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Original Article

Current Methods for Evaluating Children's Exposures for Use in Health Risk Assessment

, &
Pages 41-98 | Published online: 04 Dec 2011

REFERENCES

  • Abdel-Rahman MS. 2001. The Fourth Annual Workshop on Evaluation of Default Safety Factors in Health Risk Assessments. J Human Ecol Risk Assess 7(1):5–6.
  • Adams WC. 1993. Measurement Of Breathing Rate And Volume In Routinely Performed Daily Activities, Final Report. California Air Resources Board (CARB) Contract No. A033– 205. June. 185 pp Available at ftp://ftp.arb.ca.gov/carbis/research/apr/past/a033–205.pdf.
  • AIHC (American Industrial Health Council). 1994. Exposure Factors Sourcebook. Washington, DC.
  • Andelman JB. 1985. Human exposures to volatile halogenated organic chemicals in indoor and outdoor air. Environ Health Persp 62:313–318.
  • Anderson BD, Higuchi WI, and Raykar PV. 1988. Heterogeneity effects on permeability: Partition coefficient relationships in human stratum corneum. Pharmacol Res 5:566–573.
  • Armstrong, TW, Hushka LJ, Tell JG, and Zaleski RT. 2000. A tiered approach for assessing children’s exposure. Environ Health Persp 108:469–474.
  • ATSDR (Agency for Toxic Substances and Disease Registry). 1997. Children’s Health Initiative: Acting On The Unique Vulnerability Of Children Who Dwell Near Hazardous Waste Sites. U.S. Dept of Health and Human Services, Atlanta, GA Available at http:// www.atsdr.cdc.gov/child/chw497.html.
  • Barltrop D. 1966. The prevalence of pica. Am J Dis Child 112(2):116–123.
  • Barnes, DG and Dourson M. 1988. Reference dose (RfD): Description and use in health risk assessments. Reg Toxicol Pharmacol 8:471–486.
  • BNA, Inc. 2002. Multiple model results to be compared for EPA cumulative organophos-phate review. Chemical regulation report. 26 (09):312. March 4. Available at http:// subscript.bna.com/SAMPLES/che.nsf/336a004cfdbe7c9485256521005ec035/ 9fa6856d1b6bf5a485256b7000107caa?OpenDocument.
  • Buck RJ, Ozkaynak H, Xue J, Zartarian VG, and Hammerstrom K. 2001. Modeled estimates of chlorpyrifos exposure and dose for the Minnesota and Arizona NHEXAS populations. J Expos Anal Environ Epi 11:253–268.
  • Bruckner JV. 2000. Differences in sensitivity of children and adults to chemical toxicity: The NAS panel report. Reg Tox Pharmacol 31(3):280–285.
  • Burmaster DE and Harris RH. 1993. The magnitude of compounding conservatisms in Superfund risk assessments. Risk Anal 13:131–134.
  • Calabrese EJ, Pastides H, Barnes R, Edwards C, Kostecki PT, et al. 1989. How much soil do young children ingest: An epidemiologic study. In: Petroleum Contaminated Soils, pp 363–397. Lewis Publishers, Chelsea, MI.
  • Calabrese EJ and Stanek EJ, III. 1998. Soil ingestion in children and adult: A dominant influence in site-specific risk assessment. Environ Law Report 28:10, 660–10, 671.
  • Calabrese EJ. 2000. Uncertainty Factor for Children: Historical Precedent. J Human Ecol Risk Assess 6(5):729–730.
  • Calabrese EJ. 2001. Assessing the default assumption that children are always at risk. Human Ecol Risk. Assess 7:37–59.
  • Campbell GL, Cohan D, and North DW. 1982. The Application of Decision Analysis to Toxic Substances: Proposed Methodology and Two Case Studies. Prepared for U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances. NTIS PB82–249103.
  • CDC (Centers for Disease Control and Prevention). 2001. National Report On Human Exposure To Environmental Chemicals. NCEH Pub.No.01–0164. Atlanta, GA Available at http://www.cdc.gov/nceh/dls/report/PDF/NatExpRep.pdf.
  • CDC (Centers for Disease Control and Prevention). 2003. Second National Report On Human Exposure To Environmental Chemicals. NCEH Pub.No.03–0022. Atlanta, GA Available at http://www.cdc.gov/exposurereport/pdf/SecondNER.pdf.
  • Charnley, G. 2001. Protecting the Children: Risk Assessment, Risk Management, and Children’s Environmental Health. Reason Public Policy Institute. Policy Study 283. Los Angeles, CA.
  • Charnley G and Putzrah RM. 2001. Children’s health, susceptibility, and regulatory approaches to reducing risks from chemical carcinogens. Environ Health Persp 109:187–192.
  • Clemen RT. 1991. Making Hard Decisions, pp. 339–359. Duxbury Press, Belmont, CA.
  • Cohen-Hubal EA, Sheldon LS, Burke JM, McLundy TR, Berry MR, Rigas ML, Zartarian VG, and NCG Freeman. 1999. Children’s exposure assessment: A review of factors influencing children’s exposure, and the data available to characterize and assess that exposure. Environ Health Persp 108:475–486.
  • Consumers Union. 1998. Worst First: High-Risk Insecticide Uses, Children’s Foods and Safer Alternatives. Washington, DC.
  • Consumers Union. 1999. Do You Know What You’re Eating? An Analysis of U.S. Government Data on Pesticide Residues in Foods. Groth F, III, Benbrook C, and Lutz K (Eds). Washington, DC.
  • Cooke RM. 1991. Experts in Uncertainty: Opinion and Subjective Probability in Science, pp 3–18. Oxford University Press, New York.
  • Copeland TL, Paustenbach DJ, Harris MA, and Otani J. 1993. Comparing the results of a Monte Carlo analysis with EPA’s reasonable maximum exposed individual (RMEI): A case study of a former wood treatment site. Reg Toxicol Pharmacol 18:275–312.
  • Cullen AC and Frey HC. 1999. Probabilistic techniques in exposure assessment. Risk Anal 14:389–393.
