8,162
Views
129
CrossRef citations to date
0
Altmetric
REVIEW ARTICLE

Nanofiber: Synthesis and biomedical applications

, , , &
Pages 111-121 | Received 18 Apr 2014, Accepted 06 May 2014, Published online: 06 Jun 2014

References

  • Ashammakhi N, Ndreu A, Yang Y, Ylikauppila H, Nikkola L, Hasirci V. 2007. Tissue engineering: a new take-off using nanofiber-based scaffolds. J Craniofac Surg. 18:3–17.
  • Badami AS, Kreke MR, Thompson MS, Riffle JS, Goldstein AS. 2006. Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly (lactic acid) substrates. Biomaterials. 27:596–606.
  • Baji A, Mai Y-W, Wong SC, Abtahi M, Chen P. 2010. Electrospinning of polymer nanofibers: effects on oriented morphology, structures and tensile properties. Compos Sci Technol. 70:703–718.
  • Berndt P, Fields GB, Tirrell M. 1995. Synthetic lipidation of peptides and amino acids: monolayer structure and properties. J Am Chem Soc. 117:9515–9522.
  • Bhattarai N, Edmondson D, Veiseh O, Matsen FA, Zhang M. 2005. Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials. 26:6176–6184.
  • Boateng JS, Matthews KH, Stevens HN, Eccleston GM. 2008. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 97:2892–2923.
  • Boland ED, Matthews JA, Pawlowski KJ, Simpson DG, Wnek GE, Bowlin GL. 2004. Electrospinning collagen and elastin: preliminary vascular tissue engineering. Front Biosci. 9:1422–1432.
  • Bölgen N, Menceloğlu YZ, Acatay K, Vargel I, Pişkin E. 2005. In vitro and in vivo degradation of non-woven materials made of poly (ϵ-caprolactone) nanofibers prepared by electrospinning under different conditions. J Biomater Sci Polym Ed. 16:1537–1555.
  • Bourget J-M, Guillemette M, Veres T, Auger FA, Germain L. 2013. Alignment of Cells and Extracellular Matrix Within Tissue-Engineered Substitutes. In: Pignatello R, ed. Advances in Biomaterials Science and Biomedical Applications. Available from: http://www.intechopen.com/books/advances-in-biomaterials-science-and-biomedical-applications/alignment-of-cells-and-extracellular-matrix-within-tissue-engineered-substitutes.
  • Cao H, Jiang X, Chai C, Chew SY. 2010. RNA interference by nanofiber-based siRNA delivery system. J Control Release. 144:203–212.
  • Chakraborty S, Liao IC, Adler A, Leong KW. 2009. Electrohydrodynamics: a facile technique to fabricate drug delivery systems. Adv Drug Deliv Rev. 61:1043–1054.
  • Chaurey V, Chiang PC, Polanco C, Su YH, Chou CF, Swami NS. 2010. Interplay of electrical forces for alignment of sub-100 nm electrospun nanofibers on insulator gap collectors. Langmuir. 26:19022–19026.
  • Chen F-M, Zhang M Wu Z-F. 2010. Toward delivery of multiple growth factors in tissue engineering. Biomaterials. 31:6279–6308.
  • Chen M, Gao S, Dong M, Song J, Yang C, Howard KA, et al. 2012. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano. 6:4835–4844.
  • Chen P, Wu QS, Ding YP, Chu M, Huang ZM, Hu W. 2010. A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro. Eur J Pharm Biopharm. 76:413–420.
  • Chew SY, Wen J, Yim EK, Leong KW. 2005. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules. 6:2017–2024.
  • Choi JS, Lee SW, Jeong L, Bae SH, Min BC, Youk JH, Park WH. 2004. Effect of organosoluble salts on the nanofibrous structure of electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate). Int J Biol Macromol. 34:249–256.
  • Collector with parallel electrode. 2014. Available at: http://www.electro-spinning.com/Collectors_for_electrospun_nanofibers.html.
  • Continuous collector. 2014. Available at: http://www.electro-spinning.com/Collectors_for_electrospun_nanofibers.html.
