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REVIEW

Nanogel—an advanced drug delivery tool: Current and future

, , , , , & show all
Pages 165-177 | Received 11 Apr 2014, Accepted 28 May 2014, Published online: 23 Jul 2014

References

  • Abu Samah NH, Heard CM. 2013. Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc). Int J Pharm. 453:630–640.
  • Akiyoshi K, Kobayashi S, Shichibe S, Mix D, Baudys M, Wan Kim S, Sunamoto J. 1998. Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J Control Release. 54:313–320.
  • Alles N, Soysa NS, Hussain MD, Tomomatsu N, Saito H, Baron R, et al. 2009. Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Eur J Pharm Sci. 37:83–88.
  • Alvarez‐Lorenzo C, Moya‐Ortega MD, Loftsson T, Concheiro A, Torres‐Labandeira JJ. 2011. Cyclodextrin‐Based Hydrogels. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine: Current and Future Industrial Applications New York: John Wiley & Sons, pp. 297–321.
  • Bae BC, Na K. 2010. Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy. Biomaterials. 31:6325–6335.
  • Bae KH, Mok H, Park TG. 2008. Synthesis, characterization, and intracellular delivery of reducible heparin nanogels for apoptotic cell death. Biomaterials. 29:3376–3383.
  • Ballal NV, Tweeny A, Baumgartner JC, Ginjupalli K, Saraswathin V. 2013. Effect of maleic acid and ethylenediaminetetraacetic acid on the shear bond strength of RealSeal SE sealer to root canal dentin. Eur J Prosthodont Restor Dent. 21:152–156.
  • Bencherif SA, Siegwart DJ, Srinivasan A, Horkay F, Hollinger JO, Washburn NR, Matyjaszewski K. 2009. Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization. Biomaterials. 30:5270–5278.
  • Booth C, Attwood D. 2000. Effects of block architecture and composition on the association properties of poly (oxyalkylene) copolymers in aqueous solution. Macromol Rapid Commun. 21:501–527.
  • Castro E, Barbosa S, Juarez J, Taboada P, Katime IA, Mosquera V. 2008. Influence of external factors on the micellization process and aggregate structure of poly(oxy)styrene-poly(oxy)ethylene block copolymers. J Phys Chem B. 112:5296–5304.
  • Chang T. 2007. Artificial Cells: Biotechnology, Nanotechnology, Regenerative Medicine, Blood Substitutes Bioencapsulation and Cell/Stem Cell Therapy. Singapore: World Scientific/Imperial press, p. 454.
  • Cheng G, Mi L, Cao Z, Xue H, Yu Q, Carr L, Jiang S. 2010. Functionalizable and ultrastable zwitterionic nanogels. Langmuir. 26: 6883–6886.
  • Choi JH, Jang JY, Joung YK, Kwon MH, Park KD. 2010. Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A. J Control Release. 147:420–427.
  • Daoud-Mahammed S, Couvreur P, Bouchemal K, Chéron M, Lebas G, Amiel C, Gref R. 2009. Cyclodextrin and polysaccharide-based nanogels: entrapment of two hydrophobic molecules, benzophenone and tamoxifen. Biomacromolecules. 10:547–554.
  • Denkova AG, Mendes E, Coppens MO. 2008. Effects of salts and ethanol on the population and morphology of triblock copolymer micelles in solution. J Phys Chem B. 112:793–801.
  • Donini C, Robinson DN, Colombo P, Giordano F, Peppas NA. 2002. Preparation of poly(methacrylic acid-g-poly(ethylene glycol)) nanospheres from methacrylic monomers for pharmaceutical applications. Int J Pharm. 245:83–91.
  • Gagandeep Garg T, Malik B, Rath G, Goyal AK. 2014. Development and characterization of nano-fiber patch for the treatment of glaucoma. Eur J Pharm Sci. 53:10–16.
  • Garg T, Arora S, Murthy R, Goyal AK. 2012a. Development, optimization & evaluation of porous chitosan scaffold formulation of gliclazide for the treatment of type-2 diabetes mellitus. Drug Delive Lett. 2:251–261.
  • Garg T, Goyal AK. 2014. Biomaterial-based scaffolds – current status and future directions. Expert Opin Drug Deliv. 11:767–789.
