56
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Podophyllum hexandrum as a Potential Botanical Supplement for the Medical Management of Nuclear and Radiological Emergencies (NREs) and Free Radical-Mediated Ailments: Leads From In Vitro/In Vivo Radioprotective Efficacy Evaluation

, MSc, MPhil, PhD, , PhD, , MSc, , MSc, , MSc, , MSc, , PhD, , PhD, , PhD, , MPharm, PhD & , MD show all
Pages 31-50 | Received 01 Jun 2009, Accepted 05 Nov 2009, Published online: 03 Mar 2010

REFERENCES

  • Ainsworth EA, Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nat Protoc. 2007;2:875–877.
  • Allard JP, Aghdassi E, Chau J, Salit I, Walmsley S. Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection. Am J Clin Nutr. 1998;67:143–147.
  • Arora R, Chawla R, Sagar R, Prasad J, Singh S, Kumar R, Sharma A, Singh S, Sharma RK. Evaluation of radioprotective activities of Rhodiola imbricata Edgew- A high altitude plant. Mol Cell Biochem. 2005a;273:209–223, 205.
  • Arora R, Chawla R, Singh S, Sagar RK, Kuma R, Sharma AK, Singh S, Prasad J, Sharma RK, Tripathi RP. Radioprotection by himalayan high-altitude region plants. In: RK Sharma and R Arora ( Eds.), Herbal drugs: a twenty first century perspective, pp. 301–325. New Delhi, India: Jaypee Brothers Medical Publishers, 2006.
  • Arora R, Dhaker AS, Adhikari M, Sharma J, Chawla R, Kumar R, Sharma A, Gupta D, Prasad J, Singh S, Sinha AK, Puri SC, Qazi GN, Ahuja PS, Tripathi RP. Strengthening the armamentarium of Indian Defence Forces for Radiological/Nuclear Preparedness: potential of Radiation Countermeasure Agents of Natural Origin. In: Manas K. Mandal (Ed.), K. Ramachandran and A. Gupta (Associate Eds.), In service of the soldier: life sciences perspective, pp.72–96. New Delhi, India: (Macmillan Advanced Research Series), Macmillan, 2008.
  • Arora R, Dhaker AS, Gupta D, Chawla R, Adhikari M, Singh S, Sagar R, Kumar R, Sharma A, Sharma RK, Puri SC, Sultana S, Mathur AK, Qazi GN, Ahuja PS. Tripathi Natural bioresource of the North Himalayan region as a source of promising radiation countermeasure agents: lessons from Podophyllum hexandrum. In: JN Govil and VK Gupta ( Eds.), USA: Studium Press, (in press).
  • Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, Radioprotection by plant products: present status and future prospects. Phytother Res. 2005b;19:1–22.
  • Arora R, Sagar, R, Singh, S, Kumar, R, Sharma, AK, Prasad, J, Cytoprotective effect of Podophyllum hexandrum against gamma radiation is mediated via hemopoietic system stimulation and up-regulation of heme-oxygenase-1 and the prosurvival multidomain protein Bcl-2. Integrative Cancer Therapy. 2007;6:54–65.
  • Barcellos-Hoff MH, Park C, Wright, EG. Radiation and the microenvironment – tumorigenesis and therapy. Nat Rev Cancer. 2005;5:867–875.
  • Biaglow JE, Manevich Y, Uckun F, Held KD. Quantitation of hydroxyl radicals produced by radiation and copper-linked oxidation of ascorbate by 2-deoxy-D-ribose method. Free Radic Biol Med. 1997;22:1129–1138.
  • Burdelya, LG, Krivokrysenko, VI, Tallant, TC, Strom, E, Gleiberman, AS, Gupta, D, An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science. 2008;320:226–230.
  • Chawla R, Arora R, Kumar R, Sharma A, Prasad J, Singh S, Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protection. Mol Cell Biochem. 2005;273:193–208.
  • Chawla R, Arora R, Singh S, Sagar RK, Sharma RK, Kumar R, Podophyllum hexandrum offers radioprotection by modulating free radical flux: role of aryl-tetralin lignans. Evid Based Complement Alternat Med. 2006;3:503–511.
  • Chawla R, Arora R, Singh S, Sagar RK, Sharma RK, Kumar R, Radioprotective and antioxidant activity of fractionated extracts of berries of Hippophae rhamnoides. J Med Food. 2007;10:101–109.
  • Comporti M. Lipid peroxidation. Biopathological significance. Mol Aspects Med. 1993;14:199–207.