  • CRITFC (Columbia River Inter-Tribal Fish Commission). 1994. A fish consumption survey of the Umatilla, Nez Perce, Yakama and Warm Springs tribes of the Columbia River Basin. Technical Report 94–3. Portland, OR Available at http://www.critfc.org/tech/94–3 report.html.
  • Danford DC. 1982. Pica and nutrition. Annu Rev Nutr 2:303–322.
  • Dourson ML, Felter SP, and Robinson D. 1996. Evolution of science-based UFs in noncancer risk assessment. Reg Toxicol Pharmacol 24:108–120.
  • Dourson M, Charnley G, and Scheuplein R. 2002. Differential Sensitivity of Children and Adults to Chemical Toxicity. II, Risk and Regulation. Reg Tox Pharmacol 35(3):448–467.
  • EDF (Environmental Defense Fund). 1997. Toxic Ignorance: The Continuing Absence of Basic Health Testing for Top-Selling Chemicals in the United States. Roe D, Pease W, Florini K, and Silbergeld E (eds). Washington, DC Available at http://www.environmentaldefense.org/ documents/243_toxicignorance.pdf.
  • Ershow AG, Brown LM, and Cantor KP. 1991. Intake of tapwater and total water by pregnant and lactating women. Am J Pub Health 81:328–334.
  • Evans JS, Hawkins NC, and Graham JD. 1988. The value of monitoring for radon in the home—A decision-analysis. JAPCA 38:1380–1385.
  • Evans JS, Gray GM, Sielken RL, Jr., Smith AE, Valdez-Flores C, and Graham JD. 1994. Use of probabilistic expert judgment in uncertainty analysis of carcinogenic potency. Reg Tox Pharmacol 20:15–36.
  • EWG (Environmental Working Group). 1993. Pesticides in Children’s Food. Wiles and Cambell (Eds). Washington, DC.
  • EWG (Environmental Working Group). 1998. Overexposed: Organophosphate Insecticides in Children’s Foods. Washington, DC Available at http://www.ewg.org/pub/home/re-ports/ops/ops.html.
  • Etzel RA, Balk SJ, Bearer CF, Hendrick JG, Miller MD, Shannon MW, Shea KM, and Simon PR. 1999. Handbook of Pediatric Environmental Health. American Academy of Pediatrics, Committee on Environmental Health, Elk Grove Village, IL.
  • Feldman MD. 1986. Pica: Current perspectives. Psychosomatics (USA) 27:519–523.
  • Finkel AM and Evans JS. 1987. Evaluating the benefits of uncertainty reduction in environmental-health risk management. Intern J Air Pollut Contr Haz Waste Manag 37:1164–1171.
  • Finley, B., and Paustenbach, D. 1994. The benefits of probabilistic exposure assessment: Three case studies involving contaminated air, water, and soil. Risk Anal 14:53–73.
  • Finley BL, Scott PK, and Mayhall DA. 1994. Development of a standard soil-to-skin adherence probability density function for use in Monte Carlo analyses of dermal exposure. Risk Anal 14:555–569.
  • Flynn GL. 1990. Physicochemical Determinants of Skin Absorption. In: Gerrity TR and Henry CJ (eds), Principles of Route-To-Route Extrapolation for Risk Assessment, pp. 93–127. Elsevier, New York.
  • Freeman NCG, Mimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, Adgate JL, Pellizzari ED, Quackenboss J, Sexton K, and Lioy PJ. 2001. Quantitative analysis of children’s microactivity patterns: The Minnesota children’s pesticide exposure study. J Expos Anal Environ Epidemiol 11:501–509.
  • Frey HC. 1992. Quantitative Analysis of Uncertainty and Variability in Environmental Policy Making. AAAS/US EPA Environmental Science and Engineering Fellows Program, American Association for the Advancement of Science, Washington, DC.
  • Gargas ML, Burgess RJ, Voisard DE, Cason GH, and Andersen ME. 1989. Partition coefficients of low molecular weight volatile chemicals in various liquids and tissues. Toxicol Appl Pharmacol 98:87–99.
  • Gargas ML, Finley BL, Paustenbach DJ, and Long TF. 1999. Environmental Health Risk Assessment: Theory and Practice. In: Ballantyne B, Marrs T, and Syversen T. (Eds), General and Applied Toxicology, Volume 3, 2nd edition, pp. 1, 749–1, 809. Macmillan, London.
  • Goodman M and La Verda N. 2002. Children’s Health and Environmental Exposure to Chemicals: Implications of Risk Assessment and Public Health Policy. In: Paustenbach DJ (Ed), Human and Ecological Risk Assessment: Theory and Practice, pp. 151–188. John Wiley & Sons, New York.
  • Gradient. 2001. Evaluation of Human Health Risks from Exposure to Arsenic Associated with CCA-Treated Wood. Prepared for Arch Wood Protection, Inc. and Osmose, Inc. Gradient Corporation, Cambridge, MA.
  • Graham JD. 1995. Historical perspective on risk assessment in the federal government. Toxicol 102:29–52.
  • Graham JD and Hartwell JK. 1997. The Greening of Industry: A Risk Management Approach. Harvard University Press, Cambridge, MA.
  • Guy RH, Hadgraft J, and Maibach HI. 1982. A pharmacokinetic model for percutaneous absorption. Int J Pharmacol 11:119–129.
  • Hamill PVV, Drizd TA, Johnson CL, Reed RB, Roche AF, and Moore WM. 1979. Physical growth: National center for health statistics percentiles. American J Clin Nutr 32:607–609.
  • Hammitt JK and Cave JAK. 1991. Research Planning for Food Safety: A Value-of-Information Approach, pp 279–325. RAND Corporation, Santa Monica, CA.
  • Hattis D, Banati P, Goble R, and Burmaster DE. 1999. Human interindividual variability in parameters related to health risks. Risk Anal 19:711–724.
  • Hawkins NC, and Graham JD. 1988. Expert scientific judgment and cancer risk assessment: A pilot study of pharmacokinetic data. Risk Anal 8:615–625.
  • Hawkins NC, and Evans JS. 1989. Subjective estimation of toluene exposures: A calibration study of industrial hygienists. Appl Ind Hyg J 4:61–68.
