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Research Article

An Evidence-Based Systematic Review of Cinnamon (Cinnamomum spp.) by the Natural Standard Research Collaboration

, PharmD, , PharmD, , MPH, , PhD, , BA, , BA, BS, , MS, , PhD, , PhD, , BA, , PhD, , BS, , BA, , PharmD & , MPH, PhD show all
Pages 378-454 | Published online: 03 Nov 2011

REFERENCES

  • WORKER'S compensation acts: permanence of cinnamon sensitivity. J Am Med Assoc. 1952;149(17):1596.
  • Seychelles. Backgr. Notes Ser. 1989;1–7.
  • Cinnamon linked to oral sores, irritation. J Am Dent Assoc. 1995;126(9):1214.
  • Application of gas-liquid chromatography to the analysis of essential oils. Part XVIII: Determination of safrole in oils of cinnamon leaf, Litsea cubeba, and nutmeg. Report by the Analytical Methods Committee. Analyst 2002;127(3):428–429.
  • NTP toxicology and carcinogenesis studies of trans-cinnamaldehyde (CAS No. 14371–10-9) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser. 2004;(514):1–281.
  • [Cinnamon to control blood sugar]. MMW Fortschr Med. 2004;146(48):12.
  • Is it true that cinnamon can lower blood sugar in people with diabetes? Mayo Clin Health Lett. 2007;25(4):8.
  • Abraham SK, Singh SP, Kesavan PC. In vivo antigenotoxic effects of dietary agents and beverages co-administered with urethane: assessment of the role of glutathione S-transferase activity. Mutat Res. 1998;413(2):103–110.
  • Ackermann L, Aalto-Korte K, Jolanki R, Alanko K. Occupational allergic contact dermatitis from cinnamon including one case from airborne exposure. Contact Dermatitis 2009;60(2):96–99.
  • Akira T, Tanaka S, Tabata M. Pharmacological studies on the antiulcerogenic activity of Chinese cinnamon. Planta Med. 1986;52(6):440–443.
  • Albin KC, Carstens MI, Carstens E. Modulation of oral heat and cold pain by irritant chemicals. Chem Senses 2008;33(1):3–15.
  • Allen CM, Blozis GG. Oral mucosal reactions to cinnamon-flavored chewing gum. J Am Dent Assoc. 1988;116(6):664–667.
  • Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813–816.
  • Amalaradjou MA, Hoagland TA, Venkitanarayanan K. Inactivation of Enterobacter sakazakii in reconstituted infant formula by trans-cinnamaldehyde. Int J Food Microbiol. 2009;129(2):146–149.
  • Ammon HP. [Cinnamon in type 2 diabetics]. Med Monatsschr Pharm. 2008;31(5):179–183.
  • Ananda, Baskaran S, Kazmer GW, Hinckley L, Andrew SM, Venkitanarayanan K. Antibacterial effect of plant-derived antimicrobials on major bacterial mastitis pathogens in vitro. J Dairy Sci. 2009;92(4):1423–1429.
  • Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008;67(1):48–53.
  • Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004;52(1):65–70.
  • Andrade EL, Luiz AP, Ferreira J, Calixto JB. Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience 2008;152(2):511–520.
  • Arfa AB, Preziosi-Belloy L, Chalier P, Gontard N. Antimicrobial paper based on a soy protein isolate or modified starch coating including carvacrol and cinnamaldehyde. J Agric Food Chem. 2007;55(6):2155–2162.
  • Atta AH, Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol 1998;60(2):117–124.
  • Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care 2008;31(1):41–43.
  • Balachandran, B, Sivaramkrishnan VM. Induction of tumours by Indian dietary constituents. Indian J Cancer 1995;32(3):104–109.
  • Ballabh B, Chaurasia OP, Ahmed Z, Singh SB. Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders. J Ethnopharmacol. 2008;118(2):331–339.
  • Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004;41(6):849–857.
  • Barceloux DG. Cinnamon (Cinnamomum species). Dis Mon. 2009;55(6):327–335.
  • Bartine H, Tantaoui-Elaraki A. Growth and toxigenesis of Aspergillus flavus isolates on selected spices. J Environ Pathol Toxicol Oncol. 1997;16(1):61–65.
  • Becerril R, Gomez-Lus R, Goni P, Lopez P, Nerin C. Combination of analytical and microbiological techniques to study the antimicrobial activity of a new active food packaging containing cinnamon or oregano against E. coli and S. aureus. Anal Bioanal Chem. 2007;388(5–6):1003–1011.
  • Berrio LF, Polansky MM, Anderson RA. Insulin activity: stimulatory effects of cinnamon and brewer's yeast as influenced by albumin. Horm Res. 1992;37(6):225–229.
  • Bhattacharjee S, Rana T, Sengupta A. Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev. 2007;8(4):578–582.
  • Biswas NR, Gupta SK, Das GK, Kumar N, Mongre PK, Haldar D, Beri S. Evaluation of Ophthacare eye drops –a herbal formulation in the management of various ophthalmic disorders. Phytother Res. 2001;15(7):618–620.
  • Blank DM, Mattes RD. Sugar and spice: similarities and sensory attributes. Nurs Res. 1990;39(5):290–293.
  • Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care 2007;30(9):2236–2237.
  • Blomhoff, R. [Antioxidants and oxidative stress]. Tidsskr Nor Laegeforen. 2004;124(12):1643–1645.
  • Blumenthal, Busse WR, Goldberg A, et al. Cinnamon bark. In: Blumenthal, Busse WR, Goldberg A, et al. (Eds.), The complete German Commission E monographs: therapeutic guide to herbal medicines, pp. 110–111. Austin, TX: American Botanical Council, 1998.
  • Boudry, G, Perrier C. Thyme and cinnamon extracts induce anion secretion in piglet small intestine via cholinergic pathways. J Physiol Pharmacol. 2008;59(3):543–552.
  • Bousquet PJ, Guillot B, Guilhou JJ, Raison-Peyron N. A stomatitis due to artificial cinnamon-flavored chewing gum. Arch. Dermatol. 2005;141(11):1466–1467.
  • Brackman G, Defoirdt T, Miyamoto C, Bossier P, Van Calenbergh S, Nelis H, Coenye T. Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiol. 2008;8:149.
  • Bradley R, Oberg EB, Calabrese C, Standish LJ. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med. 2007;13(1):159–175.
  • Brahmachari, S, Pahan K. Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis. J Immunol. 2007;179(1):275–283.
  • Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000;48(3):849–852.
  • Brophy GC, Mohandas J, Slaytor M, Sternhell S, Watson TR, Wilson LA. Novel lignans from a Cinnamomum sp. from Bougainville. Tetrahedron Lett. 1969;59:5159–5162.
  • Browder LW, Williamson JH. The effects of cinnamon on xanthine dehydrogenase, aldehyde oxidase, and pyridoxal oxidase activity during development in Drosophila melanogaster. Dev Biol 1976;53(2):241–249.
  • Buch JG, Dikshit RK, Mansuri SM. Effect of certain volatile oils on ejaculated human spermatozoa. Indian J Med Res. 1988;87:361–363.
  • Buchalter, L. Identification of polymeric 5,7,3′,4′-tetrahydroxyflavan-3,4-diol from tannin extract of powdered cassia bark, Saigon, cinnamon USP, Cinnamomum loureirii Nees, family Lauraceae. J Pharm Sci. 1971;60(1):144–145.
  • Buckley DA, Basketter DA, Smith Pease CK, Rycroft RJ, White IR, McFadden JP. Simultaneous sensitivity to fragrances. Br J Dermatol. 2006;154(5):885–888.
  • Burt S. Essential oils: their antibacterial properties and potential applications in foods –a review. Int J Food Microbiol. 2004;94(3):223–253.
  • Buyukbalci A, El SN. Determination of in vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas. Plant Foods Hum Nutr. 2008;63(1):27–33.
  • Cahusac PM, Noyce R. A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation. Neuroscience 2007;148(2):489–500.
  • Calnan CD. Cinnamon dermatitis from an ointment. Contact Dermatitis 1976;2(3):167–170.
  • Calsamiglia S, Busquet M, Cardozo PW, Castillejos L, Ferret A. Invited review: essential oils as modifiers of rumen microbial fermentation. J Dairy Sci. 2007;90(6):2580–2595.
  • Calucci L, Pinzino C, Zandomeneghi M, Capocchi A, Ghiringhelli S, Saviozzi F, Tozzi S, Galleschi L. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices. J Agric Food Chem 2003;51(4):927–934.
  • Camarasa JM. First epidemiological study of contact dermatitis in Spain - 1977. Spanish Contact Dermatitis Research Group. Acta Derm Venereol Suppl (Stockh). 1979;59(85):33–37.
  • Campbell TM, Neems R, Moore J. Severe exacerbation of rosacea induced by cinnamon supplements. J Drugs Dermatol. 2008;7(6):586–587.
  • Cao GY. [Prevention and treatment of oral candidiasis with cortex cinnamon solution]. Zhonghua Hu Li Za Zhi. 1993;28(12):711–712.
  • Cao H, Polansky MM, Anderson RA. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys. 2007;459(2):214–222.
  • Cao H, Urban JF, Jr., Anderson RA. Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. J Nutr. 2008;138(5):833–840.
  • Cardozo PW, Calsamiglia S, Ferret A, Kamel, C. Effects of natural plant extracts on ruminal protein degradation and fermentation profiles in continuous culture. J Anim Sci. 2004;82(11):3230–3236.
  • Cava R, Nowak E, Taboada A, Marin-Iniesta F. Antimicrobial activity of clove and cinnamon essential oils against Listeria monocytogenes in pasteurized milk. J Food Prot. 2007;70(12):2757–2763.
  • Cavier, R, Debelmas. [Anthelmintic properties of the essences of Ceylon cinnamon and of clove.]. Therapie 1950;5(3):140–143.
  • Cervenka L, Peskova I, Foltynova E, Pejchalova M, Brozkova I, Vytrasova J. Inhibitory effects of some spice and herb extracts against Arcobacter butzleri, A. cryaerophilus, and A. skirrowii. Curr Microbiol. 2006;53(5):435–439.
  • Cervenka L, Peskova I, Pejchalova M, Vytrasova J. Inhibition of Arcobacter butzleri, Arcobacter cryaerophilus, and Arcobacter skirrowii by plant oil aromatics. J Food Prot. 2008;71(1):165–169.
  • Chaigneau, M, Muraz B. [Decontamination of some spices by ethylene oxide. Development of 2-chloroethanol and ethylene glycol during the preservation]. Ann Pharm Fr. 1993;51(1):47–53.
  • Chang CW, Chang WL, Chang ST, Cheng SS. Antibacterial activities of plant essential oils against Legionella pneumophila. Water Res. 2008;42(1–2):278–286.
  • Chang KS, Tak JH, Kim SI, Lee WJ, Ahn YJ. Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions. Pest Manag Sci. 2006;62(11):1032–1038.
  • Chao LK, Hua KF, Hsu HY, Cheng SS, Lin IF, Chen CJ, Chen ST, Chang ST. Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem Toxicol. 2008;46(1):220–231.
  • Chao LK, Hua KF, Hsu HY, Cheng SS, Liu JY, Chang ST. Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. J Agric Food Chem 2005;53(18):7274–7278.
  • Charles AS, Baskaran SA, Murcott C, Schreiber D, Hoagland T, Venkitanarayanan K. Reduction of Escherichia coli O157:H7 in cattle drinking-water by trans-cinnamaldehyde. Foodborne Pathog Dis. 2008;5(6):763–771.
  • Chase CK, McQueen CE. Cinnamon in diabetes mellitus. Am J Health Syst Pharm. 2007;64(10):1033–1035.
  • Chen CH, Lo WL, Liu YC, Chen CY. Chemical and cytotoxic constituents from the leaves of Cinnamomum kotoense. J Nat Prod. 2006;69(6):927–933.
  • Chen CY, Chen CH, Lo YC, Wu BN, Wang HM, Lo WL, Yen CM, Lin RJ. Anticancer activity of isoobtusilactone A from Cinnamomum kotoense: involvement of apoptosis, cell-cycle dysregulation, mitochondria regulation, and reactive oxygen species. J Nat Prod. 2008;71(6):933–940.