  • Cui W, Li X, Zhu X, Yu G, Zhou S, Weng J. 2006. Investigation of drug release and matrix degradation of electrospun poly (DL-lactide) fibers with paracetanol inoculation. Biomacromolecules. 7:1623–1629.
  • Doshi J, Reneker DH. 1995. Electrospinning process and applications of electrospun fibers. J Electrostat. 35: 151–160.
  • Elsdale T, Bard J. 1972. Collagen substrata for studies on cell behavior. J Cell Biol. 54:626–637.
  • Frenot A, Chronakis IS. 2003. Polymer nanofibers assembled by electrospinning. Curr Opin Coll Interface Sci. 8:64–75.
  • Fujihara K, Kotaki M Ramakrishna S. 2005. Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers.Biomaterials. 26:4139–4147.
  • Hartgerink JD, Beniash E, Stupp SI. 2001. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science. 294:1684–1688.
  • He W, Yong T, Teo WE, Ma Z, Ramakrishna S. 2005. Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: potential vascular graft for blood vessel tissue engineering. Tissue Eng. 11:1574–1588.
  • Hohman MM, Shin M, Rutledge G, Brenner MP. 2001. Electrospinning and electrically forced jets. II. Applications. Phys Fluids. (1994-present) 13:2221–2236.
  • Huang L, McMillan RA, Apkarian RP, Pourdeyhimi B, Conticello VP, Chaikof EL. 2000. Generation of synthetic elastin-mimetic small diameter fibers and fiber networks. Macromolecules. 33: 2989–2997.
  • Huang L, Nagapudi K, Apkarian RP, Chaikof EL. 2001. Engineered collagen–PEO nanofibers and fabrics. J Biomater Sci Polym Ed. 12:979–993.
  • Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV. 2005. In vitro characterization of chitosan–gelatin scaffolds for tissue engineering. Biomaterials. 26:7616–7627.
  • Huang Z-M, Zhang Y-Z, Kotaki M, Ramakrishna S. 2003. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol. 63:2223–2253.
  • Im JS, Bai BC, Lee Y-S. 2010. The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials. 31:1414–1419.
  • Ito Y, Hasuda H, Kamitakahara M, Ohtsuki C, Tanihara M, Kang IK, Kwon OH. 2005. A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material. J Biosci Bioeng. 100:43–49.
  • Jannesari M, Varshosaz J, Morshed M, Zamani M. 2011. Composite poly (vinyl alcohol)/poly (vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs. Int J Nanomedicine. 6:993–1003.
  • Jianrui Z, Yurong Y, Shicheng L. 2009. Research progress in collector and auxiliary electrode for electrospinning process. China Synthetic Fiber Industry. 5:15.
  • Jin H-J, Chen J, Karageorgiou V, Altman GH, Kaplan DL. 2004. Human bone marrow stromal cell responses on electrospun silk fibroin mats. Biomaterials. 25:1039–1047.
  • Jukola H, Nikkola L, Gomes ME, Reis RL, Ashammakhi N. 2008. Electrospun Starch–Polycaprolactone Nanofiber-Based Constructs for Tissue Engineering. In: Multiscale and functionally graded materials 2006: (M&FGM 2006). AIP Conference Proceedings. Volume 973, pp. 971–974.
  • Kadler K. 2004. Matrix loading: assembly of extracellular matrix collagen fibrils during embryogenesis. Birth Defects Res C Embryo Today. 72:1–11.
  • Kawahara Y, Nakayama A, Matsumura N, Yoshioka T, Tsuji M. 2008. Structure for electro–spun silk fibroin nanofibers. J Appl Polym Sci. 107:3681–3684.
  • Khil MS, Bhattarai SR, Kim HY, Kim SZ, Lee KH. 2005. Novel fabricated matrix via electrospinning for tissue engineering. J Biomed Mater Res B Appl Biomater. 72:117–124.
  • Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N. 2003. Electrospun nanofibrous polyurethane membrane as wound dressing. J Biomed Mater Res B Appl Biomater. 67:675–679.
  • Kim H, Yoo H. 2013. Matrix metalloproteinase-inspired suicidal treatments of diabetic ulcers with siRNA-decorated nanofibrous meshes. Gene Ther. 20:378–385.
  • Kim HS, Yoo HS. 2010. MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: in vitro and in vivo evaluation. J Control Release. 145:264–271.
