Perinatal exposure to fluoxetine via placenta and lactation inhibits the testicular development in male rat offspring

References

• Aragón, M.A., Ayala, M.E., Marín, M., Avilés, A., Damián-Matsumura, P. and Domínguez, R. (2005) Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development. Reproduction 129:717–727.
   PubMed Web of Science ®Google Scholar
• Aggarwal, A., Jethani, S.L., Rohatgi, R.K. and Kalra, J. (2012) Effects of Fluoxetine on Testis of Albino rats - A Histological Assessment. Int J Sci Eng Res 3:1–5.
   Google Scholar
• Ariyaratne, H.B and Mendis-Handagama S.C. (2000) Changes in the testis interstitium of Sprague Dawley rats from birth to sexual maturity. Biol Reprod 62:680–690.
   PubMed Web of Science ®Google Scholar
• Cooper, W.O., Willy, M.E., Pont, S.J. and Ray, W.A. (2007) Increasing use of antidepressants in pregnancy. Am J Obstet Gynecol 196:544.e1–544.e5.
   Web of Science ®Google Scholar
• Das, T.K., Mazunder, R. and Biswas, N.M. (1985) Effect of intraventricular injection of 5,6-dihydroxytryptamine on spermatogenesis and plasma testosterone levels in rats. J Endocrinol 106:395–400.
   PubMed Web of Science ®Google Scholar
• Deiró, T.C.B.J., Manhães de Castro, R., Cabral Filho, J.E., Souza, S.L., Freitas, S., Ferreira, L.M.P., (2004) Neonatal administration of citalopram delays somatic maturation in rats. Braz J Med Bio Res 37:1503–1509.
   PubMed Web of Science ®Google Scholar
• de Siqueira Bringel, S, de Amorim Júnior, A.A, Amorim, M.J., Brito, L.T., Morais, R.N., de Torres, S.M., et al. (2011) Endocrine and testicular changes induced by olanzapine in adult Wistar rats. J Appl Toxicol Published online. DOI:10.1002/jat.1702.
   Google Scholar
• França, L.R., Silva Junior, V.A., Chiarini-Garcia, H., Garcia, S.K., and Debeljuk, L. (2000) Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biol Reprod 63:1629–1636.
   PubMed Web of Science ®Google Scholar
• França, L.R., Avelar, G.F. and Almeida F.F.L. (2005) Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs. Theriogenology 63:300–318.
   PubMed Web of Science ®Google Scholar
• Frank, J.L.W., Hendricks, S.E. and Olson, C.H. (2000) Multiple ejaculations and chronic fluoxetine effects on male rat copulatory behavior. Pharmacol Biochem Behav 66:337–342.
   PubMed Web of Science ®Google Scholar
• Gandarias, J.M., Echevarria, E., Acebes, I., Abecia, L.C., Casis, O. and Casis, L. (1999) Effects of fluoxetine administration on um-opiod receptor immune-staining in the rat forebrain. Brain Res 817:236–240.
   PubMed Web of Science ®Google Scholar
• Gouvêa, T.S., Morimoto, H.K., Faria, M.J.S.S., Moreira, E.G. and Gerardin, D.C.C. (2008) Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice. Pharmacol Biochem Behav 90:416–419.
   PubMed Web of Science ®Google Scholar
• Harris, S.S., Maciag, D., Simpson, K.L., Lin, Rick C.S. and Paul, I.A. (2012) Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat. Brain Res 1429:52–60.
   PubMed Web of Science ®Google Scholar
• Heikkinen, T.M.D., Ekblad, U., Palo, P. and Laine, K. (2003) Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation. Clin Pharmacol Terap 73:330–337.
   PubMed Web of Science ®Google Scholar
• Hellani, A., Ji, J., Mauduit, C., Deschildre, C., Tabone, E. and Benahmed, M. (2000) Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. Endocrinol 141:3012–3009.
   PubMed Web of Science ®Google Scholar
• Homberg, J.R., Schubert, D. and Gaspar, P. (2010) New perspectives on the neurodevelopmental effects of SSRIs. Trends Pharmacol Sci 31:60–65.
   PubMed Web of Science ®Google Scholar
• Kaitu'u-Lino, T.J., Sluka, P., Foo, C.F. and Stanton, P.G. (2007) Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro. Reproduction 133:1169–1179.
   Google Scholar
• Kim, J.K., Riggs, W., Misri, S., Kent, N., Oberlander, T.F., Grunau, R.E., (2005) Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. Br J Clin Pharmacol 61:155–163.
   Web of Science ®Google Scholar
• Kristensen, J.H., Ilett, K., Hackett, F.L.P., Yapp, P., Paech, M. and Begg, E. J. (1999) Distribution and excretion of fluoxetine and norfluoxetine in human milk. J Clin Pharmacol 48:521–527.
