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Miscellany

Childhood Acute Bacterial Meningitis in the Suda: An Epidemiological, Clinical and Laboratory Study

Pages 1-103 | Published online: 02 Jan 2015

References

  • Abdillahi H, Crowe BA, Achtman M, Poolman JT. Two monoclonal antibodies specific for serotype 4 antigen of Neisseria meningitidis. Eur J Clin Microbiol Infect Dis 1988;7:293–6
  • Abdillahi H, Poolman JT. Neisseria meningitidis group B serosubtyping using monoclonal antibodies in whole-cell ELISA. Microb Pathogen 1988;4:27–32
  • Abdillahi H, Poolman JT. Whole-cell ELISA for typing Neisseria meningitidis with monoclonal antibodies. FEMS Microbiol Lett 1987;48:367–71
  • Achtman M, Neibert M, Crowe BA, . Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A. J Exp Med 1988;168:507–25
  • Achtman M. Molecular epidemiology of epidemic bacterial meningitis. Reviews in Medical Microbiology 1990;1: 29–38
  • Ahronheim GA, Reich B, Marks MI. Penicillin-insensitive pneumococci: Case report and review. Am J Dis Child 1979;133: 187–91
  • American Academy of Pediatrics. Committee on Infectious Diseases. Haemophilus influenzae type b conjugate vaccine. Pediatrics 1988a;81: 908–11
  • American Academy of Pediatrics. Committee on Infectious Diseases. Treatment of bacterial meningitis. Pediatrics 1988b;81:904–7
  • Ammann AJ, Addiego J, Wara DW, Lubin B, Smith WB, Mentzer WC. Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. N Engl J Med 1977;297:897–900
  • Anastasi A. Psychological Testing. New York; MacMillan, 1982:228–42
  • Andersen BM. Endotoxin release from Neisseria meningitidis. Scand J Infect Dis 1989; Suppl 64:11–12
  • Anonymous. Classification of infantile malnutrition. Lancet 1970;ii:302–3
  • Anonymous. Hepatitis: Transmission of hepatitis B associated with jet gun injection. Weekly Epidemiol Record 1986;61:309–11
  • Artenstein MS, Rust JH, Hunter DH, Lamson TH, Buescher EL. Acute respiratory disease and meningococcal infection in army recruits. JAMA 1967;201:1004–7
  • Ashton FE, Ryan A, Diena B, Jennings HJ. A new serogroup (L) of Neisseria meningitidis. J Clin Microbiol 1983;17:722–7
  • Attia HT, Sidig A. The refugee population: Policy implications and future development. In: Saghayroun AA, Farah A-AA, Ahmed SA, Kheir A-HHM, eds. Population and development in The Sudan: The quest for a national policy. Chapell Hill: JPA, 1988:177–83
  • Austrian R. Pneumococcal polysaccharide vaccines. Rev Infect Dis 1989;11( Suppl 3):S598–S602
  • Baldwin RL, Sweitzer RS, Freind DB. Meningitis and sensorineural hearing loss. Laryngoscope 1985;95:802–5
  • Band JD, Fraser DW, Ajello G, Haemophilus influenzae Disease Study Group. Prevention of Haemophilus influenzae type b disease. JAMA 1984;251:2381–6
  • Bannister BA. Chemoprophylaxis of bacterial meningitis. In: William JD, Burnie J. Bacterial meningitis. London: Academic Press, 1987:135–52
  • Barson WJ, Miller MA, Brady MT, Powell DA. Prospective comparative trial of ceftriaxone vs. conventional therapy for treatment of bacterial meningitis in children. Pediatr Infect Dis 1985;4:362–8
  • Bayoumi A. The history of Sudan health services. Nairobi: Kenya Literature Bureau, 1979:206–21
  • Beam WE, Newberg, NR, Devine LF, Pierce WE, Davies JA. The effect of rifampin on the nasopharyngeal carriage of Neisseria meningitidis in a military population. J Infect Dis 1971;124:39–46
  • Bedri Y, Hogg P, eds. The memoirs of Babikr Bedri. London: Ithaca Press, 1980:87–8
  • Belcher DW, Sherriff AC, Nimo KP, . Meningococcal meningitis in northern Ghana: Epidemiology and control measures. Am J Trop Med Hyg 1977;26:748–55
  • Bellman SC: Hearing disorders in children. Br Med Bull 1987: 43:966–82
  • Berger U. New serogroups of Neisseria meningitidis isolated in the Federal Republic of Germany. Eur J Clin Microbiol 1985; 4:351
  • Berkowitz FE. Pneumococcal bacteraemia - a study of 75 black children. Ann Trop Paediatr 1981;1:229–35
  • Bernard-Bonnin A-C, Ekoe T. Les méningites purulentes de I' enfant à Yaounde; aspects épidémiologiques et prognostiques. Ann Soc Belge Méd Tropicale 1985;65:59–68
  • Beuvery EC, van Rossum F, Lauwers S, Coignau H. Comparison of counterimmunoelectrophoresis and ELISA for diagnosis of bacterial meningitis. Lancet 1979;i:208
  • Bhushan V, Chintu C. Changing pattern of pyogenic meningitis in Lusaka. East Afr Med J 1979;56:548–56
  • Biegeleisen JZ, Mitchell MS, Marcus BB, Rhoden DL, Blumberg RW. Immunofluorescence techniques for demonstrating bacterial pathogens associated with cerebrospinal meningitis. I. Clinical evaluation of conjugates on smears prepared directly from cerebrospinal fluid sediments. J Lab Clin Med 1965; 65:976–89
  • Binkin N, Band J. Epidemic of meningococcal meningitis in Bamako, Mali: Epidemiological features and analysis of vaccine efficacy. Lancet 1982;ii:315–8
  • Bjorvatn B, Bjertnaes L, Fadnes HO, . Meningococcal septicaemia treated with combined plasmapheresis and leucap-heresis or with blood exchange. Br Med J 1984a;288:439–41
  • Bjorvatn B, Lund V, Kristiansen B.E., Korsnes L, Spanne O, Lindqvist B. Applications of restriction endonuclease fingerprinting of chromosomal DNA of Neisseria meningitidis. J Clin Microbiol 1984b;19:763–5
  • Blakebrough IS, Gilles HM. The effect of rifampicin on meningococcal carriage in family contacts in northern Nigeria. J Infect 1980;2:137–43
  • Blakebrough IS, Greenwood BM, Whittle HC, Bradley AK, Gilles HM. Failure of meningococcal vaccination to stop the transmission of meningococci in Nigerian schoolboys. Ann Trop Med Parasitol 1983;77:175–8
  • Braconier JH, Sjöholm AG, Söderström C. Fulminant meningococcal infections in a family with inherited deficiency of properdin. Scand J Infect Dis 1983;15:339–45
  • Brandtzaeg P, Dahle JS, Höiby EA. The occurrence and features of hemorrhagic skin lesions in 115 cases of systemic meningococcal disease. NIPH Annals 1983;6:183–90, 202–3
  • Brandtzaeg P, Sandset PM, Joö GB, Övstebö R, Abildgaard U, Kierulf P. The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease. Thromb Res 1989a;55:459–70
