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Systems Biology in Reproductive Medicine Volume 58, 2012 - Issue 1: Special Issue: SBiRM: Invited Papers from MPI Research Summit/Symposium: Current Trends in Developmental and Reproductive Toxicology - August 21-23, 2011
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Research Articles

Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program

Matthew T. Martin National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USACorrespondence[email protected]
,
Thomas B. Knudsen National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Richard S. Judson National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Robert J. Kavlock National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
David J. Dix National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Pages 3-9 | Received 02 Dec 2011, Accepted 18 Dec 2011, Published online: 12 Jan 2012

References

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  • Cronin, M.T.D. and Worth, A.P. (2008) (Q)SARs for predicting effects relating to reproductive toxicity. Qsar Comb Sci 27:91–100.
  • Dix, D.J., Houck, K.A., Martin, M.T., Richard, A.M., Setzer, R.W. and Kavlock, R.J. (2007) The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 95:5–12.
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  • Judson, R.S., Houck, K.A., Kavlock, R.J., Knudsen, T.B., Martin, M.T., Mortensen, H.M., (2010) In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project. Environ Health Perspect 118:485–492.
  • Kleinstreuer, N.C., Judson, R.S., Reif, D.M., Sipes, N.S., Singh, A.V., Chandler, KJ., (2011) Environmental Impact on Vascular Development Predicted by High Throughput Screening. Environ Health Perspect 119:1596–1603.
  • Martin, M.T., Knudsen, T.B., Reif, D.M., Houck, K.A., Judson, R.S., Kavlock, R.J. and Dix, D.J. (2011) Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening. Biol Reprod 85:327–339.
  • Perreault, S.D., Klinefelter G.R. and Clegg E. (2008) Assessment of Male Reproductive Toxicity. Informa Healthcare, USA.
  • Scialli, A.R. (2008) The challenge of reproductive and developmental toxicology under REACH. Regul Toxicol Pharmacol 51:244–250.
  • Sipes, N.S., Martin, M.T., Reif, D.M., Kleinstreuer, N.C., Judson, R.S., Singh, A.V., (2011) Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci 124:109–127.

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