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Review

Advances in preparation and characterization of chitosan nanoparticles for therapeutics

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Pages 305-314 | Received 21 May 2014, Accepted 28 May 2014, Published online: 19 Aug 2014

References

  • Adeli M, Mirab N, Zabihi F. 2009. Nanocapsules based on carbon nanotubes-graft-polyglycerol hybrid materials. Nanotechnology. 20:485603.
  • Aiba S. 1992. Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans. Int J Biol Macromol. 14:225–228.
  • Alam S, Khan ZI, Mustafa G, Kumar M, Islam F, Bhatnagar A, Ahmad FJ. 2012. Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study. Int J Nanomedicine. 7:5705–5718.
  • Alameh M, Jean M, Dejesus D, Buschmann MD, Merzouki A. 2010. Chitosanase-based method for RNA isolation from cells transfected with chitosan/siRNA nanocomplexes for real-time RT-PCR in gene silencing. Int J Nanomedicine. 5:473–481.
  • Alishahi A, Mirvaghefi A, Tehrani MR, Farahmand H, Koshio S, Dorkoosh FA, Elsabee MZ. 2011. Chitosan nanoparticle to carry vitamin C through the gastrointestinal tract and induce the non-specific immunity system of rainbow trout (Oncorhynchus mykiss). Carbohydr Polyme. 86:142–146.
  • Almalik A, Donno R, Cadman CJ, Cellesi F, Day PJ, Tirelli N. 2013. Hyaluronic acid-coated chitosan nanoparticles: molecular weight-dependent effects on morphology and hyaluronic acid presentation. J Control Release. 172:1142–1150.
  • Ballarin-Gonzalez B, Dagnaes-Hansen F, Fenton RA, Gao S, Hein S, Dong M, et al. 2013. Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles. Mol Ther Nucleic Acids. 2:e76.
  • Banerjee T, Mitra S, Kumar Singh A, Kumar Sharma R, Maitra A. 2002. Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles. Int J Pharm. 243:93–105.
  • Bellocq AM, Biais J, Bothorel P, Clin B, Fourche G, Lalanne P, et al. 1984. Microemulsions. Adv Colloid Interface Sci. 20:167–272.
  • Bhattarai N, Ramay HR, Chou SH, Zhang M. 2006. Chitosan and lactic acid-grafted chitosan nanoparticles as carriers for prolonged drug delivery. Int J Nanomedicine. 1:181–187.
  • Birrenbach G, Speiser PP. 1976. Polymerized micelles and their use as adjuvants in immunology. J Pharm Sci. 65:1763–1766.
  • Borchard G. 2001. Chitosans for gene delivery. Adv Drug Deliv Rev. 52:145–150.
  • Chadha R, Bhandari S, Kataria D, Gupta S, Singh Jain D. 2012. Exploring the potential of lecithin/chitosan nanoparticles in enhancement of antihypertensive efficacy of hydrochlorothiazide. J Microencapsul. 29:805–812.
  • Chu B (Ed.) 1974. Laser Light Scattering. New York: Academic Press.
  • Chuah LH, Roberts CJ, Billa N, Abdullah S, Rosli R, Manickam S. 2013. Using Nanoparticle Tracking Analysis (NTA) to decipher mucoadhesion propensity of curcumin-containing chitosan nanoparticles and curcumin release. J Dispers Sci Technol. 35:1201–1207.
  • Danielsen S, Varum KM, Stokke BT. 2004. Structural analysis of chitosan mediated DNA condensation by AFM: influence of chitosan molecular parameters. Biomacromolecules. 5:928–936.
  • De Giglio E., Trapani A, Cafagna D, Sabbatini L, Cometa S. 2011. Dopamine-loaded chitosan nanoparticles: formulation and analytical characterization. Anal Bioanal Chem. 400:1997–2002.
  • Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z. 2013. Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system. Drug Des Devel Ther. 7:1015–1026.
  • Escott GM, Adams DJ. 1995. Chitinase activity in human serum and leukocytes. Infect Immun. 63:4770–4773.
  • Gan Q, Wang T. 2007. Chitosan nanoparticle as protein delivery carrier—Systematic examination of fabrication conditions for efficient loading and release. Colloids Surf B Biointerfaces. 59:24–34.
  • Gazori T, Khoshayand MR, Azizi E, Yazdizade P, Nomani A, Haririan I. 2009. Evaluation of Alginate/Chitosan nanoparticles as antisense delivery vector: formulation, optimization and in vitro characterization. Carbohydr Polym. 77:599–606.
  • Gorochovceva N, Makuška R. 2004. Synthesis and study of water- soluble chitosan-O-poly(ethylene glycol) graft copolymers. Eur Polym J. 40:685–691.
  • Gregorio-Jauregui KM, Pineda MG, Rivera-Salinas JE, Hurtado G, Saade H, Martinez J, et al. 2012. One-step method for preparation of magnetic nanoparticles coated with chitosan. J Nanomater. 2012:8.
  • Gugliotta LM, Vega JR, Meira GR. 2000. Latex particle size distribution by dynamic light scattering: computer evaluation of two alternative calculation paths. J Colloid Interface Sci. 228:14–17.
  • Guliyeva Ü, Öner F, Özsoy S, Haziroglu R. 2006. Chitosan microparticles containing plasmid DNA as potential oral gene delivery system. Eur J Pharm Biopharm. 62:17–25.
  • Hejazi R, Amiji M. 2003. Chitosan-based gastrointestinal delivery systems. J Control Release. 89:151–65.
  • Hu Y, Jiang X, Ding Y, Ge H, Yuan Y, Yang C. 2002. Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles. Biomaterials. 23:3193–3201.
  • Huang M, Fong CW, Khor E, Lim LY. 2005. Transfection efficiency of chitosan vectors: effect of polymer molecular weight and degree of deacetylation. J Control Release. 106:391–406.
  • Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ. 2001. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release. 73:255–267.
  • Jingou J, Shilei H, Weiqi L, Danjun W, Tengfei W, Yi X. 2011. Preparation, characterization of hydrophilic and hydrophobic drug in combine loaded chitosan/cyclodextrin nanoparticles and in vitro release study. Colloids Surf B Biointerfaces. 83:103–107.
  • Kabanov AV. 1999. Taking polycation gene delivery systems from in vitro to in vivo. Pharm Sci Technolo Today. 2:365–372.
  • Koping-Hoggard M, Tubulekas I, Guan H, Edwards K, Nilsson M, Varum KM, Artursson P. 2001. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther. 8:1108–1121.
  • Lien CF, Molnar E, Toman P, Tsibouklis J, Pilkington GJ, Gorecki DC, Barbu E. 2012. In vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood-brain barrier. Biomacromolecules. 13:1067–1073.
  • Liu Z, Jiao Y, Liu F, Zhang Z. 2007. Heparin/chitosan nanoparticle carriers prepared by polyelectrolyte complexation. J Biomed Mater Res A. 83A:806–812.
  • Lopez-Leon T, Carvalho EL, Seijo B, Ortega-Vinuesa JL, Bastos-Gonzalez D. 2005. Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior. J Colloid Interface Sci. 283:344–351.
  • Lou YL, Peng YS, Chen BH, Wang LF, Leong KW. 2009. Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors. J Biomed Mater Res A. 88: 1058–1068.
  • Lu H, Dai Y, Lv L, Zhao H. 2014. Chitosan-graft-polyethylenimine/DNA nanoparticles as novel non-viral gene delivery vectors targeting osteoarthritis. PloS one. 9:e84703.
  • MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, Rolland AP. 1998a. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release. 56:259–272.
  • MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, Rolland AP. 1998b. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Controlled Release. 56:259–272.
  • Manchanda R, Nimesh S. 2010. Controlled size chitosan nanoparticles as an efficient, biocompatible oligonucleotides delivery system. J Appl Polym Sci. 118:2071–2077.
  • Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes JC. 2004. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur J Pharm Biopharm. 57:1–8.
  • Moghaddam FA, Atyabi F, Dinarvand R. 2009. Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles. Nanomedicine. 5:208–215.
  • Mumper RJ, Wang J, Claspell JM, Rolland AP. 1995. Novel polymeric condensing carriers for gene delivery. Proc Int Symp Control Release Bioact Mater. 22:178–179.
  • Nam J-P, Choi C, Jang M-K, Jeong Y-I, Nah J-W, Kim S-H, Park Y. 2010. Insulin-incorporated chitosan nanoparticles based on polyelectrolyte complex formation. Macromol Res. 18:630–635.
  • Nimesh S, Saxena A, Kumar A, Chandra R. 2012. Improved transfection efficiency of chitosan-DNA complexes employing reverse transfection. J Appl Polym Sci. 124:1771–1777.
  • Nimesh S, Thibault MM, Lavertu M, Buschmann MD. 2010. Enhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serum. Mol Biotechnol. 46:182–196.
  • Özgel G, Akbuga J. 2006. In vitro characterization and transfection of IL-2 gene complexes. IntJ Pharm. 315:44–51.
  • Pan Y, Li Y-J, Zhao H-Y, Zheng J-M, Xu H, Wei G, et al. 2002. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm. 249:139–147.
  • Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. 2007. Nanocarriers as an emerging platform for cancer therapy. Nat Nano. 2:751–760.
  • Prabha S, Zhou WZ, Panyam J, Labhasetwar V. 2002. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int J Pharm. 244:105–115.
  • Richardson SC, Kolbe HV, Duncan R. 1999. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm. 178:231–243.
  • Saha P, Goyal AK, Rath G. 2010. Formulation and evaluation of chitosan-based ampicillin trihydrate nanoparticles. Trop J Pharm Res. 9:483–488.
  • Sharma S, Mukkur TK, Benson HA, Chen Y. 2012. Enhanced immune response against pertussis toxoid by IgA-loaded chitosan–dextran sulfate nanoparticles. J Pharm Sci. 101:233–244.
  • Sugimoto M, Morimoto M, Sashiwa H, Saimoto H, Shigemasa Y. 1998. Preparation and characterization of water-soluble chitin and chitosan derivatives. Carbohydr Polym. 36:49–59.
  • van der Lubben IM, Verhoef JC, Borchard G, Junginger HE. 2001. Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur J Pharm Sci. 14:201–207.
  • Yi H, Wu LQ, Bentley WE, Ghodssi R, Rubloff GW, Culver JN, Payne GF. 2005. Biofabrication with chitosan. Biomacromolecules. 6:2881–2894.
  • You JO, Liu YC, Peng CA. 2006. Efficient gene transfection using chitosan-alginate core-shell nanoparticles. Int J Nanomedicine. 1:173–180.
  • Zhang H, Neau SH. 2002. In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents. Biomaterials. 23:2761–2766.
  • Zhang L, Zhao ZL, Wei XH, Liu JH. 2013. Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles. Int J Nanomedicine. 8:601–610.
  • Zheng F, Shi X-W, Yang G-F, Gong L-L, Yuan H-Y, Cui Y-J, et al. 2007. Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study. Life Sci. 80:388–396.

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