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Amyotrophic Lateral Sclerosis Volume 13, 2012 - Issue 3
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Research Article

Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis

Antonio Hayes-PunzoDepartment of Comparative Biosciences
,
Patrick MulcroneDepartment of Comparative Biosciences
,
Michael MeyerDepartment of Comparative Biosciences
,
Jacalyn MchughCedars-Sinai Regenerative Medicine Institute, Los Angeles, California, USA
,
Clive N. SvendsenCedars-Sinai Regenerative Medicine Institute, Los Angeles, California, USA
&
Masatoshi SuzukiDepartment of Comparative Biosciences;The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WisconsinCorrespondence[email protected]
Pages 311-314 | Received 30 Aug 2011, Accepted 29 Dec 2011, Published online: 08 May 2012

References

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  • Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci U S A. 1998;95:1852–7.
  • Fiore C, Inman DM, Hirose S, Noble LJ, Igarashi T, Compagnone NA. Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neurosci Res. 2004;75:391–400.
  • Celec P, Starka L. Dehydroepiandrosterone: is the fountain of youth drying out? Physiol Res. 2003;52:397–407.
  • Suzuki M, Bannai M, Matsumuro M, Furuhata Y, Ikemura R, Kuranaga E, . Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats. Physiol Behav. 2000;68:707–13.
  • Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, . GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum Gene Ther. 2005;16:509–21.
  • Suzuki M, Klein S, Wetzel EA, Meyer M, McHugh J, Tork C, . Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Exp Neurol. 2010;221:346–52.
  • Militello A, Vitello G, Lunetta C, Toscano A, Maiorana G, Piccoli T, . The serum level of free testosterone is reduced in amyotrophic lateral sclerosis. J Neurol Sci. 2002; 195:67–70.

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