  • HSWMR (Hazardous Substance & Waste Management Research, Inc). 2000a. Health Considerations Related to Arsenic in Soil Under Playground Equipment Constructed of CCA-Treated Wood. Prepared for Hopping Green Sams & Smith and American Wood Preservers Institute. Tallahassee, FL..
  • HSWMR (Hazardous Substance & Waste Management Research, Inc). 2000b. Health Considerations Related to Arsenic in Soil Under Decks Constructed of CCA-Treated Wood. Prepared for Hopping Green Sams & Smith and American Wood Preservers Institute. Tallahassee, FL..
  • Holmes KK, Kissel JC, and Richter KY. 1996. Investigation of the influence of oil on soil adherence to skin. J Soil Contam 5:301–308.
  • Howard RA and Matheson JF. 1983. The Principles and Applications of Decision Analysis. Strategic Decisions Group, Palo Alto, CA.
  • Hubal EA, Sheldon LS, Burke JM, McCurdy TR, Berry MR, Rigas ML, and Zartarian VG. 2000. Children’s exposure assessment: A review of factors influencing children’s exposure, and the data available to characterize and assess that exposure. Env Health Persp 108:475–486.
  • Huang YL and Batterman S. 2000. Effect of Precipitation Variability on Pollutant Concentrations in Soil: Implications for Exposure and Risk Assessment. J Human Ecol Risk Assess 6(5):809–826.
  • ILSI (International Life Sciences Institute). 1998. Aggregate exposure assessment. Washington, DC.
  • ILSI (International Life Sciences Institute). 2000. Aggregate exposure assessment: Model evaluation and refinement workshop report. Health and Environmental Sciences Institute. February. www.ilsi.org.
  • IPCS. 2001. Glossary of key exposure assessment terms. Prepared by the Exposure Terminology Subcommittee of the IPCS Exposure Assessment Planning Workgroup, for the International Programme on Chemical Safety, Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. November 1. Available at http:// www.ipcsharmonize.org/.
  • Juberg DR, Alfano K, Coughlin RJ, and Thompson KM. 2001. An observational study of object mouthing behavior by young children. Pediatrics 107(1):135–142.
  • Juberg, D.R. 2002. Are Children More Vulnerable To Environmental Chemicals? Scientific and Regulatory Issues in Perspective. American Council on Science and Health. New York.
  • Kimbrough R, Falk H, Stahr P, and Frias G. 1984. Health implication of 2,3,7,8– tetrachlorodibenzo-p-dioxin (TCDD) contamination of residential soil. J Toxicol Env Health 14:47–93.
  • Kissel JC, Richter KY, and Fenske RA. 1996. Field measurement of dermal soil loading attributable to various activities: Implications for exposure assessment. Risk Anal 16:115–125.
  • Knaak JB, Iwata Y, and Maddy KT. 1989. The worker hazard posed by reentry into pesticide-treated foliage: Development of safe reentry times, with emphasis on chlorthiophos and carbosulfan. In: Paustenbach D (Ed.), The Risk Assessment of Environmental Hazards: A Textbook of Case Studies, Chapter 24. John Wiley and Sons, New York.
  • Knaak JB, Dary CC, Patterson GT, and Blancato JN. 2002. Worker hazard posed by reentry into pesticide-treated foliage: Reassessment of reentry levels/intervals using foliar residue transfer–percutaneous absorption PBPK/PD models, with emphasis on isofenphos and parathion. In: Paustenbach DJ (Ed.), Human and Ecological Risk Assessment: Theory and Practice, ISBN 0–471–14747–8. John Wiley & Sons, New York.
  • Kolluru RV. 1996. Risk Assessment and Management: A Unified Approach. In: Kolluru RV, Bartell SM, Pitblado RM, and Stricoff RS (Eds.), Risk Assessment and Management Handbook, pp 1.3–1.41. McGraw Hill, New York.
  • Krivanek ND, McLaughlin M, and Fayweather WE. 1978. Monomethylformide levels in human urine after repetitive exposure to dimethylformamide. J Occup Med 20:179–187.
  • Layton DW. 1993. Metabolically consistent breathing rates for use in dose assessments. Health Phys 64:23–36.
  • Lehman, A.J., and Fitzhugh, O.G. 1954. 100–fold margin of safety. Q. Bull. Assoc. Food Drug Off. U.S. 18:33–35.
  • Linn WS, Shamoo DA, and Hackney JD. 1992. Documentation of Activity Patterns in “High-Risk” Groups Exposed to Ozone in the Los Angeles Area. In: Proceedings of the Second EPA/AWMA Conference on Tropospheric Ozone, Atlanta, Nov. 1991, pp 701–712. Air and Waste Management Assoc., Pittsburgh, PA.
  • Lioy PJ, Wainman T, and Weisel C. 1993. A wipe sampler for the quantitative measurement of dust on smooth surfaces: Laboratory performance studies. J Exp Anal Environ Epidemiol 3:315–320.
  • Lioy PJ, Yinn LM, Adgate J, Weisel C, and Rhoads GG. 1998. The effectiveness of a home cleaning intervention strategy in reducing potential dust and lead exposures. J Exp Anal Evniron Epidemiol 8(1):17–35.
  • Lourie RS and Cayman EM. 1963. Why children eat things that are not food. Children 10:143–146.
  • Masters GM. 1998. Risk Assessment. In: Introduction to Environmental Engineering and Science. Prentice Hall, Englewood Cliffs, NJ.
  • McClellan RO. 1998. Risk Assessment. In: Rom WN (Ed.), Environmental and Occupational Medicine. Lippincott-Raven Publishers, Philadelphia, PA.
  • MDEQ (Michigan Department of Environmental Quality). 2001a. Part 201 Generic Soil Direct Contact Criteria Technical Support Document. Environmental Response Division Operational Memorandum #18: Part 201 Generic Cleanup Criteria Tables, Revision 1. As updated September 21 Available at http://www.michigan.gov/deq/0,1607,7–135–3311_4109_9846–20527—,00.html http://www.michigan.gov/deq/0,1607,7–135–3311_4109_9846–20527—,00.html.
  • MDEQ (Michigan Department of Environmental Quality). 2001b. Part 201 Generic Soil Direct Contact Criteria Technical Support Document. Environmental Response Division. January 5.
