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Acta Orthopaedica Volume 86, 2015 - Issue 6
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Original Articles

Local infiltration analgesia is not improved by postoperative intra-articular bolus injections for pain after total hip arthroplasty

A randomized, double-blind, placebo-controlled study with 80 patients

Karen V AndersenDepartments of Orthopedic SurgeryCorrespondence[email protected]
,
Lone NikolajsenAnesthesiology, Aarhus University Hospital, AarhusCorrespondence[email protected]
,
Henrik DaugaardDepartments of Orthopedic SurgeryCorrespondence[email protected]
,
Niels T AndersenBiostatistics Section, Department of Public Health, Aarhus University, AarhusCorrespondence[email protected]
,
Viggo HaraldstedAnesthesiology, Aarhus University Hospital, AarhusCorrespondence[email protected]
&
Kjeld SøballeDepartments of Orthopedic Surgery;The Lundbeck Foundation Center for Fast-Track Hip and Knee Arthroplasty, DenmarkCorrespondence[email protected]
Pages 647-653 | Received 09 Jul 2014, Accepted 27 Jun 2015, Published online: 06 Aug 2015

  • Andersen KV, Pfeiffer-Jensen M, Haraldsted V, Soballe K. Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients. Acta Orthop 2007a; 78(2): 180–6.
  • Andersen LJ, Poulsen T, Krogh B, Nielsen T. Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration. Acta Orthop 2007b; 78(2): 187–92.
  • Andersen LO, Otte KS, Husted H, Gaarn-Larsen L, Kristensen B, Kehlet H. High-volume infiltration analgesia in bilateral hip arthroplasty. A randomized, double-blind placebo-controlled trial. Acta Orthop 2011; 82(4): 423–6.
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  • Breivik EK, Bjornsson GA, Skovlund E. A comparison of pain rating scales by sampling from clinical trial data. Clin J Pain 2000; 16(1): 22–28.
  • Busch CA, Whitehouse MR, Shore BJ, MacDonald SJ, McCalden RW, Bourne RB. The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty. Clin Orthop Relat Res 2010; 468(8): 2152–9.
  • Convery PN, Milligan KR, Quinn P, Scott K, Clarke RC. Low-dose intra-articular ketorolac for pain relief following arthroscopy of the knee joint. Anaesthesia 1998; 53(11): 1125–9.
  • Gupta A, Axelsson K, Allvin R, Liszka-Hackzell J, Rawal N, Althoff B, Augustini BG. Postoperative pain following knee arthroscopy: the effects of intra-articular ketorolac and/or morphine. Reg Anesth Pain Med 1999; 24(3): 225–30.
  • Kehlet H, Andersen LO. Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice. Acta Anaesthesiol Scand 2011; 55(7): 778–84.
  • Kerr DR, Kohan L. Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients. Acta Orthop 2008; 79(2): 174–83.
  • Lavand’homme PM, Roelants F, Waterloos H, De Kock MF. Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery. Anesthesiology 2007; 106(6): 1220–5.
  • Liu W, Cong R, Li X, Wu Y, Wu H. Reduced opioid consumption and improved early rehabilitation with local and intraarticular cocktail analgesic injection in total hip arthroplasty: a randomized controlled clinical trial. Pain Med 2011; 12(3): 387–93.
  • Lunn TH, Husted H, Solgaard S, Kristensen BB, Otte KS, Kjersgaard AG, Gaarn-Larsen L, Kehlet H. Intraoperative local infiltration analgesia for early analgesia after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial. Reg Anesth Pain Med 2011; 36(5): 424–9.
  • Parvataneni HK, Shah VP, Howard H, Cole N, Ranawat AS, Ranawat CS. Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study. J Arthroplasty 2007; 22(6 Suppl 2): 33–38.
  • Petersen MK, Andersen KV, Andersen NT, Soballe K. “To whom do the results of this trial apply?” External validity of a randomized controlled trial involving 130 patients scheduled for primary total hip replacement. Acta Orthop 2007; 78(1): 12–18.
  • Romsing J, Moiniche S, Ostergaard D, Dahl JB. Local infiltration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action. Acta Anaesthesiol Scand 2000; 44(6): 672–83.
  • Solovyova O, Lewis CG, Abrams JH, Grady-Benson J, Joyce ME, Schutzer SF, Arumugam S, Caminiti S, Sinha SK. Local infiltration analgesia followed by continuous infusion of local anesthetic solution for total hip arthroplasty: a prospective, randomized, double-blind, placebo-controlled study. J Bone Joint Surg Am 2013; 95(21): 1935–41.
  • Specht K, Leonhardt JS, Revald P, Mandoe H, Andresen EB, Brodersen J, Kreiner S, Kjaersgaard-Andersen P. No evidence of a clinically important effect of adding local infusion analgesia administrated through a catheter in pain treatment after total hip arthroplasty. Acta Orthop 2011; 82(3): 315–20.
  • Spreng UJ, Dahl V, Hjall A, Fagerland MW, Raeder J. High-volume local infiltration analgesia combined with intravenous or local ketorolac+morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth 2010; 105(5): 675–82.

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