Testicular histopathology in juvenile rat toxicity studies

References

• Anderson, T., Khan, N.K., Tassinari, M.S. and Hurtt, M.E. (2009) Comparative juvenile safety testing of new therapeutic candidates: Relevance of laboratory animal data to children. J Toxicol Sci 34:SP209–15.
   PubMed Web of Science ®Google Scholar
• Baldrick, P. (2010) Juvenile animal testing in drug development – Is it useful? Reg Toxicol Pharmacol 57:291–299.
   PubMed Web of Science ®Google Scholar
• Cappon, G.D., Graham, G.P., Buschman, J., Feuston, M.H., Fisher, J.E., Hew, K.W. (2009) Juvenile animal toxicity study designs to support pediatric drug development. Birth Defects Res 86:463–469.
   Google Scholar
• Center for Drug Evaluation and Research (CDER), Food and Drug Administration. (2006) Nonclinical safety evaluation of pediatric drug products. www.fda.gov//cder//guidance//index.htm.
   Google Scholar
• Chen, H., Stanley, E., Jin, S. and Zirkin, B. (2010) Stem Leydig cells: from fetal to aged animals. Birth Defects Res (Part C) 90:272–283.
   PubMedGoogle Scholar
• Clermont, Y. and Perey, B. (1957) Quantitative study of the cell population of the seminiferous tubules in immature rats. Am J Anat 100:241–268.
   PubMedGoogle Scholar
• Cooke, P.S., Zhao, Y.D. and Hansen, L.G. (1996) Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. Toxicol Appl Pharmacol 136:112–117.
   PubMed Web of Science ®Google Scholar
• Creasy, D.M. (1997) Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging. Toxicol Pathol 25:119–131.
   PubMed Web of Science ®Google Scholar
• European Medicines Agency EMEA Committee for Human Medicinal Products. (2008) Guideline on the need for nonclinical testing in juvenile animals on human pharmaceuticals for paediatric indications. Doc. Ref. EMEA//CHMP//SWP//169215//2005; www.emea.europa.eu//pdfs//human//swp//16921505en.pdf
   Google Scholar
• Gondos, B. and Berndtson, W.E. (1993) Postnatal and pubertal development. In The Sertoli Cell ed. Russell, L.D. and Griswold, M.D. Cache River Press, FL, USA pp.115–154.
   Google Scholar
• Hoover, D.M., Buening, M.K., Tamura, R.N. and Steinberger, E. (1989) Effects of cefamandole on spermatogenic development of young CD rats. Fund Appl Toxicol 13:737–746.
   PubMedGoogle Scholar
• International Conference on Harmonisation. (2000) E11- Clinical investigation of medicinal products in the pediatric population. www.fda.gov//cder//guidance//index.htm.
   Google Scholar
• Jahnukainen, K., Chrysis, D., Hou, M., Parvinen, M., Eksborg, S. and Söder, O. (2004) Increased apoptosis occurring during the first wave of spermatogenesis is stage-specific and primarily affects midpachytene spermatocytes in the rat testis. Biol Reprod 70:290–296.
   PubMed Web of Science ®Google Scholar
• Leblond, C.P. and Clermont, Y. (1952) Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann N Y Acad Sci 55:548–573.
   PubMed Web of Science ®Google Scholar
• Li, L.H., Jester, W.F.Jr., Laslett, A.L. and Orth, J.M. (2000) A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol 166:222–229.
   PubMed Web of Science ®Google Scholar
• Marty, M.S., Chapin, R.E., Parks, L.G. and Thorsud, B.A. (2003) Development and maturation of the male reproductive system. Birth Defects Res (Part B) 68:125–136.
   PubMed Web of Science ®Google Scholar
• McGuinness, M.P. (1992) Reinitiation of gonocyte mitosis and movement of gonocytes to the basement membrane in testes of newborn rats in vivo and in vitro. Anat Rec 233:527–537.
