Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention

References

• Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997; 82: 2904–10
   PubMed Web of Science ®Google Scholar
• Klork MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev. 2007; 8: 21–34
   Google Scholar
• Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372: 425–32
   PubMed Web of Science ®Google Scholar
• Rohner-Jeanrenaud F, Jeanrenaud B. Obesity, Leptin and the Brain. N Eng J Med. 1996; 334: 324–5
   PubMed Web of Science ®Google Scholar
• Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol. 2004; 24: 225–3
   Web of Science ®Google Scholar
• Blüher S, Mantzoros CS. The role of leptin in regulating neuroendocrine function in humans. J Nutr. 2004; 134: 2469–74S
   PubMed Web of Science ®Google Scholar
• Blum WF, Englaro P, Attanasio AM, et al. Human and clinical perspectives on leptin. Proc Nutr Soc. 1998; 57: 477–85
   PubMed Web of Science ®Google Scholar
• Bai Y, Zhang S, Kim KS, et al. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem. 1996; 271: 13939–42
   PubMed Web of Science ®Google Scholar
• Wang MY, Lee Y, Unger RH. Novel form of lipolysis induced by leptin. J Biol Chem. 1999; 274: 17541–4
   PubMed Web of Science ®Google Scholar
• Anubhuti, Arora S. Leptin and its metabolic interactions-an update. Diabetes Obes Metab. 2008; 10: 973–93
   PubMed Web of Science ®Google Scholar
• Koebnick C, Shaibi GQ, Kelly LA, et al. Leptin-to-adiponectin ratio as independent predictor of insulin sensitivity during growth in overweight Hispanic youth. J Endocrinol Invest. 2007; 30: RC13–6
   Google Scholar
• Soodini GR. Adiponectin and leptin in relation to insulin sensitivity. Metab Syndr Relat Disord. 2004; 2: 114–23
   PubMed Web of Science ®Google Scholar
• Havel PJ, Kasim-Karakas S, Mueller W, et al. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996; 81: 4406–13
   PubMed Web of Science ®Google Scholar
• Reinehr T, Kratzsch J, Kiess W, et al. Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children. Int J Obes (Lond) 2005; 29: 1230–5
   PubMed Web of Science ®Google Scholar
• Maffei MJ, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995; 1: 1155–61
   PubMed Web of Science ®Google Scholar
• El-Haschimi K, Lehnert H. Leptin Resistance – or why leptin fails to work in obesity. Exp Clin Endocrinol Diabetes. 2003; 111: 2–7
   Google Scholar
• Kalra SP. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides. 2008; 29: 127–38
   PubMed Web of Science ®Google Scholar
• Torgerson JS, Carlsson B, Stenlof K, et al. A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans. J Clin Endocrinol Metab. 1999; 84: 4197–203
   PubMed Web of Science ®Google Scholar
• Shih LY, Liou TH, Chao JC, et al. Leptin, superoxide dismutase, and weight loss: initial leptin predicts weight loss. Obesity (Silver Spring) 2006; 14: 2184–92
   Google Scholar
• Verdich C, Toubro S, Buemann B, et al. Leptin levels are associated with fat oxidation and dietary-induced weight loss in obesity. Obes Res. 2001; 9: 452–61
   Google Scholar
• Näslund E, Andersson I, Degerblad M, et al. Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men. J Intern Med. 2000; 248: 299–308
   Google Scholar
• Nakamura M, Tanaka M, Kinukawa N, et al. Association between basal serum and leptin levels and changes in abdominal fat distribution during weight loss. J Atheroscler Thromb. 2000; 6: 28–32