  • Moolgavkar S and Leubeck EG. 2002. Dose-Response Modeling for Cancer Risk Assessment. In: Paustenbach DJ (Ed.), Human and Ecological Risk Assessment: Theory and Practice, pp. 151–188. John Wiley & Sons, New York.
  • Morgan MG, Morris SC, Henrion M, Amaral DAL, and Rish WR. 1984. Technical uncertainty in quantitative policy analysis—a sulfur air pollution example. Risk Anal 4(3):201–216.
  • NAS (National Academy of Sciences). 1983. Risk Assessment in the Federal Government:
  • Managing the Process. National Research Council, National Academy Press, Washington, DC Available at http://books.nap.edu/books/0309033497/html/index.html http://books.nap.edu/books/0309033497/html/index.html.
  • NAS (National Academy of Sciences). 1994. Science and Judgment in Risk Assessment. National Research Council, National Academy Press, Washington, DC Available at http:/ /books.nap.edu/books/030904894X/html/index.html.
  • NAS (National Academy of Sciences). 1996. Understanding Risk: Informing Decisions in a Democratic Society. National Research Council, National Academy Press, Washington, DC Available at http://books.nap.edu/books/030905396X/html/index.html.
  • NCHS (National Center for Health Statistics). 1987. Anthropometric Reference Data and Prevalence of Overweight, United States, 1976–1980. Data from the National Health and Nutrition Examination Survey, Series 11, No. 238. U.S. Department of Health and Human Services, Public Health Service, Hyattsville, MD. DHHS Publication No. (PHS) 87–1688 Available at http://www.cdc.gov/nchs/data/series/sr_11/sr11_238.pdf.
  • NIEHS (National Institute of Environmental Health Sciences). 2002. Centers for Children’s Environmental Health and Disease Prevention Research. Division of Extramural Research and Training Available at http://www.niehs.nih.gov/translat/children/children.htm.
  • North DW, Selker F, and Guardino T. 1993. Estimating the value of research: An illustrative calculation for ingested inorganic arsenic, pp 1–33. Decision Focus Incorporated.
  • NRDC (Natural Resources Defense Council). 1989. Intolerable Risk: Pesticides in our Children‘s Food. Sewell B, Whyatt R, Hathaway I, and Mott L (Eds.). New York.
  • Ott WR. 1985. Total human exposure. Environ Sci Tech 19:880–886.
  • Paustenbach DJ, and Murray FJ. 1986. A critical examination of assessments of the health risks associated with 2, 3, 7, 8–TCDD in soil. Chemosphere 15:1867–1874.
  • Paustenbach DJ, Finley BL, and Long TF. 1997. The critical role of house dust in understanding the hazards posed by contaminated soils. Int J Toxicol 16:339–362.
  • Paustenbach DJ. 2000. The practice of exposure assessment: A state-of-the-art review. J Tox Environ Health (Part B) 3:179–291.
  • Paustenbach DJ (ed). 2002. Human and Ecological Risk Assessment: Theory and Practice. John Wiley & Sons, New York.
  • Piotrowski J. 1977. Exposure tests for organic compounds in industrial toxicology. National Institute for Occupational Safety and Health, Cincinnati, OH.
  • Price, P.S., Curry, C.L., Goodrum, P.E., Gray, M.N., McCrodden, J.I., Harrington, N.W., Carlson-Lynch, H. and Keenan, R.E. 1996. Monte Carlo modeling of time-dependent exposures using a microexposure event approach. Risk Anal 16:339–348.
  • Price, P.S., Scott, P.K., Wilson, N.D., and Paustenbach, D.J. En empirical approach for deriving information on total duration of exposure from information on historical exposure. Risk Anal 18:611–619.
  • Raiffa H. 1968. Decision Analysis: Introductory Lectures on Choices Under Uncertainty. Random House, New York.
  • Reed KJ, Jimenez M, Freeman NCG, and Lioy PJ. 1999. Quantification of children’s hand and mouthing activities through a videotaping methodology. J Expos Anal Environ Epidemiol 9:513–520.
  • Renwick AG and Lazarus NR. 1998. Human variability and non-cancer risk assessment: An analysis of default uncertainty factors. Reg Toxicol Pharmacol 27:3–120.
  • Roberts SM and Ochoa H. 2001. Risk Assessment of CCA-Preserved Wood in Playground Equipment. Prepared for Florida Department of Environmental Protection. University of Florida, Center for Environmental and Human Toxicology, Gainesville, FL.
  • Rodricks J and Taylor MR. 1983. Application of risk assessment to food safety decision making. Reg Toxicol Pharmacol 3:275–307.
  • Ruckelshaus WD. 1983. Science, risk and public policy. Science 221:1026–1028.
  • Sanga, R.N., Bartell, S.M., Ponce, R.A., Boischio, A.A., Joiris, C.R., Pierce, C.H., Faustman, R.M. 2001. Effects of uncertainties on exposure estimates to methylmercury: A Monte Carlo analysis of exposure biomarkers versus dietary recall estimation. Risk Anal 21:859–868.
  • SAP (Science Advisory Panel). 2002. A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Stochastic Human Exposure and Dose Simulation Model (SHEDS): System Operation Review of a Scenario Specific Model (SHEDS-wood) to Estimate Children’s Exposure and Dose to Wood Preservatives from Treated Playsets and Residential Decks Using EPA’s SHEDS Probabilistic Model. FIFRA Scientific Advisory Panel meeting, Minutes No. 2002–06.
  • Schneider D and Freeman N. 2000. Children’s Environmental Health: Reducing Risk in a Dangerous World. American Public Health Association, Washington, DC.
  • Sielken RL, Bretzlaff RS, and Stevenson DE. 1995. Challenges to default assumptions stimulate comprehensive realism as a new tier in quantitative cancer risk assessment. Regul Toxicol Pharmacol 21: 270–280.
  • Skowronski GA and Abdel-Rahman MS. 2001. Relevance of 10X uncertainty factor to the risk assessment of drugs used by children and geriatrics. J Human Ecol Risk Assess 7(1):139–153.
