Pretreatment with pPolyHb attenuates H₂O₂-induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1

References

• Al-Huseini LM, Aw Yeang HX, Hamdam JM, Sethu S, Alhumeed N, Wong W, Sathish JG. 2014. Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling. J Biol Chem. 289:16442–16451.
   PubMed Web of Science ®Google Scholar
• Ashraf MI, Ebner M, Wallner C, Haller M, Khalid S, Schwelberger H, et al. 2014. A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury. Cell Commun Signal. 12:6.
   PubMedGoogle Scholar
• Brugger J, Schick MA, Brock RW, Baumann A, Muellenbach RM, Roewer N, Wunder C. (2010). Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation. Microcirculation. 17:504–513.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 2007. Artificial Cells: Biotechnology, Nanomedicinde, Regenerative Medicine, Blood Substiture, Bioencapsulation, and Cell/Stem Cell Therapy, Vol. 1 of Regerative Medicin, Artificial Cells and Nanomedicine. Singapore: World Scientific.
   Google Scholar
• Chen SD, Yin JH, Hwang CS, Tang CM, Yang DI. 2012. Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer’s disease and cerebral ischemia. Free Radic Res 46:940–950.
   PubMed Web of Science ®Google Scholar
• Gozzelino R, Jeney V, Soares MP. 2010. Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50:323–354.
   PubMed Web of Science ®Google Scholar
• Gu W, Zhang Q, Yin W, Li C. 2014. Caspase-3-mediated splenic lymphocyte apoptosis in a porcine model of cardiac arrest. Am J Emerg Med. 32:1027–1032.
   PubMedGoogle Scholar
• Guibert EE, Petrenko AY, Balaban CL, Somov AY, Rodriguez JV, Fuller BJ. 2011. Organ preservation: current concepts and new strategies for the next decade. Transfus Med Hemother. 38:125–142.
   PubMed Web of Science ®Google Scholar
• Huang H, Ma J, Zhu W, Sun J, Yan K, Song B, et al. 2014. The application of polymerized porcine hemoglobin (pPolyHb) in the rat small bowel preservation. Artif Cells Nanomed Biotechnol. 42: 289–295.
   PubMed Web of Science ®Google Scholar
• Kohmoto J, Nakao A, Stolz DB, Kaizu T, Tsung A, Ikeda A, et al. 2007. Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway. Am J Transplant 7:2279–2290.
   PubMed Web of Science ®Google Scholar
• Kumphune S, Chattipakorn S, Chattipakorn N. 2012. Role of p38 inhibition in cardiac ischemia/reperfusion injury. Eur J Clin Pharmacol. 68:513–524.
   PubMed Web of Science ®Google Scholar
• Li LP, Zhang L, Peng LP, Cheng L. 2010. Heme oxygenase-1 is the candidate targeting for organ transplantation. Chin Med J (Engl). 123:2128–2134.
   PubMedGoogle Scholar
• Li T, Zhou R, Xiang X, Zhu D, Li Y, Liu J, et al. 2011. Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury. Artif Cells Blood Substit Immobil Biotechnol. 39:392–397.
   PubMed Web of Science ®Google Scholar
• Li T, Zhang Z, Liao D, Chen Y, Yang C, Xu X, Liu J. 2012. The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury. Artif Cells Blood Substit Immobil Biotechnol. 40:396–399.
   PubMed Web of Science ®Google Scholar
• Man W, Ming D, Fang D, Chao L, Jing C. 2014. Dimethyl sulfoxide attenuates hydrogen peroxide-induced injury in cardiomyocytes via heme oxygenase-1. J Cell Biochem. 115:1159–1165.
   PubMed Web of Science ®Google Scholar
• Morse D, Lin L, Choi AMK, Ryter SW. 2009. Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radical Biol Med. 47:1–12.
   PubMed Web of Science ®Google Scholar
• Papadopoulos D, Siempis T, Theodorakou E, Tsoulfas G. 2013. Hepatic ischemia and reperfusion injury and trauma: current concepts. Arch Trauma Res. 2:63–70.
   PubMedGoogle Scholar
• Parada E, Buendia I, Leon R, Negredo P, Romero A, Cuadrado A, et al. 2014. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. J Pineal Res. 56:204–212.
   PubMedGoogle Scholar
• Ramalingam M, Kim SJ. 2014. Insulin on hydrogen peroxide-induced oxidative stress involves ROS/Ca2 + and Akt/Bcl-2 signaling pathways. Free Radical Res. 48:347–356.
   PubMed Web of Science ®Google Scholar
• Rhee SG, Chang TS, Bae YS, Lee SR, Kang SW. 2003. Cellular regulation by hydrogen peroxide. J Am Soc Nephrol. 14:S211–215.
   PubMed Web of Science ®Google Scholar
• Runchel C, Matsuzawa A, Ichijo H. 2011. Mitogen-activated protein kinases in mammalian oxidative stress responses. Antioxid Redox Sign. 15:205–218.
   PubMed Web of Science ®Google Scholar
• Silva G, Cunha A, Gregoire IP, Seldon MP, Soares MP. 2006. The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform. J Immunol. 177:1894–1903.
   PubMedGoogle Scholar
• Topp S, Krieg A, Koch A, Tidden C, Ramp U, Hohlfeld T, et al. 2008. Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1. J Surg Res. 150:243–254.
   PubMed Web of Science ®Google Scholar
• Tzifi F, Economopoulou C, Gourgiotis D, Ardavanis A, Papageorgiou S, Scorilas A. 2012. The role of BCL2 family of apoptosis regulator proteins in acute and chronic leukemias. Adv Hematol. 2012:524308.
   PubMedGoogle Scholar
• Wang Y, Shen J, Xiong XX, Xu YH, Zhang H, Huang CJ, et al. 2014. Remote ischemic preconditioning protects against liver ischemia-reperfusion injury via heme oxygenase-1-induced autophagy. Plos One. 9:e98834.
   PubMed Web of Science ®Google Scholar
• Wu W, Li T, Liu J, Yang C. 2011. Pretreatment before ischemia induction with polymerized human placenta hemoglobin (PolyPHb) attenuates ischemia/reperfusion injury-induced myocardial apoptosis. Artif Cells Blood Substit Immobil Biotechnol. 39:3–6.
   PubMed Web of Science ®Google Scholar
• Xie Q, Li XX, Zhang P, Li JC, Cheng Y, Feng YL, et al. 2014. Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells through activation of the NF-E2-related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep. 10:1143–1149.
   PubMed Web of Science ®Google Scholar
• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, et al. 1999. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 103:129–135.
   PubMed Web of Science ®Google Scholar
• Zhu H, Dang X, Yan K, Dai P, Luo C, Ma J, et al. 2011a. Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion. Artif Cells Blood Substit Immobil Biotechnol. 39:119–126.
   PubMed Web of Science ®Google Scholar
• Zhu H, Yan K, Dang X, Huang H, Chen E, Chen B, et al. 2011b. Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute. Artif Cells Blood Substit Immobil Biotechnol. 39:398–405.
   PubMed Web of Science ®Google Scholar