  • Brandtzaeg P. Kierulf P, Gaustad P, . Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disese. J Infect Dis 1989b; 159:195–204
  • Branham SE. Milestones in the history of the meningococcus. Can J Microbiol 1956;2:175–88
  • Branham SE. Serological relationships among meningococci. Bacteriol Rev 1953;17:175–88
  • Broome CV. Epidemiology of Haemophilus influenzae type b infections in the United States. Pediatr Infect Dis J 1987; 6:779–82
  • Broome, CV, Rugh MA, Yada AA, . Epidemic group C meningococcal meningitis in Upper Volta, 1979. Bull World Health Organ 1983;61:325–30
  • Brown KGE. Meningitis in Queen Elisabeth Central Hospital, Blantyre, Malawi. East Afr Med J 1975;52:376–85
  • Bryant J, Fairman HD. Chemotherapy of cerebrospinal fever in the field. Lancet 1939;i:923–6
  • Bryant J, Fairman HD. Field experiences with the sulphanila-mide group of drugs in the southern Sudan. Tran R Soc Trop Med Hyg 1940;34:117–38
  • Buchanan RM. Chemotherapy in cerebrospinal meningitis in The Sudan. J Hyg 1940;40:605–14
  • Burans JP, El Tayeb M, Abu-Elyazeed R, Woody JN. Comparison of latex agglutination with established bacteriological tests for diagnosis of cerebrospinal meningitis. Lancet 1989;ii:158–9
  • Bövre K, Gedde-Dahl TW. Epidemiological patterns of meningococcal disease in Norway 1975–79. NIPH Ann 1980;3:9–22
  • Cadoz M, Denis F, Mar ID. Etude épidémiologique des cas de méningites purulentes hospitalisés à Dakar pendant la décen-nie 1970–1979. Bull World Health Organ 1981;59:575–84
  • Caugant DA, Bövre K, Gaustad P, Bryn K, Holten E, Höiby EA, Fröholm LO. Multilocus genotypes determined by enzyme electrophoresis of Neisseria meningitidis isolated from patients with systemic disease and from healthy carriers. J Gen Microbiol 1986a;132:641–52
  • Caugant DA, Fröholm LO, Bövre K, Holten E, Frasch CE, Mocca LF, Zollinger WD, Selander RK. Intercontinental spread of genetically distinctive complex of clones of Neisseria meningitidis causing epidemic disease. Proc Natl Acad Sci USA 1986b;83:4927–31
  • Caugant DA, Mocca LF, Frasch CE, Fröholm LO, Zollinger WD, Selander RK. Genetic structure of Neisseria meningitidis populations in relation to serogroup, serotype, and outer membrane protein pattern, J Bacteriol 1987;169:2781–92
  • Centres for Disease control, Altanta. Prevention of secondary cases of Haemophilus influenzae type b disease. MMWR 1982;31:672–4, 679–80
  • Centres for Disease Control, Atlanta. Vestibular reactions to minocycline follow up - Georgia, New York, Vermont. MMWR 1975;24:55–6
  • Chalmers AJ, O'Farrel WR. Preliminary remarks upon epidemic cerebrospinal meningitis as seen in the Anglo-Egyptian Sudan. J Trop Med Hyg 1916;19:101–27
  • Cisse MF, Sow HD, Ouangre AR, . Meningites bacteriennes dans un hopital pediatrique en zone tropicale. Med Trop (Mars) 1989;49: 265–9
  • Claesson BA, Schneerson R, Robbins JB, . Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugate. J Pediatr 1989;114: 97–100
  • Cochi SL, Fleming DW, Hightower AW, . Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors. J Pediatr 1986;108:887–96
  • Cochi SL, Markowitz LE, Joshi DD, . Control of epidemic group A meningococcal meningitis in Nepal. Int J Epidemiol 1987;16:91–7
  • Colding H, Lind I. Counterimmunoelectrophoresis in the diagnosis of bacterial meningitis. J Clin Microbiol 1977;5:405–9
  • Coovadia YM, Naidu KK. Evaluation of Bactigen latex agglutination and Phadebact coagglutination for detection of bacterial antigens in cerebrospinal fluid. J Clin Path 1985;38: 561–4
  • Coovadia YM, Van Den Ende J, Solwa Z. Comparison of gram stain and latex agglutination for diagnosis of meningococcal meningitis. Lancet 1989;ii:677
  • Corkill NL. Climate as a factor in epidemic meningitis in Kordofan. Lancet 1939;i:1203–5
  • Coulehan JL, Michaels RH, Williams KE, . Bacterial meningitis in Navajo Indians. Pub Hlth Rep 1976;91:464–8
  • Counts GW, Gregory DF, Spearman JG, . Group A meningococcal disease in the U.S. Pacific Northwest: Epidemiology, clinical features, and effect of a vaccination control program. Rev Infect Dis 1984;6:640–8
  • Crowe BA, Abdillahi H, Poolman JT, Achtman M. Correlation of serological typing and clonal typing methods for Neisseria meningitidis sero-group A. J Med Microbiol 1988;26:183–7
  • Crowe BA, Wall B, Kusecek B, . Clonal and variable properties of Neisseria meningitidis isolated from cases and carriers during and after an epidemic in The Gambia, West Africa. J Infect Dis 1989;159:686–700
  • Danielsson D, Forsum U. Diagnosis of Neisseria infections by defined immunofluorescence: Methodologic aspects and applications. Ann NY Acad Sci 1975;254:334–49
  • Davis LJ. A bacteriological investigation of epidemic cerebrospinal meningitis in the southern Sudan. Trans R Soc Trop Med Hyg 1931;24:617–22
  • Denis FA, Greenwood BD, Rey JL, . Etude multicentrique des sérotypes de pneumocoques en Afrique. Bull World Health Organ 1983;61:661–9
  • Devine LF, Hagerman CR. Relationship of serogroups of Neisseria meningitidis. I. Microagglutination, gel diffusion, and slide agglutination studies of meningococcal antisera before and after absorption with RAS-10 strains of meningococci. Infect Immun 1970;1:226–31
  • Diop Mar I, Denis F, Cadoz M. Epidémiologie des méningites á pneumocoque en Afrique. Aspects cliniques et sérotypiques. Pathol Biol 1979;27:543–8
  • Dodge PR, Davis H, Feigin RD, . Prospective evaluation of hearing impairment as sequela of acute bacterial meningitis. N Engl J Med 1984;311:869–74
  • Dodge PR, Swartz MN. Bacterial meningitis: A review of selected aspects. II. Special neurologic problems, postmeningitic complications and clinicopathological correlations. N Engl J Med 1965;272:1003–10
  • Drow DL, Maki DG, Manning DD. Indirect sandwich enzyme-linked immunosorbent assay for rapid detection of Haemophilus influenzae type b infection. J Clin Microbiol 1979;10: 442–50