  • Chen CY, Chen CH, Wong CH, Liu YW, Lin YS, Wang YD, Hsui YR. Cytotoxic constituents of the stems of Cinnamomum subavenium. J Nat Prod. 2007;70(1):103–106.
  • Chen CY, Hsu YL, Chen YY, Hung JY, Huang MS, Kuo PL. Isokotomolide A, a new butanolide extracted from the leaves of Cinnamomum kotoense, arrests cell cycle progression and induces apoptosis through the induction of p53/p21 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells. Eur J Pharmacol. 2007;574(2–3):94–102.
  • Chen CY, Liu TZ, Chen CH, Wu CC, Cheng JT, Yiin SJ, Shih MK, Wu MJ, Chern CL. Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms. Food Chem Toxicol. 2007;45(7):1268–1276.
  • Chen FC, Peng CF, Tsai IL, Chen IS. Antitubercular constituents from the stem wood of Cinnamomum kotoense. J Nat Prod. 2005;68(9):1318–1323.
  • Chen JF, Chen GX, Li XJ, Quan SM, Zeng YY, Hu YJ, Huang KE, Liu XL. [Effect of overall alkali of Tongbiling on CD69 expression activated mouse T lymphocytes]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003;19(1):93–94.
  • Chen, Y. [Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system]. Zhong Yao Tong Bao. 1981;6(5):32–34.
  • Chen Y, Ma Y, Ma W. Pharmacokinetics and bioavailability of cinnamic acid after oral administration of ramulus Cinnamomi in rats. Eur J Drug Metab Pharmacokinet. 2009;34(1):51–56.
  • Cheng SS, Liu JY, Hsui YR, Chang ST. Chemical polymorphism and antifungal activity of essential oils from leaves of different provenances of indigenous cinnamon (Cinnamomum osmophloeum). Bioresour Technol. 2006;97(2):306–312.
  • Cheng SS, Liu JY, Huang CG, Hsui YR, Chen WJ, Chang ST. Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species. Bioresour Technol. 2009;100(1):457–464.
  • Cheng SS, Liu JY, Lin CY, Hsui YR, Lu MC, Wu WJ, Chang ST. Terminating red imported fire ants using Cinnamomum osmophloeum leaf essential oil. Bioresour Technol. 2008;99(4):889–893.
  • Cheng SS, Liu JY, Tsai KH, Chen WJ, Chang ST. Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. J Agric Food Chem 2004;52(14):4395–4400.
  • Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. J Agric Food Chem 2005;53(12):4762–4765.
  • Chi AC, Ravenel MC. AAOMP case challenge: a “speckled” lesion. J Contemp Dent Pract. 2005;6(1):168–172.
  • Chipley JR, Uraih N. Inhibition of Aspergillus growth and aflatoxin release by derivatives of benzoic acid. Appl Environ Microbiol. 1980;40(2):352–357.
  • Chohan M, Forster-Wilkins G, Opara EI. Determination of the antioxidant capacity of culinary herbs subjected to various cooking and storage processes using the ABTS(*+) radical cation assay. Plant Foods Hum Nutr. 2008;63(2):47–52.
  • Choi J, Lee KT, Ka H, Jung WT, Jung HJ, Park HJ. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res. 2001;24(5):418–423.
  • Chua MT, Tung YT, Chang ST. Antioxidant activities of ethanolic extracts from the twigs of Cinnamomum osmophloeum. Bioresour Technol. 2008;99(6):1918–1925.
  • Clark L, Shivik J. Aerosolized essential oils and individual natural product compounds as brown treesnake repellents. Pest Manag Sci. 2002;58(8):775–783.
  • Cloyd RA, Galle CL, Keith SR, Kalscheur NA, Kemp KE. Effect of commercially available plant-derived essential oil products on arthropod pests. J Econ Entomol. 2009;102(4):1567–1579.
  • Cohen DM, Bhattacharyya I. Cinnamon-induced oral erythema multiforme-like sensitivity reaction. J Am Dent Assoc 2000;131(7):929–934.
  • Conner DE, Beuchat LR. Sensitivity of heat-stressed yeasts to essential oils of plants. Appl Environ Microbiol. 1984;47(2):229–233.
  • Corren J, Lemay M, Lin Y, Rozga L, Randolph RK. Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. Nutr J. 2008;7:20.
  • Cox SD, Markham JL. Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compounds. J Appl Microbiol. 2007;103(4):930–936.
  • Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22(5):507–512.
  • Cuong NM, Taylor WC, Sung VT. A new cyclobutane lignan from Cinnamomum balansae. Nat Prod Lett. 2001;15(5):331–338.
  • Danneman PJ, Booman KA, Dorsky J, Kohrman KA, Rothenstein AS, Sedlak RI, Steltenkamp RJ, Thompson GR. Cinnamic aldehyde: a survey of consumer patch-test sensitization. Food Chem Toxicol. 1983;21(6):721–725.
  • Dannemann K, Hecker W, Haberland H, Herbst A, Galler A, Schafer T, Brahler E, Kiess W, Kapellen TM. Use of complementary and alternative medicine in children with type 1 diabetes mellitus –prevalence, patterns of use, and costs. Pediatr Diabetes 2008;9(3 Pt 1):228–235.
  • De M, De AK, Banerjee AB. Antimicrobial screening of some Indian spices. Phytother Res. 1999;13(7):616–618.
  • De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40(3):165.
  • De Luis DA, Aller R, Romero E. [Cinnamon as possible treatment of diabetes mellitus type 2]. Med Clin (Barc.) 2008;131(7):279.
  • De Silva HV, Shankel DM. Effects of the antimutagen cinnamaldehyde on reversion and survival of selected Salmonella tester strains. Mutat Res. 1987;187(1):11–19.
  • Decapite TJ, Anderson BE. Allergic contact dermatitis from cinnamic aldehyde found in an industrial odour-masking agent. Contact Dermatitis 2004;51(5–6):312–313.
  • Delbressine LP, Klippert PJ, Reuvers JT, Seutter-Berlage F. Identification of two sulphur containing urinary metabolites of cinnamic aldehyde in the rat [proceedings]. Br J Pharmacol. 1980;68(1):165P.
  • Delbressine LP, Klippert PJ, Reuvers JT, Seuttler-Berlage F. Isolation and identification of mercapturic acids of cinnamic aldehyde and cinnamyl alcohol from urine of female rats. Arch Toxicol. 1981;49(1):57–64.
  • Dhuley JN. Anti-oxidant effects of cinnamon (Cinnamomum verum) bark and greater cardamom (Amomum subulatum) seeds in rats fed high-fat diet. Indian J Exp Biol. 1999;37(3):238–242.
  • Di Pasqua R, Betts G, Hoskins N, Edwards M, Ercolini D,Mauriello G. Membrane toxicity of antimicrobial compounds from essential oils. J Agric Food Chem. 2007;55(12):4863–4870.
  • Diba VC, Statham BN. Contact urticaria from cinnamal leading to anaphylaxis. Contact Dermatitis 2003;48(2):119.
  • Didry N, Dubreuil L, Pinkas M. [Antibacterial activity of thymol, carvacrol and cinnamaldehyde alone or in combination]. Pharmazie 1993;48(4):301–304.
  • Domadia P, Swarup S, Bhunia A, Sivaraman J, Dasgupta D. Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde. Biochem Pharmacol. 2007;74(6):831–840.
  • Dong L, Gordon VA, Grange RL, Johns J, Parsons PG, Porzelle A, Reddell P, Schill H, Williams CM. Structure and absolute stereochemistry of the anticancer agent EBC-23 from the Australian rainforest. J Am Chem Soc. 2008;130(46):15262–15263.
  • Dong L, Schill H, Grange RL, Porzelle A, Johns JP, Parsons PG, Gordon VA, Reddell PW, Williams CM. Anticancer agents from the Australian tropical rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76. Chemistry 2009 Oct 26;15(42):11307–11318.
  • Dooms-Goossens A, Dubelloy R, Degreef H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89–93.
  • Double KL, Rowe DB, Hayes M, Chan DK, Blackie J, Corbett A, Joffe R, Fung VS, Morris J, Halliday GM. Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test. Arch Neurol. 2003;60(4):545–549.
  • Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr. 2003;133(5):1286–1290.
  • Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112(2):202–203.
  • Du ZQ, Zhou ZM, Xiong YL, Zhao X, Li JH, Wu YH. [Pharmacodynamical research of Jingu Tongxiao granule]. Zhongguo Zhong Yao Za Zhi. 2004;29(8):796–799, 818.
  • Duan J, Zhao Y. Antimicrobial efficiency of essential oil and freeze-thaw treatments against Escherichia coli O157:H7 and Salmonella enterica Ser. Enteritidis in strawberry juice. J Food Sci. 2009;74(3):M131–M137.
  • Dudonne S, Vitrac X, Coutiere P, Woillez M, Merillon JM. Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. J Agric Food Chem. 2009.
  • Duessel S, Heuertz RM, Ezekiel UR. Growth inhibition of human colon cancer cells by plant compounds. Clin Lab Sci. 2008;21(3):151–157.
  • Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol. 2007;85(9):837–847.
  • Dunham JP, Kelly S, Donaldson LF. Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci. 2008;27(12):3151–3160.
  • Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 2008;4:48.
  • Elahi EN, Wright Z, Hinselwood D, Hotchkiss SA, Basketter DA, Pease CK. Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds. Chem Res Toxicol. 2004;17(3):301–310.
  • Elshafie AE, Al Rashdi TA, Al Bahry SN, Bakheit CS. Fungi and aflatoxins associated with spices in the Sultanate of Oman. Mycopathologia 2002;155(3):155–160.
  • Endo H, Rees TD. Clinical features of cinnamon-induced contact stomatitis. Compend Contin Educ Dent. 2006;27(7):403–409.
  • Endo H, Rees TD. Cinnamon products as a possible etiologic factor in orofacial granulomatosis. Med Oral Patol Oral Cir Bucal. 2007;12(6):E440–E444.
  • Epstein FW. Contact dermatitis due to cinnamon. Ohio Med 1950;46(7):659.
  • European Scientific Cooperative on Phytotherapy (ESCOP). Cinnamomi cortex. ESCOP Monographs, 2nd ed., Exeter: ESCOP, 2003, pp. 92–97.
  • Fabio A, Cermelli C, Fabio G, Nicoletti P, Quaglio P. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Phytother Res. 2007;21(4):374–377.
  • Fairman KA, Curtiss FR. Call for comparative effectiveness research: lowering A1C with sitagliptin, saxagliptin, or cinnamon. J Manag Care Pharm. 2009;15(8):696–700.
  • Fang SH, Rao YK, Tzeng YM. Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages. Bioorg Med Chem. 2005;13(7):2381–2388.
  • Farkas J. Perioral dermatitis from marjoram, bay leaf and cinnamon. Contact Dermatitis 1981;7(2):121.
  • Feng GP, Zhang SD, Yi NY. [Effects of Rehmannia glutinosa, Plastrum testudinis, Aconitum carmichaeli and Cinnamomum cassia on the beta-adrenergic receptors of hyperthyroid rat kidneys]. Zhong Xi Yi Jie He Za Zhi. 1986;6(10):606–608, 582.
  • Fergurson J, Sharma S. Cinnamic aldehyde test concentrations. Contact Dermatitis 1984;10(3):191–192.
  • Ferme D, Banjac M, Calsamiglia S, Busquet M, Kamel C, Avgustin G. The effects of plant extracts on microbial community structure in a rumen-simulating continuous-culture system as revealed by molecular profiling. Folia Microbiol. (Praha) 2004;49(2):151–155.
  • Ferme D, Malnersic M, Lipoglavsek L, Kamel C, Avgustin G. Effect of sodium monensin and cinnamaldehyde on the growth and phenotypic characteristics of Prevotella bryantii and Prevotella ruminicola. Folia Microbiol. (Praha) 2008;53(3):204–208.
  • Filoche SK, Soma K, Sissons CH. Antimicrobial effects of essential oils in combination with chlorhexidine digluconate. Oral Microbiol Immunol. 2005;20(4):221–225.
  • Fink RC, Roschek B, Alberte RS. HIV type-1 entry inhibitors with a new mode of action. Antivir Chem Chemother. 2009;19(6):243–255.
  • Fisher AA, Dooms-Goossens A. The effect of perfume “ageing” on the allergenicity of individual perfume ingredients. Contact Dermatitis 1976;2(3):155–159.
