk of hip fracture: a prospective study. BMJ 1989; 299: 889–92
  • Wolf S L, Barnhart H, Kutner X. N, McNeely G., Coogler E., Xu C. T. Reducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques [see comments]. J Am Geriatr Soc 1996; 44: 489–97
  • Wolfson L, Whipple I., Amerman R. P, Kleinberg A. Stressing the postural response. A quantitative method for testing balance. J Am Geriatr Soc 1986; 34: 845–50
  • Wyshak G, Frisch R E, Albright T, Albright N L, Schiff I. Bone fractures among former college athletes compared with nonathletes in the menopausal and postmenopausal years. Obstet Gynecol 1987; 69: 121–6

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