  • Garg T, Rath G, Goyal AK. 2014. Novel technology to improve drug loading in polymeric nanofibers. Drug Deliv Lett. 4:79–86.
  • Garg T, Singh O, Arora S, Murthy R. 2012b. Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst. 29:1–63.
  • Garg T, Singh S, Goyal AK. 2013. Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst. 30:369–409.
  • Gong Y, Fan M, Gao F, Hong J, Liu S, Luo S, et al . 2009. Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications. Colloids Surf B Biointerfaces. 71:243–247.
  • Goyal G, Garg T, Malik B, Chauhan G, Rath G, Goyal AK. 2013. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv.
  • Gratton SE, Pohlhaus PD, Lee J, Guo J, Cho MJ, Desimone JM. 2007. Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J Control Release. 121:10–18.
  • Gref R, Amiel C, Molinard K, Daoud-Mahammed S, Sebille B, Gillet B, et al . 2006. New self-assembled nanogels based on host-guest interactions: characterization and drug loading. J Control Release. 111:316–324.
  • Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, Veiseh O, et al . 2013. Injectable nano-network for glucose-mediated insulin delivery. ACS Nano. 7:4194–4201.
  • Guerrero-Ramírez L, Nuño-Donlucas S, Cesteros L, Katime I. 2008. Smart copolymeric nanohydrogels: Synthesis, characterization and properties. Mater Chem Phys. 112:1088–1092.
  • Hasegawa U, Sawada S, Shimizu T, Kishida T, Otsuji E, Mazda O, Akiyoshi K. 2009. Raspberry-like assembly of cross-linked nanogels for protein delivery. J Control Release. 140:312–317.
  • Hayashi H, Iijima M, Kataoka K, Nagasaki Y. 2004. pH-sensitive nanogel possessing reactive PEG tethered chains on the surface. Macromolecules. 37:5389–5396.
  • Hirakura T, Yasugi K, Nemoto T, Sato M, Shimoboji T, Aso Y, et al . 2010. Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function. J Control Release. 142:483–489.
  • Hong J, Xu D, Gong P, Yu J, Ma H, Yao S. 2008. Covalent-bonded immobilization of enzyme on hydrophilic polymer covering magnetic nanogels. Microporous Mesoporous Mater. 109:470–477.
  • Inomoto N, Osaka N, Suzuki T, Hasegawa U, Ozawa Y, Endo H, et al . 2009. Interaction of nanogel with cyclodextrin or protein: study by dynamic light scattering and small-angle neutron scattering. Polymer. 50:541–546.
  • Jayakumar R, Nair A, Rejinold NS, Maya S, Nair S. 2012. Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells. Carbohydr Polym. 87:2352–2356.
  • Kabanov AV, Alakhov VY. 2002. Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers. Crit Rev Ther Drug Carrier Syst. 19:1–72.
  • Kabanov AV, Nazarova IR, Astafieva IV, Batrakova EV, Alakhov VY, Yaroslavov AA, Kabanov VA. 1995. Micelle formation and solubilization of fluorescent probes in poly (oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules. 28:2303–2314.
  • Kabanov AV, Vinogradov SV. 2009. Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed Engl. 48:5418–5429.
  • Kataria K, Garg T, Goyal AK, Rath G. 2014. Novel technology to improve drug loading in polymeric nanofibers. Drug Deliv Lett. 4:79–86.
  • Kaur M, Garg T, Rath G, Goyal AK. 2014. Current nanotechnological strategies for effective delivery of bioactive drug molecules in the treatment of tuberculosis. Crit Rev Ther Drug Carrier Syst. 31:49–88.
  • Kettel MJ, Dierkes F, Schaefer K, Moeller M, Pich A. 2011. Aqueous nanogels modified with cyclodextrin. Polymer. 52:1917–1924.
  • Kim S, Park KM, Ko JY, Kwon IC, Cho HG, Kang D, et al. 2008. Minimalism in fabrication of self-organized nanogels holding both anti-cancer drug and targeting moiety. Colloids Surf B Biointerfaces. 63:55–63.
  • Kohli E, Han HY, Zeman AD, Vinogradov SV. 2007. Formulations of biodegradable Nanogel carriers with 5’-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity. J Control Release. 121:19–27.
  • Kriwet B, Walter E, Kissel T. 1998. Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates. J Control Release. 56:149–158.
