Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study

References

• Hanly JG, Harrison MJ. Management of neuropsychiatric lupus. Best Pract Res Clin Rheumatol. 2005;19:799–821.
   PubMed Web of Science ®Google Scholar
• ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomen-clature. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999;42:599–608.
   Google Scholar
• Nishimura K, Harigai M, Omori M, Sato E, Hara M. Blood-brain barrier damage as a risk factor for corticosteroid-induced psy-chiatric disorders in systemic lupus erythematosus. Psychoneu-roendocrinology. 2008;33:395–403.
   Google Scholar
• Zandman-Goddard G, Chapman J, Shoenfeld Y. Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syn-drome. Semin Arthritis Rheum. 2007;36:297–315.
   Google Scholar
• Fragoso-Loyo H, Cabiedes J, Orozco-Narvaez A, Davila-Maldonado L, Atisha-Fregoso Y, Diamond B, et al. Serum and cerebrospinal fluid autoantibodies in patients with neuropsychi-atric lupus erythematosus. Implications for diagnosis and patho-genesis. PLoS ONE. 2008;3:e3347.
   Google Scholar
• Hanly JG, Urowitz MB, Siannis F, Farewell V, Gordon C, Bae SC, et al. Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study. Arthritis Rheum. 2008;58:843–53.
   PubMed Web of Science ®Google Scholar
• Colasanti T, Delunardo F, Margutti P, Vacirca D, Piro E, Sirac-usano A, et al. Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus. J Neuroimmunol. 2009;212:3–9.
   Google Scholar
• Efthimiou P, Blanco M. Pathogenesis of neuropsychiatric sys-temic lupus erythematosus and potential biomarkers. Mod Rheumatol. 2009;19:457–68.
   PubMed Web of Science ®Google Scholar
• Nojima Y, Minota S, Yamada A, Takaku F, Aotsuka S, Yokohari R. Correlation of antibodies to ribosomal P protein with psy-chosis in patients with systemic lupus erythematosus. Ann Rheum Dis. 1992;51:1053–5.
   PubMed Web of Science ®Google Scholar
• Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M, Kataoka S, et al. Anti-NR2A antibody as a predictor for neuro-psychiatric systemic lupus erythematosus. Rheumatology (Oxford). 2011;50:1578–85.
   PubMed Web of Science ®Google Scholar
• Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, et al. Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches. Mol Cell Proteomics. 2011;10:M110.005330.
   PubMedGoogle Scholar
• Katzav A, Solodeev I, Brodsky O, Chapman J, Pick CG, Blank M, et al. Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis Rheum. 2007;56:938–48.
   PubMed Web of Science ®Google Scholar
• Matus S, Burgos PV, Bravo-Zehnder M, Kraft R, Porras OH, Farias P, et al. Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med. 2007;204:3221–34.
   Google Scholar
• Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, et al. NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus ery-thematosus. Arthritis Rheum. 2011;63:3952–9.
   PubMed Web of Science ®Google Scholar
• Migliorini P, Baldini C, Rocchi V, Bombardieri S. Anti-Sm and anti-RNP antibodies. Autoimmunity. 2005;38:47–54.
   PubMed Web of Science ®Google Scholar
• Maldonado ME, Perez M, Pignac-Kobinger J, Marx ET, Toanan EM, Greidinger EL, et al. Clinical and immunologic manifesta-tions of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian population. J Rheuma-tol. 2008;35:429–37.
   Google Scholar
• Greidinger EL, Hoffman RW. Autoantibodies in the pathogenesis of mixed connective tissue disease. Rheum Dis Clin N Am. 2005;31:437-50, vi.
   Google Scholar
• Greidinger EL, Zang Y, Jaimes K, Hogenmiller S, Nassiri M, Bejarano P, et al. A murine model of mixed connective tissue disease induced with Ul small nuclear RNP autoantigen. Arthritis Rheum. 2006;54:661–9.
   PubMed Web of Science ®Google Scholar
• Greidinger EL, Zang Y, Fernandez I, Berho M, Nassiri M, Martinez L, et al. Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model. Arthritis Rheum. 2009;60:534–42.
   PubMed Web of Science ®Google Scholar
• Keith MP, Moratz C, Tsokos GC. Anti-RNP immunity: impli-cations for tissue injury and the pathogenesis of connective tissue disease. Autoimmun Rev. 2007;6:232–6.
