Maladaptation of cortical circuits underlies fatigue and weakness in ALS

References

• Sanjak M, Brinkmann J, Belden DS, Roelke K, Waclawik A, Neville HE, . Quantitative assessment of motor fatigue in amyotrophic lateral sclerosis. J Neurol Sci. 2001; 191:55–9.
   PubMed Web of Science ®Google Scholar
• Sharma KR, Kent-Braun JA, Majumdar S, Huang Y, Mynhier M, Weiner MW, . Physiology of fatigue in amyotrophic lateral sclerosis. Neurology. 1995;45:733–40.
   PubMed Web of Science ®Google Scholar
• Thomas CK, Zijdewind I. Fatigue of muscles weakened by death of motor neurons. Muscle Nerve. 2006;33:21–41.
   PubMedGoogle Scholar
• Feasson L, Camdessanche JP, El Mhandi L, Calmels P, Millet GY. Fatigue and neuromuscular diseases. Ann Readapt Med Phys. 2006;49:375–84.
   Google Scholar
• Robbins RA, Simmons Z, Bremer BA, Walsh SM, Fischer S. Quality of life in ALS is maintained as physical function declines. Neurology. 2001;56:442–4.
   PubMed Web of Science ®Google Scholar
• Vucic S, Kiersan M. Pathophysiology of degeneration in familial amyotrophic lateral sclerosis. Curr Mol Med. 2009; 9:255–72.
   PubMed Web of Science ®Google Scholar
• Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, . Amyotrophic lateral sclerosis. Lancet. 2011;377:942–55.
   PubMed Web of Science ®Google Scholar
• Vucic S, Cheah BC, Kiernan MC. Dissecting the mechanisms underlying short-interval intracortical inhibition using exercise. Cereb Cortex. 2010:Nov 11, Epub.
   PubMedGoogle Scholar
• Vucic S, Krishnan AV, Kiernan MC. Fatigue and activity dependent changes in axonal excitability in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78: 1202–8.
   PubMed Web of Science ®Google Scholar
• Carpentier A, Duchateau J, Hainaut K. Motor unit behaviour and contractile changes during fatigue in the human first dorsal interosseus. J Physiol (Lond). 2001;534:903–12.
   Google Scholar
• Takahashi K, Maruyama A, Maeda M, Etoh S, Hirakoba K, Kawahira K, . Unilateral grip fatigue reduces short interval intracortical inhibition in ipsilateral primary motor cortex. Clin Neurophysiol. 2009;120:198–203.
   PubMedGoogle Scholar
• Maruyama A, Matsunaga K, Tanaka N, Rothwell JC. Muscle fatigue decreases short-interval intracortical inhibition after exhaustive intermittent tasks. Clin Neurophysiol. 2006; 117:864–70.
   PubMedGoogle Scholar
• Ziemann U. Cortical threshold and excitability measurements. Eisen A. Clinical Neurophysiology of Motor Neuron Diseases Handbook of Clinical Neurophysiology. Amsterdam: Elsevier; 2004. 317–35.
   Google Scholar
• Ziemann U. TMS and drugs. Clin Neurophysiol. 2004; 115:1717–29.
   PubMed Web of Science ®Google Scholar
• Roshan L, Paradiso GO, Chen R. Two phases of short-interval intracortical inhibition. Exp Brain Res. 2003;151: 330–7.
   PubMed Web of Science ®Google Scholar
• Vucic S, Cheah BC, Krishnan AV, Burke D, Kiernan MC. The effects of alterations in conditioning stimulus intensity on short interval intracortical inhibition. Brain Res. 2009; 1273:39–47.
   PubMed Web of Science ®Google Scholar
• Vucic S, Kiernan MC. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain. 2006;129:2436–46.
   PubMed Web of Science ®Google Scholar
• Vucic S, Nicholson GA, Kiernan MC. Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain. 2008;131:1540–50.
   PubMed Web of Science ®Google Scholar
• Ziemann U, Winter M, Reimers CD, Reimers K, Tergau F, Paulus W. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology. 1997;49:1292–8.