  • Landfester K, Willert M, Antonietti M. 2000. Preparation of polymer particles in nonaqueous direct and inverse miniemulsions. Macromolecules. 33:2370–2376.
  • Lee H, Mok H, Lee S, Oh Y-K, Park TG. 2007. Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels. J Control Release. 119:245–252.
  • Lee JI, Kim HS, Yoo HS. 2009. DNA nanogels composed of chitosan and Pluronic with thermo-sensitive and photo-crosslinking properties. Int J Pharm. 373:93–99.
  • Lee JI, Yoo HS. 2008. Pluronic decorated-nanogels with temperature-responsive volume transitions, cytotoxicities, and transfection efficiencies. Eur J Pharm Biopharm. 70:506–513.
  • Lin Y, Alexandridis P. 2002. Cosolvent effects on the micellization of an amphiphilic siloxane graft copolymer in aqueous solutions. Langmuir. 18:4220–4231.
  • Luisi PL, Straub B. 1984. Reverse Micelles: Biological and Technological Relevance of Amphiphilic Structures in Apolar Media New York: Plenum Pub Corp.
  • Ma Q, Remsen EE, Kowalewski T, Wooley KL. 2001. Two-dimensional, shell-cross-linked nanoparticle arrays. J Am Chem Soc. 123: 4627–4628.
  • Marek SR, Conn CA, Peppas NA. 2010. Cationic nanogels based on diethylaminoethyl methacrylate. Polymer. 51:1237–1243.
  • Mok H, Park TG. 2006. PEG-assisted DNA solubilization in organic solvents for preparing cytosol specifically degradable PEG/DNA nanogels. Bioconjug Chem. 17:1369–1372.
  • Nayak S, Lyon LA. 2005. Soft nanotechnology with soft nanoparticles. Angew Chem Int Ed Engl. 44:7686–7708.
  • Nomura Y, Ikeda M, Yamaguchi N, Aoyama Y, Akiyoshi K. 2003. Protein refolding assisted by self-assembled nanogels as novel artificial molecular chaperone. FEBS Lett. 553:271–276.
  • Nukolova NV, Oberoi HS, Cohen SM, Kabanov AV, Bronich TK. 2011. Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials. 32:5417–5426.
  • Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K. 2008. The development of microgels/nanogels for drug delivery applications. Prog Polym Sci. 33:448–477.
  • Oh JK, Tang C, Gao H, Tsarevsky NV, Matyjaszewski K. 2006. Inverse miniemulsion ATRP: a new method for synthesis and functionalization of well-defined water-soluble/cross-linked polymeric particles. J Am Chem Soc. 128:5578–5584.
  • Oh NM, Oh KT, Baik HJ, Lee BR, Lee AH, Youn YS, Lee ES. 2010. A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: in vitro evaluation. Colloids Surf B Biointerfaces. 78:120–126.
  • Park W, Park SJ, Na K. 2010. Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier. Colloids Surf B Biointerfaces. 79:501–508.
  • Parnami N, Garg T, Rath G, Goyal AK. 2013. Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol.
  • Peng J, Qi T, Liao J, Chu B, Yang Q, Li W, et al. 2013. Controlled release of cisplatin from pH-thermal dual responsive nanogels. Biomaterials. 34:8726–8740.
  • Raemdonck K, Naeye B, Hogset A, Demeester J, De Smedt SC 2010. Prolonged gene silencing by combining siRNA nanogels and photochemical internalization. J Control Release. 145:281–288.
  • Riess G. 2003. Micellization of block copolymers. Progr Polym Sci. 28:1107–1170.
  • Samah NA, Williams N, Heard CM. 2010. Nanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skin. Int J Pharm. 401:72–78.
  • Sasaki Y, Asayama W, Niwa T, Sawada SI, Ueda T, Taguchi H, Akiyoshi K. 2011. Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell‐Free Protein Synthesis. Macromol Biosci. 11:814–820.
  • Sasaki Y, Nomura Y, Sawada S-I, Akiyoshi K. 2010. Polysaccharide nanogel–cyclodextrin system as an artificial chaperone for in vitro protein synthesis of green fluorescent protein. Polym J. 42:823–828.
  • Sawada S-I, Sasaki Y, Nomura Y, Akiyoshi K. 2011. Cyclodextrin- responsive nanogel as an artificial chaperone for horseradish peroxidase. Colloid Polym Sci. 289:685–691.