  • Spier CE, Little DE, Trim SC, Johnson TR, Linn WS, and Hackney JD. 1992. Activity patterns in elementary and high school students exposed to oxidant pollution. J Exposure Analysis Environ Epidemiol 2:277–293.
  • Stanek EJ, III, Calabrese EJ, and Zorn M. 2001. Soil ingestion distributions for Monte Carlo risk assessment in children. J Human Ecol Risk Assess 7(2):369–387.
  • Surber C, Wilhelm KP, Maibach HI, Hall LL, and Guy RH. 1990. Partitioning of chemicals into human stratum corneum: Implications for risk assessment following dermal exposure. Fundam Appl Toxicol 15:99–107.
  • Taylor ER. 1983. How much soil do children eat? In: El Saadi O and Langley A (Eds.), The health risk assessment and management of contaminated sites, pp. 72–77. South Australian Health Commission, Adelaide, South Australia.
  • Taylor AC, Evans JS, and McKone TE. 1993. The value of animal test information in environmental-control decisions. Risk Anal 13:403–412.
  • TERA (Toxicology Excellence for Risk Assessment). 2002a. VCCEP Peer Consultation. Available at http://www.tera.org/peer/VCCEP/welcome.htm.
  • TERA (Toxicology Excellence for Risk Assessment). 2002b. Voluntary Children’s Chemical Evaluation Program (VCCEP) Peer Consultation Meeting on Vinylidene Chloride. Available at http://www.tera.org/peer/VCCEP/VDC/VDCWelcome.htm.
  • TERA (Toxicology Excellence for Risk Assessment). 2003a. The Ad Hoc Panelist Nomination Period for the VCCEP Chemicals Octabromodiphenyl Ether (CAS No. 32536–52–0) and Pentabromodiphenyl Ether (CAS No. 32534–81–9) Will Close on Friday, February 7, 2003. Available at http://www.tera.org/peer/VCCEP/ADNomClosed.htm.
  • TERA (Toxicology Excellence for Risk Assessment). 2003b. Peer Consultation Meeting for Decabromodiphenyl Ether. Available at http://www.tera.org/peer/VCCEP/ DECAWelcome.htm.
  • Thompson KM and Graham JD. 1996. Going beyond the single number: Using probabilistic risk assessment to improve risk management. Human Ecol Risk Assess 2:1008–1034.
  • Tulve NS, Suggs JC, McCurdy T, Cohen-Hubal EA, and Moya J. 2002. Frequency of mouthing behavior in young children. J Expos Anal Environ Epidemiol 12:259–264.
  • USDA (U.S. Department of Agriculture). 1995. Food And Nutrient Intakes by Individuals in the United States, 1 day, 1989–91. Agricultural Research Service. NFS Report No. 91– 2 Available by tape or CD-ROM at http://www.barc.usda.gov/bhnrc/foodsurvey/ Csfii89.html.
  • USDA (U.S. Department of Agriculture). 1998. 1994–96 Continuing Survey of Food Intakes by Individuals (CSFII) and 1994–96 Diet and Health Knowledge Survey (DKHS). Agricultural Research Service Available by tape or CD-ROM at http://www.barc.usda.gov/bhnrc/ foodsurvey/Csfii94.html.
  • U.S. EPA (Environmental Protection Agency). 1985. Development of statistical distributions or ranges of standard factors used in exposure assessments. Office of Research and Development, Office of Health and Environmental Assessment. EPA 600/8–85–010. Washington, DC.
  • U.S. EPA (Environmental Protection Agency). 1986. Guidelines for Carcinogen Risk Assessment. 51 Federal Register 33992, Washington, DC. Available at http://www.epa.gov/ ncea/raf/car2sab/guidelines_1986.pdf.
  • U.S. EPA (Environmental Protection Agency). 1989. Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part A. Office of Emergency and Remedial Response, Washington, DC. EPA/540/1–89/002. Available at http://www.epa.gov/ superfund/programs/risk/ragsa/index.htm.
  • U.S. EPA (Environmental Protection Agency). 1990. Exposure Factors Handbook. Office of Health and Environmental Assessment, Washington, DC. EPA/600/8–89/043. March.
  • U.S. EPA (Environmental Protection Agency). 1992a. Guidelines for Exposure Assessment. Notice. 57 Federal Register (104): 22888–22938,Washington, DC. May. Available for download at http://cfpub.epa.gov/ncea/raf/recordisplay.cfm?deid=15263.
  • U.S. EPA (Environmental Protection Agency). 1992b. Dermal exposure assessment: Principles and applications. Interim Report. Exposure Assessment Group, Office of Health and Environmental Assessment, Washington, DC. EPA/600/8–91/011B January Available at http://www.epa.gov/nceawww1/pdfs/derexp.pdf.
  • U.S. EPA (Environmental Protection Agency). 1995. Elements to Consider When Drafting EPA Risk Characterizations, United States Environmental Protection Agency, Science Policy Council, Washington, D.C. Available at http://www.epa.gov/ordntrn/ORD/spc/ http://www.epa.gov/ordntrn/ORD/spc/rcelemen.htm.
  • U.S. EPA (Environmental Protection Agency). 1996. Proposed Guidelines for Carcinogen Risk Assessment. Office of Research and Development, Washington, DC. EPA/600/P-92/ 003C Available at http://www.epa.gov/ORD/WebPubs/carcinogen/carcin.pdf http://www.epa.gov/ORD/WebPubs/carcinogen/carcin.pdf.
  • U.S. EPA (Environmental Protection Agency). 1997a. Exposure Factors Handbook. Office of Research and Development, Washington, DC. EPA/600/P-95/002Fa. August. Available at http://www.epa.gov/nceawww1/pdfs/efh/front.pdf.
  • U.S. EPA (Environmental Protection Agency). 1997b. Guiding Principles for Monte Carlo Analysis. Office of Research and Development, Washington, DC. EPA/630/R-97/001. Available at http://www.epa.gov/ncea/raf/montecar.pdf.
  • U.S. EPA (Environmental Protection Agency). 1997c. Methodology for assessing health risks associated with multiple exposure pathways to combustor emissions. National Center for Environmental Assessment, Washington, DC. NCEA-C-0238.