   Google Scholar
• Miraglia del GE, Santoro N, Marotta A, et al. Inadequate leptin level negatively affects body fat loss during a weight reduction programme for childhood obesity. Acta Paediatr. 2002; 91: 132–5
   Google Scholar
• Liou JM, Lin JT, Lee WJ, et al. The serial changes of ghrelin and leptin levels and their relations to weight loss after laparoscopic minigastric bypass surgery. Obes Surg. 2008; 18: 84–9
   PubMed Web of Science ®Google Scholar
• Czupryniak L, Pawlowski M, Kumor A, et al. Predicting maximum Roux-en-Y gastric bypass-induced weight reduction–preoperative plasma leptin or body weight?. Obes Surg. 2007; 17: 162–7
   Google Scholar
• Niskanen LK, Haffner S, Karhunen LJ, et al. Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol. 1997; 137: 61–7
   Google Scholar
• Wing RR, Sinha MK, Considine RV, et al. Relationship between weight loss maintenance and changes in serum leptin levels. Horm Metab Res. 1996; 28: 698–703
   PubMed Web of Science ®Google Scholar
• Faraj M, Havel PJ, Phélis S, et al. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab. 2003; 88: 1594–602
   PubMed Web of Science ®Google Scholar
• Di Stefano G, Bini V, Papi F, et al. Leptin serum concentrations predict the responsiveness of obese children and adolescents to weight excess reduction. Int J Obes Relat Metab Disord. 2000; 24: 1586–91
   Google Scholar
• Mavri A, Stegnar M, Sabovic M. Do baseline serum leptin levels predict weight regain after dieting in obese women?. Diabetes Obes Metab. 2001; 3: 293–6
   PubMed Web of Science ®Google Scholar
• Lindroos AK, Lissner L, Carlsson B, et al. Familial predisposition for obesity may modify the predictive value of serum leptin concentrations for long-term weight change in obese women. Am J Clin Nutr. 1998; 67: 1119–23
   Google Scholar
• Nicklas BJ, Katzel LI, Ryan AS, et al. Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals. Obes Res. 1997; 5: 62–8
   PubMedGoogle Scholar
• Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 1997; 3: 238–40
   Google Scholar
• Reinehr T, Brylak K, Alexy U, et al. Predictors to success in outpatient training in obese children and adolescents. Int J Obes Relat Metab Disord. 2003; 89: 419–22
   Google Scholar
• Reinehr T, de Sousa G, Toschke M, et al. Long-term follow-up of cardiovascular risk factors in obese children after intervention. Am J Clin Nutr. 2006; 84: 490–6
   PubMed Web of Science ®Google Scholar
• Kersting M, Sichert-Hellert W, Lausen B, et al. Energy intake of 1 to 18 year old German Children and adolescents. Z Ernährungswiss. 1998; 37: 47–55
   PubMedGoogle Scholar
• Reinehr T, Kersting M, Wollenhaupt A, et al. Evaluation of the Training Program "OBELDICKS" for Obese Children and Adolescents. Klin Päd. 2005; 217: 1–8
   Google Scholar
• Kromeyer-Hauschild K, Wabitsch M, Geller F, et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd. 2001; 149: 807–18
   Web of Science ®Google Scholar
• Cole TJ, Bellizzi MC, Flegal KM, et al. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000; 320: 1–6
   PubMed Web of Science ®Google Scholar
• Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr. 1990; 44: 45–60
   PubMed Web of Science ®Google Scholar
• Slaughter MH, Lohman TG, Boileau RA, et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1998; 60: 709–23
   Google Scholar
• National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004;114:555–76.