  • Foti C, Bonamonte D, Conserva A, Stingeni L, Lisi P, Lionetti N, Rigano L, Angelini G. Allergic and photoallergic contact dermatitis from ketoprofen: evaluation of cross-reactivities by a combination of photopatch testing and computerized conformational analysis. Curr Pharm Des. 2008;14(27):2833–2839.
  • Fowles J, Mitchell J, McGrath H. Assessment of cancer risk from ethylene oxide residues in spices imported into New Zealand. Food Chem Toxicol. 2001;39(11):1055–1062.
  • Friedman M, Buick R, Elliott CT. Antibacterial activities of naturally occurring compounds against antibiotic-resistant Bacillus cereus vegetative cells and spores, Escherichia coli, and Staphylococcus aureus. J Food Prot. 2004;67(8):1774–1778.
  • Friedman M, Henika PR, Levin CE, Mandrell RE. Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice. J Agric Food Chem. 2004;52(19):6042–6048.
  • Friedman M, Henika PR, Mandrell RE. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. J Food Prot. 2002;65(10):1545–1560.
  • Friedman M, Kozukue N, Harden LA. Cinnamaldehyde content in foods determined by gas chromatography-mass spectrometry. J Agric Food Chem. 2000;48(11):5702–5709.
  • Fujita, S. [Miscellaneous contributions to the essential oils of plants from various territories: XLVII. On the components of essential oils of Cinnamomum sieboldii Meisn]. Yakugaku Zasshi 1986;106(1):17–21.
  • Fundaro A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375–2380.
  • Fuselli SR, Garcia De La Rosa SB, Gende LB, Eguaras MJ, Fritz R. [Inhibition of Paenibacillus larvae employing a mixture of essential oils and thymol]. Rev Argent Microbiol. 2006;38(2):89–92.
  • Futrell JM, Rietschel RL. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288–290.
  • Garcia-Abujeta JL, de Larramendi CH, Berna JP, Palomino EM. Mud bath dermatitis due to cinnamon oil. Contact Dermatitis 2005;52(4):234.
  • Gardeta, P. [Consequences of the discovery of America on nutrition: the introduction of new foods in Europe]. Rev Med Chil. 1999;127(1):101–109.
  • Gill AO, Holley RA. Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei. Appl Environ Microbiol. 2004;70(10):5750–5755.
  • Giordani R, Regli P, Kaloustian J, Portugal H. Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia. Phytother Res. 2006;20(1):58–61.
  • Girardin P, Vigan M, Humbert P, Aubin F. Cross-reactions in patch testing with ketoprofen, fragrance mix and cinnamic derivatives. Contact Dermatitis 2006;55(2):126–128.
  • Goh CL, Ng SK. Bullous contact allergy from cinnamon. Derm Beruf Umwelt. 1988;36(6):186–187.
  • Gollhausen R, Kligman AM. Human assay for identifying substances which induce non-allergic contact urticaria: the NICU-test. Contact Dermatitis 1985;13(2):98–106.
  • Gong F, Liang YZ, Fung YS. Analysis of volatile components from cortex Cinnamomi with hyphenated chromatography and chemometric resolution. J Pharm Biomed Anal. 2004;34(5):1029–1047.
  • Gowder SJ, Devaraj H. Effect of the food flavour cinnamaldehyde on the antioxidant status of rat kidney. Basic Clin Pharmacol Toxicol. 2006;99(5):379–382.
  • Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P. Transient receptor potential A1 (TRPA1) activity in the human urethra –evidence for a functional role for TRPA1 in the outflow region. Eur Urol. 2009;55(3):696–704.
  • Gu L, Kelm MA, Hammerstone JF, Zhang Z, Beecher G, Holden J, Haytowitz D, Prior RL. Liquid chromatographic/electrospray ionization mass spectrometric studies of proanthocyanidins in foods. J Mass Spectrom. 2003;38(12):1272–1280.
  • Guin JD, Meyer BN, Drake RD, Haffley P. The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. J Am Acad Dermatol. 1984;10(1):45–51.
  • Guo JY, Huo HR, Zhao BS, Liu HB, Li LF, Guo SY, Jiang TL. Effect of 3-phenyl-2-propene-1-ol on PGE2 release from rat cerebral microvascular endothelial cells stimulated by IL-1beta. Am J Chin Med. 2006;34(4):685–693.
  • Gutierrez L, Escudero A, Batlle R, Nerin C. Effect of mixed antimicrobial agents and flavors in active packaging films. J Agric Food Chem. 2009;57(18):8564–8571.
  • Guynot ME, Ramos AJ, Seto L, Purroy P, Sanchis V, Marin S. Antifungal activity of volatile compounds generated by essential oils against fungi commonly causing deterioration of bakery products. J Appl Microbiol. 2003;94(5):893–899.
  • Ha KT, Kim JK, Kang SK, Kim DW, Lee YC, Kim HM, Kim CH. Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma. Pharmacol Res. 2004;50(3):279–285.
  • Haasch ML, Ford AW. Combined effects of ethanol and cinnamaldehyde in the Japanese medaka embryo-larval assay (MELA). Mar Environ Res. 2004;58(2–5):175–179.
  • Hafez HM, Hauck R. Efficacy of a herbal product against Histomonas meleagridis after experimental infection of turkey poults. Arch Anim Nutr. 2006;60(5):436–442.
  • Harada M, Fujii Y, Kamiya J. Pharmacological studies on chinese cinnamon: III. Electroencephalographic studies of cinnamaldehyde in the rabbit. Chem Pharm Bull. (Tokyo) 1976;24(8):1784–1788.
  • Harada M, Hirayama Y, Yamazaki R. Pharmacological studies on Chinese cinnamon: V. Catecholamine releasing effect of cinnamaldehyde in dogs. J Pharmacobiodyn. 1982;5(8):539–546.
  • Haranaka K, Satomi N, Sakurai A, Haranaka R, Okada N, Kobayashi M. Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs. Cancer Immunol Immunother. 1985;20(1):1–5.
  • Haring JI. Case #5. Cinnamon-induced stomatitis. RDH 1993;13(5):12, 50.
  • Hartmann K, Hunzelmann N. Allergic contact dermatitis from cinnamon as an odour-neutralizing agent in shoe insoles. Contact Dermatitis 2004;50(4):253–254.
  • Hasan HA. Alternaria mycotoxins in black rot lesion of tomato fruit: conditions and regulation of their production. Acta Microbiol Immunol Hung. 1996;43(2–3):125–133.
  • Hasani-Ranjbar S, Larijani B, Abdollahi M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allergy Drug Targets. 2009;8(1):2–10.
  • Hasegawa A, Yoshino M, Nakamura H, Ishii I, Watanabe T, Kiuchi M, Ishikawa T, Ohmori S, Kitada M. Identification of inhibitory component in cinnamon–O-methoxycinnamaldehyde inhibits CYP1A2 and CYP2E1. Drug Metab Pharmacokinet. 2002;17(3):229–236.
  • Haslbeck F, Senser F, Grosch W. [Detection of low lipase activities in food]. Z Lebensm Unters Forsch. 1985;181(4):271–275.
  • Hatch GG, Anderson TM, Lubet RA, Kouri RE, Putman DL, Cameron JW, Nims RW, Most B, Spalding JW, Tennant RW. Chemical enhancement of SA7 virus transformation of hamster embryo cells: evaluation by interlaboratory testing of diverse chemicals. Environ Mutagen. 1986;8(4):515–531.
  • Hayashi K, Imanishi N, Kashiwayama Y, Kawano A, Terasawa K, Shimada Y, Ochiai H. Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. Antiviral Res. 2007;74(1):1–8.
  • He ZD, Qiao CF, Han QB, Cheng CL, Xu HX, Jiang RW, But PP, Shaw PC. Authentication and quantitative analysis on the chemical profile of cassia bark (cortex Cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem. 2005;53(7):2424–2428.
  • Hernandez-Herrero LA, Giner MJ, Valero M. Effective chemical control of psychrotrophic Bacillus cereus EPSO-35AS and INRA TZ415 spore outgrowth in carrot broth. Food Microbiol. 2008;25(5):714–721.
  • Hersch-Martinez P, Leanos-Miranda BE, Solorzano-Santos F. Antibacterial effects of commercial essential oils over locally prevalent pathogenic strains in Mexico. Fitoterapia 2005;76(5):453–457.
  • Hitokoto H, Morozumi S, Wauke T, Sakai S, Ueno I. Inhibitory effects of condiments and herbal drugs on the growth and toxin production of toxigenic fungi. Mycopathologia 1979;66(3):161–167.
  • Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007;85(6):1552–1556.
  • Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009;89(3):815–821.
  • Ho SC, Tsai TH, Tsai PJ, Lin CC. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem Toxicol. 2008;46(3):920–928.
  • Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol. 2002;83(1–2):153–159.
  • Hong SH, Kim J, Kim JM, Lee SY, Shin DS, Son KH, Han DC, Sung YK, Kwon BM. Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. Biochem Pharmacol. 2007;74(4):557–565.
  • Hoskins JA. The occurrence, metabolism and toxicity of cinnamic acid and related compounds. J Appl Toxicol. 1984;4(6):283–292.
  • Hoskyn J, Guin JD. Contact allergy to cinnamal in a patient with oral lichen planus. Contact Dermatitis 2005;52(3):160–161.
  • Hsieh TJ, Liu TZ, Lu FJ, Hsieh PY, Chen CH. Actinodaphnine induces apoptosis through increased nitric oxide, reactive oxygen species and down-regulation of NF-kappaB signaling in human hepatoma Mahlavu cells. Food Chem Toxicol. 2006;44(3):344–354.
  • Hsieh TJ, Lu LH, Su CC. NMR spectroscopic, mass spectroscopic, X-ray crystallographic, and theoretical studies of molecular mechanics of natural products: farformolide B and sesamin. Biophys Chem. 2005;114(1):13–20.
  • Huang J, Wang S, Luo X, Xie Y, Shi X. Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents. Thromb Res. 2007;119(3):337–342.
  • Hurlimann AF, Wuthrich B. [Eating cinnamon in cinnamaldehyde allergy]. Hautarzt 1995;46(9):660–661.
  • Huss U, Ringbom T, Perera P, Bohlin L, Vasange M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002;65(11):1517–1521.
  • Hussain RA, Kim J, Hu TW, Pezzuto JM, Soejarto DD, Kinghorn AD. Isolation of a highly sweet constituent from Cinnamomum osmophloeum leaves. Planta Med 1986;(5):403–404.
  • Hwang SH, Choi YG, Jeong MY, Hong YM, Lee JH, Lim S. Microarray analysis of gene expression profile by treatment of Cinnamomi ramulus in lipopolysaccharide-stimulated BV-2 cells. Gene 2009;443(1–2):83–90.
  • Idle JR. Christmas gingerbread (Lebkuchen) and Christmas cheer –review of the potential role of mood elevating amphetamine-like compounds formed in vivo and in furno. Prague Med Rep. 2005;106(1):27–38.
  • Ikawati Z, Wahyuono S, Maeyama K. Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells. J Ethnopharmacol 2001;75(2–3):249–256.
  • Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, Graves DJ. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm Res. 1998;50(3):177–182.
  • Inouye S, Takizawa T, Yamaguchi H. Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. J Antimicrob Chemother. 2001;47(5):565–573.
  • Inouye S, Yamaguchi H, Takizawa T. Screening of the antibacterial effects of a variety of essential oils on respiratory tract pathogens, using a modified dilution assay method. J Infect Chemother. 2001;7(4):251–254.
  • Ishidate M, Jr., Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol. 1984;22(8):623–636.
  • Iwasaki Y, Tanabe M, Kobata K, Watanabe T. TRPA1 agonists –allyl isothiocyanate and cinnamaldehyde –induce adrenaline secretion. Biosci Biotechnol Biochem. 2008;72(10):2608–2614.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1–12.
  • Jantan I, Rafi IA, Jalil J. Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine 2005;12(1–2):88–92.
  • Janzowski C, Glaab V, Mueller C, Straesser U, Kamp HG, Eisenbrand G. Alpha,beta-unsaturated carbonyl compounds: induction of oxidative DNA damage in mammalian cells. Mutagenesis 2003;18(5):465–470.
  • Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001;20(4):327–336.