  • Kim SH, Nam YS, Lee TS, Park WH. 2003. Silk fibroin nanofiber. Electrospinning, properties, and structure. Polym J. 35:185–190.
  • Kweon H, Yoo MK, Park IK, Kim TH, Lee HC, Lee HS, et al. 2003. A novel degradable polycaprolactone networks for tissue engineering. Biomaterials. 24:801–808.
  • Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, Shin JW. 2005. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials. 26:1261–1270.
  • Li C, Vepari C, Jin HJ, Kim HJ, Kaplan DL. 2006. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials. 27:3115–3124.
  • Li D, Xia Y. 2004. Electrospinning of nanofibers: reinventing the wheel?Adv Mater. 16:1151–1170.
  • Li M, Mondrinos MJ, Gandhi MR, Ko FK, Weiss AS, Lelkes PI. 2005. Electrospun protein fibers as matrices for tissue engineering. Biomaterials. 26:5999–6008.
  • Li WJ, Danielson KG, Alexander PG, Tuan RS. 2003. Biological response of chondrocytes cultured in three–dimensional nanofibrous poly (ϵ–caprolactone) scaffolds. J Biomed Mater Res A. 67: 1105–1114.
  • Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. 2002. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 60:613–621.
  • Liang D, Hsiao BS, Chu B. 2007. Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv Rev. 59:1392–1412.
  • Liang D, Luu YK, Kim K, Hsiao BS, Hadjiargyrou M, Chu B. 2005. In vitro non-viral gene delivery with nanofibrous scaffolds. Nucleic Acids Res. 33:e170.
  • Liao I, Chen S, Liu JB, Leong KW. 2009. Sustained viral gene delivery through core-shell fibers. J Control Release. 139:48–55.
  • Liao I, Leong KW. 2011. Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers. Biomaterials. 32:1669–1677.
  • Liu D, Liu S, Jing X, Li X, Li W, Huang Y. 2012. Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats. Biomaterials. 33:4362–4369.
  • Lu H, Zhang LX, Xing WH, Wang HT, Xu NP. 2005. Preparation of TiO2 hollow fibers using poly (vinylidene fluoride) hollow fiber microfiltration membrane as a template. Mater Chem Phys. 94:322–327.
  • Luong-Van E, Grøndahl L, Chua KN, Leong KW, Nurcombe V, Cool SM. 2006. Controlled release of heparin from poly (ϵ-caprolactone) electrospun fibers. Biomaterials. 27:2042–2050.
  • Luu Y, Kim K, Hsiao BS, Chu B, Hadjiargyrou M. 2003. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA–PEG block copolymers. J Control Release. 89:341–353.
  • Ma G, Liu Y, Peng C, Fang D, He B, Nie J. 2011. Paclitaxel loaded electrospun porous nanofibers as mat potential application for chemotherapy against prostate cancer. Carbohydr Polym. 86:505–512.
  • Ma PX, Zhang R. 1999. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res. 46:60–72.
  • Ma Z, He W, Yong T, Ramakrishna S. 2005. Grafting of gelatin on electrospun poly (caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell orientation. Tissue Eng. 11:1149–1158.
  • Ma Z, Kotaki M, Inai R, Ramakrishna S. 2005. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng. 11:101–109.
  • Matthews JA, Wnek GE, Simpson DG, Bowlin GL. 2002. Electrospinning of collagen nanofibers. Biomacromolecules. 3:232–238.
  • Merritt SR, Exner AA, Lee Z, von Recum HA. 2012. Electrospinning and imaging. Adv Eng Mater. 14:B266–B278.
  • Min B-M, Lee G, Kim SH, Nam YS, Lee TS, Park WH. 2004. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials. 25:1289–1297.
  • Mo X, Xu CY, Kotaki M, Ramakrishna S. 2004. Electrospun P (LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation. Biomaterials. 25:1883–1890.
  • Mottaghitalab F, Farokhia M, Mottaghitalab V, Ziabari M, Divsalar A, Shokrgozara MA. 2011. Enhancement of neural cell lines proliferation using nano-structured chitosan/poly (vinyl alcohol) scaffolds conjugated with nerve growth factor. Carbohydr Polym. 86:526–535.