  • Shen W, Chang Y, Liu G, Wang H, Cao A, An Z. 2011. Biocompatible, antifouling, and thermosensitive core− shell nanogels synthesized by RAFT aqueous dispersion polymerization. Macromolecules. 44:2524–2530.
  • Shin Y, Chang JH, Liu J, Williford R, Exarhos GJ. 2001. Hybrid nanogels for sustainable positive thermosensitive drug release. J Control Release. 73:1–6.
  • Singh H, Sharma R, Joshi M, Garg T, Goyal AK, Rath G. 2014. Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers. Artif Cells Nanomed Biotechnol.
  • Singka GS, Samah NA, Zulfakar MH, Yurdasiper A, Heard CM. 2010. Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. Eur J Pharm Biopharm. 76:275–281.
  • Sun H, Yu J, Gong P, Xu D, Hong J, Zhang C, Yao S. 2006. Novel core–shell magnetic nanogels synthesized in an emulsion-free aqueous system under UV irradiation for potential targeted radiopharmaceutical applications. Int J Nanosci. 5:253–258.
  • Sun H, Yu J, Gong P, Xu D, Zhang C, Yao S. 2005. Novel core–shell magnetic nanogels synthesized in an emulsion-free aqueous system under UV irradiation for targeted radiopharmaceutical applications. J Magn Magn Mater. 294:273–280.
  • Takahashi H, Sawada S-I, Akiyoshi K. 2010. Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperones. ACS Nano. 5:337–345.
  • Tamura A, Oishi M, Nagasaki Y. 2010. Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core. J Control Release. 146: 378–387.
  • Tan JP, Wang Q, Tam KC. 2008. Control of burst release from nanogels via layer by layer assembly. J Control Release. 128:248–254.
  • Vinogradov SV, Bronich TK, Kabanov AV. 2002. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev. 54:135–147.
  • Vinogradov SV, Zeman AD, Batrakova EV, Kabanov AV. 2005. Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs. J Control Release. 107:143–157.
  • Vintiloiu A, Leroux J-C. 2008. Organogels and their use in drug delivery—a review. J Control Release. 125:179–192.
  • Wang C, Mallela J, Garapati US, Ravi S, Chinnasamy V, Girard Y, et al . 2013. A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine. 9:903–911.
  • Wang NX, von Recum HA. 2011. Affinity‐Based Drug Delivery. Macromolecular Bioscience. 11:321–332.
  • Wang Q, Xu H, Yang X, Yang Y. 2008. Drug release behavior from in situgelatinized thermosensitive nanogel aqueous dispersions. Int J Pharm. 361:189–193.
  • Wong JE, Mu ller CB, DI ez-Pascual AM, Richtering W. 2009. Study of layer-by-layer films on thermoresponsive nanogels using temperature-controlled dual-focus fluorescence correlation spectroscopy. J Phys Chem B. 113:15907–15913.
  • Wu W, Aiello M, Zhou T, Berliner A, Banerjee P, Zhou S. 2010. In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery. Biomaterials. 31:3023–3031.
  • Xing Z, Wang C, Yan J, Zhang L, Li L, Zha L. 2011. Dual stimuli responsive hollow nanogels with IPN structure for temperature controlling drug loading and pH triggering drug release. Soft Matter. 7: 7992–7997.
  • Xu DM, Yao SD, Liu YB, Sheng KL, Hong J, Gong PJ, Dong L. 2007. Size-dependent properties of M-PEIs nanogels for gene delivery in cancer cells. Int J Pharm. 338:291–296.
  • Yan L, Tao W. 2010. One-step synthesis of pegylated cationic nanogels of poly ( N, N′-dimethylaminoethyl methacrylate) in aqueous solution via self-stabilizing micelles using an amphiphilic macroRAFT agent. Polymer. 51:2161–2167.
  • Yu S, Yao P, Jiang M, Zhang G. 2006. Nanogels prepared by self-assembly of oppositely charged globular proteins. Biopolymers. 83:148–158.
  • Zamurovic M, Christodoulou S, Vazaios A, Iatrou E, Pitsikalis M, Hadjichristidis N. 2007. Micellization behavior of complex comblike block copolymer architectures. Macromolecules. 40:5835–5849.

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