  • Drow DL, Welch DF, Hensel D, Eisenach K, Long E, Slifkin M. Evaluation of the Phadebact CSF test for detection of the four most common causes of bacterial meningitis. J Clin Microbiol 1983;18:1358–61
  • Dudley SF, Brennan JR. High and persistent carrier rates of Neisseria meningitidis unaccompanied by cases of meningitis. J Hyg (Lond) 1934;34:525–41
  • Easton DM, Estcourt PG, Brimblecombe FSW, Burgess W, Hass L, Kurtz JB. Outbreak of meningococcal disease in Devon. Br Med J 1974;1:507–9
  • Edwards EA, Muehl PM, Peckinpaugh RO. Diagnosis of bacterial meningitis by counterimmunoelectrophoresis. J Lab Clin Med 1972;80:449–54
  • Edwards MS, Baker CJ. Complications and sequelae of meningococcal infections in children. J Pediatr 1981;99:540–5
  • Eickhoff TC. In vivo and in vitro studies of resistance to rifampin in meningococci. J Infect Dis 1971;123:414–20
  • ElTay O, Saghayroun AAR, Mills R. Population of Sudan: Implications of current trends. In: Saghayroun AA, Farah A-AA, Ahmed SA, Kheir A-AHM, eds. Population and development in The Sudan: The quest for a national policy. Chapell Hill: JPA, 1988:1–11
  • Erwa HH, Haseeb MA, Idris AA, Lapeyssonnie L, Sanborn WR, Sippel JE. A serogroup A meningococcal polysaccharide vaccine: Studies in Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A. Bull World Health Organ 1973;49:301–5
  • Erwa HH, Satti MH, Abbas AM. Cerebrospinal meningitis in The Sudan. Sudan Notes and Records 1971;52:101–9
  • Evans-Jones LG, Whittle HC, Onyewotu II, Egler LJ, Greenwood BM. Comparative study of group A and group C meningococcal infection. Arch Dis Child 1977;52:320–23
  • Feigin RD, Baker CJ, Herwaldt LA, . Epidemic meningococcal disease in an elementary-school class-room. N Engl J Med 1982;307:1255–7
  • Feigin RD, Stechenberg BW, Chang MJ, . Prospective evaluation of treatment of Haemophilus influenzae meningitis. J Pediatr 1976;88:542–8
  • Feigin RD. Bacterial meningitis beyond the neonatal period. In: Feigin RD, Cherry JD, eds. Textbook of pediatric infectious diseases. Philadelphia: Saunders, 1987:439–65
  • Feldman HM, Michaels RH. Academic achievement in children 10 to 12 years after Haemophilus influenzae meningitis. Pediatrics 1988;81:339–44
  • Ferry PC, Culbertson JL, Cooper JA, . Sequelae of Haemophilus influenzae meningitis: Preliminary report of a long-term follow-up study. In: Sell SH, Wright PF. Haemophilus influenzae, New York: Elsevier, 1982:111–7
  • Finne J, Leinonen M, Mäkelä PH. Antigenic similarities between brain components and bacteria causing meningitis: Implications for vaccine development and pathogenesis. Lancet 1983;ii:355–7
  • Frasch CE, Zahradnik JM. Human immune response to an aluminium hydroxide absorbed Neisseria meningitidis serotype 2b protein vaccine. Antonie Van Leeuwenhoek 1986;52:229–31
  • Frasch CE, Zollinger WD, Poolman JT. Serotype antigens of Neisseria meningitidis and a proposed scheme for designation of serotypes. Rev Infect Dis 1985;7:504–10
  • Fraser DW, Darby CP, Koehler RE, Jacobs CF, Feldman RA. Risk factors in bacterial meningitis: Charleston County, South Carolina. J Infect Dis 1973;127:271–7
  • Fresh JW, Girgis NI, Yassin MW, Lewis JH. Coagglutination studies in Neisseria meningitidis group A meningitis in Egypt. Thromb Res 1973;3:67–74
  • Galazka A. Meningococcal disease and its control with meningococcal polysaccharide vaccines. Bull World Health Organ 1982;60:1–7
  • Garcia H, Kaplan SL, Feigin RD. Cerebrospinal fluid concentration of arginine vasopressin in children with acute bacterial meningitis. J Pediatr 1981;98:67–70
  • Gary N, Powers N, Todd JK. Clinical identification and comparative prognosis of high-risk patients with Haemophilus influenzae meningitis. Am J Dis Child 1989;143: 307–11
  • Gaunt PN, Lambert BE. Single dose ciprofloxacin for the eradication of pharyngeal carriage of Neisseria meningitidis. J Antimicrob Chemother 1988;21:489–96
  • Geiseler PJ, Nelson KE, Levin S, Reddi KT, Moses VK. Community-acquired purulent meningitis: A review of 1316 cases during the antibiotic era, 1954–1976. Rev Infect Dis 1980;2:725–45
  • Ghanassia JP, Slim A, Bergogne-Berezin E, Modai J. Failure of diagnosing group B meningococcal meningitis by immunoelectroosmophoresis. Scand J Infect Dis 1977;9:313–4
  • Girgis NI, el Ella Abu AH, Farid Z, Haberberger RL, Galal FS, Woody JN. Intramuscular ceftriaxone versus ampicillin-chloramphenicol in childhood bacterial meningitis. Scand J Infect Dis 1988;20:613–7
  • Girgis NI, Farid Z, Kilpatrick ME. Diagnosis of bacterial meningitis. Lancet 1989a;ii:1039
  • Girgis NI, Farid Z, Mikhail IA, Farrag I, Sultan Y, Kilpatrick ME. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatr Infect Dis J 1989b;8:848–51
  • Glover JAG. Observations on the meningococcus carrier-rate in relation to density of population in sleeping quarters. J Hyg (Lond) 1918–19;17:367–79
  • Granoff DM, Cates KL. Haemophilus influenzae type b polysaccharide vaccines. J Pediatr 1985;107:330–6
  • Grant JP. The State of the World's children 1989. London: Oxford University Press, 1989:94–114
  • Gratten M, Barker J, Shann F, . Non-type b Haemophilus influenzae meningitis. Lancet 1985;i:1343–4
  • Greenwood BM, Blakebrough IS, Bradley AK, Wall S, Whittle HC. Meningococcal disease and season in sub-Saharan Africa. Lancet 1984;i:1339–42
  • Greenwood BM, Bradley AK, Cleland PG, . An epidemic of meningococcal infection at Zaria, Northern Nigeria 1. General epidemiological features. Trans R Soc Trop Med Hyg 1979; 73:557–62
  • Greenwood BM, Bradley AK, Smith AW, Wall RA. Mortality from meningococcal disease during an epidemic in the Gambia, West Africa. Trans R Soc Trop Med Hyg 1987a;81:536–8
  • Greenwood BM, Bradley AK, Wall RA. Meningococcal disease and season in sub-Saharan Africa. Lancet 1985;ii:829–30
  • Greenwood BM, Greenwood AM, Bradley AK, . Factors influencing susceptibility to meningococcal disease during an epidemic in The Gambia, West Africa. J Infect 1987b;14:167–84
  • Greenwood BM, Hassan-King M, Whittle HC. Prevention of secondary cases of meningococcal disease in household contacts by vaccination. Br Med J 1978;1:1317–9