   Web of Science ®Google Scholar
• Li, S. and Pelletier, G. (1995) Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain. Neuropeptides 29:21–25.
   PubMed Web of Science ®Google Scholar
• Macguirk, J. and Siloverstone, T. (1990) The effect of 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. Int J Obes 14:361–372.
   PubMed Web of Science ®Google Scholar
• Mendes da Silva, C., Souza, S.L., Barreto Medeiros, J.M., Freitas-Silva, S.R., Antunes, D.E.C., Cunha, A.D.U., (2002) Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats. Arq Neuropsquiatr 60:928–931.
   PubMed Web of Science ®Google Scholar
• Morrison, J.L., Riggs, K.W. and Rurak, D.W. (2005) Fluoxetine during pregnancy: impact on fetal development. Reprod Fertil Dev 17:641–650.
   PubMed Web of Science ®Google Scholar
• Mulder, E.J.H., Ververs, F.F.T., Heus, R. and Visser, G.H.A. (2011) Selective Serotonin Reuptake Inhibitors Affect Neurobehavioral Development in the Human Fetus. Neuropsychopharmacol 36:1961–1971.
   PubMed Web of Science ®Google Scholar
• Oberlander, T.F., Warburton, W., Misri, S., Aghajanian, J. and Hertzman, C. (2006) Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data. Arch Gen Psychiatry 63:898–906.
   PubMed Web of Science ®Google Scholar
• Olivier, J.D.A., Blom, T., Arentsen, T. and Homberg, J.R. (2011) The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review. Prog Neuro-Psychopharmacol Biol Psychiatry 35:1400–1408.
   PubMed Web of Science ®Google Scholar
• Orth, J.M. (1993) Cell biology of testicular development in fetus and neonate. In Cell and Molecular Biology of the Testis ed. Desjardins, C. and Ewing, L.L., Oxford University Press, NewYork, 3–42.
   Google Scholar
• Pawluski, J.L., Rayen, I., Niessen, N.A., Kristensen, S., Van Donkelaar, E.L., Balthazart, J. (2012) Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring. Neuroscience 220:131–141.
   PubMed Web of Science ®Google Scholar
• Pereira, J.D., Caricati-Neto, A., Jurkiewicz, A. and Jurkiewicz, N. (2007) Decreased noradrenergic and serotonergic reactivity of vas deferens of newborn rats from mothers treated with the serotonin reuptake inhibitor fluoxetine during pregnancy and breast-feeding. Life Sci 81:1501–1508.
   PubMed Web of Science ®Google Scholar
• Pohland, R.C., Byrd, T.K., Hamilton, M. and Koons, J.R. (1989) Placental transfer and fetal distribution of fluoxetine in the rat. Toxicol Appl Pharmacol 98:198–205.
   PubMed Web of Science ®Google Scholar
• Sharpe, R.M. (2001) Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol lett 120:221–232.
   PubMed Web of Science ®Google Scholar
• Shishkina, G.T. and Dygalo, N.N. (2000) Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans. Comp Biochem Physiol, Part C Pharmacol Toxicol 125:45–51.
   PubMed Web of Science ®Google Scholar
• Silva Júnior, V.A. and França, L.R. (2001) Células de Leydig e esteroidogênese em mamíferos. Cad Téc Vet Zootec 35:15–29.
   Google Scholar
• Silva Junior, V.A., Amorim, M.J.A.L., Amorim Júnior, A.A., Pinto, C.F., Deiró, T.C.B.J., Oliveira, J.R.M., (2008) Neonatal administration of fluoxetine decreased final Sertoli cell number in Wistar rats. Int J Morphol 26:51–62.
   Web of Science ®Google Scholar
• Simansky, K.J. (1996) Serotoninergic control of the organization of feeding and satiety. Behav Brain Res 73:37–42.
   PubMed Web of Science ®Google Scholar
• Tenorio, B.M., Jimenez, G.C., Morais, R.N., Torres, S.M., Nogueira, R.A. and Silva Junior, V.A. (2011) Testicular development evaluation in rats exposed to 60 Hz and 1 mT electromagnetic field. J Appl Toxicol 31:223–230.
   PubMed Web of Science ®Google Scholar
• Ververs, T., Kaasenbrood, H., Visser, G., Schobben, F., Berg, L.J-V.D. and Egberts, T. (2006) Prevalence and patterns of antidepressant drug use during pregnancy. Eur J Clin Pharmacol 62:863–870.
   PubMed Web of Science ®Google Scholar
• Vieira, M.L., Hamada, R.Y., Gonzaga, N.I., Bacchi, A.D., Barbieri, M., Moreira, E.G., (2012) Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats? Reprod Toxicol 35:102–107.
   Google Scholar