  • Jayaprakasha GK, Jagan Mohan, Rao L, Sakariah KK. Chemical composition of the flower oil of Cinnamomum zeylanicum Blume. J Agric Food Chem. 2000;48(9):4294–4295.
  • Jayaprakasha GK, Jagan Mohan, Rao L, Sakariah KK. Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. J Agric Food Chem. 2003;51(15):4344–4348.
  • Jayaprakasha GK, Ohnishi-Kameyama M, Ono H, Yoshida M, Jaganmohan, Rao L. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. J Agric Food Chem. 2006;54(5):1672–1679.
  • Jayaprakasha GK, Rao LJ, Sakariah KK. Chemical composition of volatile oil from Cinnamomum zeylanicum buds. Z Naturforsch. [C.] 2002;57(11–12):990–993.
  • Jeong HW, Han DC, Son KH, Han MY, Lim JS, Ha JH, Lee CW, Kim HM, Kim HC, Kwon BM. Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase. Biochem Pharmacol. 2003;65(8):1343–1350.
  • Josimovic L, Cudina I. Spectrophotometric analysis of irradiated spices. Int J Rad Appl Instrum. [A] 1987;38(4):269–274.
  • Juneja VK, Friedman M. Carvacrol, cinnamaldehyde, oregano oil, and thymol inhibit Clostridium perfringens spore germination and outgrowth in ground turkey during chilling. J Food Prot. 2007;70(1):218–222.
  • Ka H, Park HJ, Jung HJ, Choi JW, Cho KS, Ha J, Lee KT. Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancer Lett. 2003;196(2):143–152.
  • Kada T, Inoue T, Ohta T, Shirasu Y. Antimutagens and their modes of action. Basic Life Sci. 1986;39:181–196.
  • Kada T, Shirasu Y, Ikekawa N, Nomoto M. Detection of natural bio-antimutagens and in vivo and in vitro analysis of their action. Prog Clin Biol Res. 1986;209A:385–393.
  • Kamath JV, Rana AC, Chowdhury AR. Pro-healing effect of Cinnamomum zeylanicum bark. Phytother Res. 2003;17(8):970–972.
  • Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T. The effect of a traditional Chinese prescription for a case of lung carcinoma. J Altern Complement Med. 2000;6(6):557–559.
  • Kanari M, Tomoda M, Gonda R, Shimizu N, Kimura M, Kawaguchi M, Kawabe C. A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia. Chem Pharm Bull. (Tokyo) 1989;37(12):3191–3194.
  • Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35(3):157–162.
  • Kannappan S, Jayaraman T, Rajasekar P, Ravichandran MK, Anuradha CV. Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat. Singapore Med J. 2006;47(10):858–863.
  • Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr. 2009;139(3):482–487.
  • Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol. 2003;84(1):105–108.
  • Kasamaki A, Urasawa S. Transforming potency of flavoring agents in Chinese hamster cells. J Toxicol Sci. 1985;10(3):177–185.
  • Kern AB. Contact dermatitis from cinnamon. Arch Dermatol. 1960;81:599–600.
  • Khan A, Bryden NA, Polansky MM, Anderson RA. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem Res 1990;24(3):183–188.
  • Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26(12):3215–3218.
  • Kiec-Swierczynska M, Krecisz B, Swierczynska-Machura D. [Allergy to cosmetics: I. Fragrances]. Med Pract. 2004;55(2):203–206.
  • Kim DH, Kim CH, Kim MS, Kim JY, Jung KJ, Chung JH, An WG, Lee JW, Yu BP, Chung HY. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 2007;8(5):545–554.
  • Kim DS, Kim JY, Han YS. Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1–42) insult. J Altern Complement Med. 2007;13(3):333–340.
  • Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26(3):209–219.
  • Kim SI, Kim HK, Koh YY, Clark JM, Ahn YJ. Toxicity of spray and fumigant products containing cassia oil to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Pest Manag Sci. 2006;62(8):768–774.
  • Kim SI, Yi JH, Tak JH, Ahn YJ. Acaricidal activity of plant essential oils against Dermanyssus gallinae (Acari: Dermanyssidae). Vet Parasitol. 2004;120(4):297–304.
  • Kim SJ, Han D, Moon KD, Rhee JS. Measurement of superoxide dismutase-like activity of natural antioxidants. Biosci Biotechnol Biochem. 1995;59(5):822–826.
  • Kim W, Khil LY, Clark R, Bok SH, Kim EE, Lee S, Jun HS, Yoon JW. Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4. Diabetologia 2006;49(10):2437–2448.
  • Kind F, Scherer K, Bircher AJ. Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. Allergy 2009.
  • King AA, Shaughnessy DT, Mure K, Leszczynska J, Ward WO, Umbach DM, Xu Z, Ducharme D, Taylor JA, Demarini DM, Klein CB. Antimutagenicity of cinnamaldehyde and vanillin in human cells: global gene expression and possible role of DNA damage and repair. Mutat Res. 2007;616(1–2):60–69.
  • Kirton V. Contact urticaria and cinnamic aldehyde. Contact Dermatitis 1978;4(6):374–375.
  • Kirton V, Wilkinson DS. Sensitivity to cinnamic aldehyde in a toothpaste: 2. Further studies. Contact Dermatitis 1975;1(2):77–80.
  • Kleefstra N, Logtenberg SJ, Houweling ST, Verhoeven S, Bilo HJ. [Cinnamon: not suitable for the treatment of diabetes mellitus]. Ned Tijdschr Geneeskd. 2007;151(51):2833–2837.
  • Knight KP, McKellar RC. Influence of cinnamon and clove essential oils on the D- and z-values of Escherichia coli O157:H7 in apple cider. J Food Prot. 2007;70(9):2089–2094.
  • Koh WS, Yoon SY, Kwon BM, Jeong TC, Nam KS, Han MY. Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation. Int J Immunopharmacol. 1998;20(11):643–660.
  • Koller WD. [The importance of temperature on storage of ground natural spices]. Z Lebensm Unters Forsch. 1976;160(2):143–147.
  • Kong B, Wang J, Xiong YL. Antimicrobial activity of several herb and spice extracts in culture medium and in vacuum-packaged pork. J Food Prot. 2007;70(3):641–647.
  • Kong JO, Lee SM, Moon YS, Lee SG, Ahn YJ. Nematicidal activity of cassia and cinnamon oil compounds and related compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae). J Nematol. 2007;39(1):31–36.
  • Kong LD, Cai Y, Huang WW, Cheng CH, Tan RX. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J Ethnopharmacol. 2000;73(1–2):199–207.
  • Kong YH, Jo YO, Cho CW, Son D, Park S, Rho J, Choi SY. Inhibitory effects of cinnamic acid on melanin biosynthesis in skin. Biol Pharm Bull. 2008;31(5):946–948.
  • Kosugi M, Nakatsuka T, Fujita T, Kuroda Y, Kumamoto E. Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. J Neurosci. 2007;27(16):4443–4451.
  • Kovalenko S, Belenichev I, Nikitin V, Karpenko A. Search for substances with antioxidant and antiamnestic activities among 2-substituted 4-(3H)-quinazolones. Acta Pol Pharm. 2003;60(4):275–279.
  • Kreydiyyeh SI, Usta J, Copti R. Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum. Food Chem Toxicol. 2000;38(9):755–762.
  • Kuo PL, Chen CY, Tzeng TF, Lin CC, Hsu YL. Involvement of reactive oxygen species/c-Jun NH(2)-terminal kinase pathway in kotomolide A induces apoptosis in human breast cancer cells. Toxicol Appl Pharmacol. 2008;229(2):215–226.
  • Kuo SY, Hsieh TJ, Wang YD, Lo WL, Hsui YR, Chen CY. Cytotoxic constituents from the leaves of Cinnamomum subavenium. Chem Pharm Bull. (Tokyo) 2008;56(1):97–101.
  • Kuo YC, Lu CK, Huang LW, Kuo YH, Chang C, Hsu FL, Lee TH. Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. Planta Med. 2005;71(5):412–415.
  • Kurokawa M, Kumeda CA, Yamamura J, Kamiyama T, Shiraki K. Antipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected mice. Eur J Pharmacol. 1998;348(1):45–51.
  • Kwon BM, Lee SH, Choi SU, Park SH, Lee CO, Cho YK, Sung ND, Bok SH. Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells. Arch Pharm Res. 1998;21(2):147–152.
  • Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer Lett. 2009;278(2):174–182.
  • Kwon JA, Yu CB, Park HD. Bacteriocidal effects and inhibition of cell separation of cinnamic aldehyde on Bacillus cereus. Lett Appl Microbiol. 2003;37(1):61–65.
  • Lahti A. Terfenadine does not inhibit non-immunologic contact urticaria. Contact Dermatitis 1987;16(4):220–223.
  • Lahti A, Maibach HI. An animal model for nonimmunologic contact urticaria. Toxicol Appl Pharmacol. 1984;76(2):219–224.
  • Lahti A, Maibach HI. Species specificity of nonimmunologic contact urticaria: guinea pig, rat, and mouse. J Am Acad Dermatol. 1985;13(1):66–69.
  • Lahti A, McDonald DM, Tammi R, Maibach HI. Pharmacological studies on nonimmunologic contact urticaria in guinea pigs. Arch Dermatol Res. 1986;279(1):44–49.
  • Lahti A, Vaananen A, Kokkonen EL, Hannuksela M. Acetylsalicylic acid inhibits non-immunologic contact urticaria. Contact Dermatitis 1987;16(3):133–135.
  • Lai PK, Roy J. Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem 2004;11(11):1451–1460.
  • Lamey PJ, Lewis MA, Rees TD, Fowler C, Binnie WH, Forsyth A. Sensitivity reaction to the cinnamonaldehyde component of toothpaste. Br Dent J. 1990;168(3):115–118.
  • Larsen WG. Perfume dermatitis. J Am Acad Dermatol. 1985;12(1 Pt 1):1–9.
  • Lazarus SA, Adamson GE, Hammerstone JF, Schmitz HH. High-performance liquid chromatography/mass spectrometry analysis of proanthocyanidins in foods and beverages. J Agric Food Chem. 1999;47(9):3693–3701.
  • Lee CW, Hong DH, Han SB, Park SH, Kim HK, Kwon BM, Kim HM. Inhibition of human tumor growth by 2′-hydroxy- and 2′-benzoyloxycinnamaldehydes. Planta Med. 1999;65(3):263–266.
  • Lee EJ, Kim JR, Choi DR, Ahn YJ. Toxicity of cassia and cinnamon oil compounds and cinnamaldehyde-related compounds to Sitophilus oryzae (Coleoptera: Curculionidae). J Econ Entomol. 2008;101(6):1960–1966.
  • Lee HS. Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase. J Pharm Pharm Sci. 2002;5(3):226–230.
  • Lee HS, Kim BS, Kim MK. Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase. J Agric Food Chem. 2002;50(26):7700–7703.
  • Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, Choi MS. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food. 2003;6(3):183–191.
  • Lee JY, Kang HS, Park BE, Moon HJ, Sim SS, Kim CJ. Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis. J Ethnopharmacol. 2009;126:244–251.
  • Lee KG, Shibamoto T. Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J Agric Food Chem. 2002;50(17):4947–4952.
  • Lee KK, Kim JH, Cho JJ, Choi JD. Inhibitory effects of 150 plant extracts on elastase activity and their anti-inflammatory effects. Int J Cosmet Sci. 1999;21(2):71–82.
  • Lee R, Balick MJ. Sweet wood –cinnamon and its importance as a spice and medicine. Explore. (NY) 2005;1(1):61–64.
  • Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, Oh KW, Han DC, Kwon BM, Hong JT. Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol. 2005;69(5):791–799.
  • Leifer W. Contact dermatitis due to cinnamon: recurrence of dermatitis following oral administration of cinnamon oil. AMA Arch Derm Syphilol. 1951;64(1):52–55.
  • Li CH, Zhou J, Huo HR, Kang XL, Jiang TL. [Effect of guizhi tang and its active components on the fever induced by EP3 agonist]. Zhongguo ZhongYao Za Zhi. 2003;28(11):1056–1060.
  • Li TJ, Qiu Y, Mao JQ, Yang PY, Rui YC, Chen WS. Protective effects of Guizhi-Fuling capsules on rat brain ischemia/reperfusion injury. J Pharmacol Sci. 2007;105(1):34–40.