  • Greenwood BM, Wali SS. Control of meningococcal infection in the African meningitis belt by selective vaccination. Lancet 1980;i:729–32
  • Greenwood BM, Whittle HC, Dominic-Rajkovic O. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections. Lancet 1971;ii:519–21
  • Greenwood BM. Selective primary health care: Strategies for control of disease in the developing world. XIII. Acute bacterial meningitis. Rev Infect Dis 1984;6:374–89
  • Greenwood BM. The epidemiology of acute bacterial meningitis in tropical Africa. In: Williams JD, Burnie J, eds. Bacterial meningitis. London: Academic Press, 1987:61–91
  • Griffiss JM, Apicella MA, Greenwood BM, Mäkelä PH. Vaccines against encapsulated bacteria: A global agenda. Rev Infect Dis 1987;9:176–88
  • Griffiss JM. Epidemic meningococcal disease: Synthesis of a hypothetical immunoepidemiologic model. Rev Infect Dis 1982;4:159–72
  • Habte-Gabr E, Muhe L, Olcén P. Rapid etiological diagnosis of pyogenic meningitis by coagglutination, latex agglutination and immunoosmophoresis of cerebrospinal fluid, serum and urine. Trop Geogr Med 1987;39:137–43
  • Habte-Gabr E, Tekle E. Cerebrospinal meningitis in West and Central Ethiopia (1974–1977). Ethiop Med J 1979;17:9–16
  • Habte-Gabr E, Yohannes AG, Tekle E. Cerebrospinal meningitis in Addis Ababa: A study in 110 cases. Ethiop Med J 1979;17: 17–21
  • Haffejee IE. Cefotaxime versus penicillin-chloramphenicol in purulent meningitis: A controlled single-blind clinical trial. Ann Trop Paediatr 1988;8:225–9
  • Hailemeskel H, Tafari N. Bacterial meningitis in childhood in an African city: Factors influencing aetiology and outcome. Acta Paediatr Scand 1978;67:725–30
  • Haimanot RT, Caugant DA, Fekadu D, . Characteristics of serogroup A Neisseria meningitidis responsible for an epidemic in Ethiopia, 1988–89. Scand J Infect Dis, in press.
  • Haneberg B, Tonjum T, Rodahl K, Gedde-Dahl TW. Factors preceding the onset of meningococcal disease, with special emphasis on passive smoking, stressful events, physical fitness and general symptoms of ill health. NIPH Ann 1983;6:169–73
  • Harding SA, Scheld WM, McGowan MD, Sande MA. Enzyme-linked immunosorbent assay for detection of Streptococcus pneumoniae antigen. J Clin Microbiol 1979;10:339–42
  • Harrison SA, Risser WL. Repeat lumbar puncture in the differential diagnosis of meningitis. Pediatr Infect Dis J 1988; 7:143–5
  • Hassan MM, Hasab-El-Rasoul A. Non-tuberculous meningitis in Sudanese children. J Trop Med Hyg 1969;72:19–21
  • Hassan-King M, Greenwood BM, Whittle HC, Abbott JD, Sutcliffe EM. An epidemic of meningococcal infection at Zaria, Northern Nigeria. 3. Meningococcal carriage. Trans R Soc Trop Med Hyg 1979;73:567–73
  • Hayden GF, Sato PA, Wright PF, Henderson RH. Progress in worldwide control and elimination of disease through immunization. J Pediatr 1989;114:520–7
  • Heckels JE, Virji M. Monoclonal antibodies against gonococcal pili: Uses in the analysis of gonococcal immunochemistry and virulence. In: Macario AJL, de Macario EC, eds. Monoclonal antibodies against bacteria. New York: Academic Press 1985:1–35
  • Herson VC, Todd JK. Prediction of morbidity in Haemophilus influenzae meningitis. Pediatrics 1977;59:35–9
  • Hoban DJ, Witwicki E, Hammond GW. Bacterial antigen detection in cerebrospinal fluid of patients with meningitis. Diagn Microbiol Infect Dis 1985;3:373–9
  • Hoffman SL, Rustama D, Punjabi NH, . High-dose dexamet-hasone in quinine-treated patients with cerebral malaria: A double-blind placebo-controlled trial. J Infect Dis 1988;158:325–31
  • Hu Z, Rou YL, Chen C, . An epidemiological and serological study on duration of protection after meningococcal group A polysaccharide (APS) vaccination. In: Poolman JT, Zanen HC, Meyer TF, Gonococci and meningococci. London: Kluwer Academic Publishers, 1988:199–207
  • Huttenlocher PR. The comatose child. In: Behrman RE, Vaughan VC, eds. Nelson textbook of pediatrics. Philadelphia: Saunders, 1983:1557–9
  • Höiby EA, Moe PJ, Lystad A, Fröholm LO, Bövre K. Phenoxymet-hylpenicillin treatment of household contacts of meningococcal disease patients. Antonie Van Leeuwenhoek 1986;52:255–7
  • Ingram DL, Pearson AW, Occhiuti AR. Detection of bacterial antigens in body fluids with the wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (A C Y W135) latex agglutination tests. J Clin Microbiol 1983;18:1119–21
  • Istre GR, Conner JS, Broome CV, . Risk factors for primary invasive Haemophilus influenzae disease: increased risk from daycare attendance and shool-aged household members. J Pediatr 1985;106:190–5
  • Jackson MA, Shelton S, Nelson JD, . Relatively penicillin-resistant pneumococcal infections in pediatric patients. Pediatr Infect Dis 1984;3:129–32
  • Jordan WS Jr. Impediments to the development of additional vaccines: Vaccines against important diseases that will not be available in the next decade. Rev Infect Dis 1989; 11 ( Suppl 3):S603-12
  • Jorgensen JH. Current uses of the Limulus amoebocyte lysate test. In: Coonrod JD, Kunz LJ, Ferraro MJ. The direct detection of microorganisms in clinical samples. Orlando: Academic Press, 1983:283–95
  • Kaplan SL, Catlin FI, Weaver T, Feigin RD. Onset of hearing loss in children with bacterial meningitis. Pediatrics 1984; 73:575–8
  • Kaplan SL, Mason SK, Mason EO, . Follow-up of prospective randomized trial of ampicillin or chloramphenicol verus moxalactam treatment of Haemophilus influenzae type b meningitis. J Pediatr 1988;112:795–8
  • Kaplan SL. Dexamethasone for children with bacterial meningitis. Am J Dis Child 1989;143:290–2
  • Kearney JF, Radbruch A, Liesegang B, Rajewsky K. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody- secreting hybrid cell lines. J Immunol 1979;123:1548–50
  • Kellogg DS Jr, Peacock WL Jr, Deacon WE, Brown L, Pirkle CI. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J Bact 1963;85:1274–9