  • U.S. EPA (Environmental Protection Agency). 1998. Guidance for Submission of Probabilistic Human Health Exposure Assessments to the Office of Pesticide Programs. Draft. November 4, 1998.
  • U.S. EPA (Environmental Protection Agency). 1999a. EPA glossary of IRIS terms. Integrated Risk Information System, Washington, DC.
  • U.S. EPA (Environmental Protection Agency). 1999b. Draft Guidance on Developing Robust Summaries. October 22. Available at http://www.epa.gov/oppt/chemrtk/robsumgd.htm.
  • U.S. EPA (Environmental Protection Agency). 1999c. Guidelines for Carcinogen Risk Assessment (SAB review copy, July). Washington, DC Available at http://www.epa.gov/IRIS/ cancer_gls.pdf.
  • U.S. EPA (Environmental Protection Agency). 1999d. Children and Drinking Water Standards. Office of Water (4607). 815–K-99–001. December. Available at http://www.epa.gov/ safewater/kids/health.html.
  • U.S. EPA (Environmental Protection Agency). 1999e. Risk Assessment Guidelines for Dermal Assessment. Washington, DC.
  • U.S. EPA (Environmental Protection Agency). 1999f. Guidance For Performing Aggregate Exposure and Risk Assessments. Office of Pesticide Programs. October 29. Washington, DC. Available at http://www.epa.gov/fedrgstr/EPA-PEST/1999/November/Day-10/ 6043.pdf.
  • U.S. EPA (Environmental Protection Agency). 1999g. Guidance For Identifying Pesticide Chemicals and Other Substances That Have A Common Mechanism of Toxicity. January 29. Washington, DC. Available at http://www.epa.gov/fedrgstr/EPA-PEST/1999/Febru-ary/Day-05/6055.pdf.
  • U.S. EPA (U.S. Environmental Protection Agency). 2000. Summary Report of the Technical Workshop on Issues Associated with Considering Developmental Changes in Behavior and Anatomy when Assessing Exposure to Children. EPA/630/R-00/005. December. Available at http://cfpub.epa.gov/ncea/raf/wrkshops.cfm.
  • U.S. EPA (U.S. Environmental Protection Agency). 2001a. Preliminary Evaluation of the Non-Dietary Hazard and Exposure to Children from Contact with Chromated Copper Arsenate Treated Wood Playground Structures and Contaminated Soil. Final Report for the FIFRA Scientific Advisory Panel Meeting, October 23–25, 2001. SAP Report No. 2001– 12. Office of Pesticide Programs, Washington, DC. Available at http://www.epa.gov/ oscpmont/sap/2001/october/ccawood.pdf.
  • U.S. EPA (U.S. Environmental Protection Agency). 2001b. Aggregate Residential Exposure Model Comparison Workshop. Research Triangle Park, NC. October.
  • U.S. EPA (Environmental Protection Agency). 2002a. Fact Sheet: EPA Leadership–Office of Children’s Health Protection. Office of Children’s Health Protection, Washington, DC.
  • U.S. EPA (Environmental Protection Agency). 2002b. Fact Sheet: Voluntary Children’s Chemical Evaluation Program (VCCEP). Washington, DC.
  • U.S. EPA (Environmental Protection Agency). 2002c. Child-Specific Exposure Factors Handbook (Interim Report). Office of Research and Development, National Center for Environmental Assessment, Washington, DC. EPA-600–P-00–002B. September 1. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=55145.
  • U.S. EPA (Environmental Protection Agency). 2002d. Six Year Review of Drinking Water Standards. Available at http://www.epa.gov/safewater/review.html.
  • U.S. EPA (U.S. Environmental Protection Agency). 2003a. Supplemental Guidance for Assessing Cancer Susceptibility from Early-Life Exposure to Carcinogens (External Review Draft). EPA/630/R-03/003. Available at http://cfpub.epa.gov/ncea/cfm/ recordisplay.cfm?deid=55446.
  • U.S. EPA (U.S. Environmental Protection Agency). 2003b. CHAD (Consolidated Human Activity Database). Available at http://www.epa.gov/chadnet1. [accessed 25 January 2003].
  • U.S. FDA (Food and Drug Administration). 2001. Additional Safeguards for Children in Clinical Investigations of FDA_Regulated Products. Federal Register: 66(79): 20589–20600. April 24.
  • Walker KD, Evans JS, and Macintosh D. 2001. Use of expert judgment in exposure assessment, Part I. Characterization of personal exposure to benzene. J Exp Anal Environ Epidemiol 11:308–322.
  • Wallsten TS and Whitfield RG. 1986. Assessing the Risks to Young Children of Three Effects Associated with Elevated Blood Lead Levels. Argonne National Laboratory, Argonne, IL. ANL/AA –32.
  • Wargo J. 1996. Our Childern’s Toxic Legacy: How Science and Law Fail to Protect Us From Pesticides. Yale University Press, New Haven, CT.
  • Weaver V, Buckley T, and Groopman J. 1998. Approaches to environmental exposure assessment in children. Environ Health Persp 106:827–832.
  • Wepierre J and Marty JP. 1979. Percutaneous absorption of drugs. Trends Pharmacol Sci 1:23–26.
  • WHO (World Health Organization). 1996. Principles for evaluating health risks from chemicals during infancy and early childhood: The need for a special approach. Environmental Health Criteria 59, World Health Organization, International Programme on Chemical Safety.
  • Wilson RW and Crouch EAC. 2001. Risk-Benefit Analysis. Center for Risk Analysis, Harvard University, Harvard University Press, Boston, MA.
  • Winkler RL, Wallsten TS, Whitfield RG, Richmond HM, Hayes SR, and Rosenbaum AS. 1995. An assessment of the risk of chronic lung injury attributable to long-term ozone exposure. Oper Res 43:19–28.
  • Williams PL and Burson JL. 1985. Industrial Toxicology: Safety and Health Applications in the Workplace. Van Nostrand Reinhold, New York.
  • Williams, P.R.D., P.K. Scott, P. J. Sheehan, and D.J. Paustenbach. 2000. A probabilistic assessment of household exposures to MTBE in California drinking water. Human Ecol Risk Assess 6:827–849.
