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ALS-UNTANGLED

ALSUntangled No. 29: MitoQ

References

  • http://www.alsuntangled.com/open.php. Accessed April 12, 2015.
  • http://www.mitoq.com. Accessed April 20, 2015.
  • Kelso G, Porteous C, Coulter C, Hughes G, Porteous W, Ledgerwood E, et al.Selective targeting of a redox-active ubiquinone to mitochondria within cells. J Biol Chem. 2001;276:4588–96.
  • Jauslin M, Meier T, Smith R, Murphy M.Mitochondrial-targeted antioxidants protect Friedrich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J. 2003;17:1972–4.
  • Cocheme H, Kelso G, James A, Ross M, Trnka J, Mahendiran T, et al. Mitchondrial targeting of quinolones: therapeutic implications. Mitochondrion. 2007;7:S94–102.
  • Smith R, Porteous C, Gane A, Murphy M.Delivery of bioactive molecules to mitochondria in vivo. PNAS. 2003;100:5407–12.
  • Carri M, Valle C, Bozzo F, Cozzolino M.Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS . Front Cell Neurosci. 2015;9:41.
  • Kaufmann P, Thompson J, Buchsbaum R, Shefner J, Krivickas L, Katz J, et al.Phase II trial of coq10 for ALS finds insufficient evidence to justify phase III. Ann Neurol. 2009;66:234–44.
  • Graf M, Ecker D, Horowski R, Kramer B, Riederer P, Gerlach M, et al.High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo controlled double-blind study. J Neural Transm. 2005;112:646–60.
  • Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de Leon A, et al.Journal Neurosci. 2008;16:4115–22.
  • Miquel E, Cassina A, Martinez-Palma L, Souza J, Bolatto C, Rodriquez-Botter S, et al.Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis . Free Radical Biology and Medicine. 2014;70:204–13.
  • Ludolph A, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler J, et al .Guidelines for preclinical animal research in ALS/MND: a consensus meeting. Amyotroph Lateral Scler. 2010;11:38–45.
  • http://www.patientslikeme.com/treatments/show/26368-mitoq-side-effects-and-efficacy#overview. Accessed April 26, 2015.
  • http://www.patientslikeme.com/treatment_evaluations/browse?condition_id = 9&id = 26368-mitoq-side-effects-and-efficacy. Accessed April 26, 2015.
  • Emails between patients and caregivers and ALSUntangled. April 2015.
  • Emails between Greg Macpherson and ALSUntangled. April 2015.
  • Snow B, Rolfe F, Lockhart M, Frampton C, O’Sullivan J, Fung V, et al. A double-blind, placebo controlled study to assess the mitochondrial-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Movement Dis. 2010;11:1670–4.
  • Gane E, Weilert F, Orr D, Keough G, Gibson M, Lockhart M, et al.The mitochondria-targeted antioxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver International. 2010; 30:1019–26.
  • http://www.mitoq.com/mitoq-5mg-capsules-60.html/. Accessed April 26, 2015.

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