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RESEARCH COMMUNICATIONS

Analysis of sperm nuclear protein gene polymorphisms and DNA integrity in infertile men

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Pages 124-132 | Received 29 Sep 2010, Accepted 17 Nov 2010, Published online: 22 Mar 2011

References

  • Adham, I.M., Nayernia, K., Burkhardt-Gottges, E., Topaloglu, O., Dixkens, C., Holstein, A.F., (2001) Teratozoospermia in mice lacking the transition protein 2 (Tnp2). Mol Hum Reprod 7:513–520.
  • Aoki, V.W., Christensen, G.L., Atkins, J.F. and Carrell, D.T. (2006) Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. Fertil Steril 86:1416–1422.
  • Balhorn, R., Reed, S. and Tanphaichitr, N. (1988) Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males. Experientia 44:52–55.
  • Bianchi, F., Rousseaux-Prevost, R., Sautiere, P. and Rousseaux, J. (1992) P2 protamines from human sperm are zinc-finger proteins with one CYS2/HIS2 motif. Biochem Biophys Res Commun 182:540–547.
  • Carrell, D.T. and Liu, L. (2001) Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis. J Androl 22:604–610.
  • Castillo, J., Simon, L., de Mateo, S., Lewis, S. and Oliva, R. Protamine/DNA Ratios and DNA Damage in Native and Density Gradient Centrifugated Sperm from Infertile Patients. J Androl, Oct 21, doi:10.2164/jandrol.110.011015.
  • Cho, C., Jung-Ha, H., Willis, W.D., Goulding, E.H., Stein, P., Xu, Z., (2003) Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice. Biol Reprod 69:211–217.
  • Cho, C., Willis, W.D., Goulding, E.H., Jung-Ha, H., Choi, Y.C., Hecht, N.B., (2001) Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet 28:82–86.
  • Dada, R., Gupta, N.P. and Kucheria, K. (2004) Yq microdeletions–azoospermia factor candidate genes and spermatogenic arrest. J Biomol Tech 15:176–183.
  • de Mateo, S., Martinez-Heredia, J., Estanyol, J.M., Dominguez-Fandos, D., Vidal-Taboada, J.M., Ballesca, J.L., (2007) Marked correlations in protein expression identified by proteomic analysis of human spermatozoa. Proteomics 7:4264–4277.
  • de Yebra, L., Ballesca, J.L., Vanrell, J.A., Bassas and L., Oliva, R. (1993) Complete selective absence of protamine P2 in humans. J Biol Chem 268:10553–10557.
  • Evenson, D.P., Larson, K.L. and Jost, L.K. (2002) Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23:25–43.
  • Garcia-Peiro, A., Martinez-Heredia, J., Oliver-Bonet, M., Abad, C., Amengual, M.J., Navarro, J., (2011) Protamine 1 to protamine 2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm. Fertil Steril 95:105–109.
  • Gázquez, C., Oriola, J., de Mateo, S., Vidal-Taboada, J.M., Ballesca, J.L. and Oliva, R. (2008) A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. J Androl 29:540–548.
  • Giwercman, A., Richthoff, J., Hjollund, H., Bonde, J.P., Jepson, K., Frohm, B., (2003) Correlation between sperm motility and sperm chromatin structure assay parameters. Fertil Steril 80:1404–1412.
  • Hammadeh, M.E., Hamad, M.F., Montenarh, M. and Fischer-Hammadeh, C. (2010) Protamine contents and P1/P2 ratio in human spermatozoa from smokers and non-smokers. Hum Reprod 25:2708–2720.
  • Hammoud, S., Emery, B.R., Aoki, V.W. and Carrell, D.T. (2007) Identification of genetic variation in the 5' and 3' non-coding regions of the protamine genes in patients with protamine deregulation. Arch Androl 53:267–274.
  • Hammoud, S., Liu, L. and Carrell, D.T. (2009) Protamine ratio and the level of histone retention in sperm selected from a density gradient preparation. Andrologia 41:88–94.
  • Haraguchi, T., Ishikawa, T., Yamaguchi, K. and Fujisawa, M. (2009) Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia. Fertil Steril 91:1424–1426.
  • Huynh, T., Mollard, R. and Trounson, A. (2002) Selected genetic factors associated with male infertility. Hum Reprod Update 8:183–198.
  • Iguchi, N., Yang, S., Lamb, D.J. and Hecht, N.B. (2006) An SNP in protamine 1: a possible genetic cause of male infertility? J Med Genet 43:382–384.
  • Imken, L., Rouba, H., El Houate, B., Louanjli, N., Barakat, A., Chafik, A., (2009) Mutations in the protamine locus: association with spermatogenic failure? Mol Hum Reprod 15:733–738.