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28: 412–9
   PubMed Web of Science ®Google Scholar
• Kettaneh A, Heude B, Romon M, et al. High plasma leptin predicts an increase in subcutaneous adiposity in children and adults. Eur J Clin Nutr. 2007; 61: 719–26
   Google Scholar
• Fleisch A, Agarwal N, Roberts M, et al. Influence of Serum Leptin on Weight and Body Fat Growth in Children at High Risk for Adult Obesity. J Clin Endocrinol Metab. 2007; 92: 948–54
   PubMed Web of Science ®Google Scholar
• Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell. 2004; 116: 337–50
   PubMed Web of Science ®Google Scholar
• Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinalfluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996; 348: 159–61
   PubMed Web of Science ®Google Scholar
• Van Heek M, Compton DS, France CF, et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997; 99: 385–90
   PubMed Web of Science ®Google Scholar
• El-Haschimi K, Pierroz DD, Hileman SM, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest. 2000; 105: 1827–32
   PubMed Web of Science ®Google Scholar
• Mori H, Hanada R, Hanada T, et al. Socs3 defciency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004; 10: 739–43
   PubMed Web of Science ®Google Scholar
• Bjorbaek C, Elmquist JK, Frantz JD, et al. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998; 1: 619–25
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhou YT, Kakuma T, et al. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochem Biophys Res Commun. 2000; 277: 20–6
   PubMed Web of Science ®Google Scholar
• Yiannakouris N, Yannakoulia M, Melistas L, et al. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab. 2001; 86: 4434–9
   PubMed Web of Science ®Google Scholar
• Wu-Peng XS, Chua SC, Jr, Okada N, et al. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr). Evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes. 1997; 46: 513–8
   PubMed Web of Science ®Google Scholar
• Chua SC, Jr, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996; 271: 994–6
   PubMed Web of Science ®Google Scholar
• Holtkamp K, Hebebrand J, Mika C, et al. High serum leptin levels subsequent to weight gain predict renewed weight loss in patients with anorexia nervosa. Psychoneuroendocrinology. 2004; 29: 791–7
   PubMedGoogle Scholar
• Reinehr, T. Obesity and Thyroid Function. Mol Cell Endocrinol. 2009; in press.
   Google Scholar
• Reinehr T, Isa A, de Sousa G, et al. Thyroid hormones and their relationship to weight status. Horm Res. 2008; 70: 51–7
   PubMed Web of Science ®Google Scholar
• Pinkney JH, Goodrick SJ, Katz J, et al. Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin Endocrinol (Oxf) 1998; 49: 583–8
   PubMed Web of Science ®Google Scholar
• Ortiga-Carvalho TM, Oliveira KJ, Soares BA, et al. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J Endocrinol. 2002; 174: 121–5
   PubMedGoogle Scholar
• Hassink SG, Sheslow DV, de Lancey E, et al. Serum leptin in children with obesity: relationship to gender and development. Pediatrics. 1996; 98: 201–3
   PubMed Web of Science ®Google Scholar
• Horlick MB, Rosenbaum M, Nicolson M, et al. Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab. 2000; 85: 2509–18
   PubMed Web of Science ®Google Scholar
• Ahmed ML, Ong KK, Morrell DJ, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab. 1999; 84: 899–905
   PubMed Web of Science ®Google Scholar
• Wunsch R, de Sousa G, Toschke AM, et al. Intima-media thickness in obese children before and after weight loss. Pediatrics. 2006; 118: 2334–40
   PubMed Web of Science ®Google Scholar
• Reinehr T, Hinney A, Nguyen TT, et al. Evidence for an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents. Diabetes. 2008; 57: 623–6
   Google Scholar
• Reinehr T, Hebebrand J, Friedel S, et al. Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) 2009; 17(2)382–9
   Google Scholar
• Bray GA, DeLany JP, Volaufova J, et al. Prediction of body fat in 12-y-old African American and white children: evaluation of methods. Am J Clin Nutr. 2002; 76: 980–90
   PubMed Web of Science ®Google Scholar
• Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabet Med. 2002; 19: 527–34
   PubMed Web of Science ®Google Scholar
• Keskin M, Kurtoglou S, Kenderci M, et al. Homeostasis Model Assessment is more reliable than Fasting Glucose to Insulin Ratio and Quantitative Insulin Sensitivity Check Index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005; 115: 500–3
   PubMed Web of Science ®Google Scholar
• Sinha MK, Opentanova I, Ohannesian JP, et al. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest. 1996; 98: 1277–82
   PubMed Web of Science ®Google Scholar
• Keim NL, Stern JS, Havel PJ. Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women. Am J Clin Nutr. 1998; 68: 794–801
   PubMed Web of Science ®Google Scholar
• Dubuc GR, Phinney SD, Stern JS, et al. Changes of serum leptin and endocrine and metabolic parameters after 7 days of energy restriction in men and women. Metabolism. 1998; 47: 429–34
   PubMed Web of Science ®Google Scholar
• Havel PJ, Townsend R, Chaump L, et al. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes. 2001; 48: 334–41
   Google Scholar