  • Kim JJ, Mandrell RE, Hu Z, Westerink MA, Poolman JT, Griffiss JM. Electromorphic characterization and description of conserved epitopes of the lipooligosaccharides of group A Neisseria meningitidis. Infect Immun 1988;56:2631–8
  • Kirby KS. New method for isolation of ribonucleic acids from mammalian tissues. Biochem J 1956;64:405–8
  • Kirk R. Annual report of Sudan medical service 1950–1951, Khartoum. Ministry of Health 43, 1951
  • Kleiman MB, Reynolds JK, Watts NH, Schreiner RL, Smith JW. Superiority of acridine orange stain versus Gram stain in partially treated bacterial meningitis. J Pediatr 1984;104:401–4
  • Klein JO, Geigin RD, Mc Cracken GH. Report of the task force on diagnosis and management of meningitis. Pediatrics 1986; 78 ( S5 Pt 2):959–82
  • Klugman KP, Koornhof HJ, Kuhnle V, Miller SD, Ginsburg PJ, Mauff AC. Meningitis and pneumonia due to novel multiply resistant pneumococci. Br Med J 1986;292:730
  • Kristiansen B-E, Bjorvatn B, Lund V, Lindqvist B, Holten E. Differentiation of B15 strains of Neisseria meningitidis by DNA restriction endonuclease fingerprinting. J Infect Dis 1984a;150:672–7
  • Kristiansen B-E, Sörensen B, Bjorvatn B, . An outbreak of group B meningococcal disease: Tracing the causative strain of Neisseria meningitidis by DNA fingerprinting. J Clin Microbiol 1986; 23:764–7
  • Kristiansen B-E, Sörensen B, Simonsen T, Spanne O, Lund V, Bjorvatn B. Isolates of Neisseria meningitidis from different sites in the same patient; phenotypic and genomic studies, with special reference to adherence, piliation, and DNA restriction endonuclease pattern. J Infect Dis 1984b;150:389–96
  • Kronvall G. A rapid slide-agglutination method for typing pneumococci by means of specific antibody adsorbed to protein A-containing staphylococci. J Med Microbiol 1973;6:187–90
  • Kurzynski TA, Kimball JL, Polyak MB, Cembrowski GS, Schell RF. Evaluation of the Phadebact and Bactigen reagents for detection of Neisseria meningitidis in cerebrospinal fluid. J Clin Microbiol 1985;21:989–90
  • Käyhty H, Eskola J, Peltola H, Rönnberg P-R, Kela E, Karanko V. Antibody responses and adverse reactions to four Haemophilus influenzae type b protein-polysaccharide conjugate vaccines. J Ped (in press)
  • Käyhty H, Karanko V, Peltola H, Sarna S, Mäkelä PH. Serum antibodies to capsular polysaccharide vaccine of group A Neisseria meningitidis followed for three years in infants and children. J Infect Dis 1980;142:861–8
  • Käyhty H, Mäkelä PH, Ruoslahti E. Radioimmunoassay of capsular polysaccharide antigens of group A and C meningococci and Haemophilus influenzae type b in cerebrospinal fluid. J Clin Pathol 1977;30:831–3
  • Lapeyssonie L. La méningite cérébro-spinale en Afrique. Bull World Health Organ 1963;28 ( Suppl):3–114
  • Lauer BA, Reller LB, Mirret S. Comparison of acridine orange and Gram stains for detection of microorganisms in cerebrospinal fluid and other clinical specimens. J Clin Microbiol 1981;14:201–5
  • Lawson D, Metcalfe M, Pampiglione G. Meningitis in childhood. Br Med J 1965;1:577–62
  • Lebel MH, Freij BJ, Syrogiannopoulos GA, . Dexamethasone therapy for bacterial meningitis. I: Results of two double-blind, placebo-controlled trials. N Engl J Med 1988;319: 964–71
  • Lebel MH, Hoyt MJ, McCracken GH. Comparative efficacy of ceftriaxone and cefuroxime for treatment of bacterical meningitis. J Pediatr 1989;114:1049–54
  • Leinonen M, Herva E. The latex agglutination test for the diagnosis of meningococcal and Haemophilus influenzae meningitis. Scand J Infect Dis 1977;9:187–91
  • Lepow M. Clinical trials of the Haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine. Pediatr Infect Dis J 1987;6:804–7
  • Levy J. Rapid laboratory methods for the diagnosis of bacterial meningitis. In: Williams JD, Burnie J. Bacterial meningitis. London: Academic Press, 1987:187–202
  • Lin TY, Nelson JD, McCracken GH. Fever during treatment for bacterial meningitis. Pediatr Infect Dis 1984; 3:319–22
  • Lindberg J, Rosenhall U, Nylén O, Ringnert A. Long-term outcome of Hemophilus influenzae meningitis related to antibiotic treatment. Pediatrics 1977;60:1–6
  • Loggie BW, Hinchey EJ. Does splenectomy predispose to meningococcal sepsis?: An experimental study and clinical review. J Pediatr Surg 1986;21:326–30
  • Macchiavello A, Omar W, El Sayed MA, Rahman Abdel K. Control of cerebrospinal meningitis epidemics with sulphadimidine and penicillin. Bull World Health Organ 1954;10:1–34
  • Macone AB, Arakere G, Letourneau JM, Goldmann DA. Comparison of a new, rapid enzyme-linked immunosorbent assay with latex particle agglutination for the detection of Haemophilus influenzae type b infections. J Clin Microbiol 1985;21:711–4
  • McCracken GH, Lebel MH. Dexamethasone therapy for bacterial meningitis in infants and children. Am J Dis Child 1989;143:287–9
  • Meningococcal Disease Surveillance Group. Meningococcal disease. Secondary attack rate and chemoprophylaxis in the United States, 1974. JAMA 1976;235:261–5
  • Millar JW, Siess EE, Feldman HA, . In vivo and in vitro resistance to sulfadiazine in strains of Neisseria meningitidis. J Am Med Asoc 1963;186:139–41
  • Ministry of Health, Annual Reports. Republic of The Sudan, 1965–1987
  • Mitchison DA, Ellard GA, Grosset J. New antibacterial drugs for the treatment of mycobacterial disease in man. Br Med Bull 1988;44:757–74
  • Montefiore D, Alausa OK, Sobayo E. Pyogenic meningitis in Ibadan, Nigeria. A 15-month prospective study. Scand J Infect Dis 1978;10:113–7
  • Moore PS, Harrison LH, Telzak EE, Ajello GW, Broome CV. Group A meningococcal carriage in travelers returning from Saudi Arabia. JAMA 1988;260:2686–9
  • Moore PS, Reeves MW, Schwartz B, Gellin BG, Broome CV. Intercontinental spread of epidemic group A Neisseria meningitidis strain. Lancet 1989;ii:260–3
  • Mpairwe Y, Matovu HL. Cerebrospinal meningitis in East Africa 1911–1965. Trans R Soc Trop Med Hyg 1971;65:70–7
  • Mulla MI, Moosajee I, Rubidge CJ, Moosa A. Nutritional status of children with pyogenic meningitis. J Trop Pediatr 1984;30:303–6
