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Acta Orthopaedica Volume 86, 2015 - Issue 3
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Cartilage

Muscular forces affect the glycosaminoglycan content of joint cartilage

Unloading in human volunteers with the HEPHAISTOS lower leg orthosis

Bergita GanseDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne;Department of Orthopaedic Trauma, RWTH Aachen University, AachenCorrespondence[email protected]
,
Jochen ZangeDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), CologneCorrespondence[email protected]
,
Tobias WeberDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne;Space Medicine Office, Directorate of Human Spaceflight and Operations (D/HSO), European Astronaut Center, European Space Agency, CologneCorrespondence[email protected]
,
Regina Pohle-FröhlichInstitute for Pattern Recognition, Hochschule Niederrhein, KrefeldCorrespondence[email protected]
,
Bernd W JohannesDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), CologneCorrespondence[email protected]
,
Matthias HackenbrochDepartment of Radiology and Correspondence[email protected]
,
Jörn RittwegerDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), CologneCorrespondence[email protected]
,
Peer EyselDepartment of Orthopaedic and Trauma Surgery, University of Cologne, Cologne, GermanyCorrespondence[email protected]
&
Timmo KoyDepartment of Orthopaedic and Trauma Surgery, University of Cologne, Cologne, GermanyCorrespondence[email protected]
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Pages 388-392 | Received 02 Jul 2014, Accepted 27 Sep 2014, Published online: 24 Nov 2014

  • Bashir A, Gray ML, Burstein D. Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med 1996; 36 (5): 665-73.
  • Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 1997; 205 (2): 551-8.
  • Bashir A, Gray ML, Hartke J, Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 1999; 41 (5): 857-65.
  • Burstein D, Velyvis J, Scott KT, Stock KW, Kim YJ, Jaramillo D et al. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 2001; 45: 36-41.
  • Cohen RS, Balcom TA. Current treatment options for ankle injuries: lateral ankle sprain, Achilles tendonitis, and Achilles rupture. Curr Sports Med Rep 2003; 2 (5): 251-4.
  • . Domayer SE, Trattnig S, Stelzeneder D, Hirschfeld C, Quirbach S, Dorotka R et al. Delayed gadolinium-enhanced MRI of cartilage in the ankle at 3 T: feasibility and preliminary results after matrix-associated autologous chondrocyte implantation. J Magn Reson Imaging 2010; 31 (3): 732-9.
  • Eckstein F, Hudelmaier M, Putz R. The effects of exercise on human articular cartilage. J Anat 2006; 208: 491-512.
  • Eckstein F, Boeth H, Diederichs G, Wirth W, Hudelmaier M, Cotofana S et al. Longitudinal change in femorotibial cartilage thickness and subchondral bone plate area in male and female adolescent vs. mature athletes. Ann Anat 2014; 196 (2-3): 150-7.
  • Hinterwimmer S, Krammer M, Kroetz M, Glaser C, Baumgart R, Reiser M et al. Cartilage atrophy in the knees of patients after seven weeks of partial load bearing. Arthritis Rheum 2004; 50 (8): 2516-20.
  • Jiang N, Wang B, Chen A, Dong F, Yu B. Operative versus nonoperative treatment for acute Achilles tendon rupture: a meta-analysis based on current evidence. Int Orthop 2012; 36 (4): 765-73.
  • Liphardt AM, Mündermann A, Koo S, Baecker N, Andriacchi TP, Zange J et al. Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization. Osteoarthritis Cartilage 2009; 17 (12): 1598-603.
  • . Mayerhoefer ME, Welsch HG, Mamisch TC, Kainberger F, Weber M, Nemec S et al. The in vivo effects of unloading and compression on T1-Gd (dGEMRIC) relaxation times in healthy articular knee cartilage at 3.0 Tesla. Eur Radiol 2010; 20: 443-449.
  • Mueller F, Hoechel S, Klaws J, Wirz D, Mueller-Gerbl M. The subtalar and talonavicular joints: a way to access the long-term load intake using conventional CT-data. Surg Radiol Anat 2014; 36 (5): 463-72.
  • Niehoff A, Müller M, Brüggemann L, Savage T, Zaucke F, Eckstein F et al. Deformational behaviour of knee cartilage and changes in serum cartilage oligometric matrix protein (COMP) after running and drop landing. Osteoarthritis Cartilage 2011; 19 (8): 1003-10.
  • Rittweger J. Ten years muscle-bone hypothesis: what have we learned so far?-almost a festschrift-. J Musculoskelet Neuronal Interact 2008; 8 (2): 174-8.
  • Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 2005; 52(11): 3507-14.
  • Vanwanseele B, Eckstein F, Knecht H, Stussi E, Spaepen A. Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement. Arthritis Rheum 2002a; 46: 2073-8.
  • Vanwanseele B, Lucchinietti E, Strussi E. The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions. Osteoarthritis Cartilage 2002b; 10: 408-19.
  • Van Ginckel A, Baelde N, Almqvist KF, Roosen P, McNair P, Witvrouw E. Functional adaptation of knee cartilage in asymptomatic female novice runners compared to sedentary controls. A longitudinal analysis using delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC). Osteoarthritis Cartilage 2010; 18(12): 1564-9.
  • Wang Q, Zheng YP, Wang XY, Huang YP, Liu MQ, Wang SZ et al. Ultrasound evaluation of site-specific effect of simulated microgravity on articular cartilage. Ultrasound Med Biol 2010; 36 (7): 1089-97.
  • Weber T, Ducos M, Mulder E, Herrera F, Brüggemann GP, Bloch W et al. The specific role of gravitational accelerations for arterial adaptations. J Appl Physiol 2013a; 114 (3): 387-93.
  • . Weber T, Ducos M, Yang P-F, Jos D, Frings-Meuthen P, Brüggemann G-P et al. The HEPHAISTOS study: Compliance, adherence and rehabilitation with a novel orthotic device for calf muscle silencing. J Musculoskelet Neuron Interact 2013b; 13 (4): 487-495.
  • Weber T, Ducos M, Mulder E, Beijer A, Herrera F, Zange J et al. The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading. Clin Physiol Funct Imaging 2014; 34 (3): 218-29.
  • Wiewiorski M, Miska M, Kretzschmar M, Studler U, Bieri O, Valderrabano V. Delayed gadolinium-enhanced MRI of cartilage of the ankle joint: results after autologous matrix-induced chondrogenesis (AMIC)-aided reconstruction of osteochondral lesions of the talus. Clin Radiol 2013; 68 (10): 1031-8.

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