  • Jodar, M., Oriola, J., Mestre, G., Castillo, J., Giwercman, A., Vidal-Taboada, J.M., (2010) Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes. Int J Androl. Oct 1. doi: 10.1111/j.1365-2605.2010.01115.x.
  • Kichine, E., Msaidie, S., Bokilo, A.D., Ducourneau, A., Navarro, A., Levy, N., (2008) Low-frequency protamine 1 gene transversions c.102G->T and c.-107G->C do not correlate with male infertility. J Med Genet 45:255–256.
  • Kremling, H., Luerssen, H., Adham, I.M., Klemm, U., Tsaousidou, S. and Engel, W. (1989) Nucleotide sequences and expression of cDNA clones for boar and bull transition protein 1 and its evolutionary conservation in mammals. Differentiation 40:184–190.
  • Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R. and Berns, A. (1991) Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19:4293.
  • Lewis, J.D., Saperas, N., Song, Y., Zamora, M.J., Chiva, M. and Ausio, J. (2004) Histone H1 and the origin of protamines. Proc Natl Acad Sci U S A 101:4148–4152.
  • Mengual, L., Ballesca, J.L., Ascaso, C. and Oliva, R. (2003) Marked differences in protamine content and P1/P2 ratios in sperm cells from percoll fractions between patients and controls. J Androl 24:438–447.
  • Miyagawa, Y., Nishimura, H., Tsujimura, A., Matsuoka, Y., Matsumiya, K., Okuyama, A., (2005) Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. J Androl 26:779–786.
  • Moskovtsev, S.I., Willis, J., Azad, A. and Mullen, J.B. (2005) Sperm DNA integrity: correlation with sperm plasma membrane integrity in semen evaluated for male infertility. Arch Androl 51:33–40.
  • Nili, H.A., Mozdarani, H. and Aleyasin, A. (2009) Correlation of sperm DNA damage with protamine deficiency in Iranian subfertile men. Reprod Biomed Online 18:479–485.
  • Oliva, R. (2006) Protamines and male infertility. Hum Reprod Update 12:417–435.
  • Poongothai, J., Gopenath, T.S. and Manonayaki, S. (2009) Genetics of human male infertility. Singapore Med J 50:336–347.
  • Ravel, C., Chantot-Bastaraud, S., El Houate, B., Berthaut, I., Verstraete, L., De Larouziere, V., (2007) Mutations in the protamine 1 gene associated with male infertility. Mol Hum Reprod 13:461–464.
  • Steger, K., Wilhelm, J., Konrad, L., Stalf, T., Greb, R., Diemer, T., (2008) Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men. Hum Reprod 23:11–16.
  • Tanaka, H., Miyagawa, Y., Tsujimura, A., Matsumiya, K., Okuyama, A. and Nishimune, Y. (2003) Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations. Mol Hum Reprod 9:69–73.
  • Tavalaee, M., Razavi, S. and Nasr-Esfahani, M.H. (2009) Influence of sperm chromatin anomalies on assisted reproductive technology outcome. Fertil Steril 91:1119–1126.
  • Tseden, K., Topaloglu, O., Meinhardt, A., Dev, A., Adham, I., Muller, C., (2007) Premature translation of transition protein 2 mRNA causes sperm abnormalities and male infertility. Mol Reprod Dev 74:273–279.
  • Venkatesh, S., Deecaraman, M., Kumar, R., Shamsi, M.B. and Dada, R. (2009) Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility. Indian J Med Res 129:127–137.
  • WHO (1999) Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. World Health Organization. Cambridge University Press.
  • Wykes, S.M. and Krawetz, S.A. (2003) Conservation of the PRM1 –> PRM2 –> TNP2 domain. DNA Seq 14:359–367.
  • Yu, Y.E., Zhang, Y., Unni, E., Shirley, C.R., Deng, J.M., Russell, L.D., (2000) Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci U S A 97:4683–4688.
  • Zhang, X., San Gabriel, M. and Zini, A. (2006) Sperm nuclear histone to protamine ratio in fertile and infertile men: evidence of heterogeneous subpopulations of spermatozoa in the ejaculate. J Androl 27:414–420.
  • Zhao, M., Shirley, C.R., Hayashi, S., Marcon, L., Mohapatra, B., Suganuma, R., (2004) Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis 38:200–213.
  • Zhao, M., Shirley, C.R., Yu, Y.E., Mohapatra, B., Zhang, Y., Unni, E., (2001) Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol 21:7243–7255

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