  • Naik S, Chiang AST, Thompson RW, Huang FC. 2003. Formation of silicalite-1 hollow spheres by the self-assembly of nanocrystals. Chem Mater. 15:787–792.
  • Ngawhirunpat T, Opanasopit P, Rojanarata T, Akkaramongkolporn P, Ruktanonchai U, Supaphol P. 2009. Development of meloxicam-loaded electrospun polyvinyl alcohol mats as a transdermal therapeutic agent. Pharm Dev Technol. 14:73–82.
  • Nie H, Wang C-H. 2007. Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. J Control Release. 120:111–121.
  • Nikkola L, Viitanen P Ashammakhi N. 2005. Multi-component implant for true controlled release of diclofenac sodium. In: Sixth International Symposium on Frontiers in Biomedical Polymers, June 16–19, 2005, Hotel Saray, Granada, Spain.
  • Parallel-electrodes collector. 2014. Available at: http://www.electro-spinning.com/Collectors_for_electrospun_nanofibers.html.
  • Park S, Park K Yoon H Son J Min T Kim G. 2007. Apparatus for preparing electrospun nanofibers: designing an electrospinning process for nanofiber fabrication. Polym Int. 56:1361–1366.
  • Piras A, Nikkola L, Chiellini F, Ashammakhi N, Chiellini E. 2006. Development of diclofenac sodium releasing bio-erodible polymeric nanomats. J Nanosci Nanotechnol. 6:9–10.
  • Plate collector. 2014. Available at: http://www.mecc.co.jp/en/html/nanon/collector/plate.html.
  • Polaskova M, Cermak R, Verney V, Ponizil P, Commereuc S, Gomes MF, et al. 2013. Preparation of microfibers from wood/ionic liquid solutions. Carbohydr Polym. 92:214–217.
  • Pradilla G, Wang PP, Gabikian P, Li K, Magee CA, Walter KA, Brem H. 2006. Local intracerebral administration of paclitaxel with the Paclimer® delivery system: toxicity study in a canine model. J Neurooncol. 76: 131–138.
  • Reneker DH, Chun I. 1996. Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology. 7:216.
  • Reneker DH, Yarin AL, Fong H, Koombhongse S. 2000. Bending instability of electrically charged liquid jets of polymer solutions in electrospinning. J Appl Phys. 87:4531–4547.
  • Riboldi SA, Sampaolesi M, Neuenschwander P, Cossu G, Mantero S. 2005. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering. Biomaterials. 26:4606–4615.
  • Rujitanaroj P-O, Wang YC, Wang J, Chew SY. 2011. Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications. Biomaterials. 32:5915–5923.
  • Sahoo S, Ouyang H, Goh JC, Tay TE, Toh SL. 2006. Characterization of a novel polymeric scaffold for potential application in tendon/ligament tissue engineering. Tissue Eng. 12:91–99.
  • Said SS, Aloufy AK, El-Halfawy OM, Boraei NA, El-Khordagui LK. 2011. Antimicrobial PLGA ultrafine fibers: interaction with wound bacteria. Eur J Pharm Biopharm. 79:108–118.
  • Saraf A, Baggett LS, Raphael RM, Kasper FK, Mikos AG. 2010. Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds. J Control Release. 143:95–103.
  • Schneider A, Wang XY, Kaplan DL, Garlick JA, Egles C. 2009. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater. 5:2570–2578.
  • Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P. 1996. Polylactide macroporous biodegradable implants for cell transplantation. II. Preparation of polylactide foams by liquid–liquid phase separation. J Biomed Mater Res. 30:449–461.
  • Shao S, Li L, Yang G, Li J, Luo C, Gong T, Zhou S. 2011. Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. Int J Pharm. 421:310–320.
  • Shields KJ, Beckman MJ, Bowlin GL, Wayne JS. 2004. Mechanical properties and cellular proliferation of electrospun collagen type II. Tissue Eng. 10:1510–1517.
  • Shin Y, Hohman M, Brenner MP, Rutledge GC. 2001. Experimental characterization of electrospinning: the electrically forced jet and instabilities. Polymer. 42:09955–09967.
