Advanced search
Publication Cover
Acta Orthopaedica Volume 83, 2012 - Issue 1
Journal homepage
1,137
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats

Yoshihiro NozakiDepartment of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences
,
Kenji KumagaiDepartment of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical SciencesCorrespondence[email protected]
,
Noriaki MiyataDepartment of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences
&
Masami NiwaDepartment of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Pages 87-92 | Received 29 Oct 2010, Accepted 26 Sep 2011, Published online: 08 Feb 2012

  • Aoki S. Sample size calculation:[updated 2004 May 21; cited 2011 May 18]. Available from: http://aoki2.si.gunma-u.ac.jp/lecture/SampleSize/ptest.html.
  • Arlet J, Durroux R. Lagnostic histologique precoce de l'osteonecrose aseptique do la tete femorale par le forage biopsie. In: Arlet J, Ficat P, eds. La Ciculation Osseuse. Paris, France: Ed INSERM, 1973: 293-302.
  • Cheras PA. Role of hyperlipidemia, hypercoagulability, and hypofibrinolysis in osteonecrosis and osteoarthritis. In: Osteonecrosis: Etiology, Diagnosis, and Treatment ( eds Urbaniak JR, Jones JP). Rosemont, IL: American Academy of Orthopaedic Surgeons, 1997: 97-104.
  • Cui Q, Wang GJ, Su CC, Balian G. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin Orthop 1997; (344): 8-19.
  • Endo A. The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 1992; 33: 1569-82.
  • Fisher DE. The role of fat embolism in the etiology of corticosteroid-induced avascular necrosis: clinical and experimental results. Clin Orthop 1978; (130): 68-80.
  • Fujioka T, Tsujita Y, Shimotsu H. Induction of fatty acid synthesis by pravastatin sodium in rat liver and primary hepatocytes. Eur J Pharmacol. 1997; 328: 235-9.
  • Glueck CJ, Freiberg RA, Sieve L, Wang P. Enoxaparin prevents progression of Stages I and II osteonecrosis of the hip. Clin Orthop 2005; (435): 164-70.
  • Hirano T, Iwasaki K, Sagara K, Nishimura Y, Kumashiro T. Necrosis of the femoral head in growing rats: occlusion of lateral epiphyseal vessels. Acta Orthop Scand 1989; 60: 407-10.
  • Hirota Y, Hotokebuchi T, Sugioka Y. Idiopathic osteonecrosis of the femoral head: nationwide epidemiologic studies in Japan. In: Urbaniak JR, Jones JP, eds. Osteonecrosis: Etiology, Diagnosis, and Treatment. Rosemont, IL: American Academy of Orthopaedic Surgeons, 1997: 51-8.
  • Ichiseki T, Matsumoto T, Nishino M, Kaneuji A, Katsuda S. Oxidative stress and vascular permeability in steroid-induced osteonecrosis model. J Orthop Sci 2004; 9: 509-15.
  • Ichiseki T, Ueda Y, Katsuda S, Kitamura K, Kaneuji A, Matsumoto T. Oxidative stress by glutathione depletion induces osteonecrosis in rats. Rheumatology 2006; 45: 287-90.
  • Jasinska M, Owczarek J, Orszulak-Michalak D. Statins: a new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol Rep 2007; 59: 483-99.
  • Kuribayashi M, Fujioka M, Takahashi KA, Arai Y, Ishida M, Goto T, Kubo T. Vitamin E prevents steroid-induced osteonecrosis in rabbits. Acta Orthop 2010; 81: 154-60.
  • Li X, Cui Q, Kao C, Wang GJ, Balian G. Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures. Bone 2003; 33: 652-9.
  • Li Y, Han R, Geng C, Wang Y, Wei L. A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop 2009; 33: 573-80.
  • Mont AM, Jones CL, Hungerford SD. Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg (Am) 2006; 88: 1117-32.
  • Moon Seok Park, Sung Ju Kim, Chin Youb Chung, In Ho Choi, Sang Hyeong Lee, Kyoung Min Lee. Statistical consideration for bilateral cases in orthopaedic research. J Bone Joint Surg (Am) 2010; 92: 1732-7.
  • Murata M, Kumagai K, Miyata N, Osaki M, Shindo H. Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid. J Orthop Sci 2007; 12: 289-95.
  • Nagasawa K, Tada Y, Koarada S, Tsukamoto H, Horiuchi T, Yoshizawa S, Murai K, Ueda A, Haruta Y, Ohta A. Prevention of steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus by anti-coagulant. Lupus 2006; 15: 354-7.
  • Nakamura T, Yamamoto E, Kataoka K, Yamashita T, Tokutomi Y, Dong Y-F, Matsuba S, Ogawa H, Kim-Mitsuyama S. Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, Independently of blood pressure. Stroke 2007; 38: 3016-22.
  • Nishida K, Yamamoto T, Motomura G, Jingushi S, Iwamoto Y. Pitavastatin may reduce risk of steroid-induced osteonecrosis in rabbits: a preliminary histological study. Clin Orthop 2008; (66): 1054.
  • Okamoto K. Spontaneous hypertension in rats. Int Rev Exp Pathol 1969; 7: 227-70.
  • Pritchett JW. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop 2001; (386): 173-8.
  • Suzuki M, Kumagai K, Osaki M, Murata M, Tomita M, Miyata N, Hozumi A, Niwa M. Osteonecrosis of femoral head in the stroke-prone spontaneously hypertensive rats, especially old rats. Clin Exp Hypertens 2008; 30: 689-97.
  • Wada M, Kumagai K, Murata M, S-Yamashita Y, Shindo H. Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats. J Orthop Sci 2004; 9: 585-90.
  • Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Yoshida S, Ise T, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T. Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency. Circ Res 2008; 102: 68-76.
  • Yamori Y. Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications. In: Handbook of Hypertension. Vol. 4. Experimental and Genetic Models of Hypertension (ed. de Jong W). New York, NY: Elsevier, 1984: 224-39.
  • Yao EH, Fukuda N, Matsumoto T, Kobayashi N, Katakawa M, Yamamoto C, Tsunemi A, Suzuki R, Ueno T, Matsumoto K. Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect. Hypertens Res 2007; 30 : 1119–28.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.