  • Li XR, Liang YZ, Li XN. [Analysis of essential oil in Herba ephedrae-ramulus Cinnamomi by GC-MS and chemometric resolution method]. Yao Xue Xue Bao 2007;42(2):187–191.
  • Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS. Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol. 2008;229(2):161–171.
  • Lijinsky W, Andrews AW. Mutagenicity of vinyl compounds in Salmonella typhimurium. Teratog Carcinog Mutagen. 1980;1(3):259–267.
  • Lima EO, Gompertz OF, Giesbrecht AM, Paulo MQ. In vitro antifungal activity of essential oils obtained from officinal plants against dermatophytes. Mycoses 1993;36(9–10):333–336.
  • Lin CC, Wu SJ, Chang CH, Ng LT. Antioxidant activity of Cinnamomum cassia. Phytother Res. 2003;17(7):726–730.
  • Lin CT, Chen CJ, Lin TY, Tung JC, Wang SY. Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. Bioresour Technol. 2008;99(18):8783–8787.
  • Lin RJ, Cheng MJ, Huang JC, Lo WL, Yeh YT, Yen CM, Lu CM, Chen CY. Cytotoxic compounds from the stems of Cinnamomum tenuifolium. J Nat Prod. 2009;72:1816–1824.
  • Lin RJ, Lo WL, Wang YD, Chen CY. A novel cytotoxic monoterpenoid from the leaves of Cinnamomum subavenium. Nat Prod Res. 2008;22(12):1055–1059.
  • Lirussi D, Li J, Prieto JM, Gennari M, Buschiazzo H, Rios JL, Zaidenberg A. Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine. Fitoterapia 2004;75(7–8):718–723.
  • Liu CH, Mishra AK, Tan RX, Tang C, Yang H, Shen YF. Repellent and insecticidal activities of essential oils from Artemisia princeps and Cinnamomum camphora and their effect on seed germination of wheat and broad bean. Bioresour Technol. 2006;97(15):1969–1973.
  • Liu HY, Li WY, Hao TG, Gao HY, Ma Y. [Quantitative study of effects of cinnamaldehyde on levels of endotoxin in root canals in rats’ periapical periodontitis model]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2007;25(3):233–236.
  • Liu TZ, Cheng JT, Yiin SJ, Chen CY, Chen CH, Wu MJ, Chern CL. Isoobtusilactone A induces both caspase-dependent and -independent apoptosis in Hep G2 cells. Food Chem Toxicol. 2008;46(1):321–327.
  • Llewellyn GC, Burkett ML, Eadie T. Potential mold growth, aflatoxin production, and antimycotic activity of selected natural spices and herbs. J Assoc Off Anal Chem. 1981;64(4):955–960.
  • Lockwood GB. Phenylpropanoids from a Nigerian sample of Cinnamomum cassia [proceedings]. J Pharm Pharmacol. 1979;31(Suppl):8P.
  • Lopez P, Sanchez C, Batlle R, Nerin C. Development of flexible antimicrobial films using essential oils as active agents. J Agric Food Chem. 2007;55(21):8814–8824.
  • Lopez P, Sanchez C, Batlle R, Nerin C. Vapor-phase activities of cinnamon, thyme, and oregano essential oils and key constituents against foodborne microorganisms. J Agric Food Chem. 2007;55(11):4348–4356.
  • Ludera-Zimoch, G. [Case of urticaria with immediate local and generalized reaction to cinnamon oil and benzaldehyde]. Przegl Dermatol. 1981;68(1):67–70.
  • Lungarini S, Aureli F, Coni E. Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural chemical hazard? Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25(11):1297–1305.
  • Luo H, Lin S, Ren F, Wu L, Chen L, Sun Y. Antioxidant and antimicrobial capacity of Chinese medicinal herb extracts in raw sheep meat. J Food Prot. 2007;70(6):1440–1445.
  • Mabrouk SS, El Shayeb NM. Inhibition of aflatoxin formation by some spices. Z Lebensm Unters Forsch. 1980;171(5):344–347.
  • MacDonald S, Castle L. A UK retail survey of aflatoxins in herbs and spices and their fate during cooking. Food Addit Contam. 1996;13(1):121–128.
  • Magnusson B, Wilkinson DS. Cinnamic aldehyde in toothpaste: 1. Clinical aspects and patch tests. Contact Dermatitis 1975;1(2):70–76.
  • Maibach HI. Cheilitis: occult allergy to cinnamic aldehyde. Contact Dermatitis 1986;15(2):106–107.
  • Maisey J, Miller K. Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers. Contact Dermatitis 1986;15(1):17–23.
  • Majeti VA, Suskind RR. Mechanism of cinnamaldehyde sensitization. Contact Dermatitis 1977;3(1):16–18.
  • Malten KE, van Ketel WG, Nater JP, Liem DH. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis 1984;11(1):1–10.
  • Mancini-Filho J, Van Koiij A, Mancini DA, Cozzolino FF, Torres RP. Antioxidant activity of cinnamon (Cinnamomum zeylanicum Breyne) extracts. Boll Chim Farm. 1998;137(11):443–447.
  • Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006;36(5):340–344.
  • Manzanilla EG, Perez JF, Martin M, Kamel C, Baucells F, Gasa J. Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. J Anim Sci. 2004;82(11):3210–3218.
  • Maralhas A, Monteiro A, Martins C, Kranendonk M, Laires A, Rueff J, Rodrigues AS. Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol. Mutagenesis 2006;21(3):199–204.
  • Margineanu DG, Katona E, Popa J. Kinetics of nerve impulse blocking by protein cross-linking aldehydes: apparent critical thermal points. Biochim Biophys Acta 1981;649(3):581–586.
  • Marongiu B, Piras A, Porcedda S, Tuveri E, Sanjust E, Meli M, Sollai F, Zucca P, Rescigno A. Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity. J Agric Food Chem. 2007;55(24):10022–10027.
  • Martin KW, Ernst E. Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials. J Antimicrob Chemother. 2003;51(2):241–246.
  • Marzulli FN, Maibach HI. Effects of vehicles and elicitation concentration in contact dermatitis testing: I. Experimental contact sensitization in humans. Contact Dermatitis 1976;2(6):325–329.
  • Marzulli FN, Maibach HI. Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans. Contact Dermatitis 1980;6(2):131–133.
  • Mastura M, Nor Azah MA, Khozirah S, Mawardi R, Manaf AA. Anticandidal and antidermatophytic activity of Cinnamomum species essential oils. Cytobios 1999;98(387):17–23.
  • Mathew S, Abraham TE. In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies. Food Chem Toxicol. 2006;44(2):198–206.
  • Mathias CG, Chappler RR, Maibach HI. Contact urticaria from cinnamic aldehyde. Arch Dermatol. 1980;116(1):74–76.
  • Matsuda H, Matsuda R, Fukuda S, Shiomoto H, Kubo M. Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from cinnamomi cortex. Chem Pharm Bull. (Tokyo) 1987;35(3):1275–1280.
  • Mayaud L, Carricajo A, Zhiri A, Aubert G. Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics. Lett Appl Microbiol. 2008;47(3):167–173.
  • McCarty MF. Nutraceutical resources for diabetes prevention –an update. Med Hypotheses 2005;64(1):151–158.
  • McCarty MF. Toward prevention of Alzheimers disease –potential nutraceutical strategies for suppressing the production of amyloid beta peptides. Med Hypotheses 2006;62(3):139–48.
  • McKemy DD. How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain 2005;1(1):16.
  • Meding B. Skin symptoms among workers in a spice factory. Contact Dermatitis 1993;29(4):202–205.
  • Merrill AW, Cuellar JM, Judd JH, Carstens MI, Carstens E. Effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar spinal wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats. J Neurophysiol. 2008;99(2):415–425.
  • Mi ZG, Liu SX, Cao YQ, Yang XF. [Adjustive effect of yi qi tong lin chongji on the three growth factors in rats prostatic tissues]. Zhongguo Zhong Yao Za Zhi. 2003;28(7):653–655.
  • Mihail RC. Oral leukoplakia caused by cinnamon food allergy. J Otolaryngol. 1992;21(5):366–367.
  • Miller RL, Gould AR, Bernstein ML. Cinnamon-induced stomatitis venenata: clinical and characteristic histopathologic features. Oral Surg Oral Med Oral Pathol 1992;73(6):708–716.
  • Mino Y, Ota N. Inorganic chemical approaches to pharmacognosy: V. X-ray fluorescence spectrometric studies on the inorganic constituents of crude drugs. Chem Pharm Bull. (Tokyo) 1990;38(3):709–713.
  • Mishra AK, Mishra A, Kehri HK, Sharma B, Pandey AK. Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvularia lunata, the pathogenic dematiaceous moulds. Ann Clin Microbiol Antimicrob. 2009;8:9.
  • Miyazawa M, Hashimoto Y, Taniguchi Y, Kubota K. Headspace constituents of the tree remain of Cinnamomum camphora. Nat Prod Lett. 2001;15(1):63–69.
  • Moon EY, Lee MR, Wang AG, Lee JH, Kim HC, Kim HM, Kim JM, Kwon BM, Yu DY. Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes. Eur J Pharmacol. 2006;530(3):270–275.
  • Moon KH, Pack MY. Cytotoxicity of cinnamic aldehyde on leukemia L1210 cells. Drug Chem Toxicol. 1983;6(6):521–535.
  • Morozumi S. Isolation, purification, and antibiotic activity of o-methoxycinnamaldehyde from cinnamon. Appl Environ Microbiol. 1978;36(4):577–583.
  • Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res. 2009;42(1):93–98.
  • Moskaug JO, Borge GI, Fagervoll AM, Paur I, Carlsen H, Blomhoff R. Dietary polyphenols identified as intracellular protein kinase A inhibitors. Eur J Nutr. 2008;47(8):460–469.
  • Mosqueda-Melgar J, Raybaudi-Massilia RM, Martin-Belloso O. Combination of high-intensity pulsed electric fields with natural antimicrobials to inactivate pathogenic microorganisms and extend the shelf-life of melon and watermelon juices. Food Microbiol. 2008;25(3):479–491.
  • Mosqueda-Melgar J, Raybaudi-Massilia RM, Martin-Belloso O. Inactivation of Salmonella enterica Ser. Enteritidis in tomato juice by combining of high-intensity pulsed electric fields with natural antimicrobials. J Food Sci. 2008;73(2):M47–M53.
  • Murcia MA, Egea I, Romojaro F, Parras P, Jimenez AM, Martinez-Tome M. Antioxidant evaluation in dessert spices compared with common food additives: influence of irradiation procedure. J Agric Food Chem. 2004;52(7):1872–1881.
  • Nadiminti H, Ehrlich A, Udey MC. Oral erosions as a manifestation of allergic contact sensitivity to cinnamon mints. Contact Dermatitis 2005;52(1):46–47.
  • Nagai H, Shimazawa T, Matsuura N, Koda A. Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq): I. Anti-allergic action. Jpn J Pharmacol. 1982;32(5):813–822.
  • Nagai H, Shimazawa T, Takizawa T, Koda A, Yagi A, Nishioka I. Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq): II. Effect of CCAq on experimental glomerulonephritis. Jpn J Pharmacol. 1982;32(5):823–831.
  • Nahas R, Moher M. Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam Physician 2009;55(6):591–596.
  • Nair S, Nagar R, Gupta R. Antioxidant phenolics and flavonoids in common Indian foods. J Assoc Physicians India 1998;46(8):708–710.
  • Namer B, Kleggetveit IP, Handwerker H, Schmelz M, Jorum E. Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury. Pain 2008;139(1):63–72.
  • Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, Braun A, Undem BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol. 2008;586(6):1595–1604.
  • Nater JP, De Jong MC, Baar AJ, Bleumink E. Contact urticarial skin responses to cinnamaldehyde. Contact Dermatitis 1977;3(3):151–154.
  • Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006;164(9):898–906.
  • Ngoc TM, Lee I, Ha, do T, Kim H, Min B, Bae K. Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia. J Nat Prod. 2009;72(6):1205–1208.
  • Nguyen SH, Dang TP, MacPherson C, Maibach H, Maibach HI. Prevalence of patch test results from 1970 to 2002 in a multi-centre population in North America (NACDG). Contact Dermatitis 2008;58(2):101–106.
  • Niinimaki A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34–40.