  • Williams PRD and Paustenbach DJ. 2002. Risk characterization: Principles and practice. J Tox Environ Health (Part B) 5337–5406.
  • Winter CK. 1992. Dietary pesticide risk assessment. Rev Environ Contam Toxicol 127:23–67.
  • Wolt. 1999. Exposure Endpoint Selection in Acute Dietary Risk Assessment. Regul Toxicol Pharmacol 29:279.
  • Wright GW and Ayton P. 1994. Subjective Probability. John Wiley and Sons, New York.
  • Yeh, S. and Small, M.J. 2002. Incorporation exposure models in probabilistic assessment of the risks of premature mortality from particulate matter. J Exposure Anal Environ Epi 12:389–403.
  • Yokota F and Thompson KM. 2002a. Value of information (VOI) analysis in environmental health risk management (EHRM): past, present, and future. Submitted to Risk Analysis.
  • Yokota F and Thompson KM. 2002b. Value of information literature analysis (VOILA): A review of applications in health risk management. Submitted to Medical Decision Making.
  • Zartarian VG, Ott WR, and Duan N. 1997a. A quantitative definition of exposure and related concepts. Feature article. J Exposure Anal Environ Epidemiol 7(4):411–437.
  • Zartarian VG, Ferguson AC, and Leckie JO. 1997b. Quantified dermal activity data from a four-child pilot field study. J Expos Anal Environ Epidemiol 7(4):534–553.
  • Zartarian VG and Leckie JO. 1998. Dermal exposure: The missing link. The emerging understanding of this exposure route will help complete the human health risk model. Feature article. Environ Sci Technol 3(3):134A–137A.
  • Zartarian VG, Xue J, Ozkaynak H, Glen G, Stallings C, Smith L, Dang W, Cook N, Aviado D, Mostaghi S, and Chen J. 2002. Technical Manual: Using SHEDS-Wood (Stochastic Human Exposure and Dose Simulation Model for a Wood Preservative Scenario) for the Assessment of Children’s Exposure and Dose from Treated Wood Preservatives on Playsets and Residential Decks. Prepared for U.S. EPA Office Of Pesticide Programs FIFRA (Federal Insecticide, Fungicide, Rodenticide Act) Science Advisory Panel meeting, August 30.

SUPPLEMENTAL BIBLIOGRAPHY

  • ATSDR (Agency for Toxic Substances and Disease Registry). 1997. Healthy children–Toxic environments. Report of the Child Health Workgroup Board of Scientific Counselors.
  • U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA Available at http://www.atsdr.cdc.gov/child/chw497.html.
  • Adams J, Barone S, Jr., LaMantia A, Philen R, Rice D, Spear L, and Susser E. 2000. Workshop to identify critical windows of exposure for children’s health: Neurobehavioral work group summary. Environ Health Persp 108(Suppl3):535–544.
  • Bates DV. 1995. The effects of air pollution on children. Environ Health Persp 103(Suppl 6):49–53.
  • Bearer CF. 1995. How are children different from adults? Environ Health Persp 103(Suppl 6):7–12.
  • Beck BD, Mattuck RL, and Bowers TS. 2002. Adult:childdifferences in the intraspecies uncertainty factor: A case study using lead. J Human Ecol Risk Assess 8(4).
  • Bolt HM. 2001. Occupational vs. environmental and lifestyle exposures of children and adolescents in the European Union. Toxicol Letters Shannon 123(Suppl 1):123–5.
  • Borrud LG, Krebs-Smith SM, Friedman L, and Guenther PM. 1993. Food and nutrient intakes of pregnant and lactating women in the United States. J Nutr Edu 25(4):176–185.
  • Bowers TS and Mattuck RL. 2001. Further comparisons of empirical and epidemiological data using the Integrated Exposure Uptake Biokinetic Model for Lead in Children. J Human Ecol Risk Assess 7(6):1699–1715.
  • Bruckner JV and Weil WB. 1999. Biological factors which may influence an older child’s adolesent’s responses to toxic chemicals. Regul Toxicol Pharmacol 29:158–164.
  • Bukowski JA, Lewis RJ, Gamble JF, Wojcik NC, and Laumbach RJ. 2002. Range-finding study of risk factors for childhood asthma development and national asthma prevalence. J Human Ecol Risk Assess 8(4).
  • Burmaster DE. 1998. Lognormal distributions for total water intake and tap water intake by pregnant and lactating women in the United States. Risk Anal 18(2):215–219.
  • Daniels JL, Olshan AF, and Savitz DA. 1997. Pesticides and childhood cancers. Environ Health Persp 105(10):1068–1076.
  • Dietrich KN. 1999. Environmental chemicals and child development. J Pediatrics 134 (1):7–9.Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, and Ponce RA. 2000. Mechanisms underlying children’s susceptibility to environmental toxicants. Environ Health Perspect 108(Suppl 1):108–21.
  • Fenske R, Kissel J, Lu C, Simcox NJ, Knutson D, and Koch D. 1999. Biologically based analysis of organophosphorus pesticide exposures in children in agricultural communities. Epidemiology 10(4):Supplement.
  • Fenske R. 2000. Pesticide exposure and children. Part 1: Why focus on kids? Agrichem Environ News.
  • Fitzgerald JD. 2001. Young’s old uncertainty factor formula for the young. J Human Ecol Risk Assess 7(2):467–471.
  • Goldman LR. 1995. Children—Unique and vulnerable. Environmental risks facing children and recommendations for response. Environ Health Persp 103(Suppl 6):103–18.
  • Gurney JG, Davis S, Severson RK, Fang J, Ross JA, and Robison LL. 1996. Trends in cancer incidence among children in the U.S. Cancer 78(3):532–541.
  • Hietanen E and Vainio H. 2000. Comparison of Early Childhood and Adult Exposure on Cancer Expression. Nestle Nutrition Workshop Series: Risk Assessment in the Food Chain of Children. Williams and Wilkins Lippincott. Philadelphia, PA. 44:23–33.
  • Holmes H. 1995. Building healthy communities for children: The transportation link. Environ Health Persp 103(Suppl 6):103–72.