   PubMedGoogle Scholar
• Meistrich, M.L. (1986) Components of testicular function and sensitivity to disruption. Biol Reprod 34:17–28.
   PubMed Web of Science ®Google Scholar
• Mikkila, T.F.M., Toppari, J. and Paranko, J. (2006) Effects of neonatal exposure to 4-Tert-Octylpheno, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis. Toxicol Sci 91:456–466.
   PubMed Web of Science ®Google Scholar
• Morales, A., Mohamed, F. and Cavicchia, J.C. (2007) Apoptosis and blood-testis barrier during the first spermatogenic wave in the pubertal rat. Anat Rec 290:206–214.
   Google Scholar
• Noden, D.M. and De Lahunta, A. (1985) Embryology of Domestic Animals, Williams and Wilkins, Baltimore, MD, USA.
   Google Scholar
• Nurmio, M., Toppari, J., Zaman, F., Andersson, A-M., Paranko, J., Söder, O., (2007) Inhibition of tyrosine kinases PDGFR and c-kit by imatinib mesylate interferes with postnatal testicular development in the rat. Int J Androl 30:366–376.
   PubMedGoogle Scholar
• Orth, J.M. (1982) Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study. Anat Rec 203:485–492.
   PubMedGoogle Scholar
• Orth, J.M., Jester, W.F. and Qiu, J. (1996) Gonocytes in testes of neonatal rats express the c-kit gene. Mol Reprod Dev 45:123–131.
   PubMed Web of Science ®Google Scholar
• Orth, J.M., Qiu, J., Jester, W.F. and Pilder, S. (1997) Expression of the c-kit gene is critical for migration of neonatal rat gonocytes in vitro. Biol Reprod 57:676–683.
   PubMed Web of Science ®Google Scholar
• Pelliniemi, L.J., Fröjdman, K. and Parank, J. (1993) Embryological and prenatal development and function of Sertoli cells. In The Sertoli Cell ed. Russell, L.D. and Griswold, M.D. Cache River Press, Clearwater, FL, USA 87–114.
   Google Scholar
• Russell, L.D. (1992) Normal development of the testis. In Pathobiology of the Aging Rat ed. Mohr, U., Dungworth, D.L. and Capen, C.C. ILSI Press, Washington, DC., USApp. 395–405.
   Google Scholar
• Russell, L.D., Alger, L.E. and Nequin, L.G. (1987) Hormonal control of pubertal spermatogenesis. Endocrinol 120:1615–1632.
   PubMed Web of Science ®Google Scholar
• Russell, L.D., Bartke, A. and Goh, J.C. (1989) Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow. Am J Anat 184:179–189.
   PubMedGoogle Scholar
• Russell, L.D., Ettlin, R.A., SinhaHikim, A.P. and Clegg, E.D. (1990) Histological and Histopathological Evaluation of the Testis. Cache River Press, Clearwater, FL, USA.
   Google Scholar
• Steinberger, E. and Steinberger, A. (1972) The testis: growth versus function. In Regulation of Organ and Tissue Growth ed. Goss, R.J. Academic Press, New York, NY, USApp. 299–314.
   Google Scholar
• Stoker, T.E., Parks, L.G., Gray, L.E. and Cooper, R.L. (2000) Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Crit Rev Toxicol 30:197–252.
   PubMed Web of Science ®Google Scholar
• Thomson, S.D., Lendon, R.G. and Morris, I.D. (1991) Testicular effects of the Leydig cell toxicant ethane dimethanesulphonate given to neonatal rats. Reprod Toxicol 5:497–504.
   PubMed Web of Science ®Google Scholar
• Toyama, Y., and Yuasa, S. (2004) Effects of neonatal administration of 17beta-estradiol, beta-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis. Reprod Toxicol 19:181–188.
   PubMed Web of Science ®Google Scholar
• Zheng, S., Turner, T.T. and Lysiak, J.L. (2006) Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesis. Biol Repro 74:1026–1033.
   PubMed Web of Science ®Google Scholar