  • Niinimaki A. Double-blind placebo-controlled peroral challenges in patients with delayed-type allergy to balsam of Peru. Contact Dermatitis 1995;33(2):78–83.
  • Nir Y, Potasman I, Stermer E, Tabak M, Neeman I. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter 2000;5(2):94–97.
  • Nishida S, Kikuichi S, Yoshioka S, Tsubaki M, Fujii Y, Matsuda H, Kubo M, Irimajiri K. Induction of apoptosis in HL-60 cells treated with medicinal herbs. Am J Chin Med. 2003;31(4):551–562.
  • Niu C, Afre S, Gilbert ES. Subinhibitory concentrations of cinnamaldehyde interfere with quorum sensing. Lett Appl Microbiol. 2006;43(5):489–494.
  • Niu C, Gilbert ES. Colorimetric method for identifying plant essential oil components that affect biofilm formation and structure. Appl Environ Microbiol. 2004;70(12):6951–6956.
  • Nixon R. Cinnamon allergy in a baker. Australas J Dermatol. 1995;36(1):41.
  • Noonan V, Kemp S. Cinnamon stomatitis. J Mass Dent Soc. 2007;56(3):43.
  • Nozawa K, Kawabata-Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, Sano Y, Inamura K, Matsushime H, Koizumi T, Yokoyama T, Ito H. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci USA 2009;106(9):3408–3413.
  • Nuryastuti T, van der Mei HC, Busscher HJ, Iravati S, Aman AT, Krom BP. Effect of cinnamon oil on icaA expression and biofilm formation by Staphylococcus epidermidis. Appl Environ Microbiol. 2009;75:6850–6855.
  • O'Keefe JH, Gheewala NM, O'Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol. 2008;51(3):249–255.
  • Obaidat MM, Frank JF. Inactivation of Salmonella and Escherichia coli O157:H7 on sliced and whole tomatoes by allyl isothiocyanate, carvacrol, and cinnamaldehyde in vapor phase. J Food Prot. 2009;72(2):315–324.
  • Ohta T, Watanabe K, Moriya M, Shirasu Y, Kada T. Analysis of the antimutagenic effect of cinnamaldehyde on chemically induced mutagenesis in Escherichia coli. Mol Gen Genet. 1983;192(3):309–315.
  • Ohta T, Watanabe K, Moriya M, Shirasu Y, Kada T. Antimutagenic effects of cinnamaldehyde on chemical mutagenesis in Escherichia coli. Mutat Res. 1983;107(2):219–227.
  • Okawa M, Kinjo J, Nohara T, Ono M. DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants. Biol Pharm Bull. 2001;24(10):1202–1205.
  • Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol. 1999;51(11):1305–1312.
  • Orihara Y, Hamamoto H, Kasuga H, Shimada T, Kawaguchi Y, Sekimizu K. A silkworm baculovirus model for assessing the therapeutic effects of antiviral compounds: characterization and application to the isolation of antivirals from traditional medicines. J Gen Virol. 2008;89(Pt 1):188–194.
  • Osawa K, Matsumoto T, Yasuda H, Kato T, Naito Y, Okuda K. The inhibitory effect of plant extracts on the collagenolytic activity and cytotoxicity of human gingival fibroblasts by Porphyromonas gingivalis crude enzyme. Bull Tokyo Dent Coll. 1991;32(1):1–7.
  • Oussalah M, Caillet S, Salmieri S, Saucier L, Lacroix M. Antimicrobial effects of alginate-based film containing essential oils for the preservation of whole beef muscle. J Food Prot. 2006;69(10):2364–2369.
  • Oussalah M, Caillet S, Salmieri S, Saucier L, Lacroix M. Antimicrobial effects of alginate-based films containing essential oils on Listeria monocytogenes and Salmonella typhimurium present in bologna and ham. J Food Prot. 2007;70(4):901–908.
  • Panickar KS, Polansky MM, Anderson RA. Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells. Exp Neurol. 2009;216(2):420–427.
  • Patton DW, Ferguson MM, Forsyth A, James J. Oro-facial granulomatosis: a possible allergic basis. Br J Oral Maxillofac Surg. 1985;23(4):235–242.
  • Pauli A, Knobloch K. Inhibitory effects of essential oil components on growth of food-contaminating fungi. Z Lebensm Unters Forsch. 1987;185(1):10–13.
  • Perry PA, Dean BS, Krenzelok EP. Cinnamon oil abuse by adolescents. Vet Hum Toxicol. 1990;32(2):162–164.
  • Perry TL, Yong VW, Clavier RM, Jones K, Wright JM, Foulks JG, Wall RA. Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse. Neurosci Lett. 1985;60(2):109–114.
  • Peterson DW, George RC, Scaramozzino F, LaPointe NE, Anderson RA, Graves DJ, Lew J. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis. 2009;17:585–597.
  • Pham AQ, Kourlas H, Pham DQ. Cinnamon supplementation in patients with type 2 diabetes mellitus. Pharmacotherapy 2007;27(4):595–599.
  • Pilapil VR. Toxic manifestations of cinnamon oil ingestion in a child. Clin Pediatr. (Phila.) 1989;28(6):276.
  • Pina-Perez MC, Silva-Angulo AB, Muguerza-Marquinez B, Aliaga DR, Lopez AM. Synergistic effect of high hydrostatic pressure and natural antimicrobials on inactivation kinetics of Bacillus cereus in a liquid whole egg and skim milk mixed beverage. Foodborne Pathog Dis. 2009;6(6):649–656.
  • Placzek M, Fromel W, Eberlein B, Gilbertz KP, Przybilla B. Evaluation of phototoxic properties of fragrances. Acta Derm Venereol. 2007;87(4):312–316.
  • Prabuseenivasan S, Jayakumar M, Ignacimuthu S. In vitro antibacterial activity of some plant essential oils. BMC Complement Altern Med 2006;6:39.
  • Prakash D, Suri S, Upadhyay G, Singh BN. Total phenol, antioxidant and free radical scavenging activities of some medicinal plants. Int J Food Sci Nutr. 2007;58(1):18–28.
  • Prasad NS, Raghavendra R, Lokesh BR, Naidu KA. Spice phenolics inhibit human PMNL 5-lipoxygenase. Prostaglandins Leukot Essent Fatty Acids 2004;70(6):521–528.
  • Premanathan M, Rajendran S, Ramanathan T, Kathiresan K, Nakashima H, Yamamoto N. A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity. Indian J Med Res 2000;112:73–77.
  • Preuss HG, Echard B, Polansky MM, Anderson R. Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr. 2006;25(2):144–150.
  • Pumbwe L, Skilbeck CA, Wexler HM. Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents. J Antimicrob Chemother. 2007;60(6):1288–1297.
  • Qidwai W, Alim SR, Dhanani RH, Jehangir S, Nasrullah A, Raza A. Use of folk remedies among patients in Karachi, Pakistan. J Ayub Med Coll. Abbottabad 2003;15(2):31–33.
  • Qin B, Dawson H, Polansky MM, Anderson RA. Cinnamon extract attenuates TNF-alpha-induced intestinal lipoprotein ApoB48 overproduction by regulating inflammatory, insulin, and lipoprotein pathways in enterocytes. Horm Metab Res. 2009;41(7):516–522.
  • Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract. 2003;62(3):139–148.
  • Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm. Metab Res. 2004;36(2):119–125.
  • Qin B, Polansky MM, Sato Y, Adeli K, Anderson RA. Cinnamon extract inhibits the postprandial overproduction of apolipoprotein B48-containing lipoproteins in fructose-fed animals. J Nutr Biochem. 2009;20(11):901–908.
  • Quale JM, Landman D, Zaman MM, Burney S, Sathe SS. In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med. 1996;24(2):103–109.
  • Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part–II. Indian J Physiol Pharmacol. 1975;19(1): 47–49.
  • Rao CV, Vijayakumar M, Sairam K, Kumar V. Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats. Nat Med. (Tokyo) 2008;62(4):396–402.
  • Rao YK, Fang SH, Tzeng YM. Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J Ethnopharmacol. 2007;114(1):78–85.
  • Rastogi SC, Johansen JD, Frosch P, Menne T, Bruze M, Lepoittevin JP, Dreier B, Andersen KE, White IR. Deodorants on the European market: quantitative chemical analysis of 21 fragrances. Contact Dermatitis 1998;38(1):29–35.
  • Ravishankar S, Zhu L, Law B, Joens L, Friedman M. Plant-derived compounds inactivate antibiotic-resistant Campylobacter jejuni strains. J Food Prot. 2008;71(6):1145–1149.
  • Ravishankar S, Zhu L, Olsen CW, McHugh TH, Friedman M. Edible apple film wraps containing plant antimicrobials inactivate foodborne pathogens on meat and poultry products. J Food Sci. 2009;74(8):M440–M445.
  • Raybaudi-Massilia RM, Mosqueda-Melgar J, Martin-Belloso O. Edible alginate-based coating as carrier of antimicrobials to improve shelf-life and safety of fresh-cut melon. Int J Food Microbiol. 2008;121(3):313–327.
  • Raybaudi-Massilia RM, Rojas-Grau MA, Mosqueda-Melgar J, Martin-Belloso O. Comparative study on essential oils incorporated into an alginate-based edible coating to assure the safety and quality of fresh-cut Fuji apples. J Food Prot. 2008;71(6):1150–1161.
  • Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min KR, Kim Y. Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med. 2004;70(9):823–827.
  • Reiter M, Brandt W. Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneimittelforschung 1985;35(1A):408–414.
  • Rodriguez M, Alvarez M, Zayas M. [Microbiological quality of spices consumed in Cuba]. Rev Latinoam Microbiol. 1991;33(2–3):149–151.
  • Roffey B, Atwal A, Kubow S. Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. Mol Nutr Food Res. 2006;50(8):739–745.
  • Rojas-Grau MA, Avena-Bustillos RJ, Friedman M, Henika PR, Martin-Belloso O, McHugh TH. Mechanical, barrier, andantimicrobial properties of apple puree edible films containing plant essential oils. J Agric Food Chem. 2006;54(24):9262–9267.
  • Romaguera C, Grimalt F. Sensitization to cinnamic aldehyde in toothpaste. Contact Dermatitis 1978;4(6):377–378.
  • Roselli M, Britti MS, Huerou-Luron I, Marfaing H, Zhu WY, Mengheri E. Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic Escherichia coli K88 in pig intestinal cells. Toxicol In Vitro 2007;21(2):224–229.
  • Rosti L, Gastaldi G. Chronic salmonellosis and cinnamon. Pediatrics 2005;116(4):1057.
  • Rosti L, Gastaldi G, Frigiola A. Cinnamon and bacterial enteric infections. Indian J Pediatr. 2008;75(5):529–530.
  • Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr. 2009;28(1):16–21.
  • Rudkowska I. Functional foods for health: focus on diabetes. Maturitas 2009;62(3):263–269.
  • Rudzki E, Grzywa Z. [Value of a cinnamon and citronellyl oil mixture for the detection of allergy to perfumes]. Przegl Dermatol. 1982;69(1–2):33–38.
  • Saeki Y, Ito Y, Shibata M, Sato Y, Okuda K, Takazoe I. Antimicrobial action of natural substances on oral bacteria. Bull Tokyo Dent Coll. 1989;30(3):129–135.
  • Sainio EL, Kanerva L. Contact allergens in toothpastes and a review of their hypersensitivity. Contact Dermatitis 1995;33(2):100–105.
  • Sakai S, Harada M, Morishita I, Kikuchi T. [Relation between the combination among the chief components of ephedra, Chinese cinnamon, Japanese apricot seeds and their pharmacological actions.]. Yakugaku Zasshi 1964;84:183–187.
  • Salam TN, Fowler JF, Jr. Balsam-related systemic contact dermatitis. J Am Acad Dermatol. 2001;45(3):377–381.
  • Salmieri S, Lacroix M. Physicochemical properties of alginate/polycaprolactone-based films containing essential oils. J Agric Food Chem 2006;54(26):10205–10214.
  • Sambaiah K, Srinivasan K. Influence of spices and spice principles on hepatic mixed function oxygenase system in rats. Indian J Biochem Biophys 1989;26(4):254–258.
  • Sambaiah K, Srinivasan K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Nahrung 1991;35(1):47–51.
