Temperature stability of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at −80 °C, 4 °C, 25 °C and 37 °C or pasteurization at 70 °C

References

• Alayash AI, D’Agnillo F, Buehler PW. 2007. First generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther. 7:665–675.
   PubMed Web of Science ®Google Scholar
• Bian Y, Chang TM. 2015. A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume. Artif Cells Nanomed Biotechnol. 43:1–9.
   PubMed Web of Science ®Google Scholar
• Bian Y, Rong Z, Chang TM. 2011. Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant. Artif Cells Blood Substit Immobil Biotechnol. 39:127–136.
   PubMed Web of Science ®Google Scholar
• Bian Y, Wei G, Chang TM. 2013. Lowering of elevated tissue pCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties. Artif Cells Nanomed Biotechnol. 41:60–68.
   PubMed Web of Science ®Google Scholar
• Chang TM. 1964. Semipermeable microcapsules. Science. 146:524–525.
   PubMed Web of Science ®Google Scholar
• Chang TM. 1971. Stabilisation of enzymes by microencapsulation with a concentrated protein solution or by cross-linking with glutaraldehyde. Biochem Biophys Res Commun. 44:1531–1533.
   PubMed Web of Science ®Google Scholar
• Chang TM. 2007. Monograph on Artificial cells: Biotechnology, Nano-technology, Blood Substitutes, Regenerative Medicine, Bioencapsulation, Cell/Stem Cell Therapy. Singapore/London: World Science Publisher/Imperial College Press.
   Google Scholar
• Chang TM. 2009. Nanobiotechnology for hemoglobin-based blood substitutes. Crit Care Clin. 25:373–382.
   PubMed Web of Science ®Google Scholar
• Chang TM. 2012. From artificial red blood cells, oxygen carriers, oxygen therapeutics to artificial cells and nanomedicine and beyond. Artif Cells Blood Substit Immobil Biotechnol. 40:197–199.
   PubMed Web of Science ®Google Scholar
• Chang TM. 2014. From hemoglobin based oxygen carrier to oxygen therapeutics, blood substitutes, nanomedicine and artificial cells. In: Kim HW, Greenburg AG, Eds. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. New York, Dordrecht, London: Springer Heidelberg, pp. 3–26.
   Google Scholar
• Chang TM. 2015. Red blood cell replacement or nanobiotherapeutics with enhanced red blood cell functions? Artif Cells Nanomed Biotechnol. 43:145–147.
   PubMed Web of Science ®Google Scholar
• D’Agnillo F, Chang TM. 1998. Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties. Nat Biotechnol. 16:667–671.
   PubMed Web of Science ®Google Scholar
• Geers C, Gros G. 2000. Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiol Rev. 80:681–715.
   PubMed Web of Science ®Google Scholar
• Guo C, Gynn M, Chang TM. 2015. Extraction of superoxide dismutase, catalase and carbonic anhydrase from stroma-free red blood cell hemolysate for the preparation of the nanobiotechnological complex of polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase. Artif Cells Nanomed Biotechnol. 43:157–162.
   PubMed Web of Science ®Google Scholar
• Guyton AC. 1991. Monograph on Text Book of Medical Physiology. W.B. Saunders Company. Amsterdam: Academic Press.
   Google Scholar
• Hoffman A, Goldstein S, Samuni A, Borman JB., Schwalb H. 2003. Effect of nitric oxide and nitroxide SOD-mimic on the recovery of isolated rat heart following ischemia and reperfusion. Biochem Pharmacol. 66:1279–1286.
   PubMed Web of Science ®Google Scholar
• Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. 2008. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 64:1484–1497.
   PubMed Web of Science ®Google Scholar
• Keipert PE, Chang TM. 1988. Pyridoxylated-polyhemoglobin solution: a low viscosity oxygen-delivering blood replacement fluid with normal oncotic pressure and long-term storage feasibility. Biomater Artif Cells Artif Organs. 16:185–196.
   PubMed Web of Science ®Google Scholar
• Kim HW, Greenburg AG. (Eds.) 2014. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. New York, Dordrecht, London: Springer Heidelberg.
   Google Scholar
• Moore E, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, et al. 2009. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial. J Am Coll Surg. 208:1–13.
   PubMed Web of Science ®Google Scholar
• Mun KC, Bae JH, Suh SI, Kim YH, Lee SH, Kim SP, et al. 2003. Effect of modified polyhemoglobin on the oxidative damage after ischemia-reperfusion in the liver. Transplant Proc. 33:126–127.
   Web of Science ®Google Scholar
• OPK Biotech LLC. 2011. Hemopure now approved in Russia [press release]. Retrieved from: http://www.investorvillage.com/smbd.asp?mb=1666&mid=10711724&pt=msg.
   Google Scholar
• Powanda DD, Chang TM. 2002. Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion. Artif Cells Blood Substit Immobil Biotechnol. 30:23–37.
   PubMed Web of Science ®Google Scholar
• Ristagno G, Tang W, Sun S, Weil MH. 2006. Role of buccal pCO2 in the management of fluid resuscitation during hemorrhagic shock. Crit Care Med. 34:s442–s447.
   PubMed Web of Science ®Google Scholar
• Sims C, Seigne P, Menconi M, Monarca J, Barlow C, Pettit J, et al. 2001. Skeletal muscle acidosis correlates with the severity of blood volume loss during shock and resuscitation. J Trauma. 51:1137–1146.
   PubMed Web of Science ®Google Scholar
• Tronstad C, Pischke SE, Holhjem L, Tonnessen TI, Martinsen OG, Grimnes S. 2010. Early detection of cardiac ischemia using a conductometric pCO2 sensor: real-time drift correction and parameterization. Physiol Meas. 31:1241–1255.
   PubMed Web of Science ®Google Scholar
• Winslow R. (Ed.) 2006. Blood Substitutes. Amsterdam: Academic Press.
   Google Scholar
• Zhao L, Zhou W, Wang J, Li S, Chen G, Liu J, et al. 2014. The properties research of polymerized human placenta hemoglobin before and after lyophilization. Artif Cells Nanomed Biotechnol. 42:78–82.
   PubMed Web of Science ®Google Scholar