Advanced search
Publication Cover
Acta Orthopaedica Volume 84, 2013 - Issue 6
Journal homepage
1,551
Views
66
CrossRef citations to date
0
Altmetric
Basic science

Toll-like receptors in human chondrocytes and osteoarthritic cartilage

Tarvo SillatInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;;Institute of Biomedicine, Department of Anatomy, University of Helsinki;;Radiology Centre, North Estonia Medical Centre, Tallinn, Estonia.
,
Gonçalo BarretoInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;
,
Paul ClarijsInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;
,
Antti SoininenORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki;
,
Mari AinolaInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;
,
Jukka PajarinenInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;;Institute of Biomedicine, Department of Anatomy, University of Helsinki;
,
Matti KorhonenInstitute of Biomedicine, Department of Anatomy, University of Helsinki;
,
Yrjö T KonttinenInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;;ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki;;COXA Hospital for Joint Replacement, Tampere,Finland;
,
Regina SakalyteInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;
,
Mika HukkanenInstitute of Biomedicine, Department of Anatomy, University of Helsinki;
,
Pekka YlinenORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki;
&
Dan C E NordströmInstitute of Clinical Medicine, Department of Medicine, Helsinki University Central Hospital;Correspondence[email protected]
 show all
Pages 585-592 | Received 11 Jan 2013, Accepted 29 Aug 2013, Published online: 18 Nov 2013

  • Alsalameh S, Amin R, Gemba T, Lotz M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 2004; 50 (5): 1522-32.
  • Bianchi M E. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007; 81 (1): 1-5.
  • Bobacz K, Sunk I G, Hofstaetter J G, Amoyo L, Toma C D, Akira S, et al. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum 2007; 56 (6): 1880-93.
  • Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331 (14): 889-95.
  • Brittberg M, Tallheden T, Sjögren-Jansson B, Lindahl A, Peterson L. Autologous chondrocytes used for articular cartilage repair: an update. Clin Orthop (Suppl) 2001; (391): S337-48.
  • Campo G M, Avenoso A, Campo S, D’Ascola A, Nastasi G, Calatroni A. Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochem Pharmacol 2010; 80 (4): 480-90.
  • Campo G M, Avenoso A, D’Ascola A, Scuruchi M, Prestipino V, Nastasi G, et al. Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β. FEBS J 2012; 279 (12): 2120-33.
  • Chang Z L. Important aspects of Toll-like receptors, ligands and their signaling pathways. Inflamm Res 2010; 59 (10): 791-808.
  • Erridge C. Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol 2010; 87 (6): 989-99.
  • Garrafa E, Imberti L, Tiberio G, Prandini A, Giulini S M, Caimi L. Heterogeneous expression of toll-like receptors in lymphatic endothelial cells derived from different tissues. Immunol Cell Biol 2011; 89 (3): 475-81.
  • Grogan S P, Miyaki S, Asahara H, D’Lima D D, Lotz M K. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 2009; 11 (3): R85.
  • Heinegård D, Saxne T. The role of the cartilage matrix in osteoarthritis. Nat Rev Rheumatol 2011; 7 (1): 50-6.
  • Hodgkinson C P, Ye S. Toll-like receptors, their ligands, and atherosclerosis. Sci World J 2011; 11: 437-53.
  • Kim H A, Cho M L, Choi H Y, Yoon C S, Jhun J Y, Oh H J, Kim H Y. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum 2006; 54 (7): 2152-63.
  • Koelling S, Kruegel J, Irmer M, Path J R, Sadowski B, Miro X, Miosge N. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 2009; 4 (4): 324-35.
  • Konttinen Y T, Sillat T, Barreto G, Ainola M, Nordström D C. Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses. Arthritis Rheum 2012; 64 (3): 613-6.
  • Lee C C, Avalos A M, Ploegh H L. Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol 2012; 12 (3): 168-79.
  • Lee H J, Choi B H, Min B H, Park S R. Changes in surface markers of human mesenchymal stem cells during the chondrogenic differentiation and dedifferentiation processes in vitro. Arthritis Rheum 2009; 60 (8): 2325-32.
  • Liu-Bryan R, Pritzker K, Firestein G S, Terkeltaub R. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol 2005; 174 (8): 5016-23.
  • Liu-Bryan R, Terkeltaub R. Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice. Arthritis Rheum 2010; 62 (7): 2004-12.
  • Ozinsky A, Underhill D M, Fontenot J D, Hajjar A M, Smith K D, Wilson C B, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 2000; 97(25): 13766-71.
  • Pitsillides A A, Beier F. Cartilage biology in osteoarthritis—lessons from developmental biology. Nat Rev Rheumatol 2011; 7 (11): 654-63.
  • Pretzel D, Linss S, Rochler S, et al. Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther 2011; 13 (2): R64.
  • Pritzker K P, Gay S, Jimenez SA, Ostergaard K, Pelletier J P, Revell P A, Salter D, van den Berg W B. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006; 14 (1): 13-29.
  • Raicevic G, Najar M, Stamatopoulos B, De Bruyn C, Meuleman N, Bron D, et al. The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties. Cell Cell Immunol 2011; 270 (2): 207-16.
  • Romieu-Mourez R, Franã§ois M, Boivin M N, Bouchentouf M, Spaner D E, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol 2009; 182 (12): 7963-73.
  • Scanzello C R, Plaas A, Crow M K. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol 2008; 20 (5): 565-72.
  • Schelbergen R F, Blom A B, van den Bosch M H, Slöetjes A, Abdollahi-Roodsaz S, Schreurs B W, et al. Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. Arthritis Rheum 2012; 64 (5):1477-87.
  • Sillat T, Pöllänen R, Lopes J R, Porola P, Ma G, Korhonen M, et al. Intracrine androgenic apparatus in human bone marrow stromal cells. J Cell Mol Med 2009; 13 (9B): 3296-302.
  • Squires G R, Okouneff S, Ionescu M, Poole A R. The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum 2003; 48 (5): 1261-70.
  • Su S L, Tsai C D, Lee C H, Salter D M, Lee H S. Expression and regulation of Toll-like receptor 2 by IL-1β and fibronectin fragments in human articular chondrocytes. Osteoarthritis Cartilage 2005; 13 (10): 879-86.
  • Takeda K. Evolution and integration of innate immune recognition systems: the Toll-like receptors. J Endotoxin Res 2005; 11 (1): 51-5.
  • van Osch G J, Brittberg M, Dennis J E, et al. Cartilage repair: past and future—lessons for regenerative medicine.J Cell Mol Med 2009; 13 (5): 792-810.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.