Advanced search
Publication Cover
Journal of Dietary Supplements Volume 7, 2010 - Issue 1
Submit an article Journal homepage
120
Views
10
CrossRef citations to date
0
Altmetric
Research Article

A Normative Study of the Components of Niprisan—an Herbal Medicine for Sickle Cell Anemia

Obiageli O. Obodozie Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, PhD,
Sunday J. Ameh Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.Correspondence[email protected]
, BSc (Hon),
Ernest K. Afolabi Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, HND.,
Eunice O. Oyedele Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, HND.,
Theophilus A. Ache Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, ND.,
Cordelia E. Onanuga Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, HND.,
Martha C. Ibe Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, HND. &
Uford S. Inyang Dr Obodozie, Mr. Ameh, Mr. Afolabi, Mrs Oyedele, Mr. Ache, Mrs Cordelia, Mrs Ibe, and Dr. Inyang are all affiliated with the Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.
, PhD. show all
Pages 21-30 | Received 23 Apr 2009, Accepted 05 Nov 2009, Published online: 03 Mar 2010

REFERENCES

  • Ankrah EK, Dovlo FE. The properties of trona and its effect on the cooking time of cowpeas. J Sci Food Agric. 2006;29(11):950–952.
  • Awodogan A, Wambebe C, Gamaniel K, Okogun J, Orisadipe A, Akah P. Acute and short-term toxicity of NIPRISAN® in Rats I: biochemical study. J Pharmaceut Res Dev. 1996;2:39–45.
  • Awosiyan K. Nigeria has highest sickle cell patients. Nigeria Tribune, 14th December, 2006. Lagos, Nigeria, p.1.
  • Bandaranayake WM. Quality control, screening, toxicity, and regulation of herbal drugs. In: Iqbal Ahmad, Farrukh Aqil, and Mohammad Owais ( Eds.), Modern Phytomedicine – Turning Medicinal Plants into Drugs, pp. 25–57. Weinheim, Germany: WILEY-VCH Verlag GmbH & Co. KGaA, 2006.
  • British Pharmacopoeia. British Pharmacopoeia, 2004. Volume IV. The Stationery Office Limited, London. Appendix II D, Atomic spectrophotometry: emission and absorption, pp. A143-145. Determination of pH, pp. A143-145; Appendix VL, Determination of pH Values, pp. A199-A200, 2004.
  • Cordeiro NJV, Oniyangi O. Phytomedicines [medicines derived from plants] for sickle cell disease. The Cochrane Database of Systematic Review 2006 Issue 3. The Cochrane Library (ISSN 1464-780X), 2006.
  • Gamaniel K, Amos S, Akah P, Samuel B, Olusola A, Abayomi O, Pharmacological profile of NIPRD 94/002/1-0: a novel herbal antisickling agent. J Pharmaceut Res Dev. 1998;3(2):89–94.
  • Iyamu EW, Turner EA, Asakawa T. Niprisan [Nix-0699] improves the survival rates of transgenic sickle cell mice under acute severe hypoxic conditions. Brit J Haematol. 2003;122(6):1001–1008.
  • Pandey RC. Xechem's Sickle Cell Drug, NIPRISAN -HEMOXIN- Granted Orphan Drug Status by the FDA NEW BRUNSWICK, N.J.–(BUSINESS WIRE)–Sept. 2, 2003–Xechem International, Inc. (OTC BB: XKEM). Xechem's Sickle Cell Drug, NIPRISAN -HEMOXIN- Granted Orphan Drug Status by… (cited November, 20th 2009), 2003.
  • Steinberg MH. Management of sickle cell disease. New Engl J Med. 1999;340(13):1021–1030. http://content.nejm.org/cgi/content/full/3401/1021
  • The mineral trona – Accessed from: http://minerals.galleries.com/minerals/carbonate/class.htm (cited November, 20th 2009)
  • Waknine Y. Orphan Drug Niprisan (Nicosan/Hemoxin) for Sickle Cell Disease in EU. International Approvals. October, 2005 http://www.medscape.com/px/viewindex/more?Bucket=columns&sectionId=2557 (cited November, 20th 2009), 2005.
  • Wambebe CO, Elijah AB, Badru BO, Khamofu H, Momoh JA, Ekpeyong M, Efficacy of Niprisan in the prophylactic management of patients with sickle cell disease. Curr Ther Res. 2001;62(1):26–34. ISSN 0011-393X CODEN CTCEA9. Efficacy of niprisan in the prophylactic management of patients with sickle cell disease
  • Wambebe C, Khamofu H, Momoh JA, Ekpeyong M, Audu BS, Njoku SO, Double-blind, placebo-controlled, randomized cross-over clinical trial of NIPRISAN in patients with sickle cell disorder. Phytomedicine. 2001 Jul;8(4):252–261. doi:10.1078/0944-7113-00040
  • WHO. Chemistry-Manufacturing-Control (CMC) considerations for herbal products. Information needed to support Clinical Trials of herbal products. 2005. pp. 1–16.
  • WHO. Sickle-cell disease and other haemoglobin disorders. August 2006, WHO, Geneva, Fact sheet N°308, 2006.
  • WHO. 1998. Quality control methods for medicinal plant materials, pp. 1–115. Geneva: WHO, 1998.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.