  • Sindelar T, Nikkola L, Ashammakhi N, van Griensven M, Redl H. 2006. Electrospinning of fibrinogen nanofibers. Eur Cells Mater. 11:59.
  • Son WK, Youk JH Park WH. 2004. Preparation of ultrafine oxidized cellulose mats via electrospinning. Biomacromolecules. 5:197–201.
  • Stitzel J, Liu J, Lee SJ, Komura M, Berry J, Soker S, et al. 2006. Controlled fabrication of a biological vascular substitute. Biomaterials. 27:1088–1094.
  • Stitzel JD, Bowlin GL, Mansfield K, Wnek GE, Simpson DG. 2000. Electrospraying and electrospinning of polymers for biomedical applications. Poly (lactic-co-glycolic acid) and poly (ethylene- co-vinylacetate). In: International SAMPE Technical Conference.
  • Sun Z, Zussman E, Yarin AL, Wendorff JH, Greiner A. 2003. Compound core–shell polymer nanofibers by co–electrospinning. Adv Mater. 15:1929–1932.
  • Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P. 2007. Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer. 48:7546–7557.
  • Tabata Y. 2000. The importance of drug delivery systems in tissue engineering. Pharm Sci Technolo Today. 3:80–89.
  • Taepaiboon P, Rungsardthong U, Supaphol P. 2007. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm Biopharm. 67:387–397.
  • Tan S, Inai R, Kotaki M, Ramakrishna S. 2005. Systematic parameter study for ultra-fine fiber fabrication via electrospinning process. Polymer. 46:6128–6134.
  • Taylor G. 1969. Electrically driven jets. Proc R Soc Lond.313:453–475.
  • Teo W, Ramakrishna S. 2006. A review on electrospinning design and nanofibre assemblies. Nanotechnology. 17: R89.
  • Teo W-E, Inai R, Ramakrishna S. 2011. Technological advances in electrospinning of nanofibers. Sci Technol Adv Mater. 12:013002.
  • Tian L, Prabhakaran MP, Ding X, Kai D, Ramakrishna S. 2012. Emulsion electrospun vascular endothelial growth factor encapsulated poly (l-lactic acid-co-ϵ-caprolactone) nanofibers for sustained release in cardiac tissue engineering. J Mater Sci. 47:3272–3281.
  • Tuzlakoglu K, Bolgen N, Salgado AJ, Gomes ME, Piskin E, Reis RL. 2005. Nano-and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci Mater Med. 16:1099–1104.
  • Um IC, Fang D, Hsiao BS, Okamoto A, Chu B. 2004. Electro-spinning and electro-blowing of hyaluronic acid. Biomacromolecules. 5: 1428–1436.
  • Venugopal J, Low S, Choon AT, Ramakrishna S. 2008. Interaction of cells and nanofiber scaffolds in tissue engineering. J Biomed Mater Res B Appl Biomater. 84:34–48.
  • Venugopal J, Ma LL, Yong T, Ramakrishna S. 2005. In vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices. Cell Biol Int. 29:861–867.
  • Venugopal J, Ramakrishna S. 2005. Biocompatible nanofiber matrices for the engineering of a dermal substitute for skin regeneration. Tissue Eng. 11:847–854.
  • Venugopal J, Zhang Y, Ramakrishna S. 2005. Fabrication of modified and functionalized polycaprolactone nanofibre scaffolds for vascular tissue engineering. Nanotechnology. 16:2138.
  • Water bath collector. 2014. Available at: http://www.electro-spinning.com/Collectors_for_electrospun_nanofibers.html.
  • Webster TJ, Siegel RW, Bizios R. 1999. Osteoblast adhesion on nanophase ceramics. Biomaterials. 20:1221–1227.
  • West JL, Halas NJ. 2000. Applications of nanotechnology to biotechnology: Commentary.Curr Opin Biotechnol. 11:215–217.
  • Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans GR, Brandt K, et al. 1998. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials. 19:1945–1955.
  • Williamson MR, Coombes AG. 2004. Gravity spinning of polycaprolactone fibres for applications in tissue engineering. Biomaterials. 25:459–465.
  • Wnek GE, Carr ME, Simpson DG, Bowlin GL. 2003. Electrospinning of nanofiber fibrinogen structures. Nano Lett. 3:213–216.
