1,185
Views
24
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Gene silencing effect of SiRNA-magnetic modified with biodegradable copolymer nanoparticles on hTERT gene expression in lung cancer cell line

, , , , &
Pages 188-193 | Received 14 May 2014, Accepted 10 Jun 2014, Published online: 14 Jul 2014

References

  • Agrawal N, Dasaradhi P, Mohmmed A, Malhotra P, Bhatnagar R, Mukherjee S. 2003. RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev. 67:657–685.
  • Akbarzadeh A, Mikaeili H, Zarghami N, Rahmati M, Barkhordari A, Davaran S. 2012d. Preparation and in vitro evaluation of doxorubicin loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers. Int J Nanomedicine. 7:511–526.
  • Akbarzadeh A, Nejati-Koshki K, Mahmoudi Soghrati M, et al. 2013b. In vitro studies of NIPAAM-MAA-VP copolymer coated magnetic nanoparticles for controlled anticancer drug release. JEAS. 3: 108–115.
  • Akbarzadeh A, Nejati-Koshki K, Mahmoudi Soghrati M, et al. 2013c. In vitro studies of NIPAAM-MAA-VP copolymer coated magnetic nanoparticles for controlled anticancer drug release. JEAS. 3:108–115.
  • Akbarzadeh A, Rezaei A, Nejati-Koshki K, et al. 2014. Synthesis and physicochemical characterization of biodegradable star-shaped poly lactide-co-glycolide– β -cyclodextrin copolymer nanoparticles containing albumin. J Adv Nanoparticles. 3:1–9.
  • Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et al. 2013a. Liposome: classification, preparation, and applications. Nanoscale Res Lett. 8:102.
  • Akbarzadeh A, Samiei M, Davaran S. 2012c. Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Letrs. 7:144.
  • Akbarzadeh A, Samiei M, Joo SW, Anzaby M, Hanifehpour Y, Nasrabadi HT, Davaran S. 2012a. Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart Copolymers on A549 lung cancer cell line. J Nanobiotechnology. 10:46.
  • Akbarzadeh A, Zarghami N, Mikaeili H, Asgari D, Goganian AM, Khaksar Khiabani H, et al. 2012b. Synthesis, characterization and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin. Nanotechnol Sci Appl. 5:1–13.
  • Armanios M, Greider CW. 2005. Telomerase and cancer stem cells. Cold Spring Harbor Symp Quant Biol. 70:205–208.
  • Blackburn EH. 2005. Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett. 579:859–862.
  • Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. 1998. Extention of life-span by introduction of telomerase into normal human cells. Science. 279:349–352.
  • Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. 2009. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials. 30:2790–2798.
  • Chen H, Li Y, Tollefsbol TO. 2009. Strategies targeting telomerase inhibition. Mol Biotechnol. 41:194–199.
  • El Daly H, Martens U. 2007. Telomerase inhibition and telomere targeting in hematopoietic cancer cell lines with small non- nucleosidic synthetic compounds (BIBR1532). Methods Mol Biol. 405:47–60.
  • Fletcher T, Cathers B, Ravikumar K, Mamiya B, Kerwin S. 2001. Inhibition of human telomerase by 7-deaza-2′-deoxy-guanosine nucleoside triphosphate analogs: Potent inhibition by 6-thio- 7-deaza-2′-deoxyguanosine 5′-triphosphate. Bioorg Chem. 29:36–55.
  • Hu Y, Jiang X, Ding Y, Zhang L, Yang C, Zhang J, et al. 2003. Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphiphilic copolymer nanoparticles. Biomaterials. 24:2395–2404.
  • Kalambur V, Han B, Hammer BE, Shield TW, Bischof JC. 2005. In vitro characterization of movement, heating and visualization of magnetic nanoparticles for biomedical applications. Nanotechnology. 16:1221.
  • Kazemi F, Zarghami N, Fekri S, Monfaredan A. 2012.β-Cyclodextrin-curcumin complex inhibit telomerase gene expression in T47-D breast cancer cell line. Afr J Biotechnol. 10:19481–19488.
  • Kedar E, Algi O, Golod G, Babai I, Barenholz Y. 1997. Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNF-alpha show improved pharmacokinetics and biological activity and reduced toxicity in mice.J Immunother. 20:180–193.
  • Kim WJ, Kim SW. 2009. Efficient siRNA Delivery with non-viral polymeric vehicles. Pharm Res. 26:657–666.
  • Lee SH, Sinko PJ. 2006. siRNA—Getting the message out. Eur J Pharm Sci. 27:401–410.
  • Li H, Katik I, Liu J. 2007. Uses of telomerase peptides in anti-tumor immune therapy. Methods Mol Biol. 405:61–86.
  • Mo Y, Gan Y, Song S, Johnston J, Xiao X, Wientjes MG, Au JL. 2003. Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach. Cancer Res. 63:579–585.
  • Mollazadeh M, Nejati-Koshki K, Akbarzadeh A, Zarghami N, Nasiri M, Jahanban-Esfahlan R, Alibakhshi A. 2013. PAMAM dendrimers arugment inhibitory effect of curcumin on cancer cell proliferation: possible inhibition of telomerase. Asian Pac J Cancer Prev.14:6925–6929.
  • Nakamura M, Masutomi K, Kyo S, Hashimoto M, Maida Y, Kanaya T, et al. 2005. Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy. Hum Gene Ther. 16:859–868.
  • Natarajan S, Chen Z, Wancewicz EV, Monia BP, Corey DR. 2004. Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity. Oligonucleotides. 14:263–273.
  • Nejati-Koshki K, Akbarzadeh A, Pourhasan-Moghadam M, et al. 2013. Inhibition of leptin and leptin receptor gene expression by silibinin- curcumin combination. Asian Pac J Cancer Prev. 14: 6595–6599.
  • Nejati-Koshki K, Zarghami N, Pourhassan-Moghaddam M, et al. 2012. Inhibition of leptin gene expression and secretion by silibinin: possible role of estrogen receptors. Cytotechnology. 64:719–726.
  • Phatak P, Burger AM. 2007. Telomerase and its potential for therapeutic intervention. Br J Pharmacol. 152:1003–1011.
  • Qaddoumi MG, Ueda H, Yang J, Davda J, Labhasetwar V, Lee VH. 2004. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Pharm Res. 21:641–648.
  • Scherer L, Rossi J. 2004. RNAi applications in mammalian cells. BioTechniques. 36:557–561.
  • Shay JW, Gazdar AF. 1997. Telomerase in the early detection of cancer. J Clin Pathol. 50:106–109.
  • Valizadeh A, Mikaeili H, Samiei M, Farkhani SM, Zarghami N, Kouhi M, et al. 2012. Quantum dots: synthesis, bioapplications, and toxicity Nanoscale. Res Lett. 7:480.
  • Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, et al. 1997. Reconstitution of human telomerase with the catalytic protein subunit hTRT. Nat Genet. 17:498–502.
  • Widder KJ, Senyel AE, Scarpelli GD. 1978. Magnetic microspheres: a model system of site specific drug delivery in vivo. Proc Soc Exp Biol Med. 58:141.
  • Yallapu MM, Jaggi M, Chauhan SC. 2010. beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. Colloids Surf B Biointerfaces. 79:113–125.
  • Zablotskaya A, Segal I, Lukevics E. 2010. Iron oxide-based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapy. Appl Organometa Chem. 24: 150–157.
  • Zhang PH, Zou L, Tu ZG. 2006. RNAi-hTERT inhibition hepatocellular carcinoma cell proliferation via decreasing telomerase activity. J Surg Res. 131:143–149.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.