  • Muller PD, Donald PR, Burger PJ, van der Horst W. Detection of bacterial antigens in cerebrospinal fluid by a latex agglutination test in “septic unknown” meningitis and serogroup B meningococcal meningitis. S Afr Med J 1989;76:214–5
  • Munford RS, Sussuarana de Vasconcelos ZJ, Philip CL, . Eradication of carriage of Neisseria meningitidis in families: a study in Brazil. J Infect Dis 1974;129:644–9
  • Munson RS Jr, Kabeer MH, Lenoir AA, Granoff DM. Epidemiology and prospects for prevention of disease due to Haemophilus influenzae in developing countries. Rev Infect Dis 1989;11 ( Suppl 3):S588–97
  • Murphy TV, Clements JF, Breedlove JA, Hansen EJ, Seibert GB. Risk of subsequent disease among day-care contacts of patients with systemic Hemophilus influenzae type b disease. N Engl J Med 1987;316:5–10
  • Nachum R, Lipsey A, Siegel SE. Rapid detection of gram-negative bacterial meningitis by the limulus lysate test. N Engl J Med 1973;289:931–4
  • Nesbitt A, Jitta JS, Bubi J, Ndinya-Achola J. Pyogenic meningitis in Nairobi Children. East Afr Med J 1988;65:189–96
  • Newman RB, Stevens RW, Gaafar HA. Latex agglutination test for the diagnosis of Haemophilus influenzae meningitis. J Lab Clin Med 1970;76:107–13
  • Niklasson P-M, Lundberg P, Strandell T. Prognostic factors in meningococcal disease. Scand J Infect Dis 1971;3:17–25
  • Noah ND. Epidemiology of bacterial meningitis: UK and USA. In: Williams JD, Burnie J, eds. Bacterial meningitis. London: Academic Press, 1987:93–115
  • Nottidge VA. Haemophilus influenzae meningitis: a 5-year study in Ibadan, Nigeria. J Infect 1985;11:109–17
  • Nottidge VA. Meningococcal meningitis in childhood. A five-year study of meningococcal meningitis in Ibadan, southern Nigeria. J Infect 1983a;7:39–45
  • Nottidge VA. Pneumococcal meningitis in sickle cell disease childhood. Am J Dis Child 1983b;137:29–31
  • Oakley JR, Stanton AN. Meningococcal infections during infancy: Confidential inquiries into 10 deaths. Br Med J 1979;2:468–9
  • Obiako MN. Profound childhood deafness in Nigeria: A three year survey. Ear Hear 1987:8:74–7
  • Olcén P, Barr J, Kjellander J. Meningitis and bacteremia due to Neisseria meningitidis: clinical and laboratory findings in 69 cases from Örebro county, 1965 to 1977. Scand J Infect Dis 1979;11:111–9
  • Olcén P, Danielsson D, Kjellander J. The use of protein A-containing staphylococci sensitized with anti-meningococcal antibodies for grouping Neisseria meningitidis and demonstration of meningococcal antigen in cerebrospinal fluid. Acta Pathol Microbiol Scand (B) 1975; 83:387–96
  • Olcén P, Eeg-Olofsson O, Frydén A, Kernell A, Ansehn S. Benign meningococcemia in childhood, a report of five cases with clinical and diagnostic remarks. Scand J Infect Dis 1978;10:107–11
  • Olcén P. Prognostic factors in meningococcal disease. NIPH Ann 1980;3:91–4
  • Olcén P. Serological methods for rapid diagnosis of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae in cerebrospinal fluid: a comparison of Co-agglutination, immunofluorescence and immunoelectroosmophoresis. Scand J Infect Dis 1978;10:283–9
  • Olyhoek T, Crowe BA, Achtman M. Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983. Rev Infect Dis 1987;9:665–92
  • Olyhoek T, Crowe BA, Wall RA, Achtman M. Comparison of clonal analysis and DNA restriction analysis for typing of Neisseria meningitidis. Microb Pathog 1988;4:45–51
  • Omer MI, Omer HO, El Khidir A, Hassan MM. Treatment of meningococcal meningitis in children in Khartoum. Indian Pediatr 1975;12:387–91
  • Omer MIA, el Dawla IG, Nicolas A, Roumiantzeff R, Lapeyssonie L. Humoral antibody responses to biannual multiantigen vaccination: Report of a field trial on children in Sudan. Ann Trop Paediatr 1986;6:243–8
  • Osterholm MT, Pierson LM, White KE, Libby TA, Kuritsky JN, McCullough JG. The risk of subsequent transmission of Haemophilus influenzae type B disease among children in day care. Results of a two-year statewide prospective surveillance and contact survey. N Engl J Med 1987;316:1–5
  • Parke JC Jr. Capsular polysaccharide of Haemophilus influenzae type b as a vaccine. Pediatr Infect Dis J 1987;6: 795–8
  • Peltola H, Antilla M, Renkonen O-V. Randomised comparison of chloramphenicol, ampicillin, cefotaxime and ceftriaxone for childhood bacterial meningitis. Finish Study Group. Lancet 1989;i:1281–6
  • Peltola H, Kataja JM, Mäkelä PH. Shift in the age distribution of meningococcal disease as a predictor of an epidemics? Lancet 1982;ii:595–7
  • Peltola H, Käyhty H, Virtanen M Mäkelä PH. Prevention of Haemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine. N Engl J Med 1984;310:1561–6
  • Peltola H. Group A meningococcal polysaccharide vaccine and course of the group A meningococcal epidemic in Finland. Scand J Infect Dis 1978;10:41–4
  • Peltola H. Meningococcal disease: Still with us. Rev Infect Dis 1983;5:71–91
  • Pepple J, Moxon ER, Yolken RH. Indirect enzyme-linked immunosorbent assay for the quantitation of the type-specific antigen of Haemophilus influenzae b: A preliminary report. J Pediatr 1980;97:233–7
  • Peter G. Treatment and prevention of Haemophilus influenzae type b meningitis. Pediatr Infect Dis J 1987;6:787–90
  • Petersen BH, Lee TJ, Snyderman R, Brooks GF. Neisseria meningitidis and Neisseria gonorrhoea bacteremia associated with C6, C7 or C8 deficiency. Ann Intern Med 1979;90:917–20
  • Puddicombe JB, Wall SS, Greenwood BM. A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis. Trans R Soc Trop Med Hyg 1984;78:399–403
  • Reingold AL, Broome CV, Hightower AW, . Age-specific differences in duration of clinical protection after vaccination with meningococcal polysaccharide A vaccine. Lancet 1985;ii:114–8
  • Rey M. Treatment of purulent meningitis in developing countries. In: Williams JD, Burnie J, eds. Bacterial meningitis. London: Academic Press, 1987:211–29
  • Riding D, Corkill NL. Prophylactic vaccination in epidemic meningococcal meningitis. J Hyg (Lond) 1932;32:258–67
