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Original Article

Abrogation of Treg function deteriorates rheumatoid arthritis

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Pages 80-88 | Received 10 Mar 2011, Accepted 16 May 2011, Published online: 02 Jan 2014

References

  • Zvaifer NJ. Pathogenesis of the joint disease of rheumatoid arthritis. Am J Med. 1983;75(6):3–8.
  • Warren JS, Yabroff KR, Remick DG, Kunkel SL, Chensue SW, Kunkel RG, et al. Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J Clin Invest. 1989;84(6):1873–82.
  • Okusawa S, Yancey KB, van der Meer JW, Endres S, Lonnemann G, Hefter K, et al. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin-1 beta and interleukin-1 alpha. J Exp Med. 1988;168(1):443–8.
  • Gosset P, Perez T, Lassalle P, Duquesnoy B, Farre JM, Tonnel AB, et al. Increased TNF-alpha secretion by alveolar macro-phages from patients with rheumatoid arthritis. Am Rev Respir Dis. 1991;143(3):593–7.
  • Lentsch AB, Czermak BJ, Bless NM, Ward PA. NF-kappa B activation during IgG immune complex-induced lung injury: requirement for TNF-alpha and IL-1 beta but not complement. Am J Pathol. 1998;152(5):1327–36.
  • Wu X, Wittwer AJ, Carr LS, Crippes BA, DeLarco JE, Lefkowith JB. Cytokine-induced neutrophil chemoattractant mediates neu-trophil influx in immune complex glomerulonephritis in rat. J Clin Invest. 1994;94(1):337–44.
  • Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, et al. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and inter-leukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med. 1988;168(5):1573–86.
  • Lotz M, Kekow J, Carson DA. Transforming growth factor-beta and cellular immune responses in synovial fluids. J Immunol. 1990; 144(11):4189–94.
  • Möttönen M, Heikkinen J, Mustonen L, Isomäki P, Luukkainen R, Lassila 0. CD4+CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. 2005;140(2):360–7.
  • de Kleer IM, Wedderburn LR, Taams LS, Patel A, Varsani H, Klein M, et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol. 2004;172(10): 6435–43.
  • Mimran A, Mor F, Carmi P, Quintana FJ, Rotter V, Cohen IR. DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. J Clin Invest. 2004; 113(6):924–32.
  • Cuzzocrea S, Ayroldi E, Di Paola R, Agostini M, Mazzon E, Bruscoli S, et al. Role of glucocorticoid-induced TNF receptor family gene(GITR) in collagen-induced arthritis. FASEB J. 2005; 19(10): 1253–65.
  • de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol. 2003;10(1):133–9.
  • Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, et al. Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J Immunol. 2003; 171(2):708–16.
  • Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, Carreno BM, et al. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol. 2004;173(8):5008–20.
  • Ji HB, Liao G, Faubion WA, Abadia-Molina AC, CozzoC Laroux FS, et al. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol. 2004;172(10):5823–7.
  • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002;3(2):135–42.
  • Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Thl lineage commitment. Cell. 2000;100(6):655–69.
  • Zheng W, Flavell RA. The transcription factor GATA-3 is nec-essary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997;89(4):587–96.
  • Chai JG, Xue SA, Coe D, Addey C, Bartok I, Scott D, et al. Regulatory T cells, derived from naive CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation. 2005;79(10):1310–6.
  • Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, Uchiyama T, et al. Foxp3-dependent and -independent mole-cules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol. 2006;18(8): 1197–209.
  • Read S, Malmström V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+) CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 2000;192(2):295–302.
  • Sufi-Payer E, Cantor H. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+) CD25(+) T cells. J Autoimmun. 2001;16(2):115–23.
  • Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 dia-betes. Proc Natl Acad Sci USA. 2003;100(19):10878–83.
  • Maini RN, Breedveld FC, Kalden JR, Smolen JS, Furst D, Weisman MH, et al. Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate. Arthritis Rheum. 2004;50(4):1051–65.
  • Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis. 2007;66(9):1162–7.
  • Giavedoni LD. Simultaneous detection of multiple cytokines and chemokines from nonhuman primates using luminex technology. J Immunol Methods. 2005;301(1-2):89–101.
  • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–62.
  • Albert MH, Liu Y, Anasetti C, Yu XZ. Antigen-dependent sup-pression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur J Immunol. 2005;35(9):2598–607.
  • Hoffmann P, Ermann J, Edinger M. CD4+CD25+ regulatory T cells in hematopoietic stem cell transplantation. Curr Top Microbiol Immunol. 2005;293: 265–85.
  • Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP, et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood. 2005;105(5):2220–6.
  • Nagahama K, Nishimura E, Sakaguchi S. Induction of tolerance by adoptive transfer of Treg cells. Methods Mol Biol. 2007;380:431–42.
  • Hong JC, Kahan BD. Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression. Transplanta-tion. 1999;68(5):701–4.
  • Cole E, Landsberg D, Russell D, Zaltzman J, Kiberd B, Cara-vaggio C, et al. A pilot study of steroid-free immunosuppression in the prevention of acute rejection in renal allograft recipients. Transplantation. 2001;72(5):845–50.
  • Honey CR, Shen H. Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibody. J Neurosurg. 1999;91(1):109–13.
  • Otto G, Thies J, Kabelitz D, Schlag H, Hofmann WJ, Herfarth C, et al. Anti-CD25 monoclonal antibody prevents early rejection in liver transplantation: a pilot study. Transplant Proc. 1991; 23(1):1387–9.
  • Cahn JY, Bordigoni P, Tiberghien P, Milpied N, Brion A, Widjenes J, et al. Treatment of acute graft-versus-host disease with methylprednisolone and cyclosporine with or without an anti-interleukin-2 receptor monoclonal antibody. A multicenter phase III study. Transplantation. 1995;60(9):939–42.
  • Yu KY, Kim HS, Song SY, Min SS, Jeong JJ, Youn BS. Iden-tification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. Bio-chem Biophys Res Commun. 2003;310(2):433–8.
  • Kim BJ, Li Z, Fariss RN, Shen DF, Mahesh SP, Egwuagu C, et al. Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors. Invest Ophthalmol Vis Sci. 2004;45(9):3170–6.

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