  • Samuelsen OB, Brenna J, Solheim E, Scheline RR. Metabolism of the cinnamon constituent o-methoxycinnamaldehyde in the rat. Xenobiotica 1986;16(9):845–852.
  • Sanchez-Perez J, Garcia-Diez A. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Contact Dermatitis 1999;41(6):346–347.
  • Sato K, Krist S, Buchbauer G. Antimicrobial effect of trans-cinnamaldehyde, (-)-perillaldehyde, (-)-citronellal, citral, eugenol and carvacrol on airborne microbes using an airwasher. Biol Pharm Bull. 2006;29(11):2292–2294.
  • Scheidegger UA, Fluck CE, Scheidegger K, Diem P, Mullis PE. [Role of complementary medicine in type 1 diabetes mellitus in two Swiss centres]. Praxis (Bern) 2009;98(18):1001–1005.
  • Schirmer BC, Heiberg R, Eie T, Moretro T, Maugesten T, Carlehog M, Langsrud S. A novel packaging method with a dissolving CO(2) headspace combined with organic acids prolongs the shelf life of fresh salmon. Int J Food Microbiol. 2009;133(1–2):154–160.
  • Schnuch A, Lessmann H, Geier J, Frosch PJ, Uter, W. Contact allergy to fragrances: frequencies of sensitization from 1996 to 2002. Results of the IVDK*. Contact Dermatitis 2004;50(2):65–76.
  • Schoene NW, Kelly MA, Polansky MM, Anderson RA. Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines. Cancer Lett. 2005;230(1):134–140.
  • Schoene NW, Kelly MA, Polansky MM, Anderson RA. A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest. J Nutr Biochem. 2009;20(8):614–620.
  • Schorr WF. Cinnamic aldehyde allergy. Contact Dermatitis 1975;1(2):108–111.
  • Schubert HJ. Skin diseases in workers at a perfume factory. Contact Dermatitis 2006;55(2):81–83.
  • Schwab AH, Harpestad AD, Swartzentruber A, Lanier JM, Wentz BA, Duran AP, Barnard RJ, Read RB, Jr. Microbiological quality of some spices and herbs in retail markets. Appl Environ Microbiol. 1982;44(3):627–630.
  • Schwartz RH. Cinnamon oil: kids use it to get high. Clin Pediatr. (Phila.) 1990;29(3):196.
  • Scully C. Reaction to cinnamon. Br Dent J. 2006;201(8):489.
  • Sedghizadeh PP, Allen CM. White plaque of the lateral tongue. J Contemp Dent Pract. 2002;3(3):46–50.
  • Sekizawa J, Shibamoto T. Genotoxicity of safrole-related chemicals in microbial test systems. Mutat Res. 1982;101(2):127–140.
  • Senhaji O, Faid M, Kalalou I. Inactivation of Escherichia coli O157:H7 by essential oil from Cinnamomum zeylanicum. Braz J Infect Dis. 2007;11(2):234–236.
  • Senma M, Fujiwara N, Sasaki S, Toyama M, Sakaguchi K, Takaoka I. Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals. Acta Derm Venereol. 1978;58(2):121–124.
  • Seo UK, Lee YJ, Kim JK, Cha BY, Kim DW, Nam KS, Kim CH. Large-scale and effective screening of Korean medicinal plants for inhibitory activity on matrix metalloproteinase-9. J Ethnopharmacol. 2005;97(1):101–106.
  • Shah AH, Al Shareef AH, Ageel AM, Qureshi S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods Hum Nutr. 1998;52(3):231–239.
  • Shahverdi AR, Monsef-Esfahani HR, Tavasoli F, Zaheri A, Mirjani R. Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro. J Food Sci. 2007;72(1):S055–S058.
  • Shakila RJ, Vasundhara TS, Rao DV. Inhibitory effect of spices on in vitro histamine production and histidine decarboxylase activity of Morganella morganii and on the biogenic amine formation in mackerel stored at 30 degrees C. Z Lebensm Unters Forsch. 1996;203(1):71–76.
  • Shan B, Cai YZ, Brooks JD, Corke H. Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria. J Agric Food Chem. 2007;55(14):5484–5490.
  • Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem. 2005;53(20):7749–7759.
  • Shan BE, Yoshida Y, Sugiura T, Yamashita U. Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. Int J Immunopharmacol. 1999;21(3):149–159.
  • Shan R, Lee KJ, Kwon BM, Lee CH. Protein binding characteristics of 2′-benzoyloxycinnamaldehyde. Drug Dev Ind Pharm. 2005;31(6):545–549.
  • Sharififar F, Moshafi MH, Dehghan-Nudehe G, Ameri A, Alishahi F, Pourhemati A. Bioassay screening of the essential oil and various extracts from 4 spices medicinal plants. Pak J Pharm Sci. 2009;22(3):317–322.
  • Sharma N, Trikha P, Athar M, Raisuddin S. Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia. Mutat Res 2001;480–481:179–188.
  • Shaughnessy DT, Schaaper RM, Umbach DM, Demarini DM. Inhibition of spontaneous mutagenesis by vanillin and cinnamaldehyde in Escherichia coli: dependence on recombinational repair. Mutat Res. 2006;602(1–2):54–64.
  • Shen LR, Li HY, Zhou YG, Gu S, Lou YG. [Ovicidal activity of nine essential oils against Chrysomya megacephara in bacon and kipper]. Ying Yong Sheng Tai Xue Bao. 2007;18(10):2343–2346.
  • Shen Q, Chen F, Luo J. [Comparison studies on chemical constituents of essential oil from ramulus Cinnamomi and cortex Cinnamomi by GC-MS]. Zhong Yao Cai. 2002;25(4):257–258.
  • Shen YC, Chou CJ, Wang YH, Chen CF, Chou YC, Lu MK. Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiol Lett. 2004;231(1):137–143.
  • Shimada Y, Goto H, Kogure T, Kohta K, Shintani T, Itoh T, Terasawa K. Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells. Phytother Res. 2000;14(6):466–468.
  • Shimada Y, Yokoyama K, Goto H, Sekiya N, Mantani N, Tahara E, Hikiami H, Terasawa K. Protective effect of keishi-bukuryo-gan and its constituent medicinal plants against nitric oxide donor-induced neuronal death in cultured cerebellar granule cells. Phytomedicine 2004;11(5):404–410.
  • Shin DS, Kim J, Han DC, Son KH, Lee CW, Kim HM, Hong SH, Kwon BM. Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents. Bioorg Med Chem Lett. 2007;17(19):5423–5427.
  • Shobana S, Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins Leukot Essent Fatty Acids 2000;62(2):107–110.
  • Si W, Gong J, Chanas C, Cui S, Yu H, Caballero C, Friendship RM. In vitro assessment of antimicrobial activity of carvacrol, thymol and cinnamaldehyde towards Salmonella serotype Typhimurium DT104: effects of pig diets and emulsification in hydrocolloids. J Appl Microbiol. 2006;101(6):1282–1291.
  • Simic A, Sokovic MD, Ristic M, Grujic-Jovanovic S, Vukojevic J, Marin PD. The chemical composition of some Lauraceae essential oils and their antifungal activities. Phytother Res. 2004;18(9):713–717.
  • Singh G, Maurya S, DeLampasona MP, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food ChemToxicol. 2007;45(9):1650–1661.
  • Smith-Palmer A, Stewart J, Fyfe L. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Lett Appl Microbiol. 1998;26(2):118–122.
  • Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007;9(6):895–901.
  • Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009;105(6):969–976.
  • Sparks T. Cinnamon oil burn. West J Med. 1985;142(6):835.
  • Speer F. Food allergy: the 10 common offenders. Am Fam Physician 1976;13(2):106–112.
  • Stager J, Wuthrich B, Johansson SG. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475–478.
  • Strauss RM, Orton DI. Allergic contact cheilitis in the United Kingdom: a retrospective study. Am J Contact Dermat. 2003;14(2):75–77.
  • Su MJ, Chen WP, Lo TY, Wu TS. Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart. J Biomed Sci. 1999;6(6):376–386.
  • Subash, Babu P, Prabuseenivasan S, Ignacimuthu S. Cinnamaldehyde –a potential antidiabetic agent. Phytomedicine 2007;14(1):15–22.
  • Subehan, Usia T, Iwata H, Kadota S, Tezuka Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 2006;105(3):449–455.
  • Subehan S, Kadota S, Tezuka Y. In vitro mechanism-based inactivation of cytochrome P450 3A4 by a new constituent of Cinnamomum burmani. Planta Med. 2008;74(12):1474–1480.
  • Suganthi R, Rajamani S, Ravichandran MK, Anuradha CV. Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. J Med Food 2007;10(1):149–153.
  • Sui Y, Qiu D, Xie C, Chen K. [Observation of antiarrhythmic effects of Cinnamomum migao H. W. Li on experimental arrhythmia]. Zhongguo Zhong Yao Za Zhi. 1998;23(8):495–497.
  • Sun WS, Imai A, Tagami K, Sugiyama M, Furui T, Tamaya T. In vitro stimulation of granulosa cells by a combination of different active ingredients of unkei-to. Am J Chin Med. 2004;32(4):569–578.
  • Sun X, Sui Y, Qiu D. [Influence of Cinnamomum migao H.W. Li oil on hemodynamic action in anesthetized cats]. Zhongguo Zhong.Yao Za Zhi. 1995;20(10):622–624.
  • Suppapitiporn S, Kanpaksi N, Suppapitiporn S. The effect of Cinnamon cassia powder in type 2 diabetes mellitus. J Med Assoc Thai. 2006;89(Suppl 3):S200–S205.
  • Svedman C, Bruze M, Johansen JD, Andersen KE, Goossens A, Frosch PJ, Lepoittevin JP, Rastogi S, White IR, Menne T. Deodorants: an experimental provocation study with hydroxycitronellal. Contact Dermatitis 2003;48(4):217–223.
  • Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol Lat. 1989;26(1):51–55.
  • Tabak M, Armon R, Neeman I. Cinnamon extracts’ inhibitory effect on Helicobacter pylori. J Ethnopharmacol. 1999;67(3):269–277.
  • Tabak M, Armon R, Potasman I, Neeman I. In vitro inhibition of Helicobacter pylori by extracts of thyme. J Appl Bacteriol. 1996;80(6):667–672.
  • Taher M, Abdul Majid FA, Sarmidi MR. Cinnamtannin B1 activity on adipocytes formation. Med J Malaysia 2004;(59 Suppl B):97–98.
  • Takenaga M, Hirai A, Terano T, Tamura Y, Kitagawa H, Yoshida S. In vitro effect of cinnamic aldehyde, a main component of Cinnamomi cortex, on human platelet aggregation and arachidonic acid metabolism. J Pharmacobiodyn. 1987;10(5):201–208.
  • Talpur N, Echard B, Ingram C, Bagchi D, Preuss H. Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study. Diabetes Obes Metab. 2005;7(2):193–199.
  • Tanaka N, Sekiya N, Hattori M, Goto H, Shibahara N, Shimada Y, Terasawa K. Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat. Phytomedicine 2003;10(2–3):122–126.
  • Tanaka S, Yoon YH, Fukui H, Tabata M, Akira T, Okano K, Iwai M, Iga Y, Yokoyama K. Antiulcerogenic compounds isolated from Chinese cinnamon. Planta Med. 1989;55(3):245–248.
  • Tang M, Larson-Meyer DE, Liebman M. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. Am J Clin Nutr. 2008;87(5):1262–1267.
  • Tatrai E, Adamis Z, Ungvary G. The pulmonary toxicity of cinnamon dust in rats. Indian J Med Res. 1995;102:287–292.
  • Tayel AA, El Tras WF. Possibility of fighting food borne bacteria by Egyptian folk medicinal herbs and spices extracts. J Egypt Public Health Assoc. 2009;84(1–2):21–32.
  • Temesvari E, Soos G, Podanyi B, Kovacs I, Nemeth I. Contact urticaria provoked by balsam of Peru. Contact Dermatitis 1978;4(2):65–68.
  • Teuscher E. Ein Handbuch der Gewürze, Gewürzkräuter, Ihrer Ätherischen Öle und Gewürzmischungen. Gewürzdrogen. 2003;423–429.
  • Thantsin K, Zhang Q, Yang J, Wang Q. Composition of semivolatile compounds of 10 Cinnamomum species from China and Myanmar. Nat Prod Res. 2008;22(7):576–583.
