References
- Bosco DA, Landers JE. Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets. CNS Neurol Disord Drug Targets. 2010;9:779–90.
- Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, . Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science. 1998;281:1851–4.
- Chattopadhyay M, Valentine JS. Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS. Antioxid Redox Signal. 2009;11:1603–14.
- Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien JP. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci. 2006;9:108–18.
- Magrane J, Hervias I, Henning MS, Damiano M, Kawamata H, Manfredi G. Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities. Hum Mol Genet. 2009;18:4552–64.
- Forsberg K, Jonsson PA, Andersen PM, Bergemalm D, Graffmo KS, Hultdin M, . Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients. PLoS One. 2010;5:11552.
- Urushitani M, Ezzi SA, Julien JP. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2007;104:2495–500.
- Ezzi SA, Urushitani M, Julien JP. Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation. J Neurochem. 2007;102:170–8.
- Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, . Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci. 2010;13:1396–403.
- Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, . Axonal transport defects in neurodegenerative diseases. J Neurosci. 2009;29:12776–86.
- Gros-Louis F, Soucy G, Lariviere R, Julien JP. Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS. J Neurochem. 2010;113:1188–99.
- Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, . Induction of protective immunity by vaccination with wild-type apo superoxide dismutase-1 in mutant SOD1 transgenic mice. J Neuropathol Exp Neurol. 2010;69:1044–56.
- Ray SS, Nowak RJ, Strokovich K, Brown RH Jr, Walz T, Lansbury PT Jr. An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis. Biochemistry. 2004;43:4899–905.
- Hayward LJ, Rodriguez JA, Kim JW, Tiwari A, Goto JJ, Cabelli DE, . Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis. J Biol Chem. 2002;277:15923–31.
- Engvall E, Perlmann P. Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J Immunol. 1972;109:129–35.
- Steinitz M. Quantitation of the blocking effect of tween 20 and bovine serum albumin in ELISA microwells. Anal Biochem. 2000;282:232–8.
- McQuillen DP, Gulati S, Ram S, Turner AK, Jani DB, Heeren TC, . Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis. 1999;179:124–35.
- Ngampasutadol J, Rice PA, Walsh MT, Gulati S. Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resultant immune responses and function. Vaccine. 2006;24:157–70.
- Gnehm HE, Pelton SI, Gulati S, Rice PA. Characterization of antigens from non-typeable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins. J Clin Invest. 1985;75:1645–58.
- Rice PA, Vayo HE, Tam MR, Blake MS. Immunoglobulin G antibodies directed against protein III block killing of serum-resistant Neisseria gonorrhoeae by immune serum. J Exp Med. 1986;164:1735–48.
- Mehta C, Patel N. StatXact8. In: Software CS, Cambridge: MA; 2008.
- Stavnezer J, Guikema JE, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol. 2008;26:261–92.
- Knipe DM, Howley PM. In: Knipe DM, Howley PM, Fields Virology. 5th edn. Philidelphia: Lippincott, Williams and Wilkins; 2007.
- Tandan R, Bradley WG. Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management. Ann Neurol. 1985;18:271–80.
- Rakhit R, Cunningham P, Furtos-Matei A, Dahan S, Qi XF, Crow JP, . Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. J Biol Chem. 2002;277:47551–6.
- Durazo A, Shaw BF, Chattopadhyay M, Faull KF, Nersissian AM, Valentine JS, . Metal-free superoxide dismutase-1 and three different ALS variants share a similar partially unfolded {beta}-barrel at physiological temperature. J Biol Chem. 2009;284:34382–9.
- Estevez AG, Crow JP, Sampson JB, Reiter C, Zhuang Y, Richardson GJ, . Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science. 1999;286:2498–500.
- Lindberg MJ, Normark J, Holmgren A, Oliveberg M. Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci USA. 2004;101:15893–8.
- Rakhit R, Crow JP, Lepock JR, Kondejewski LH, Cashman NR, Chakrabartty A. Monomeric Cu/Zn superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. J Biol Chem. 2004;279:15499–504.
- Cimini V, Ruggiero G, Buonomo T, Seru R, Sciorio S, Zanzi C, . Cu/Zn superoxide dismutase in human thymus: immunocytochemical localization and secretion in thymus-derived epithelial and fibroblast cell lines. Histochem Cell Biol. 2002;118:163–9.
- Mondola P, Ruggiero G, Seru R, Damiano S, Grimaldi S, Garbi C, . The Cu/Zn superoxide dismutase in neuroblastoma SK-N-BE cells is exported by a microvesicles dependent pathway. Brain Res Mol Brain Res. 2003;110:45–51.
- Garbuzova-Davis S, Saporta S, Haller E, Kolomey I, Bennett SP, Potter H, . Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS One. 2007;2:1205.
- Zhang R, Gascon R, Miller RG, Gelinas DF, Mass J, Hadlock K, . Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (SALS). J Neuroimmunol. 2005;159:215–24.
- Donnenfeld H, Kascsak RJ, Bartfeld H. Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients. J Neuroimmunol. 1984;6:51–7.
- Engelhardt JI, Appel SH. IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol. 1990;47:1210–6.
- Demestre M, Pullen A, Orrell RW, Orth M. ALS-IgG- induced selective motor neuron apoptosis in rat mixed primary spinal cord cultures. J Neurochem. 2005;94:268–75.
- Smith RG, Alexianu ME, Crawford G, Nyormoi O, Stefani E, Appel SH. Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line. Proc Natl Acad Sci U S A. 1994;91:3393–7.
- Pullen AH, Humphreys P. Ultrastructural analysis of spinal motoneurons from mice treated with IgG from ALS patients, healthy individuals, or disease controls. J Neurol Sci. 2000; 180:35–45.
- Fridovich I. Superoxide anion radical (O2-.), superoxide dismutases, and related matters. J Biol Chem. 1997;272:18515–7.