  • Riley ID, Everingham FA, Smith DE, Douglas RM. Immunisation with a polyvalent pneumococcal vaccine. Effect of respiratory mortality in children living in the New Guinea highlands. Arch Dis Child 1981;56:354–7
  • Riley ID, Tarr PI, Andrews M, . Immunisation with polyvalent pneumococcal vaccine. Reduction of adult respiratory mortality in a New Guinea Highlands community. Lancet 1977;i:1338–41
  • Robbins JB, Schneerson R. Haemophilus influenzae type b: the search for a vaccine. Pediatr Infect Dis J 1987; 6:791–4
  • Roeser RJ, Campbell JC, Daly DD. Recovery of auditory function following meningitis deafness. J Speech Hear Disord 1975;40:405–11
  • Rosen EU, Davis MD. Nutritional status of children with bacterial meningitis. S Afr Med J 1980; 58:1004–6
  • Rosenqvist E, Harthug S, Fröholm LO, Höiby EA, Bövre K, Zollinger WD. Antibody responses to serogroup B meningococcal outer membrane antigens after vaccination and infection. J Clin Microbiol 1988;26:1543–8
  • Ross SC, Densen P. Complement deficiency states and infection: Epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine (Baltimore) 1984;63:243–73
  • Rubin LG, Moxon ER. Immunoassays in meningitis. In: Coonrod LD, Kunz LJ, Ferraro MJ, eds. The direct detection of microorganisms in clinical sampels. Orlando: Academic Press, 1983:159–73
  • Ryder CS, Beatty DW, de V Heese H. Group B meningocccal infection in children during an epidemic in Cape Town, South Africa. Ann Trop Paediatr 1987;7:47–53
  • Salih MAM. Laboratory diagnosis of meningitis: An overview in relation to The Sudan. Sudan J Paediatr 1984;3:10–19
  • Salmi I, Pettay O, Simula I, Kallio A-K, Waltimo O. An epidemic due to sulphonamide-resistant group A meningococci in the Helsinki Area (Finland). Epidemiological and clinical observations. Scand J Infect Dis 1976;8:249-54
  • Salwén KM, Vikerfors T, Olcén P. Increased incidence of childhood bacterial meningitis. A 25-year study in a defined population in Sweden. Scand J Infect Dis 1987;19: 1–11
  • Sanborn WR, Toure IM. A simple kit system for rapid diagnosis of cerebrospinal meningitis in rural areas of developing countries. Bull World Health Organ 1984;62:293–7
  • Sande MA, Tauber MG, Scheld M, McCracken GH Jr. Pathophysiology of bacterial meningitis: Summary of the workshop. Pediatr Infect Dis J 1989;8:929–33
  • Schaad UB, Suter S, Gianella-Borradori A, . A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. N Engl J Med 1990;322:141–7
  • Schaad UB. Arthritis in disease due to Neisseria meningitidis. Rev Infect Dis 1980;2:880–8
  • Schneider H, Hale TL, Zollinger WD, Seid RC Jr, Hammack CA, Griffiss JM. Heterogeneity of molecular size and antigenic expression within the lipooligosaccharides of individual strains of Neisseria gonorrhoeae and Neisseria meningitidis. Infect Immun 1984;45:544–9
  • Schwartz B, Al-Tobaiqi A, Al-Ruwais A, . Comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group A Neisseria meningitidis. Lancet 1988;i:1239–42
  • Schwartz JF. Ataxia in bacterial meningitis. Neurology 1972;22:1071–4
  • Selander RK, Caugant DA, Ochman H, Musser JM, Gilmour MN, Whittam TS. Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol 1986;51:873–84
  • Sell SH. Haemophilus influenzae type b meningitis: manifestations and long term sequelae. Pediatr Infect Dis J 1987;6:775–8
  • Sell SHW, Webb WW, Pate JE, Doyne EO. Psychological sequelae of bacterial meningitis: Two controlled studies. Pediatrics 1972;49:212–7
  • Severin WPJ. Latex agglutination in the diagnosis of meningococcal meningitis. J Clin Pathol 1972;25:1079–82
  • Shann F, Baker J, Poore P. Chloramphenicol alone versus chloramphenicol plus penicillin for bacterial meningitis in children. Lancet 1985;ii:681–4
  • Sippel JE, Hider PA, Controni G, . Use of the directigen latex agglutination test for detection of Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis antigens in cerebrospinal fluid from meningitis patients. J Clin Microbiol 1984a;20:884–6
  • Sippel JE, Prato CM, Girgis NI, Edwards EA. Detection of Neisseria meningitidis group A, Haemophilus influenzae type b, and Streptococcus pneumoniae antigens in cerebrospinal fluid specimens by antigen capture enzyme-linked immunosorbent assays. J Clin Microbiol 1984b;20:259–65
  • Sippel JE, Sid Ahmed H, Aub Ahmed H, Mikhail IA. Cerebrospinal meningitis in The Sudan in 1980. Sudan Med J 1982;18:39–46
  • Sippel JE, Sid Ahmed H, Mikhail IA. Epidemiologic studies on meningococcal meningitis in The Sudan. Med Trop 1983;43:39–41
  • Smith AL. Antibiotic resistance in bacteria causing meningitis. In: Williams JD, Burnie J. Bacterial meningitis. London: Academic Press, 1987a:117–34
  • Smith AL. Neurologic sequelae of meningitis. N Engl J Med 1988;319:1012–4
  • Smith AW, Bradley AK, Wall RA, Mc Pherson B, Secka A, Dunn DT, Greenwood BM. Sequelae of epidemic meningococcal meningitis in Africa. Trans R Soc Trop Med Hyg 1988;82:312–20
  • Smith JWG. The use of existing vaccines against bacterial meningitis. In: Williams JD, Burine J. Bacterial meningitis. London: Academic Press 1987:153–76
  • Snyderman R, Durack DT, McCarthy GA, Ward FE, Meadows L. Deficiency of the fifth component of complement in human subjects: Clinical, genetic and immunologic studies in a large kindred. Am J Med 1979;67:638–45
  • Somers RBU. M&B. 693 in cerebrospinal fever: Review of 143 cases treated under field conditions. Lancet 1939;i: 921–2
  • Sotto MN, Langer B, Hoshino-Shimizu S, de Brito T. Pathogenesis of cutaneous lesions in acute meningococcemia in humans: Light, immunofluorescent, and electron microscopic studies of skin biopsy specimens. J Infect Dis 1976;133:506–14
  • Spanjaard L, Bol P, de Jong MC, Zanen HC. Bacterial meningitis in 366 children in the Netherlands, 1982–1983. epidemiology and antibiotic therapy. Tijdschr Kindergeneeskd 1986;54:1–8
  • Steel RW, Kearns GL. Antimicrobial therapy for pediatric patients. Pediatr Clin North Am 1989;36:1321–49
  • Steele RW. Controversies in the medical management of bacterial meningitis. Pediatr Infect Dis J 1987;6:1163–5