  • Xie C, Li X, Luo X, Yang Y, Cui W, Zou J, Zhou S. 2010. Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-β-cyclodextrin inoculations. Int J Pharm. 391:55–64.
  • Xu C, Inai R, Kotaki M, Ramakrishna S. 2004. Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials. 25:877–886.
  • Xu C, Inai R, Kotaki M, Ramakrishna S. 2004. Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. Tissue Eng. 10:1160–1168.
  • Yang F, Murugan R, Ramakrishna S, Wang X, Ma YX, Wang S. 2004. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials. 25:1891–1900.
  • Yang F, Murugan R, Wang S, Ramakrishna S. 2005. Electrospinning of nano/micro scale poly (L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials. 26: 2603–2610.
  • Yang F, Xu CY, Kotaki M, Wang S, Ramakrishna S. 2004. Characterization of neural stem cells on electrospun poly (L-lactic acid) nanofibrous scaffold. J Biomater Sci Polym Ed. 15:1483–1497.
  • Yang Y, Ylikauppila H, Nikkola L, Ashammakhi N. 2006. Investigation of cell attachment on the scaffolds manufactured by electrospun PCL-hyaluronan blend. 04–08 September 2006, Grenoble, France.
  • Yang Y, Li X, Cheng L, He S, Zou J, Chen F, Zhang Z. 2011. Core–sheath structured fibers with pDNA polyplex loadings for the optimal release profile and transfection efficiency as potential tissue engineering scaffolds. Acta Biomater. 7:2533–2543.
  • Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C, Li X. 2011. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 32:4243–4254.
  • Yoshimoto H, Shin YM, Terai H, Vacanti JP. 2003. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. 24:2077–2082.
  • Yun J, Im JS, Lee Y-S, Kim H-I. 2011. Electro-responsive transdermal drug delivery behavior of PVA/PAA/MWCNT nanofibers. Eur Polym J. 47:1893–1902.
  • Zeng J, Chen X, Xu X, Liang Q, Bian X, Yang L, Jing X. 2003. Ultrafine fibers electrospun from biodegradable polymers. J Appl Polym Sci. 89:1085–1092.
  • Zhang S. 2003. Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol. 21:1171–1178.
  • Zhang X, Shi Z, Fu W, Liu Z, Fang Z, Lu W, Wang Y, Chen F. 2012. In vitro biocompatibility study of electrospun copolymer ethylene carbonate-ε-caprolactone and vascular endothelial growth factor blended nanofibrous scaffolds. Appl Surf Sci. 258:2301–2306.
  • Zhang Y, Lim CT, Ramakrishna S, Huang ZM. 2005. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci Mater Med. 16:933–946.
  • Zhang Y, Su B, Venugopal J, Ramakrishna S, Lim CT. 2007. Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers. Int J Nanomedicine. 2:623.
  • Zhong S, Zhang Y, Lim CT. 2011. Fabrication of large pores in electrospun nanofibrous scaffolds for cellular infiltration: a review. Tissue Eng Part B Rev. 18:77–87.
  • Zhu XH, Wang CH, Tong YW. 2009. In vitro characterization of hepatocyte growth factor release from PHBV/PLGA microsphere scaffold. J Biomed Mater Res A. 89:411–423.
  • Zomer Volpato F, Almodóvar J, Erickson K, Popat KC, Migliaresi C, Kipper MJ. 2012. Preservation of FGF-2 bioactivity using heparin-based nanoparticles, and their delivery from electrospun chitosan fibers. Acta Biomater. 8:1551–1559.
  • Zong X, Bien H, Chung CY, Yin L, Fang D, Hsiao BS, et al. 2005. Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials. 26:5330–5338.
  • Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B. 2002. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer. 43:4403–4412.
  • Zou B, Liu Y, Luo X, Chen F, Guo X, Li X. 2012. Electrospun fibrous scaffolds with continuous gradations in mineral contents and biological cues for manipulating cellular behaviors. Acta Biomater. 8:1576–1585.
  • Zou J, Yang Y, Liu Y, Chen F, Li X. 2011. Release kinetics and cellular profiles for bFGF-loaded electrospun fibers: Effect of the conjugation density and molecular weight of heparin. Polymer. 52:3357–3367.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.