  • Ellnain-Wojtaszek M, Kruczynski Z, Kasprzak J. Investigation of the free radical scavenging activity of Ginkgo biloba L. leaves. Fitoterapia. 2003;74:1–6.
  • Garcia-Alonso M, Rimbach G, Rivas-Gonzalo JC, De Pascual-Teresa S. Antioxidant and cellular activities of anthocyanins and their corresponding vitisins A–studies in platelets, monocytes, and human endothelial cells. J Agric Food Chem. 2004;52:3378–3384.
  • Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol. 2005;99:165–178.
  • Graf E, Mahoney JR, Bryant RG, Eaton JW. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J Biol Chem. 1984;259:3620–3624.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126:131–138.
  • Gulcin I, Elmastas M, Aboul-Enein HY. Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. Phytother Res. 2007;21:354–361.
  • Gupta D, Arora R, Garg AP, Bala M, Goel HC. Modification of radiation damage to mitochondrial system in vivo by Podophyllum hexandrum: mechanistic aspects. Mol Cell Biochem. 2004;266:65–77.
  • Gupta D, Arora R, Garg AP, Goel HC. Radiation protection of HepG2 cells by Podophyllum hexandrum Royale. Mol Cell Biochem. 2003;250:27–40.
  • Halliwell B, Gutteridge JM, Aruoma OI. The deoxyribose method: a simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 1987;165:215–219.
  • Jagetia GC, Venkatesha VA, Reddy TK. Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. Mutagenesis. 2003;18:337–343.
  • Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Ind J BIophys Biochem. 1984;21:110–133.
  • Koc M, Taysi S, Emin Buyukokuroglu M, Bakan N. The effect of melatonin against oxidative damage during total-body irradiation in rats. Radiat Res. 2003;160:251–255.
  • Lerndal T, Svensson B. A clinical study of CPH 82 vs methotrexate in early rheumatoid arthritis. Rheumatology (Oxford). 2000;39:316–320.
  • May JM. Is ascorbic acid an antioxidant for the plasma membrane? Faseb J. 1999;13:995–1006.
  • Neta R, Oppenheim JJ. Radioprotection with cytokines: a clarification of terminology. Cancer Cells. 1991;3:457.
  • Prabhakar KR, Veerapur VP, Parihar KV, Priyadarsini KI, Rao BS, Unnikrishnan MK. Evaluation and optimization of radioprotective activity of Coronopus didymus Linn. in gamma-irradiated mice. Int J Radiat Biol. 2006;82:525–536.
  • Pugh N, Khan IA, Moraes RM, Pasco DS. Podophyllotoxin lignans enhance IL-1beta but suppress TNF-alpha mRNA expression in LPS-treated monocytes. Immunopharmacol Immunotoxicol. 2001;23:83–95.
  • Sagar RK, Chawla R, Arora R, Singh S, Krishna B, Sharma RK, Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damage. Planta Med. 2006;72:114–120.
  • Santini V. Amifostine: chemotherapeutic and radiotherapeutic protective effects. Expert Opin Pharmacother. 2001;2:479–489.
  • Seed TM. Radiation protectants: current status and future prospects. Health Phys. 2005;89:531–545.
  • Srour, Bilto YY, Juma M, Irhimeh MR. Exposure of human erythrocytes to oxygen radicals causes loss of deformability, increased osmotic fragility, lipid peroxidation and protein degradation. Clin Hemorheol Microcirc. 2000;23:13–21.
  • Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the Ocimum flavonoids orientin and vicenin: mechanisms of action. Radiat Res. 2000;154:455–460.
  • Velazquez E, Tournier HA, Mordujovich de Buschiazzo P, Saavedra G, Schinella GR. Antioxidant activity of Paraguayan plant extracts. Fitoterapia. 2003;74:91–97.
  • Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 2004;140:1037–1051.
  • Weiss JF, Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 2003;189:1–20.
  • Xiang Y, Wan XR, Sun ZJ, Yang XY. [Etopside, methotrexate, kengshengmycin/etopside, cisplatin chemotherapy for chemorefractory gestational trophoblastic tumour]. Zhonghua Fu Chan Ke Za Zhi. 2005;40:79–82.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.