  • Kacew S. 1993. Adverse effects of drugs and chemicals in breast milk on the nursing infant. J Clin Pharmacol 33 (3):213–221.Kacew, S. Neonatal Toxicology. General and Applied Toxicology, Chapter 55, pp. 1215–1232.
  • Kimbrough RD and Krouskas CA. 2001. Polychlorinated Biphenyls, Dibenzo-p-dioxins, and Dibenzofurans and Birth Weight and Immune and Thyroid Function in Children. Reg Tox Pharmacol 34(1): 42–52.
  • Kimmel CA. 2001. 1999 Warkany lecture: Improving the science for predicting risks to children’s health. Teratol 63(5):202–209.
  • Kimmel G and Vu V. 2001. Framework for Human Health Risk Assessment. J Human Ecol Risk Assess 7(1):153–156.
  • Krasnegor NA, Otto DA, Holmes Bernstein J, Burke R, Chappell W, Eckerman DA, Needleman HL, Oakley G, Rogan W, Terracciano G, and Hutchinson L. 1994. Neurobehavioral test strategies for environmental exposures in pediatric populations. Neurotoxicol Teratol 16(5):499–509.
  • Landrigan PJ, Carlson JE, Pearer CF, Cranmer SJ, Bullard RD, Etzel RA, Groopman J, McLachlan JA, Perera FP, Reigart JR, Robison L, Schell L, and Suk WA. 1998. Children’s health and the environment: A new agenda for prevention research. Environ Health Persp 106(Suppl):787–794.
  • Landrigan PJ, Sonawane B, Mattison D, McCally M, and Garg A. 2002. Chemical contaminants in breast milk and their impacts on children’s health: An overview. Environ Health Persp 110(6):A313–A315.
  • McBride ML. 1998. Childhood cancer and environmental contaminants. Can J Public Health 8(Suppl):53–62.
  • Mott L. 1995. The disproportionate impact of environmental health threats on children of color. Environ Health Persp 103(Suppl 6):103–35.
  • National Cancer Institute. Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975–1995. SEER Pediatric Monograph. Available at http://www.seer.cancer.gov/publications/childhood/.
  • Needham LL and Sexton K. 2000. Assessing children’s exposure to hazardous environmental chemicals: An overview of selected research challenges and complexities. J Expo Anal Environ Epidemiol 10(6 Pt 2):611–629.
  • Needleman HL. 1995. Behavioral toxicology. Environ Health Persp 103(6):77–79.
  • Paustenbach DJ. 1995. The practice of health risk assessment in the United States (1975–1995): How the U.S. and other countries can benefit from that experience. Human Ecol Risk Assess 1:29–79.
  • Paustenbach DJ. 2000. Patty’s Industrial Hygiene, Fifth Edition, Volume 3, pp 1903–2000. John Wiley & Sons, New York.
  • Paustenbach DJ. 2002. Children’s health study points to need for cumulative risk reviews of chemicals. Chemical Policy Alert. Avaliable at www.ChemicalPolicyAlert.com.
  • Pelekis M, Gephart LA, and Lerman SE. 2001. Physiological-Model-Based Derivation of the Adult and Child Pharmacokinetic Intraspecies Uncertainty Factors for Volatile Organic Compounds. Reg Tox Pharmacol 33(1): 12–20.
  • Pohl HR and Tylenda CA. 2000. Breast-feeding exposure of infants to selected pesticides: A public health viewpoint. Toxicol Indust Health 16(2):65–77.
  • Rees NMA and Day MJL. 2000. UK consumption databases relevant to acute exposure assessment. Food Addit Contamin 17(7):575–581.
  • Renwick AG, Dorne JL, and Walton K. 2000. An analysis of the need for an additional uncertainty factor for infants and children. Reg Tox Pharmacol 31(3):286–296.
  • Richter-Reichhelm HB, Althoff J, Schulte A, Ewe S, and Gundert-Remy U. 2002. Children as a special subpopulation: Focus on immunotoxicity. Federal Institute for Health Protection of Consumers and Veterinary Medicine. Arch Toxicol 76(7):377–382.
  • Rogan WJ. 1995. Environmental poisoning of children–Lessons from the past. Environ Health Persp 103(Suppl 6):103–23.
  • Rogan WJ and Ragan NB. 2000. Hazards to Infants in the Food Chain: Exposure through Breast Milk. Nestle Nutrition Workshop Series: Risk Assessment in the Food Chain of Children. Williams and Wilkins Lippincott. Philadelphia, PA. 44:163–178.
  • Ryan AS. 1997. The resurgence of breastfeeding in the United States. Pediatrics 99 (4):E12.Scheuplein, RJ. 2000. Pesticides and Infant Risk: Is There a Need for an Additional Safety Margin? Reg Tox Pharmacol 31(3): 267–279.
  • Scheuplein R, Charnley G, and Dourson M. 2002. Differential Sensitivity of Children and Adults to Chemical Toxicity, I. Biological Basis. Reg Tox Pharmacol 35(3): 429–447.
  • Schmidt CW. 1999. Poisoning young minds. Environ Health Persp 107(6):A302–A307.
  • Shu H, Paustenbach D, Murray FJ, Marple L, Brunck B, Dei Rossi D, and Teitelbaum P. 1988.
  • Bioavailability of soil-bound TCDD: Dermal bioavailability in the rat. Fundam Appl Toxicol 10:648–654.
  • Sonawane BR. 1995. Chemical contaminants in human milk: An overview. Environ Health Persp 103(Suppl 6):103–205.
  • Thomas RD. 1995. Age-specific carcinogenesis: Environmental exposure and susceptibility. Environ Health Persp 103(Suppl 6):103–48.
  • Van Klaveren JD, Van Dooren MMH, Kloet D, and Kuiper HA. 2000. The Process of Exposure Assessment. Nestle Nutrition Workshop Series: Risk Assessment in the Food Chain of Children. Williams and Wilkins Lippincott. Philadelphia, PA. 44:145–161.
  • Van-Veen MP, Van-Engelen JGM, Fan-Raaij MTM. 2001. Crossing the river stone by stone: Approaches for residential risk assessment for consumers. Annals Occupat Hyg 45(Suppl1):S107–S118.

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