   PubMed Web of Science ®Google Scholar
• Zanette G, Tamburin S, Manganotti P, Refatti N, Forgione A, Rizzuto N. Different mechanisms contribute to motor cortex hyperexcitability in amyotrophic lateral sclerosis. Clin Neurophysiol. 2002;113:1688–97.
   PubMed Web of Science ®Google Scholar
• Brooks BR, Miller RG, Swash M, Munsat TL. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:293–9.
   PubMed Web of Science ®Google Scholar
• Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, . she ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999;169:13–21.
   PubMed Web of Science ®Google Scholar
• Medical Research Council. Aid to the examination of the peripheral nervous system. London: Her Majesty's Stationary Office; 1976.
   Google Scholar
• Kos D, Nagels G, D'Hooghe MB, Duportail M, Kerckhofs E. A rapid screening tool for fatigue impact in multiple sclerosis. BMC Neurol. 2006;6:27.
   PubMed Web of Science ®Google Scholar
• de Carvalho M, Swash M. Nerve conduction studies in amyotrophic lateral sclerosis. Muscle Nerve. 2000;23:344–52.
   PubMed Web of Science ®Google Scholar
• Vucic S, Howells J, Trevillion L, Kiernan MC. Assessment of cortical excitability using threshold tracking techniques. Muscle Nerve. 2006;33:477–86.
   PubMed Web of Science ®Google Scholar
• Fisher RJ, Nakamura Y, Bestmann S, Rothwell JC, Bostock H. Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking. Exp Brain Res. 2002;143:240–8.
   PubMed Web of Science ®Google Scholar
• Rossini PM, di Stefano E, Stanzione P. Nerve impulse propagation along central and peripheral fast conducting motor and sensory pathways in man. Electroencephalogr Clin Neurophysiol. 1985;60:320–34.
   PubMedGoogle Scholar
• Mills KR, Murray NM. Electrical stimulation over the human vertebral column: which neural elements are excited? Electroencephalogr Clin Neurophysiol. 1986;63:582–9.
   PubMedGoogle Scholar
• Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, . Corticocortical inhibition in human motor cortex. J Physiol (Lond). 1993;471:501–19.
   Google Scholar
• Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W. Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol. 1996;40:367–78.
   PubMed Web of Science ®Google Scholar
• Muller-Dahlhaus J, Liu Y, Ziemann U. Inhibitory circuits and the nature of their interactions in the human motor cortex: a pharmacological TMS study. J Physiol. 2008;586:495–514.
   PubMedGoogle Scholar
• Vucic S, Cheah BC, Kiernan MC. Dissecting the mechanisms underlying short-interval intracortical inhibition using exercise. Cereb Cortex. 2011, Nov 11.
   PubMedGoogle Scholar
• Nihei K, McKee AC, Kowall NW. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol. 1993;86:55–64.
   PubMed Web of Science ®Google Scholar
• Vagg R, Mogyoros I, Kiernan MC, Burke D. Activity-dependent hyperpolarization of human motor axons produced by natural activity. J Physiol (Lond). 1998;507:919–25.
   Google Scholar
• Kiernan MC, Lin CS, Burke D. Differences in activity-dependent hyperpolarization in human sensory and motor axons. J Physiol (Lond). 2004;558:341–9.
   Google Scholar
• Vucic S, Burke D, Kiernan MC. Fatigue in multiple sclerosis: mechanisms and management. Clin Neurophysiol. 2010; 121:809–17.
   PubMed Web of Science ®Google Scholar
• Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005;128:472–6.
   PubMed Web of Science ®Google Scholar
• Vucic S, Kiernan MC. Abnormalities in cortical and peripheral excitability in flail arm variant amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78:849–52.
   PubMed Web of Science ®Google Scholar
• Vucic S, Cheah BC, Kiernan MC. Defining the mechanisms that underlie cortical hyperexcitability in amyotrophic lateral sclerosis. Exp Neurol. 2009;220:177–82.
   PubMed Web of Science ®Google Scholar