  • Thyne G, Young DW, Ferguson MM. Contact stomatitis caused by toothpaste. N Z Dent J. 1989;85(382):124–126.
  • Toda S. Inhibitory effects of aromatic herbs on lipid peroxidation and protein oxidative modification by copper. Phytother Res. 2003;17(5):546–548.
  • Tonkal AM, Morsy TA. An update review on Commiphora molmol and related species. J Egypt Soc Parasitol. 2008;38(3):763–796.
  • Tremblay S, Avon SL. Contact allergy to cinnamon: case report. J Can Dent Assoc. 2008;74(5):445–461.
  • Tsai PJ, Tsai TH, Yu CH, Ho SC. Evaluation of NO-suppressing activity of several Mediterranean culinary spices. Food Chem Toxicol. 2007;45(3):440–447.
  • Tunc S, Chollet E, Chalier P, Preziosi-Belloy L, Gontard N. Combined effect of volatile antimicrobial agents on the growth of Penicillium notatum. Int J Food Microbiol. 2007;113(3):263–270.
  • Tung YT, Chua MT, Wang SY, Chang ST. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour. Technol. 2008;99(9):3908–3913.
  • Turgis M, Han J, Borsa J, Lacroix M. Combined effect of natural essential oils, modified atmosphere packaging, and gamma radiation on the microbial growth on ground beef. J Food Prot. 2008;71(6):1237–1243.
  • Ungsurungsie M, Paovalo C, Noonai A. Mutagenicity of extracts from Ceylon cinnamon in the rec assay. Food Chem Toxicol. 1984;22(2):109–112.
  • Ungsurungsie M, Suthienkul O, Paovalo C. Mutagenicity screening of popular Thai spices. Food Chem Toxicol. 1982;20(5):527–530.
  • Uragoda CG. Asthma and other symptoms in cinnamon workers. Br J Ind Med. 1984;41(2):224–227.
  • Uragoda CG. Symptoms in spice workers. J Trop Med Hyg. 1992;95(2):136–139.
  • Usta J, Kreydiyyeh S, Bajakian K, Nakkash-Chmaisse H. In vitro effect of eugenol and cinnamaldehyde on membrane potential and respiratory chain complexes in isolated rat liver mitochondria. Food Chem Toxicol. 2002;40(7):935–940.
  • Usta J, Kreydiyyeh S, Barnabe P, Bou-Moughlabay Y, Nakkash-Chmaisse H. Comparative study on the effect of cinnamon and clove extracts and their main components on different types of ATPases. Hum Exp Toxicol. 2003;22(7):355–362.
  • Valcarcel R, Bennett JW, Vitanza J. Effect of selected inhibitors on growth, pigmentation, and aflatoxin production by Aspergillus parasiticus. Mycopathologia 1986;94(1):7–10.
  • Valero M, Frances E. Synergistic bactericidal effect of carvacrol, cinnamaldehyde or thymol and refrigeration to inhibit Bacillus cereus in carrot broth. Food Microbiol. 2006;23(1):68–73.
  • Valero M, Giner MJ. Effects of antimicrobial components of essential oils on growth of Bacillus cereus INRA L2104 in and the sensory qualities of carrot broth. Int J Food Microbiol. 2006;106(1):90–94.
  • Valero M, Salmeron MC. Antibacterial activity of 11 essential oils against Bacillus cereus in tyndallized carrot broth. Int J Food Microbiol. 2003;85(1–2):73–81.
  • Van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T. Contact allergy to spices. Contact Dermatitis 1990;22(5):267–272.
  • Van Tol RW, Swarts HJ, van der Linden A, Visser JH. Repellence of the red bud borer Resseliella oculiperda from grafted apple trees by impregnation of rubber budding strips with essential oils. Pest Manag Sci. 2007;63(5):483–490.
  • Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr. 2006;136(4):977–980.
  • Veal L. The potential effectiveness of essential oils as a treatment for headlice, Pediculus humanus capitis. Complement Ther Nurs Midwifery 1996;2(4):97–101.
  • Wang G, Wang L, Xiong ZY, Mao B, Li TQ. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci Monit. 2006;12(1):SR1–SR7.
  • Wang HF, Wang YK, Yih KH. DPPH free-radical scavenging ability, total phenolic content, and chemical composition analysis of forty-five kinds of essential oils. J Cosmet Sci. 2008;59(6):509–522.
  • Wang JG, Anderson RA, Graham GM, III, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril 2007;88(1):240–243.
  • Wang SY, Chen PF, Chang ST. Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi. Bioresour Technol. 2005;96(7):813–818.
  • Wang SY, Yang CW, Liao JW, Zhen WW, Chu FH, Chang ST. Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice. Phytomedicine 2008 [Epub ahead of print].
  • Wang WK, Hsu TL, Huang ZY, Wang YY. Collective effect of a Chinese formula –a study of xiao-jian-zhong-tang. Am J Chin Med. 1995;23(3–4):299–304.
  • Wannissorn B, Jarikasem S, Siriwangchai T, Thubthimthed S. Antibacterial properties of essential oils from Thai medicinal plants. Fitoterapia 2005;76(2):233–236.
  • Warin RP, Smith RJ. Chronic urticaria investigations with patch and challenge tests. Contact Dermatitis 1982;8(2):117–121.
  • Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E. The battle against multi-resistant strains: renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009;37(7):392–397.
  • Warshaw EM, Furda LM, Maibach HI, Rietschel RL, Fowler JF, Jr, Belsito DV, Zug KA, DeLeo VA, Marks JG, Jr, Mathias CG, Pratt MD, Sasseville D, Storrs FJ, Taylor JS. Anogenital dermatitis in patients referred for patch testing: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 1994–2004. Arch Dermatol. 2008;144(6):749–755.
  • Watt K, Christofi N, Young R. The detection of antibacterial actions of whole herb tinctures using luminescent Escherichia coli. Phytother Res. 2007;21(12):1193–1199.
  • Wei A, Shibamoto T. Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation. Cutan Ocul Toxicol. 2007;26(3):227–233.
  • Weibel H, Hansen J, Andersen KE. Cross-sensitization patterns in guinea pigs between cinnamaldehyde, cinnamyl alcohol and cinnamic acid. Acta Derm Venereol. 1989;69(4):302–307.
  • Westra WH, McMurray JS, Califano J, Flint PW, Corio RL. Squamous cell carcinoma of the tongue associated with cinnamon gum use: a case report. Head Neck 1998;20(5):430–433.
  • White A, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD. Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet. Inflamm Bowel Dis. 2006;12(6):508–514.
  • Wickramasinghe RH, Muller G, Norpoth K. Spectral evidence of interaction of spice constituents with hepatic microsomal cytochrome P-450. Cytobios 1980;29(113):25–27.
  • Wijesekera RO. Historical overview of the cinnamon industry. CRC Crit Rev Food Sci Nutr. 1978;10(1):1–30.
  • Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008;45(4):385–395.
  • Wong SY, Grant IR, Friedman M, Elliott CT, Situ C. Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis. Appl Environ Microbiol. 2008;74(19):5986–5990.
  • Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677–702.
  • Wortelboer HM, Usta M, van Zanden JJ, van Bladeren PJ, Rietjens IM, Cnubben NH. Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds. Biochem Pharmacol. 2005;69(12):1879–1890.
  • Wu SJ, Ng LT. MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food Chem Toxicol. 2007;45(12):2446–2453.
  • Wu SJ, Ng LT, Lin CC. Effects of vitamin E on the cinnamaldehyde-induced apoptotic mechanism in human PLC/PRF/5 cells. Clin Exp Pharmacol Physiol. 2004;31(11):770–776.
  • Xiao X, Satake M. [Calcium oxalate crystals in several kinds of Cinnamon bark]. Zhongguo Zhong Yao Za Zhi. 1998;23(9):515–518, 574.
  • Yang SS, Hou WC, Huang LW, Lee TH. A new gamma-lactone from the leaves of Cinnamomum kotoense. Nat Prod Res. 2006;20(13):1246–1250.
  • Yang ZY, Pei J, Liu RM, Cheng J, Wan DG, Hu R. [Study on relative bioavailability of ferulic acid of combination radix Angelicae sinensis and cortex Cinnamomi in mice]. Zhongguo Zhong Yao Za Zhi. 2006;31(12):1012–1015.
  • Yeh RY, Shiu YL, Shei SC, Cheng SC, Huang SY, Lin JC, Liu CH. Evaluation of the antibacterial activity of leaf and twig extracts of stout camphor tree, Cinnamomum kanehirae, and the effects on immunity and disease resistance of white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol. 2009;27(1):26–32.
  • Yin XJ, Liu DX, Wang HC, Zhou Y. A study on the mutagenicity of 102 raw pharmaceuticals used in Chinese traditional medicine. Mutat Res. 1991;260(1):73–82.
  • Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol. 2008;75(2):494–502.
  • Yousef RT, Tawil GG. Antimicrobial activity of volatile oils. Pharmazie 1980;35(11):698–701.
  • Yu HS, Lee SY, Jang CG. Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice. Pharmacol Biochem Behav. 2007;87(1):164–170.
  • Yu SM, Wu TS, Teng CM. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor. Br J Pharmacol. 1994;111(3):906–912.
  • Yuste J, Fung DY. Inactivation of Listeria monocytogenes Scott A 49594 in apple juice supplemented with cinnamon. J Food Prot. 2002;65(10):1663–1666.
  • Yuste J, Fung DY. Inactivation of Salmonella typhimurium and Escherichia coli O157:H7 in apple juice by a combination of nisin and cinnamon. J Food Prot. 2004;67(2):371–377.
  • Zanotto KL, Iodi, Carstens M., Carstens E. Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol. Neurosci Lett. 2008;430(1):29–33.
  • Zanotto KL, Merrill AW, Carstens MI, Carstens E. Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli. J Neurophysiol 2007;97(2):966–978.
  • Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods Find Exp Clin Pharmacol. 1992;14(9):725–736.
  • Zenner L, Callait MP, Granier C, Chauve, C. In vitro effect of essential oils from Cinnamomum aromaticum, Citrus limon and Allium sativum on two intestinal flagellates of poultry, Tetratrichomonas gallinarum and Histomonas meleagridis. Parasite 2003;10(2):153–157.
  • Zhang BG, Liu QF. [Clinic utilization of Guizhi decoction in modern times]. Zhongguo Zhong Yao Za Zhi. 2007;32(8):757–760.
  • Zhao JX, Li P, Sheng X, Liu X, Liang DY. [Effects of cinnamyl aldehyde on cell cycle and relafeol proteins expression in NIH3T3 cells]. Zhongguo Zhong Yao Za Zhi. 2007;32(16):1692–1694.
  • Zhao X, Zhu JX, Mo SF, Pan Y, Kong LD. Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2006;103(3):357–365.
  • Zhou L, Chen ZX, Chen JY. [Effect of wu lin powder and its ingredients on atrial natriuretic factor level in mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(1):36–37.
  • Zhou Q, Liang G. [Effect of plant alcohol extracts on vegetable aphids and their parasitoids]. Ying Yong Sheng Tai Xue Bao. 2003;14(2):249–252.
  • Zhu S, Liu P, Sun S. [Identification of cortex Cinnamomi and its confused species “yin xiang” by FT-Raman spectroscopy]. Zhong Yao Cai. 2001;24(9):636–637.
  • Zhu YJ, Song KK, Li ZC, Pan ZZ, Guo YJ, Zhou JJ, Wang Q, Liu B, Chen QX. Antityrosinase and antimicrobial activities of trans-cinnamaldehyde thiosemicarbazone. J Agric Food Chem. 2009;57(12):5518–5523.
  • Zhu ZP, Zhang MF, Shen YQ, Chen GJ. [Pharmacological study on spleen-stomach warming and analgesic action of Cinnamomum cassia Presl]. Zhongguo Zhong Yao Za Zhi. 1993;18(9):553–555.
  • Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45–53.
  • Ziment I. History of the treatment of chronic bronchitis. Respiration 1991;58(Suppl 1):37–42.
  • Zuskin E, Kanceljak B, Skuric Z, Pokrajac D, Schachter EN, Witek TJ, Maayani S. Immunological and respiratory findings in spice-factory workers. Environ Res. 1988;47(1):95–108.

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