  • Stiehm ER, Damrosch DS. Factors in the prognosis of meningococcal infection: Review of 63 cases with emphasis on recognition and management of the severely ill patient. J Pediatr 1966;68:457–67
  • Stokes EJ. Diagnosis of bacterial meningitis. Lancet 1989;ii:1285
  • Sugasawara RJ, Prato C, Sippel JE. Monoclonal antibodies against Neisseria meningitidis lipopolysaccharide. Infect Immun 1983;42:863–8
  • Sugasawara RJ. The use of monoclonal antibodies for detecting and serotyping Neisseria meningitidis. In: Macario AJL, de Macario EC, eds. Monoclonal antibodies against bacteria. volume II. New York: Academic Press, 1985:61–79
  • Suksanong M, Dajani AS. Detection of Haemophilus influenzae type b antigens in body fluids, using specific antibody-coated staphylococci. J Clin Microbiol 1977;5: 81–5
  • Takala AK, Eskola J, Palmgren J, . Risk factors of invasive Haemophilus influenzae type b disease among children in Finland. J Pediatr 1989;115:694–701
  • Taylor HG, Michaels RH, Mazur PM, Bauer RE, Liden CB. Intellectual, neuropsychological, and achievement outcomes in children six to eight years after recovery from Haemophilus influenzae meningitis. Pediatric 1984;74:198–205
  • Tejani A, Dobias B, Sambursky J. Long-term prognosis after Haemophilus influenzae meningitis: prospective evaluation. Dev Med Child Neurol 1982;24:338–43
  • Tekle E. Review of meningococcal meningitis in Ethiopia. In: Control of cerebro spinal (Meningococcal) Meningitis in Ethiopia: proceedings of symposium and workshop held in Addis Ababa, Ethiopia (November, 20–23, 1981);pp18–29
  • Terman LM, Merrill MA. Measuring intelligence. Boston: Houghton Mifflin, 1937
  • Thirumoorthi MC, Dajani AS. Comparison of staphylococcal coagglutination, latex agglutination, and counterimmunoelectrophoresis for bacterial antigen detection. J Clin Microbiol 1979;9:28–32
  • Tilton RC, Dias F, Ryan RW. Comparative evaluation of three commercial products and counterimmunoelectrophoresis for the detection of antigens in cerebrospinal fluid. J Clin Microbiol 1984;20:231–4
  • Toews WH, Bass JW. Skin manifestations of meningococcal infection: An immediate indicator of prognosis. Am J Dis Child 1974;127:173–6
  • Tsai C-M, Frasch CE, Mocca LF. Five structural classes of major outer membrane proteins in Neisseria meningitidis. J Bacteriol 1981;146:69–78
  • United States Department of Health, Education and Welfare, National Centre for Health Statistics. NCH's growth charts 1976. Monthly vital statistics report, 1976;25: SNo.3 (Suppl)
  • Valmari P, Peltola H, Ruuskanen O, Korvenranta H. Childhood bacterial meningitis: Initial symptoms and signs related to age, and reason for consulting a physician. Eur J Pediatr 1987;146:515–8
  • Van Esso D, Fontanals D, Uriz S, . Neisseria meningitidis strains with decreased susceptibility to penicillin. Pediatr Infect Dis J 1987;6:438–9
  • Vienny H, Despland PA, Lutschg J, Deonna T, Dutoit-Marco ML, Gander C. Early diagnosis and evolution of deafness in childhood bacterial meningitis: A study using brainstem auditory evoked potentials. Pediatrics 1984; 73( S5):579–86
  • Vik-Mo H, Lote K, Nordöy A. Disseminated intravascular coagulation in patients with meningococcal infection: Laboratory diagnosis and prognostic factors. Scand J Infect Dis 1978;10:187–91
  • Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock: Association between interleukin G, interleukin 1, and fatal outcome. J Exp Med 1989;169:333–8
  • Waddy BB. African epidemic cerebrospinal meningitis. Part II. Cerebrospinal meningitis in other related African territories. J Trop Med Hyg 1957;60:218–23
  • Wara DW. Host defense against Streptococcus pneumoniae: the role of the spleen. Rev Infect Dis 1981;3:299–309
  • Ward JI, Margolis HS, Lum MK, Fraser DW, Bender TR. Haemophilus influenzae disease in Alaskan Eskimos: Characteristics of a population with an unusual incidence of invasive disease. Lancet 1981;i:1281–5
  • Washington II JA. Susceptibility tests: Agar dilution. In: Lennette EH, Balows A, Hausler WJ, Shadomy HJ, eds. Manual of clinical microbiology. Washington DC: American Society for Microbiology. 1985:967–71
  • Weidmer CE, Dunkel TB, Pettyjohn FS, Smith CD, Leibovitz A. Effectiveness of rifampin in eradicating the meningococcal carrier state in a relatively closed population: Emergence of resistant strains. J Infect Dis 1971;24:172–8
  • Weinberg GA, Granoff DM. Polysaccharide-protein conjugate vaccines for the prevention of Haemophilus influenzae type b disease. J Pediatr 1988;113:621–31
  • Whittle HC, Davidson NM, Greenwood BM, . Trial of chloramphenicol for meningitis in northern savanna of Africa. Br Med J 1973;3:379–81
  • WHO Temporary Advisers. Epidemiological surveillance and control of cerebrospinal meningitis in Africa. WHO Chron 1973;27:347–51
  • Wilson HD, Haltalin KC. Ampicillin in Haemophilus influenzae meningitis: clinicopharmacologic evaluation of intramuscular vs intravenous administration. Am J Dis Child 1975;129:208–15
  • Wong VK, Hitchcock W, Mason WH. Meningococcal infections in children: A review of 100 cases. Pediatr Infect Dis J 1989;8:224–7
  • Word BM, Klein JO. Therapy of bacterial sepsis and meningitis in infants and children: 1989 poll of directors of programs in pediatric infectious diseases. Pediatr Infect Dis J 1989;8:635–7
  • Young LS, LaForce FM, Head JJ, Feeley JC, Bennett JV. A simultaneous outbreak of meningococcal and influenza infections. N Engl J Med 1972;287:5–9
  • Zollinger WD, Mandrell RE. Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide. Infect Immun 1983;40:257–64
  • Zollinger WD, Mandrell RE. Type-specific antigens of group A Neisseria meningitidis: lipopolysaccharide and heat-modifiable outermembrane proteins. Infect Immun 1980;28:451–8
  • Österud B, Flaegstad T. Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: Related to unfavourable prognosis. Thromb Haemost 1983;49: 5–7
  • Özdamar O, Kraus N, Stein L. Auditory brainstem responses in infants recovering from bacterial meningitis. Arch Otolaryngol 1983;109:13–8

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