Novel Nanodimension artificial red blood cells that act as O₂ and CO₂ carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated PolySFHb-superoxide dismutase-catalase-carbonic anhydrase

References

• Alayash AI. 2004. Oxygen therapeutics: can we tame haemoglobin?. Nat Rev Drug Discov. 3:152–159.
   PubMed Web of Science ®Google Scholar
• Bian Y, Rong Z, Chang TMS. 2011. A novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant. Artif Cells Blood Substit Biotechnol. 39:127–136.
   PubMed Web of Science ®Google Scholar
• Bian Y, Gao W, Chang TMS. 2013. Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and carbon dioxide carrier with enhanced antioxidant properties. Artif Cells Nanomedicine Biotechnol. 41:60–68.
   PubMed Web of Science ®Google Scholar
• Biro GP, Ou C, Ryan-MacFarlane C, Anderson PJ. 1995. Oxyradicaly generation after resuscitation of hemorrhagic shock with blood or stromafree hemoglobin. Artif Cells Blood Substit Immobil Biotechnol. 23:631–645.
   PubMed Web of Science ®Google Scholar
• Buehler PW, Haney CR, Gulati A, Ma L, Hsia CJ. 2004. Resuscitative effects of polynitroxylated alpha-alpha-cross-linked Hb following severe hemorrhage in the rat. Free Radic Biol Med. 37:124–135.
   PubMed Web of Science ®Google Scholar
• Cammarata GA, Weil MH, Castillo CJ, Fries M, Wang H, Sun S, Tang W. 2009. Buccal capnometry for quantitating the severity of hemorrhagic shock. Shock. 31:207–211.
   PubMedGoogle Scholar
• Chang TM. 1964. Semipermeable microcapsules. Science. 146: 524–525.
   PubMed Web of Science ®Google Scholar
• Chang TM. 1971. Stabilisation of enzymes by microencapsulation with a concentrated protein solution or by microencapsulation followed by cross-linking with glutaraldehyde. Biochem Biophys Res Commun. 44:1531–1536.
   PubMed Web of Science ®Google Scholar
• Chang TMS, Powanda D, Yu WP. 2003. Analysis of polyethylene-glycol-polylactide nano-dimension artificial red blood cells in maintaining systemic hemoglobin levels and prevention of methemoglobin formation. Biotechnology. 31:231–247.
   Google Scholar
• Chang TM. 2005. Therapeutic applications of polymeric artificial cells. Nat Rev Drug Discov. 4:221–235.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 2007. Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy. Singapore/London: World Scientific/ Imperial College.
   Google Scholar
• Chang EJ, Lee TH, Mun KC, Kim HC, Suh SI, Bae JH, et al. 2004. Effects of polyhemoglobin-antioxidant enzyme complex on ischemia- reperfusion in kidney. Transplant Proc.;36:1952–1954.
   PubMed Web of Science ®Google Scholar
• D’Agnillo F, Chang TM. 1998. Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties. Nat Biotechnol. 16:667–671.
   PubMed Web of Science ®Google Scholar
• Geers C, Gros G. 2000. Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiol Rev. 80:681–715.
   PubMed Web of Science ®Google Scholar
• Djordjevich L, Miller IF. 1980. Synthetic erythrocytes from lipid encapsulated hemoglobin. Exp Hematol. 8:584–592.
   PubMed Web of Science ®Google Scholar
• Fustier C, Chang TMS. 2012. PEG-PLA nanocapsules containing a nanobiotechnological complex of polyhemoglobin-tyrosinase for the depletion of tyrosine in melanoma: preparation and in vitro characterisation. Nanomedicine Biotherapeu Discover. 2:1–6.
   PubMedGoogle Scholar
• Gao W, Sha B, Zou W, Liang X, Meng X, Xu H, et al. 2011. Cationic amylose-encapsulated bovine hemoglobin as a nanosized oxygen carrier. Biomaterials. 32:9425–9433.
   PubMedGoogle Scholar
• Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. 2008. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopaedic surgery. J Traum. 64:1484–1497.
   PubMed Web of Science ®Google Scholar
• Luo W, Li S, Bei J, Wang S. 2002. Synthesis and characterization of poly ( L-lactide ) - poly ( ethylene glycol ) multiblock copolymers. Polymer. 84:1729–1736.
   Google Scholar
• Moore EE, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, et al. 2009. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: The USA multicenter trial. Shock. 208:1–13.
   Google Scholar
• Piras AM, Dessy A, Chiellini F, Chiellini E, Farina C, Ramelli M, Della Valle E. 2008. Polymeric nanoparticles for hemoglobin-based oxygen carriers. Biochim Biophys Acta. 1784:1454–1461.
   PubMed Web of Science ®Google Scholar
• Powanda DD, Chang TM. 2003. Cross-linked polyhemoglobin- superoxide dismutase-catalase supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion. Artif Cells Blood Substit Biotechnol. 30:23–37.
   Google Scholar
• Tsuchida E, Sou K, Nakagawa A, Sakai H, Komatsu T, Kobayashi K. 2009. Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry. Bioconjug Chem. 20:1419–1440.
   PubMed Web of Science ®Google Scholar
• Winslow RM. Ed. 2006. Blood Substitutes. Amsterdam: Academic Press.
   Google Scholar
• Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. 2008. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 117:1982–1990.
   PubMed Web of Science ®Google Scholar
• Yu WP, Chang TM. 1994. Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes: a preliminary report. Artif Cells Blood Substit Immobil Biotechnol. 22:889–893.
   PubMed Web of Science ®Google Scholar
• Zhang X, Liu C, Yuan Y, Shan X, Sheng Y, Xu F. 2009. A noninvasive method for measuring the oxygen binding-releasing capacity of hemoglobin-loaded polymeric nanoparticles as oxygen carrier. J Mater Sci Mater Med. 20:1025–1030.
   PubMed Web of Science ®Google Scholar
• Zhu H, Du Q, Chen C, Chang TM. 2010. The immunological properties of stroma-free polyhemolysate containing catalase and superoxide dismutase activities prepared by polymerized bovine stroma-free hemolysate. Artif Cells Blood Substit Biotechnol. 38: 57–63.
   PubMed Web of Science ®Google Scholar