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Original Articles

Effects of insulin-like growth factor-1 on the relaxation responses of the cavernous smooth muscle from aged rats

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Pages 260-266 | Received 21 Nov 2014, Accepted 17 Feb 2015, Published online: 08 Apr 2015

References

  • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994;151:54–61.
  • Bai Q, Xu QQ, Jiang H, Zhang WL, Wang XH, Zhu JC. Prevalence and risk factors of erectile dysfunction in three cities of China: a community-based study. Asian J Androl 2004;6:343–8.
  • Bivalacqua TJ, Champion HC, Hellstrom WJ, Kadowitz PJ. Pharmacotherapy for erectile dysfunction. Trends Pharmacol Sci 2000;21:484–9.
  • Andersson KE. Pharmacology of penile erection. Pharmacol Rev 2001;53:417–50.
  • Moreland RB, Hsieh G, Nakane M, Brioni JD. The biochemical and neurologic basis for the treatment of male erectile dysfunction. J Pharmacol Exp Ther 2001;296:225–34.
  • Brioni JD, Nakane M, Hsieh GC, Moreland RB, Kolasa T, Sullivan JP. Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res 2002;14:8–14.
  • El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res 1999;11:123–32.
  • Pu XY, Hu LQ, Wang HP, Luo YX, Wang XH. Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats. Asian J Androl 2007;9:83–91.
  • Bochinski D, Hsieh PS, Nunes L, Lin GT, Lin CS, Spencer EM, et al. Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation. Int J Impot Res 2004;16:418–23.
  • Abdel-Gawad M, Huynh H, Brock GB. Experimental chronic renal failure-associated erectile dysfunction: molecular alterations in nitric oxide synthase pathway and IGF-1 system. Mol Urol 1999;3:117–25.
  • Jung GW, Kwak JY, Kim IH, Koo MY, Park JI, Yoon S, et al. The role of growth factor on regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in the rats. Int J Impot Res 1999;11:227–35.
  • Jung GW, Kwak JY, Yoon S, Yoon JH, Lue TF. IGF-1 and TGF-beta2 have a key role on regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in rats. Int J Impot Res 1999;11:247–59.
  • Jung GW, Spencer EM, Lue TF. Growth hormone enhances regeneration of nitric oxide synthase-containing penile nerves after cavernous nerve neurotomy in rats. J Urol 1998;160:1899–904.
  • Pu XY, Wang XH, Wang HP, Gao WC, Yang ZH, Li SL, et al. Dose and long-term effect of hIGF-1 injection for erectile dysfunction in aged rats. Zhonghua Nan Ke Xue 2008;14:690–4.
  • Pu XY, Wang XH, Gao WC, Yang ZH, Li SL, Wang HP, et al. Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide–cyclic guanosine monophosphate signaling activity. J Sex Med 2008;5:1345–54.
  • Sadeghipour H, Dehghani M, Ghasemi M, Riazi K, Asadi S, Ebrahimi F, et al. The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: improvement with L-arginine. Eur J Pharmacol 2008;586:300–5.
  • Muniyappa R, Walsh MF, Rangi JS, Zayas RM, Standley PR, Ram JL, et al. Insulin like growth factor 1 increases vascular smooth muscle nitric oxide production. Life Sci 1997;61:925–31.
  • Delafontaine P. Insulin-like growth factor 1 and its binding proteins in the cardiovascular system. Cardiovasc Res 1995;30:825–34.
  • Punglia RS, Lu M, Hsu J, Kuroki M, Tolentino MJ, Keough K, et al. Regulation of vascular endothelial growth factor expression by insulin-like growth factor 1. Diabetes 1997;46:1619–26.
  • Grosskreutz CL, Anand-Apte B, Duplaa C, Quinn TP, Terman BI, Zetter B, et al. Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvasc Res 1999;58:128–36.
  • Vorwerk P, Oh Y, Lee PD, Khare A, Rosenfeld RG. Synthesis of IGFBP-3 fragments in a baculovirus system and characterization of monoclonal anti-IGFBP-3 antibodies. J Clin Endocrinol Metab 1997;82:2368–70.
  • Pu XY, Zheng XG, Zhang Y, Xiao HJ, Xu ZP, Liu JM, et al. Higher expression of mRNA and protein of insulin-like growth factor binding protein-3 in old rat penile tissues: implications for erectile dysfunction. J Sex Med 2011;8:2181–90.
  • Soh J, Katsuyama M, Ushijima S, Mizutani Y, Kawauchi A, Yabe-Nishimura C, et al. Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: implications for erectile dysfunction. Urology 2007;70:1019–23.
  • Laron Z, Klinger B. Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance). Eur J Endocrinol 1998;138:176–80.
  • Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802–13.
  • Liu X, Lin CS, Spencer EM, Lue TF. Insulin-like growth factor-I promotes proliferation and migration of cavernous smooth muscle cells. Biochem Biophys Res Commun 2001;280:1307–15.
  • Kim M, Hwang EC, Park IK, Park K. Insulin-like growth factor-1 gene delivery may enhance the proliferation of human corpus cavernosal smooth muscle cells. Urology 2010;76:511.e515–19.
  • Cartledge JJ, Eardley I, Morrison JF. Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes. BJU Int 2001;87:394–401.
  • Christ GJ. The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection. Urol Clin North Am 1995;22:727–45.
  • Andersson KE. Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol 2003;170:S6–13.
  • Park K, Ahn KY, Kim MK, Lee SE, Kang TW, Ryu SB. Intracavernosal injection of vascular endothelial growth factor improves erectile function in aged rats. Eur Urol 2004;46:403–7.
  • Haas CA, Seftel AD, Razmjouei K, Ganz MB, Hampel N, Ferguson K. Erectile dysfunction in aging: upregulation of endothelial nitric oxide synthase. Urology 1998;51:516–22.
  • Musicki B, Palese MA, Crone JK, Burnett AL. Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection. Biol Reprod 2004;70:282–9.
  • Xie D, Pippen AM, Odronic SI, Annex BH, Donatucci CF. Intracavernosal basic fibroblast growth factor improves vasoreactivity in the hypercholesterolemic rabbit. J Sex Med 2006;3:223–32.

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