   Google Scholar
• Greidinger EL, Hoffman RW. The appearance of Ul RNP anti-body specificities in sequential autoimmune human antisera fol-lows a characteristic order that implicates the U1-70 kd and B'/B proteins as predominant Ul RNP immunogens. Arthritis Rheum. 2001;44:368–75.
   PubMed Web of Science ®Google Scholar
• Okada J, Hamana T, Kondo H. Anti-U1RNP antibody and aseptic meningitis in connective tissue diseases. Scand J Rheumatol. 2003;32: 247–52.
   Google Scholar
• Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, et al. RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. Arthritis Rheum. 2010;62:3730–40.
   PubMed Web of Science ®Google Scholar
• Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of sys-temic lupus erythematosus. Arthritis Rheum. 1982;25:1271–7.
   PubMed Web of Science ®Google Scholar
• Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythe-matosus. Arthritis Rheum. 1997;40:1725.
   PubMed Web of Science ®Google Scholar
• Katsumata Y, Harigai M, Kawaguchi Y, Fukasawa C, Soejima M, Takagi K, et al. Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin. J Rheumatol. 2007;34:2010–7.
   PubMed Web of Science ®Google Scholar
• Katsumata Y, Harigai M, Kawaguchi Y, Fukasawa C, Soejima M, Kanno T, et al. Diagnostic reliability of magnetic resonance imaging for central nervous system syndromes in systemic lupus erythematosus: a prospective cohort study. BMC Musculoskelet Disord. 2010;11:13.
   PubMed Web of Science ®Google Scholar
• Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–24.
   PubMed Web of Science ®Google Scholar
• Subcommittee for Scleroderma Criteria of the American Rheu-matism Association Diagnostic and Therapeutic Criteria Com-mittee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Thera-peutic Criteria Committee. Arthritis Rheum. 1980;23:581–90.
   Google Scholar
• Vitali C, Bombardieri S, Moutsopoulos HM, Coll J, Gerli R, Hatron PY, et al. Assessment of the European classification criteria for Sjogren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjogren's Syndrome. Ann Rheum Dis. 1996;55:116–21.
   Google Scholar
• Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol. 2005;58:840–6.
   PubMed Web of Science ®Google Scholar
• Katsumata Y, Ridgway WM, Oriss T, Gu X, Chin D, Wu Y, et al. Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation. J Autoimmun. 2007;29:174–86.
   PubMed Web of Science ®Google Scholar
• Murakami A, Kojima K, Ohya K, Imamura K, Takasaki Y. A new conformational epitope generated by the binding of recom-binant 70-kd protein and Ul RNA to anti-U1 RNP autoantibodies in sera from patients with mixed connective tissue disease. Arthritis Rheum. 2002;46: 3273–82.
   Google Scholar
• Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Samma-ritano LR, et al. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005;353:2550–8.
   Google Scholar
• Luyckx A, Westhovens R, Oris E, Papisch W, Bossuyt X. Clin-ical relevance of measurement of antibodies to individual snUl - RNP proteins. Clin Chem. 2005;51:1888–90.
   Google Scholar
• Koren E, Reichlin MW, Koscec M, Fugate RD, Reichlin M. Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells. J Clin Invest. 1992;89:1236–41.
   Google Scholar
• Okawa-Takatsuji M, Aotsuka S, Uwatoko S, Sumiya M, Yoko-hari R. Enhanced synthesis of cytokines by peripheral blood monocytes cultured in the presence of autoantibodies against Ul-ribonucleoprotein and/or negatively charged molecules: implication in the pathogenesis of pulmonary hypertension in mixed connective tissue disease (MCTD). Clin Exp Immunol. 1994;98:427–33.
   Google Scholar
• Okawa-Takatsuji M, Aotsuka S, Fujinami M, Uwatoko S, Kinoshita M, Sumiya M. Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against Ul-ribonucleoprotein. Clin Exp Immunol. 1999;116: 174–80.
   Google Scholar
• Okawa-Takatsuji M, Aotsuka S, Uwatoko S, Takaono M, Iwasaki K, Kinoshita M, et al. Endothelial cell-binding activity of anti-Ul -ribonucleoprotein antibodies in patients with connective tis-sue diseases. Clin Exp Immunol. 2001;126:345–54.
   Google Scholar
• Santer DM, Yoshio T, Minota S, Moller T, Elkon KB. Potent induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus. J Immunol. 2009;182:1192–201.
   Google Scholar